ATE485298T1 - Pteridinonderivate als inhibitoren von pi3- kinasen - Google Patents

Pteridinonderivate als inhibitoren von pi3- kinasen

Info

Publication number
ATE485298T1
ATE485298T1 AT08708304T AT08708304T ATE485298T1 AT E485298 T1 ATE485298 T1 AT E485298T1 AT 08708304 T AT08708304 T AT 08708304T AT 08708304 T AT08708304 T AT 08708304T AT E485298 T1 ATE485298 T1 AT E485298T1
Authority
AT
Austria
Prior art keywords
kinases
inhibitors
pteridinone derivatives
pteridinone
derivatives
Prior art date
Application number
AT08708304T
Other languages
English (en)
Inventor
Riccardo Giovannini
Sara Frattini
Trixi Brandl
Steffen Breitfelder
Enzo Cereda
Matthias Grauert
Matthias Hoffmann
Anne T Joergensen
Udo Maier
Alexander Pautsch
Monica Quai
Stefan Scheuerer
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of ATE485298T1 publication Critical patent/ATE485298T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08708304T 2007-02-01 2008-01-28 Pteridinonderivate als inhibitoren von pi3- kinasen ATE485298T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101544A EP1953163A1 (de) 2007-02-01 2007-02-01 Pteridinon-Derivate als PI3-Kinases Inhibitoren
PCT/EP2008/050986 WO2008092831A1 (en) 2007-02-01 2008-01-28 Pteridinone derivatives as pi3-kinases inhibitors

Publications (1)

Publication Number Publication Date
ATE485298T1 true ATE485298T1 (de) 2010-11-15

Family

ID=38054568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08708304T ATE485298T1 (de) 2007-02-01 2008-01-28 Pteridinonderivate als inhibitoren von pi3- kinasen

Country Status (11)

Country Link
US (1) US8410100B2 (de)
EP (2) EP1953163A1 (de)
JP (1) JP5484072B2 (de)
AR (1) AR065123A1 (de)
AT (1) ATE485298T1 (de)
CA (1) CA2677168C (de)
CL (1) CL2008000287A1 (de)
DE (1) DE602008003098D1 (de)
ES (1) ES2352443T3 (de)
TW (1) TW200838538A (de)
WO (1) WO2008092831A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5599783B2 (ja) 2008-05-30 2014-10-01 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
WO2013071217A1 (en) 2011-11-10 2013-05-16 OSI Pharmaceuticals, LLC Dihydropteridinones
CN103664845B (zh) * 2013-12-27 2016-02-10 湖南欧亚生物有限公司 一种Plk激酶抑制剂药物中间体7-氨基-2,3-二氢苯并呋喃-4-甲酸的制备方法
US11155556B2 (en) * 2016-04-07 2021-10-26 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
CN110343109B (zh) * 2019-08-21 2021-11-23 郑州大学 一种二氢蝶啶酮-磺酰胺类衍生物及其药学上可接受的盐、其制备方法及其应用
US20240252665A1 (en) * 2021-06-02 2024-08-01 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Chemical coupling linker and use thereof
CN115124473B (zh) * 2022-07-12 2023-11-10 河北科技大学 西咪替丁有关物质b的合成方法
CN117466785B (zh) * 2023-11-02 2026-03-03 韶远科技（上海)有限公司 一种2-卤代-4-(甲基磺酰基)-1-硝基苯的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020027649A (ko) * 1999-09-15 2002-04-13 로즈 암스트롱, 크리스틴 에이. 트러트웨인 카이나제 억제제로서의 프테리딘온
EA007062B1 (ru) * 2001-09-04 2006-06-30 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств
AU2003293310B2 (en) * 2002-09-30 2010-04-01 Bayer Intellectual Property Gmbh Fused azole-pyrimidine derivatives
JP2006510661A (ja) * 2002-12-06 2006-03-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Ｐｉ３ｋの阻害剤としてのベンズオキサジン−３−オン類及びその誘導体
CA2517020C (en) * 2003-02-26 2012-06-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, method for the production and use thereof in the form of drugs
EP1761540B1 (de) * 2004-05-13 2016-09-28 Icos Corporation Chinazolinone als inhibitoren der humanen phosphatidylinosit-3-kinase delta
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
WO2006091737A1 (en) * 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity

Also Published As

Publication number Publication date
WO2008092831A1 (en) 2008-08-07
ES2352443T3 (es) 2011-02-18
JP2010517957A (ja) 2010-05-27
CA2677168A1 (en) 2008-08-07
JP5484072B2 (ja) 2014-05-07
EP2114945A1 (de) 2009-11-11
DE602008003098D1 (de) 2010-12-02
EP1953163A1 (de) 2008-08-06
US8410100B2 (en) 2013-04-02
AR065123A1 (es) 2009-05-20
US20100099680A1 (en) 2010-04-22
TW200838538A (en) 2008-10-01
CL2008000287A1 (es) 2008-05-23
EP2114945B1 (de) 2010-10-20
CA2677168C (en) 2016-09-27

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