ATE445610T1 - Neue, sich als antiproliferative mittel eignende benzimidazolderivate - Google Patents

Neue, sich als antiproliferative mittel eignende benzimidazolderivate

Info

Publication number
ATE445610T1
ATE445610T1 AT03791110T AT03791110T ATE445610T1 AT E445610 T1 ATE445610 T1 AT E445610T1 AT 03791110 T AT03791110 T AT 03791110T AT 03791110 T AT03791110 T AT 03791110T AT E445610 T1 ATE445610 T1 AT E445610T1
Authority
AT
Austria
Prior art keywords
benzimidazole derivatives
antiproliferative agents
derivatives suitable
new benzimidazole
new
Prior art date
Application number
AT03791110T
Other languages
English (en)
Inventor
John KATH
Joseph Lyssikatos
Huifen Wang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE445610T1 publication Critical patent/ATE445610T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03791110T 2002-08-28 2003-08-14 Neue, sich als antiproliferative mittel eignende benzimidazolderivate ATE445610T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40652402P 2002-08-28 2002-08-28
US41704702P 2002-10-08 2002-10-08
PCT/IB2003/003634 WO2004020431A2 (en) 2002-08-28 2003-08-14 Novel benzoimidazole derivatives useful as antiproliferative agents

Publications (1)

Publication Number Publication Date
ATE445610T1 true ATE445610T1 (de) 2009-10-15

Family

ID=31981411

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03791110T ATE445610T1 (de) 2002-08-28 2003-08-14 Neue, sich als antiproliferative mittel eignende benzimidazolderivate

Country Status (40)

Country Link
US (1) US7071337B2 (de)
EP (1) EP1594858B1 (de)
JP (1) JP4551771B2 (de)
KR (2) KR20070086768A (de)
CN (1) CN1319966C (de)
AP (1) AP2005003237A0 (de)
AR (1) AR041055A1 (de)
AT (1) ATE445610T1 (de)
AU (1) AU2003250499B2 (de)
BR (1) BRPI0313942C1 (de)
CA (1) CA2495577C (de)
CR (1) CR7698A (de)
CU (1) CU23413B7 (de)
CY (1) CY1110580T1 (de)
DE (1) DE60329715D1 (de)
DK (1) DK1594858T3 (de)
DO (1) DOP2003000694A (de)
EA (1) EA008448B1 (de)
EC (1) ECSP055633A (de)
ES (1) ES2333219T3 (de)
GE (1) GEP20064005B (de)
HN (1) HN2003000257A (de)
HR (1) HRP20050191B1 (de)
IL (1) IL166832A (de)
IS (1) IS2738B (de)
MA (1) MA27389A1 (de)
MX (1) MXPA05001256A (de)
MY (1) MY139357A (de)
NO (1) NO20051303L (de)
NZ (1) NZ538427A (de)
OA (1) OA12916A (de)
PA (1) PA8580301A1 (de)
PE (1) PE20050131A1 (de)
PL (1) PL377678A1 (de)
PT (1) PT1594858E (de)
RS (1) RS20050180A (de)
SI (1) SI1594858T1 (de)
TW (1) TW200407131A (de)
UY (1) UY27952A1 (de)
WO (1) WO2004020431A2 (de)

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BRPI0509580A (pt) * 2004-03-30 2007-11-27 Pfizer Prod Inc combinações de inibidores de transdução de sinal
GB0411421D0 (en) * 2004-05-21 2004-06-23 Glaxo Group Ltd Novel compounds
CA2582479C (en) * 2004-10-07 2011-07-12 Pfizer Products Inc. Benzoimidazole derivatives useful as antiproliferative agents
EP1877444A2 (de) 2005-04-26 2008-01-16 Pfizer, Inc. P-cadherin-antikörper
SI2447283T1 (sl) 2005-09-07 2015-12-31 Amgen Fremont Inc. Človeška monoklonska protitelesa proti aktivin receptorski kinazi-1 (ALK-1)
EA200802058A1 (ru) 2006-05-09 2009-06-30 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и их фармацевтические композиции
UA101611C2 (ru) 2007-04-03 2013-04-25 Аррей Байофарма Инк. СОЕДИНЕНИЯ ИМИДАЗО[1,2-а]ПИРИДИНА КАК ИНГИБИТОРЫ ТИРОЗИНКИНАЗЫ РЕЦЕПТОРОВ
SI2300455T1 (sl) 2008-05-21 2017-12-29 Incyte Holdings Corporation Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo
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US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
JP6039559B2 (ja) 2010-09-02 2016-12-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｌｐａ受容体アンタゴニストとしてのピラゾロピリジノン誘導体
GB201103578D0 (en) 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
JP6407504B2 (ja) * 2012-09-21 2018-10-17 アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法
US10835525B2 (en) 2012-09-26 2020-11-17 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
US11642340B2 (en) 2012-09-26 2023-05-09 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
TWI599356B (zh) 2012-09-26 2017-09-21 安羅格製藥有限責任公司 抑制突變型ｃ－ｋｉｔ的方法
BR112015016282A2 (en) 2013-01-07 2017-07-11 Arog Pharmaceuticals, Inc. crenolanib for treatment of mutated flt3 proliferative disorders
US10463658B2 (en) 2013-10-25 2019-11-05 Videra Pharmaceuticals, Llc Method of inhibiting FLT3 kinase
PL3212629T3 (pl) * 2014-10-31 2019-05-31 Genoscience Pharma Sas Podstawione 2,4-diamino-chinoliny jako nowe środki przeciwnowotworowe
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
DK3452465T3 (da) 2016-05-04 2021-02-08 Genoscience Pharma Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme
US12534764B2 (en) 2016-11-02 2026-01-27 Arog Pharmaceuticals, Inc. Crenolanib for treating FLT3 mutated proliferative disorders associated mutations
US12662706B2 (en) 2016-11-02 2026-06-23 Arog Pharmaceuticals, Inc. Crenolanib for treating FLT3 mutated proliferative disorders associated mutations
KR20180074792A (ko) 2016-11-02 2018-07-03 아로그 파마슈티칼스, 인코퍼레이티드 돌연변이 연관된 flt3 돌연변이된 증식성 장애를 치료하기 위한 크레노라닙
CN107382983B (zh) * 2017-08-24 2020-08-07 扬州市三药制药有限公司 一种治疗白血病药物的合成方法
CN107382984B (zh) * 2017-08-24 2020-07-10 扬州市三药制药有限公司 一种治疗白血病药物的制备方法
CN110840893A (zh) 2018-12-13 2020-02-28 安罗格制药有限责任公司 含克莱拉尼的药物组合物及其用途
US11471451B2 (en) 2019-08-19 2022-10-18 Arog Pharmaceuticals, Inc. Uses of crenolanib
CN117447376B (zh) * 2019-12-09 2026-06-09 苏州恩华生物医药科技有限公司 连双环结构sigma-1受体抑制剂
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
WO2022019998A1 (en) 2020-07-20 2022-01-27 Arog Pharmaceuticals, Inc. Crystal forms of crenolanib and methods of use thereof
AU2021320860A1 (en) * 2020-08-05 2023-02-23 The General Hospital Corporation Salt inducible kinase inhibitors
US11524006B2 (en) 2020-09-17 2022-12-13 Arog Pharmaceuticals, Inc. Crenolanib for treating TRK kinase associated proliferative disorders
WO2022090547A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. Production of carotenoids by fermentation
US11969420B2 (en) 2020-10-30 2024-04-30 Arog Pharmaceuticals, Inc. Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders
CN113683594B (zh) * 2021-09-07 2022-12-27 曲靖师范学院 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用
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Also Published As

Publication number Publication date
IS7660A (is) 2005-01-20
DOP2003000694A (es) 2004-02-29
JP4551771B2 (ja) 2010-09-29
OA12916A (en) 2006-10-13
IS2738B (is) 2011-06-15
EA008448B1 (ru) 2007-06-29
CA2495577C (en) 2010-06-15
MA27389A1 (fr) 2005-06-01
ES2333219T3 (es) 2010-02-18
IL166832A (en) 2011-03-31
CR7698A (es) 2007-11-23
RS20050180A (sr) 2007-08-03
NO20051303L (no) 2005-05-18
HRP20050191A9 (hr) 2013-11-22
EA200500174A1 (ru) 2005-08-25
EP1594858B1 (de) 2009-10-14
BR0313942A (pt) 2005-07-12
AR041055A1 (es) 2005-04-27
JP2006501309A (ja) 2006-01-12
BRPI0313942B8 (pt) 2020-08-04
HRP20050191A2 (en) 2005-10-31
CN1678604A (zh) 2005-10-05
WO2004020431A3 (en) 2004-05-13
DK1594858T3 (da) 2009-12-14
PE20050131A1 (es) 2005-03-21
AU2003250499B2 (en) 2009-04-23
KR20070086768A (ko) 2007-08-27
BRPI0313942B1 (pt) 2019-06-04
PL377678A1 (pl) 2006-02-06
CY1110580T1 (el) 2015-04-29
HN2003000257A (es) 2004-12-01
UY27952A1 (es) 2004-03-31
MY139357A (en) 2009-09-30
CA2495577A1 (en) 2004-03-11
WO2004020431A2 (en) 2004-03-11
PT1594858E (pt) 2009-12-14
MXPA05001256A (es) 2005-06-08
US7071337B2 (en) 2006-07-04
CU23413B7 (es) 2009-09-08
HK1078571A1 (en) 2006-03-17
SI1594858T1 (sl) 2010-01-29
CN1319966C (zh) 2007-06-06
GEP20064005B (en) 2006-12-25
AU2003250499A1 (en) 2004-03-19
US20050124599A1 (en) 2005-06-09
DE60329715D1 (de) 2009-11-26
KR20050036984A (ko) 2005-04-20
NZ538427A (en) 2007-04-27
TW200407131A (en) 2004-05-16
HRP20050191B1 (hr) 2013-12-20
PA8580301A1 (es) 2005-05-24
EP1594858A2 (de) 2005-11-16
KR100816166B1 (ko) 2008-03-21
BRPI0313942C1 (pt) 2021-05-25
ECSP055633A (es) 2005-04-18
AP2005003237A0 (en) 2005-03-31

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