ATE485834T1 - Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten - Google Patents

Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten

Info

Publication number
ATE485834T1
ATE485834T1 AT99948154T AT99948154T ATE485834T1 AT E485834 T1 ATE485834 T1 AT E485834T1 AT 99948154 T AT99948154 T AT 99948154T AT 99948154 T AT99948154 T AT 99948154T AT E485834 T1 ATE485834 T1 AT E485834T1
Authority
AT
Austria
Prior art keywords
growth factor
connective tissue
tissue growth
kidney diseases
diagnosing kidney
Prior art date
Application number
AT99948154T
Other languages
English (en)
Inventor
Bruce Riser
Mark Denichilo
Original Assignee
Ford Henry Health System
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ford Henry Health System, Fibrogen Inc filed Critical Ford Henry Health System
Application granted granted Critical
Publication of ATE485834T1 publication Critical patent/ATE485834T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99948154T 1998-09-08 1999-09-08 Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten ATE485834T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9947198P 1998-09-08 1998-09-08
US11285598P 1998-12-16 1998-12-16
PCT/US1999/020601 WO2000013706A1 (en) 1998-09-08 1999-09-08 Methods for detecting, preventing, and treating renal disorders by modulating, regulating, and inhibiting connective tissue growth factor

Publications (1)

Publication Number Publication Date
ATE485834T1 true ATE485834T1 (de) 2010-11-15

Family

ID=26796145

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99948154T ATE485834T1 (de) 1998-09-08 1999-09-08 Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten

Country Status (11)

Country Link
US (3) US20040224360A1 (de)
EP (1) EP1112088B1 (de)
JP (1) JP4863548B2 (de)
KR (1) KR20010085767A (de)
CN (1) CN1326361A (de)
AT (1) ATE485834T1 (de)
AU (1) AU6138799A (de)
CA (1) CA2342280A1 (de)
DE (1) DE69942893D1 (de)
HK (1) HK1038318A1 (de)
WO (1) WO2000013706A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173757B1 (de) * 1999-04-23 2008-08-06 Shiva Biomedical, LLC Diagnostisches verfahren für nierenkrankheiten in menschen
US6933104B1 (en) 1999-04-23 2005-08-23 Shiva Biomedical, Llc Diagnosis and treatment of human kidney diseases
WO2002007747A1 (en) 2000-07-18 2002-01-31 Joslin Diabetes Center, Inc. Methods of modulating fibrosis
ES2545526T3 (es) 2001-02-01 2015-09-11 Sigma-Aldrich Co. Llc Matrices de afinidad mejorada con visibilidad mejorada para aplicaciones de arrastre molecular e inmunoprecipitación
AU2002326939A1 (en) 2001-09-18 2003-04-01 Fibrogen, Inc. Methods of assaying connective tissue growth factor
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
US20060074018A1 (en) * 2002-06-04 2006-04-06 Metabolex Inc Methods of diagnosing & treating diabetes and insulin resistance
JPWO2004033687A1 (ja) * 2002-10-11 2006-02-09 アステラス製薬株式会社 腎不全治療薬をスクリーニングする方法
US7405274B2 (en) 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
WO2005038013A1 (en) 2003-10-07 2005-04-28 Isis Pharmaceuticals, Inc. Artisense oligonucleotides optimized for kidney targeting
US20050191653A1 (en) 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
AU2005212371B2 (en) 2004-02-11 2010-05-13 Fibrogen, Inc. CTGF as target for the therapy of diabetic nephropathy
ZA200607588B (en) * 2004-02-11 2008-05-28 Fibrogen Inc CTGF as target for the therapy of diabetic nephropathy
US7780949B2 (en) * 2005-01-10 2010-08-24 Rosalind Franklin University Of Medicine And Science Regulation of CCN2 by CCN3 and its therapeutic and diagnostic potential in fibrosis, sclerosis and other diseases
MX2007013831A (es) * 2005-05-05 2008-02-05 Fibrogen Inc Marcador de diagnostico para complicaciones vasculares diabeticas.
WO2007096142A2 (en) * 2006-02-22 2007-08-30 Philogen Spa Vascular tumor markers
EP2074429B1 (de) 2006-10-16 2012-04-04 Bayer Pharma Aktiengesellschaft Ctgf als biomarker, therapeutisches und diagnostisches ziel
EP3081648A1 (de) 2008-08-25 2016-10-19 Excaliard Pharmaceuticals, Inc. Gegen den bindegewebe-wachstumsfaktor gerichtete antisense-oligonukleotide und verwendungen davon
US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
EP2448971A1 (de) * 2009-07-02 2012-05-09 Fibrogen, Inc. Verfahren zur behandlung von muskeldystrophie
ES2561437T3 (es) 2010-04-02 2016-02-26 Rosalind Franklin University Of Medicine And Science Péptidos de CCN3 y análogos de los mismos para uso terapéutico
US9114112B2 (en) 2010-04-02 2015-08-25 Rosalind Franklin University Of Medicine And Science CCN3 and CCN3 peptides and analogs thereof for therapeutic uses
SI2670411T1 (sl) 2011-02-02 2019-06-28 Excaliard Pharmaceuticals, Inc. Protismiselne spojine, ki so usmerjene na rastni faktor veznega tkiva (CTGF), za uporabo v postopku zdravljenja keloidov ali hipertrofnih brazgotin
US10028906B2 (en) 2016-03-22 2018-07-24 Rosalind Franklin University Of Medicine And Science Method and kit for treating a solid tumor and associated desmoplasia
CN109402127B (zh) * 2018-09-29 2021-12-10 复旦大学附属眼耳鼻喉科医院 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用
BR112021023669A2 (pt) 2019-06-04 2022-03-29 Jiangsu Hengrui Medicine Co Anticorpo do fator de crescimento de tecido anti-conjuntivo e aplicação do mesmo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
US5408040A (en) 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5753517A (en) * 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
US5928888A (en) 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
WO1999033878A1 (en) * 1997-12-25 1999-07-08 Japan Tobacco Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
AU2005212371B2 (en) * 2004-02-11 2010-05-13 Fibrogen, Inc. CTGF as target for the therapy of diabetic nephropathy

Also Published As

Publication number Publication date
EP1112088B1 (de) 2010-10-27
WO2000013706A1 (en) 2000-03-16
WO2000013706A9 (en) 2000-09-28
US8110367B2 (en) 2012-02-07
KR20010085767A (ko) 2001-09-07
US20050136502A1 (en) 2005-06-23
AU6138799A (en) 2000-03-27
CN1326361A (zh) 2001-12-12
EP1112088A1 (de) 2001-07-04
JP2002524422A (ja) 2002-08-06
CA2342280A1 (en) 2000-03-16
US20090017559A1 (en) 2009-01-15
DE69942893D1 (de) 2010-12-09
HK1038318A1 (zh) 2002-03-15
JP4863548B2 (ja) 2012-01-25
WO2000013706A8 (en) 2000-08-10
US20040224360A1 (en) 2004-11-11

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