ATE399154T1 - Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit - Google Patents

Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit

Info

Publication number: ATE399154T1
Authority: AT; Austria
Prior art keywords: amlodipine; enantiomer; producing; optical purity; high optical
Prior art date: 2004-10-20

Application number

AT05792229T

Other languages

English (en)

Inventor

Milind Moreshwar Gharpure

Baburao Manikrao Bhawal

Prasad Vasudeo Ranade

Rajendra Dagadu Deshmukh

Satish Ramanlal Mehta

Original Assignee

Emcure Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-20

Filing date

2005-10-17

Publication date

2008-07-15

2005-10-17 Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399154T1 publication Critical patent/ATE399154T1/de

Links

HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title abstract 2
229960000528 amlodipine Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000003287 optical effect Effects 0.000 title 1
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 7
239000012453 solvate Substances 0.000 abstract 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05792229T 2004-10-20 2005-10-17 Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit ATE399154T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN1123MU2004		2004-10-20

Publications (1)

Publication Number	Publication Date
ATE399154T1 true ATE399154T1 (de)	2008-07-15

Family

ID=35708803

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05792229T ATE399154T1 (de)	2004-10-20	2005-10-17	Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit

Country Status (11)

Country	Link
US (2)	US7858801B2 (de)
EP (1)	EP1802576B1 (de)
JP (1)	JP4932728B2 (de)
KR (1)	KR101130622B1 (de)
AT (1)	ATE399154T1 (de)
BR (1)	BRPI0511095B8 (de)
DE (1)	DE602005007763D1 (de)
ES (1)	ES2307209T3 (de)
PT (1)	PT1802576E (de)
RU (1)	RU2376288C2 (de)
WO (1)	WO2006043148A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0500570A3 (en) *	2005-06-08	2008-03-28	Richter Gedeon Nyrt	Process for the preparation of (s)-(-)-amlodipine
KR100913791B1 (ko) *	2006-07-21	2009-08-26	한미약품 주식회사	(ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
KR101088488B1 (ko)	2006-08-30	2011-11-30	주식회사 씨트리	광학활성을 갖는 암로디핀의 제조방법
KR100828883B1 (ko) *	2006-10-27	2008-05-09	씨제이제일제당 (주)	라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
CN101773500B (zh) *	2010-02-09	2012-05-23	施慧达药业集团(吉林)有限公司	抗高血压的药物组合物
CN101766611B (zh) *	2010-02-09	2011-10-12	施慧达药业集团(吉林)有限公司	一种左旋氨氯地平或其可药用盐和β受体阻滞剂的药物组合物及其应用
KR101313842B1 (ko) *	2010-09-15	2013-10-01	대화제약 주식회사	에스-암로디핀 베실레이트 및 그 수화물의 제조방법
CN111689894B (zh) *	2019-03-13	2023-05-02	鲁南制药集团股份有限公司	一种苯磺酸左旋氨氯地平晶型
CN112110850B (zh) *	2019-06-20	2023-05-02	鲁南制药集团股份有限公司	一种苯磺酸左旋氨氯地平新晶型
CN110882249B (zh)	2019-11-08	2021-04-30	北京吾为尔创科技有限公司	含苯磺酸左氨氯地平水合物的组合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8804630D0 (en)	1988-02-27	1988-03-30	Pfizer Ltd	Preparation of r-& s-amlodipine
WO1993010779A1 (en) *	1991-11-26	1993-06-10	Sepracor, Inc.	Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine
US6057344A (en) *	1991-11-26	2000-05-02	Sepracor, Inc.	Methods for treating hypertension, and angina using optically pure (-) amlodipine
GB9317773D0 (en) *	1993-08-26	1993-10-13	Pfizer Ltd	Therapeutic compound
GB9405833D0 (en) *	1994-03-24	1994-05-11	Pfizer Ltd	Separation of the enantiomers of amlodipine
CN1100038C (zh) *	2000-02-21	2003-01-29	张喜田	氨氯地平对映体的拆分
EP1448527A1 (de) *	2001-10-24	2004-08-25	Sepracor, Inc.	Verfahren zur spaltung eines amylodipinracemats
US20030176706A1 (en) *	2002-03-18	2003-09-18	Joshi Rohini Ramesh	Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate]
EP1348697A1 (de)	2002-03-28	2003-10-01	Council Of Scientific & Industrial Research	Verfahren zur Herstellung von S(-)-amlodipine-L(+)-hemitartrate
KR100476636B1 (ko) *	2002-09-11	2005-03-17	한림제약(주)	엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법
EP1407773A1 (de)	2002-10-08	2004-04-14	Council of Scientific and Industrial Research	Verfahren zur Herstellung von s(-)Amlodipin-Salzen
US6608206B1 (en) *	2002-10-30	2003-08-19	Council Of Scientific & Industrial Research	Process for making S(-) Amlodipine salts
WO2005049571A1 (en) *	2003-11-20	2005-06-02	Council Of Scientific And Industrial Research	Process for preparation of chiral amlodipine salts

2005
- 2005-10-17 AT AT05792229T patent/ATE399154T1/de active
- 2005-10-17 JP JP2007537409A patent/JP4932728B2/ja not_active Expired - Fee Related
- 2005-10-17 ES ES05792229T patent/ES2307209T3/es not_active Expired - Lifetime
- 2005-10-17 KR KR1020067024198A patent/KR101130622B1/ko not_active Expired - Fee Related
- 2005-10-17 DE DE602005007763T patent/DE602005007763D1/de not_active Expired - Lifetime
- 2005-10-17 PT PT05792229T patent/PT1802576E/pt unknown
- 2005-10-17 BR BRPI0511095A patent/BRPI0511095B8/pt not_active IP Right Cessation
- 2005-10-17 RU RU2006138705/04A patent/RU2376288C2/ru active
- 2005-10-17 US US11/574,781 patent/US7858801B2/en not_active Expired - Fee Related
- 2005-10-17 EP EP05792229A patent/EP1802576B1/de not_active Expired - Lifetime
- 2005-10-17 WO PCT/IB2005/003108 patent/WO2006043148A1/en not_active Ceased
2010
- 2010-09-30 US US12/895,303 patent/US8445688B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR101130622B1 (ko)	2012-04-02
WO2006043148A1 (en)	2006-04-27
BRPI0511095A (pt)	2007-12-26
KR20070062946A (ko)	2007-06-18
JP2008517050A (ja)	2008-05-22
US8445688B2 (en)	2013-05-21
RU2376288C2 (ru)	2009-12-20
RU2006138705A (ru)	2008-05-10
BRPI0511095B1 (pt)	2021-01-19
EP1802576B1 (de)	2008-06-25
US20080262239A1 (en)	2008-10-23
JP4932728B2 (ja)	2012-05-16
BRPI0511095B8 (pt)	2021-05-25
PT1802576E (pt)	2008-09-15
US20110021783A1 (en)	2011-01-27
EP1802576A1 (de)	2007-07-04
WO2006043148B1 (en)	2006-06-08
DE602005007763D1 (de)	2008-08-07
ES2307209T3 (es)	2008-11-16
US7858801B2 (en)	2010-12-28

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2008-12-15

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