ATE485273T1 - Verfahren zur optischen auftrennung von amlodipin - Google Patents
Verfahren zur optischen auftrennung von amlodipinInfo
- Publication number
- ATE485273T1 ATE485273T1 AT05821317T AT05821317T ATE485273T1 AT E485273 T1 ATE485273 T1 AT E485273T1 AT 05821317 T AT05821317 T AT 05821317T AT 05821317 T AT05821317 T AT 05821317T AT E485273 T1 ATE485273 T1 AT E485273T1
- Authority
- AT
- Austria
- Prior art keywords
- amlodipine
- optically active
- optical separation
- amlodipines
- obtaining
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000528 amlodipine Drugs 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
- 239000002904 solvent Substances 0.000 abstract 2
- HTIQEAQVCYTUBX-KRWDZBQOSA-N (S)-amlodipine Chemical class CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-KRWDZBQOSA-N 0.000 abstract 1
- -1 (S)-amlodipine dibenzoyl tartrate salt Chemical class 0.000 abstract 1
- 239000012069 chiral reagent Substances 0.000 abstract 1
- 229950008554 levamlodipine Drugs 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040100613A KR101152608B1 (ko) | 2004-12-02 | 2004-12-02 | (ｒ,ｓ)-암로디핀으로부터 암로디핀 이성질체의 분리방법 |
| KR1020040105612A KR100760014B1 (ko) | 2004-12-14 | 2004-12-14 | 암로디핀의 광학 분리방법 |
| PCT/KR2005/004101 WO2006059886A1 (en) | 2004-12-02 | 2005-12-02 | Optical resolution method of amlodipine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE485273T1 true ATE485273T1 (de) | 2010-11-15 |
Family
ID=36565300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05821317T ATE485273T1 (de) | 2004-12-02 | 2005-12-02 | Verfahren zur optischen auftrennung von amlodipin |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7772400B2 (de) |
| EP (1) | EP1831166B1 (de) |
| JP (1) | JP5124281B2 (de) |
| AT (1) | ATE485273T1 (de) |
| AU (1) | AU2005310406B2 (de) |
| BR (1) | BRPI0519093A2 (de) |
| CA (1) | CA2589099C (de) |
| DE (1) | DE602005024303D1 (de) |
| MX (1) | MX2007006663A (de) |
| RU (1) | RU2394026C2 (de) |
| WO (1) | WO2006059886A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101235116B1 (ko) * | 2005-10-17 | 2013-02-20 | 에스케이케미칼주식회사 | 광학활성 암로디핀 겐티세이트 염의 제조방법 |
| KR100828883B1 (ko) * | 2006-10-27 | 2008-05-09 | 씨제이제일제당 (주) | 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법 |
| KR100868160B1 (ko) * | 2007-02-14 | 2008-11-12 | 한미약품 주식회사 | Ｓ-(-)-암로디핀 또는 이의 염의 제조방법 및 이에사용되는 중간체 |
| WO2017125351A1 (en) * | 2016-01-21 | 2017-07-27 | Laboratorios Lesvi Sl | Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole |
| EP3960158B1 (de) | 2016-10-07 | 2025-05-21 | Silvergate Pharmaceuticals, Inc. | Amlodipinformulierungen |
| WO2019200143A1 (en) | 2018-04-11 | 2019-10-17 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
| EP3560922A1 (de) * | 2018-04-24 | 2019-10-30 | Bayer Aktiengesellschaft | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester |
| CN121889375A (zh) * | 2023-09-12 | 2026-04-17 | 海思科医药集团股份有限公司 | 一种制备(R)-1,4-二氯-5-(甲基-d3)-6,7-二氢-5H-环戊[d]哒嗪的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804630D0 (en) | 1988-02-27 | 1988-03-30 | Pfizer Ltd | Preparation of r-& s-amlodipine |
| GB9405833D0 (en) * | 1994-03-24 | 1994-05-11 | Pfizer Ltd | Separation of the enantiomers of amlodipine |
| US5621140A (en) * | 1994-12-22 | 1997-04-15 | Syntex (U.S.A.) Inc. | Resolution of ibuprofen |
| CN1100038C (zh) | 2000-02-21 | 2003-01-29 | 张喜田 | 氨氯地平对映体的拆分 |
| EP1448527A1 (de) * | 2001-10-24 | 2004-08-25 | Sepracor, Inc. | Verfahren zur spaltung eines amylodipinracemats |
| US20030176706A1 (en) | 2002-03-18 | 2003-09-18 | Joshi Rohini Ramesh | Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate] |
| KR100515294B1 (ko) * | 2002-09-11 | 2005-09-15 | 한림제약(주) | 에스-(-)-암로디핀 니코티네이트 결정성 2수화물 |
| CN100420673C (zh) * | 2002-09-11 | 2008-09-24 | 韩林制药株式会社 | S-(-)-氨氯地平烟酸盐及其制备方法 |
| KR100476636B1 (ko) * | 2002-09-11 | 2005-03-17 | 한림제약(주) | 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법 |
| US6846932B1 (en) * | 2003-11-20 | 2005-01-25 | Council Of Scientific And Industrial Research | Process for preparation of chiral amlodipine salts |
| KR101235116B1 (ko) * | 2005-10-17 | 2013-02-20 | 에스케이케미칼주식회사 | 광학활성 암로디핀 겐티세이트 염의 제조방법 |
-
2005
- 2005-12-02 CA CA2589099A patent/CA2589099C/en not_active Expired - Fee Related
- 2005-12-02 AU AU2005310406A patent/AU2005310406B2/en not_active Ceased
- 2005-12-02 AT AT05821317T patent/ATE485273T1/de not_active IP Right Cessation
- 2005-12-02 DE DE602005024303T patent/DE602005024303D1/de not_active Expired - Lifetime
- 2005-12-02 EP EP05821317A patent/EP1831166B1/de not_active Expired - Lifetime
- 2005-12-02 BR BRPI0519093-2A patent/BRPI0519093A2/pt not_active IP Right Cessation
- 2005-12-02 RU RU2007119610/04A patent/RU2394026C2/ru not_active IP Right Cessation
- 2005-12-02 WO PCT/KR2005/004101 patent/WO2006059886A1/en not_active Ceased
- 2005-12-02 US US11/792,281 patent/US7772400B2/en not_active Expired - Fee Related
- 2005-12-02 MX MX2007006663A patent/MX2007006663A/es not_active Application Discontinuation
- 2005-12-02 JP JP2007544270A patent/JP5124281B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008521887A (ja) | 2008-06-26 |
| US20080249314A1 (en) | 2008-10-09 |
| AU2005310406A1 (en) | 2006-06-08 |
| RU2394026C2 (ru) | 2010-07-10 |
| EP1831166A4 (de) | 2009-09-02 |
| RU2007119610A (ru) | 2009-01-20 |
| EP1831166B1 (de) | 2010-10-20 |
| CA2589099C (en) | 2014-03-25 |
| WO2006059886A1 (en) | 2006-06-08 |
| MX2007006663A (es) | 2012-10-05 |
| AU2005310406B2 (en) | 2012-02-02 |
| US7772400B2 (en) | 2010-08-10 |
| CA2589099A1 (en) | 2006-06-08 |
| JP5124281B2 (ja) | 2013-01-23 |
| BRPI0519093A2 (pt) | 2008-12-23 |
| AU2005310406A2 (en) | 2006-06-08 |
| EP1831166A1 (de) | 2007-09-12 |
| DE602005024303D1 (de) | 2010-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |