ATE483698T1 - 5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel - Google Patents

5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel

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Publication number
ATE483698T1
ATE483698T1 AT04819591T AT04819591T ATE483698T1 AT E483698 T1 ATE483698 T1 AT E483698T1 AT 04819591 T AT04819591 T AT 04819591T AT 04819591 T AT04819591 T AT 04819591T AT E483698 T1 ATE483698 T1 AT E483698T1
Authority
AT
Austria
Prior art keywords
yliden
thiazolidine
benz
derivatives
immune system
Prior art date
Application number
AT04819591T
Other languages
English (en)
Inventor
Martin Bolli
Michael Scherz
Claus Mueller
Boris Mathys
Christoph Binkert
Oliver Nayler
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34639216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE483698(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE483698T1 publication Critical patent/ATE483698T1/de

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D277/38—Nitrogen atoms
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Rheumatology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
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  • Neurosurgery (AREA)
  • Endocrinology (AREA)
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  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
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AT04819591T 2003-11-21 2004-11-16 5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel ATE483698T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0313072 2003-11-21
PCT/EP2004/012953 WO2005054215A1 (en) 2003-11-21 2004-11-16 5-(benz- (z) -ylidene) -thiazolidin-4-one derivatives as immunosuppressant agents

Publications (1)

Publication Number Publication Date
ATE483698T1 true ATE483698T1 (de) 2010-10-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT04819591T ATE483698T1 (de) 2003-11-21 2004-11-16 5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel

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Country Link
US (8) USRE43728E1 (de)
EP (2) EP1689726B1 (de)
JP (2) JP4061332B2 (de)
KR (1) KR100783835B1 (de)
CN (1) CN100567275C (de)
AR (1) AR047128A1 (de)
AT (1) ATE483698T1 (de)
AU (1) AU2004295047B2 (de)
BR (1) BRPI0416752B8 (de)
CA (1) CA2545582C (de)
CY (1) CY1111087T1 (de)
DE (1) DE602004029493D1 (de)
DK (1) DK1689726T3 (de)
ES (1) ES2352555T3 (de)
HR (1) HRP20100714T1 (de)
IL (1) IL175758A (de)
MY (1) MY145074A (de)
NO (1) NO336734B1 (de)
NZ (1) NZ547962A (de)
PL (1) PL1689726T3 (de)
PT (1) PT1689726E (de)
RU (1) RU2379299C2 (de)
SI (1) SI1689726T1 (de)
TW (1) TWI323659B (de)
WO (1) WO2005054215A1 (de)
ZA (1) ZA200605077B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43728E1 (en) 2003-11-21 2012-10-09 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
EP1718642A4 (de) * 2004-02-25 2010-11-24 Glaxosmithkline Llc Neue chemische verbindungen
MX2007001661A (es) 2004-08-13 2007-04-23 Praecis Pharm Inc Metodos y composiciones para modular la actividad del receptor de esfingosina -1 fosfato (sip).
WO2007059195A1 (en) * 2005-11-14 2007-05-24 University Of Southern California Integrin-binding small molecules
JP4182986B2 (ja) * 2006-04-19 2008-11-19 トヨタ自動車株式会社 半導体装置とその製造方法
TWI460166B (zh) * 2006-11-23 2014-11-11 Actelion Pharmaceuticals Ltd 製備２-亞胺基-四氫噻唑-４-酮衍生物之新穎方法
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
PL2278960T5 (pl) * 2008-03-17 2020-06-29 Actelion Pharmaceuticals Ltd. Schemat dawkowania dla selektywnego agonisty receptora sip1
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
JP2013533286A (ja) * 2010-07-30 2013-08-22 セントルイス ユニバーシティ 疼痛を治療する方法
SMT202000298T1 (it) * 2012-08-17 2020-07-08 Actelion Pharmaceuticals Ltd Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
WO2014175287A1 (ja) 2013-04-26 2014-10-30 国立大学法人 京都大学 脳動脈瘤の形成および／または増大の抑制若しくは縮小用医薬組成物
EP2862574A1 (de) 2013-10-15 2015-04-22 Sanofi {4-[5-(3-chlorophenoxy)-oxazolo[5,4 d]pyrimidin-2-yl]-2,6-dimethylphenoxy}essigsäure zur Verwendung bei der Prävention oder Behandlung von akutem Nierenversagen
PL3148990T3 (pl) * 2014-05-28 2022-05-30 Universität Bern Związki tiazolidynonu i ich zastosowanie w leczeniu zaburzeń psychiatrycznych neurologicznych i stanów zapalnych, w szczególności stanów zapalnych układu nerwowego
EP2952188A1 (de) * 2014-06-03 2015-12-09 Universität Bern Thiazolidinone als zelluläre Anandamidaufnahmehemmer und ihre Verwendung bei der Behandlung von psychiatrischen oder neurologischen Erkrankungen und Entzündungen, insbesondere Nervenentzündungen
EP3148541B1 (de) * 2014-05-28 2020-09-02 Universität Bern Thiazolidinone als zelluläre anandamidaufnahmehemmer und ihre verwendung bei der behandlung von psychiatrischen oder neurologischen erkrankungen und entzündungen, insbesondere nervenentzündungen
KR20200013086A (ko) 2014-12-11 2020-02-05 액테리온 파마슈티칼 리미티드 선택적 s1p1 수용체 효능제에 대한 투약 섭생
MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
US10111841B2 (en) 2015-06-19 2018-10-30 University Of South Florida Stabilization of alcohol intoxication-induced cardiovascular instability
JP6691218B2 (ja) * 2015-12-25 2020-04-28 クリスタル ファーマテック カンパニー、リミテッドＣｒｙｓｔａｌ Ｐｈａｒｍａｔｅｃｈ Ｃｏ．， Ｌｔｄ． 選択的なｓ１ｐ１受容体アゴニストの新規な結晶形及びその製造方法
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
EP3684358A4 (de) 2017-09-19 2021-01-13 Teva Pharmaceuticals International GmbH Neue kristalline polymorphe form von ponesimod
TWI647229B (zh) * 2017-11-14 2019-01-11 國立暨南國際大學 Method for synthesizing 3,4-hydroisoquinoline thiazolidine
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
JP7749552B2 (ja) 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤
EP4101445B1 (de) 2020-02-06 2025-04-30 Mitsubishi Tanabe Pharma Corporation Amiselimod zur verwendung bei der behandlung von myalgischer enzephalomyelitis/chronischem müdigkeitssyndrom
EP4387960A1 (de) 2021-08-17 2024-06-26 Teva Czech Industries s.r.o Polymorphe von ponesimod
EP4212156A1 (de) 2022-01-13 2023-07-19 Abivax Kombination von 8-chlor-n-(4-trifluormethoxy)phenyl)chinolin-2-amin und dessen derivaten mit einem s1p-rezeptormodulator
WO2023152691A1 (en) * 2022-02-10 2023-08-17 Metrochem Api Pvt Ltd Process for the preparation of ponesimod and its intermediates thereof
WO2025083549A1 (en) 2023-10-16 2025-04-24 Sun Pharma Advanced Research Company Limited Methods and combinations of inhibitors of il-23 pathway and modulators of s1p signaling pathway for the treatment of autoimmune disorders

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077402A (en) 1954-12-06 1963-02-12 Polaroid Corp Photographic color processes, products, and compositions
NL270002A (de) 1960-10-08
OA03835A (fr) 1970-07-17 1971-12-24 Rhone Poulenc Sa Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent.
PT97507B (pt) 1990-04-27 1998-08-31 Orion Yhtymae Oy Processo para apreparacao de novos derivados de catecol farmacologicamente activos
TW221689B (de) 1991-08-27 1994-03-11 Otsuka Pharma Co Ltd
EP0638075B1 (de) 1993-02-26 2002-01-16 Otsuka Pharmaceutical Co., Ltd. Thiazole oder imidazole derivate als maillard reaktion inhibitoren
KR960022486A (ko) * 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
WO2001036402A1 (en) 1998-07-14 2001-05-25 Fujimoto Brothers Co., Ltd. Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives
US6353006B1 (en) 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
CN1247553C (zh) 1999-09-14 2006-03-29 盐野义制药株式会社 2－亚氨基－1,3－噻嗪衍生物
US20050019825A9 (en) * 2002-03-15 2005-01-27 Qing Dong Common ligand mimics: pseudothiohydantoins
JP4782564B2 (ja) 2002-07-10 2011-09-28 メルク セローノ ソシエテ アノニム アゾリジノン−ビニル縮合−ベンゼン誘導体
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
AU2003264038A1 (en) 2002-08-12 2004-02-25 Bristol-Myers Squibb Company Combination pharmaceutical agents as inhibitors of hcv replication
CN100579978C (zh) 2002-11-22 2010-01-13 史密丝克莱恩比彻姆公司 化合物
US20040167192A1 (en) * 2003-01-16 2004-08-26 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
USRE43728E1 (en) 2003-11-21 2012-10-09 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
EP1718642A4 (de) 2004-02-25 2010-11-24 Glaxosmithkline Llc Neue chemische verbindungen
WO2006094233A1 (en) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N,n'-dicyclic isothiourea sirtuin modulators
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
TWI460166B (zh) 2006-11-23 2014-11-11 Actelion Pharmaceuticals Ltd 製備２-亞胺基-四氫噻唑-４-酮衍生物之新穎方法
PL2278960T5 (pl) 2008-03-17 2020-06-29 Actelion Pharmaceuticals Ltd. Schemat dawkowania dla selektywnego agonisty receptora sip1
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms

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