NO20080594L - Heteroaryl-substituerte diazatricykloalkaner, fremgangsmater for fremstilling og anvendelse derav - Google Patents

Heteroaryl-substituerte diazatricykloalkaner, fremgangsmater for fremstilling og anvendelse derav

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Publication number
NO20080594L
NO20080594L NO20080594A NO20080594A NO20080594L NO 20080594 L NO20080594 L NO 20080594L NO 20080594 A NO20080594 A NO 20080594A NO 20080594 A NO20080594 A NO 20080594A NO 20080594 L NO20080594 L NO 20080594L
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NO
Norway
Prior art keywords
compounds
methods
substituted
nachr
activity
Prior art date
Application number
NO20080594A
Other languages
English (en)
Inventor
Anatoly A Mazurov
Lan Miao
Jozef Klucik
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Targacept Inc
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Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of NO20080594L publication Critical patent/NO20080594L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår amid- og urinstoff-derivater av heteroaryl-substituerte diazatricykloalkaner med formel (I) med definisjonene angitt i beskrivelsen, farmasøytiske preparater omfattende forbindelsene, metoder for fremstilling av forbindelsene og metoder for behandling ved anvendelse av forbindelsene. Mer spesifikt involverer metodene for behandling modulering av aktiviteten til a7 nAChR undertype ved administrering av én eller flere av forbindelsene for å behandle eller forhindre lidelser mediert av a7 nAChR undertype. Diazatricykloalkaner består typisk av et 1-azabicyklooktan kondensert til en pyrrolidin-ring. Substituent heteroarylgrupper er 5- eller 6-leddede heteroaromatiske ringgrupper, så som 3-pyridinyl- og 5-pyrimidinylgrupper, som er tilknyttet direkte til diazatricykloalkanet. Det sekundære nitrogen i pyrrolidingruppen er substituert med en arylkarbonyl- (amidtype derivat) eller arylaminokarbonyl- (N-arylkarbamoyl) (urinstoff-type derivat) gruppe. Forbindelsene er fordelaktige for terapeutiske anvendelser som krever selektiv interaksjon ved visse nAChR undertyper. Dvs. forbindelsene modulerer aktiviteten til visse nAChR undertyper, spesielt a7 nAChR undertype og har ikke merkbar aktivitet mot muskarine reseptorer. Radioaktivt merkede versjoner av forbindelsene kan anvendes for diagnostiske metoder. (I)
NO20080594A 2005-08-22 2008-02-01 Heteroaryl-substituerte diazatricykloalkaner, fremgangsmater for fremstilling og anvendelse derav NO20080594L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71013005P 2005-08-22 2005-08-22
PCT/US2006/032685 WO2007024814A1 (en) 2005-08-22 2006-08-21 HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF

Publications (1)

Publication Number Publication Date
NO20080594L true NO20080594L (no) 2008-05-16

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Country Status (17)

Country Link
US (2) US7732607B2 (no)
EP (1) EP1917265B1 (no)
JP (1) JP2009506037A (no)
KR (1) KR20080035649A (no)
CN (1) CN101248073A (no)
AT (1) ATE482959T1 (no)
AU (1) AU2006283453A1 (no)
BR (1) BRPI0614874A2 (no)
CA (1) CA2618700A1 (no)
DE (1) DE602006017235D1 (no)
EA (1) EA014738B1 (no)
IL (1) IL189204A0 (no)
MX (1) MX2008002467A (no)
NO (1) NO20080594L (no)
NZ (1) NZ565628A (no)
WO (1) WO2007024814A1 (no)
ZA (1) ZA200801242B (no)

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US20100179186A1 (en) * 2008-10-10 2010-07-15 University Of Kentucky Research Foundation USE OF A NOVEL ALPHA-7 nAChR ANTAGONIST TO SUPPRESS PATHOGENIC SIGNAL TRANSDUCTION IN CANCER AND AIDS
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Also Published As

Publication number Publication date
HK1115594A1 (en) 2008-12-05
DE602006017235D1 (de) 2010-11-11
CA2618700A1 (en) 2007-03-01
CN101248073A (zh) 2008-08-20
NZ565628A (en) 2011-03-31
JP2009506037A (ja) 2009-02-12
WO2007024814A1 (en) 2007-03-01
EP1917265A1 (en) 2008-05-07
IL189204A0 (en) 2009-08-03
EA014738B1 (ru) 2011-02-28
EA200800656A1 (ru) 2008-08-29
EP1917265B1 (en) 2010-09-29
US20100197720A1 (en) 2010-08-05
KR20080035649A (ko) 2008-04-23
AU2006283453A1 (en) 2007-03-01
MX2008002467A (es) 2008-04-07
US7732607B2 (en) 2010-06-08
BRPI0614874A2 (pt) 2011-04-19
ZA200801242B (en) 2009-02-25
ATE482959T1 (de) 2010-10-15
US20070197579A1 (en) 2007-08-23

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