ATE485834T1 - Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten - Google Patents

Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten

Info

Publication number
ATE485834T1
ATE485834T1 AT99948154T AT99948154T ATE485834T1 AT E485834 T1 ATE485834 T1 AT E485834T1 AT 99948154 T AT99948154 T AT 99948154T AT 99948154 T AT99948154 T AT 99948154T AT E485834 T1 ATE485834 T1 AT E485834T1
Authority
AT
Austria
Prior art keywords
growth factor
connective tissue
tissue growth
kidney diseases
diagnosing kidney
Prior art date
Application number
AT99948154T
Other languages
English (en)
Inventor
Bruce Riser
Mark Denichilo
Original Assignee
Ford Henry Health System
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ford Henry Health System, Fibrogen Inc filed Critical Ford Henry Health System
Application granted granted Critical
Publication of ATE485834T1 publication Critical patent/ATE485834T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99948154T 1998-09-08 1999-09-08 Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten ATE485834T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9947198P 1998-09-08 1998-09-08
US11285598P 1998-12-16 1998-12-16
PCT/US1999/020601 WO2000013706A1 (en) 1998-09-08 1999-09-08 Methods for detecting, preventing, and treating renal disorders by modulating, regulating, and inhibiting connective tissue growth factor

Publications (1)

Publication Number Publication Date
ATE485834T1 true ATE485834T1 (de) 2010-11-15

Family

ID=26796145

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99948154T ATE485834T1 (de) 1998-09-08 1999-09-08 Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten

Country Status (11)

Country Link
US (3) US20040224360A1 (de)
EP (1) EP1112088B1 (de)
JP (1) JP4863548B2 (de)
KR (1) KR20010085767A (de)
CN (1) CN1326361A (de)
AT (1) ATE485834T1 (de)
AU (1) AU6138799A (de)
CA (1) CA2342280A1 (de)
DE (1) DE69942893D1 (de)
HK (1) HK1038318A1 (de)
WO (1) WO2000013706A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60039756D1 (de) * 1999-04-23 2008-09-18 Shiva Biomedical Llc Diagnostisches verfahren für nierenkrankheiten in menschen
US6933104B1 (en) 1999-04-23 2005-08-23 Shiva Biomedical, Llc Diagnosis and treatment of human kidney diseases
EP1311277A4 (de) * 2000-07-18 2004-08-25 Joslin Diabetes Center Inc Methoden zur fibrose-modulation
US6887377B2 (en) 2001-02-01 2005-05-03 Sigma-Aldrich Co. Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications
US20030113816A1 (en) 2001-09-18 2003-06-19 Weitz Stephen L. Methods of assaying connective tissue growth factor
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
US20060074018A1 (en) * 2002-06-04 2006-04-06 Metabolex Inc Methods of diagnosing & treating diabetes and insulin resistance
CA2487854A1 (en) * 2002-10-11 2004-04-22 Yamanouchi Pharmaceutical Co., Ltd. Method for screening an agent for treating renal failure
US7405274B2 (en) 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
WO2005038013A1 (en) 2003-10-07 2005-04-28 Isis Pharmaceuticals, Inc. Artisense oligonucleotides optimized for kidney targeting
US20050191653A1 (en) 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
CN1929861B (zh) * 2004-02-11 2010-12-29 法布罗根股份有限公司 Ctgf作为糖尿病肾病的治疗靶点
CN101884789A (zh) 2004-02-11 2010-11-17 法布罗根股份有限公司 Ctgf作为糖尿病肾病的治疗靶点
US7780949B2 (en) * 2005-01-10 2010-08-24 Rosalind Franklin University Of Medicine And Science Regulation of CCN2 by CCN3 and its therapeutic and diagnostic potential in fibrosis, sclerosis and other diseases
WO2006122043A2 (en) * 2005-05-05 2006-11-16 Fibrogen, Inc. Diagnostic marker for diabetic vascular complications
EP1987359B1 (de) * 2006-02-22 2015-03-18 Philogen S.p.A. Marker für gefässtumore
ES2383235T3 (es) 2006-10-16 2012-06-19 Bayer Pharma Aktiengesellschaft CTGF como biomarcador , diana terapéutica y diagnóstica
NZ601660A (en) * 2008-08-25 2014-05-30 Excaliard Pharmaceuticals Inc Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
EP2448971A1 (de) * 2009-07-02 2012-05-09 Fibrogen, Inc. Verfahren zur behandlung von muskeldystrophie
US9114112B2 (en) 2010-04-02 2015-08-25 Rosalind Franklin University Of Medicine And Science CCN3 and CCN3 peptides and analogs thereof for therapeutic uses
JP5939584B2 (ja) 2010-04-02 2016-06-22 ロザリンド フランクリン ユニバーシティー オブ メディスン アンド サイエンス 治療用ｃｃｎ３ペプチドおよびそれらの類似体
PT2670411T (pt) 2011-02-02 2019-06-18 Excaliard Pharmaceuticals Inc Compostos anti sentido visando um fator de crescimento do tecido conetivo (ctfg) para utilização num método de tratamento de queloides ou cicatrizes hipertróficas
US10028906B2 (en) 2016-03-22 2018-07-24 Rosalind Franklin University Of Medicine And Science Method and kit for treating a solid tumor and associated desmoplasia
CN109402127B (zh) * 2018-09-29 2021-12-10 复旦大学附属眼耳鼻喉科医院 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用
KR20220016890A (ko) 2019-06-04 2022-02-10 지앙수 헨그루이 메디슨 컴퍼니 리미티드 항-결합조직 성장인자 항체 및 이의 응용

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
US5408040A (en) 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5753517A (en) * 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
US5928888A (en) 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
AU1682699A (en) * 1997-12-25 1999-07-19 Japan Tobacco Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
CN101884789A (zh) * 2004-02-11 2010-11-17 法布罗根股份有限公司 Ctgf作为糖尿病肾病的治疗靶点

Also Published As

Publication number Publication date
WO2000013706A1 (en) 2000-03-16
AU6138799A (en) 2000-03-27
JP4863548B2 (ja) 2012-01-25
HK1038318A1 (zh) 2002-03-15
CA2342280A1 (en) 2000-03-16
US20040224360A1 (en) 2004-11-11
DE69942893D1 (de) 2010-12-09
US20050136502A1 (en) 2005-06-23
KR20010085767A (ko) 2001-09-07
EP1112088B1 (de) 2010-10-27
EP1112088A1 (de) 2001-07-04
JP2002524422A (ja) 2002-08-06
WO2000013706A8 (en) 2000-08-10
US8110367B2 (en) 2012-02-07
WO2000013706A9 (en) 2000-09-28
US20090017559A1 (en) 2009-01-15
CN1326361A (zh) 2001-12-12

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