ATE486850T1 - Synthese von enantiomerenreinen, aminosubstituierten kondensierten bicyclischen ringen - Google Patents
Synthese von enantiomerenreinen, aminosubstituierten kondensierten bicyclischen ringenInfo
- Publication number
- ATE486850T1 ATE486850T1 AT02775823T AT02775823T ATE486850T1 AT E486850 T1 ATE486850 T1 AT E486850T1 AT 02775823 T AT02775823 T AT 02775823T AT 02775823 T AT02775823 T AT 02775823T AT E486850 T1 ATE486850 T1 AT E486850T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- fused bicyclic
- substituted fused
- synthesis
- bicyclic rings
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000011914 asymmetric synthesis Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009935 nitrosation Effects 0.000 abstract 1
- 238000007034 nitrosation reaction Methods 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32320101P | 2001-09-12 | 2001-09-12 | |
| PCT/US2002/029372 WO2003022785A2 (en) | 2001-09-12 | 2002-09-12 | Synthesis of enantiomerically pure amino-substituted fused bicyclic rings |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486850T1 true ATE486850T1 (de) | 2010-11-15 |
Family
ID=23258145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02775823T ATE486850T1 (de) | 2001-09-12 | 2002-09-12 | Synthese von enantiomerenreinen, aminosubstituierten kondensierten bicyclischen ringen |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6825351B2 (de) |
| EP (1) | EP1487795B1 (de) |
| JP (1) | JP4431389B2 (de) |
| KR (1) | KR20040044909A (de) |
| CN (3) | CN101353324A (de) |
| AT (1) | ATE486850T1 (de) |
| BR (1) | BR0212443A (de) |
| CA (1) | CA2456614A1 (de) |
| DE (1) | DE60238218D1 (de) |
| HU (1) | HUP0600777A2 (de) |
| IL (2) | IL160115A0 (de) |
| MX (1) | MXPA04002356A (de) |
| NO (1) | NO20041012L (de) |
| NZ (1) | NZ531482A (de) |
| PL (1) | PL372705A1 (de) |
| RU (1) | RU2308451C2 (de) |
| WO (1) | WO2003022785A2 (de) |
| ZA (1) | ZA200400750B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| WO2006052514A1 (en) * | 2004-11-04 | 2006-05-18 | Merck & Co., Inc. | Asymmetric hydrogenation of enamides |
| US8569280B2 (en) * | 2005-04-25 | 2013-10-29 | Immune Disease Institute | Methods for the treatment of multiple myeloma |
| US7825088B2 (en) * | 2005-04-25 | 2010-11-02 | The Cbr Institute For Biomedical Research, Inc. | Methods for the treatment of multiple myeloma |
| CA2624138A1 (en) * | 2005-09-29 | 2007-04-05 | British Columbia Cancer Agency Branch | Method and composition for increasing the engraftment efficiency of stem cells |
| US20080155015A1 (en) * | 2006-12-20 | 2008-06-26 | Omx Technology Ab | Intelligent information dissemination |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| US20110105798A1 (en) * | 2008-06-27 | 2011-05-05 | O'shea Paul | Synthesis of chiral amines |
| KR20100032496A (ko) * | 2008-09-18 | 2010-03-26 | 주식회사 이큐스팜 | 신규 5-(4-아미노페닐)-이소퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 Ｒａｆ 키나제의 과활성에 의해 유발되는 질환의 예방 또는 치료용 조성물 |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| HRP20210334T1 (hr) | 2009-12-11 | 2021-04-02 | Medregen, Llc | Metode liječenja u kojima se primjenjuju mobilizatori matičnih stanica i imunosupresivna sredstva |
| EP2549992B1 (de) | 2010-03-23 | 2019-08-14 | The Johns Hopkins University | Behandlungsverfahren mithilfe von stammzellenmobilisatoren |
| CN102911996B (zh) * | 2011-10-26 | 2014-04-23 | 苏州同力生物医药有限公司 | 一种左旋吡喹酮的制备方法 |
| FR2993561B1 (fr) * | 2012-07-17 | 2014-10-31 | Servier Lab | Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels |
| EP3030232B1 (de) | 2013-04-29 | 2022-07-06 | Medregen, LLC | Wundheilung durch mobilisierung von autologen stammzellen |
| US9440899B2 (en) | 2014-12-15 | 2016-09-13 | Rohm And Haas Electronic Materials Llc | Purification method |
| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| ES2907489T3 (es) | 2015-12-14 | 2022-04-25 | X4 Pharmaceuticals Inc | Métodos para el tratamiento del cáncer |
| HUE060517T2 (hu) | 2015-12-22 | 2023-03-28 | X4 Pharmaceuticals Inc | Immunhiányos betegség kezelésére szolgáló eljárások |
| WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CA3027500A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| WO2017223229A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| JP7054529B2 (ja) | 2016-06-21 | 2022-04-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| US20190194122A1 (en) * | 2017-12-27 | 2019-06-27 | Apotex Inc. | Processes for the Preparation of Dasotraline and Intermediates Thereof |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| MX2021008824A (es) | 2019-01-23 | 2021-10-13 | Univ Johns Hopkins | Análogos no inmunosupresores de tacrolimus (fk506) y uso de los mismos. |
| US20230022146A1 (en) | 2019-06-17 | 2023-01-26 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| JP2023517956A (ja) | 2020-03-10 | 2023-04-27 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 好中球減少症を処置する方法 |
| CA3205138A1 (en) | 2020-12-17 | 2022-06-23 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| CN115872820B (zh) * | 2021-09-28 | 2024-08-06 | 中国科学院大连化学物理研究所 | 仿生催化不对称氢化合成手性2-官能团化四氢喹啉的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA321A (en) | 1870-03-29 | C.A. Gregory | Improvements on apparatus for filling bottles, vials and other vessels and gauging their contents | |
| DE1207930B (de) * | 1956-02-03 | 1965-12-30 | Basf Ag | Verfahren zur Herstellung von Pyridin- bzw. Tetrahydrochinolinderivaten |
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9200245D0 (en) | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| NZ331875A (en) | 1996-03-22 | 2000-01-28 | Du Pont Pharm Co | Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs |
| GB9726229D0 (en) | 1997-12-12 | 1998-02-11 | Zeneca Ltd | Resolution of chiral amines |
| US6172061B1 (en) | 1997-12-19 | 2001-01-09 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative |
| US6365583B1 (en) | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| AP1654A (en) * | 1999-03-24 | 2006-09-01 | Anormed Inc | Chemokine receptor binding heterocyclic compounds. |
-
2002
- 2002-09-12 PL PL02372705A patent/PL372705A1/xx unknown
- 2002-09-12 DE DE60238218T patent/DE60238218D1/de not_active Expired - Lifetime
- 2002-09-12 NZ NZ531482A patent/NZ531482A/en unknown
- 2002-09-12 EP EP02775823A patent/EP1487795B1/de not_active Expired - Lifetime
- 2002-09-12 JP JP2003526864A patent/JP4431389B2/ja not_active Expired - Lifetime
- 2002-09-12 MX MXPA04002356A patent/MXPA04002356A/es active IP Right Grant
- 2002-09-12 KR KR10-2004-7003699A patent/KR20040044909A/ko not_active Withdrawn
- 2002-09-12 HU HU0600777A patent/HUP0600777A2/hu unknown
- 2002-09-12 CA CA002456614A patent/CA2456614A1/en not_active Abandoned
- 2002-09-12 WO PCT/US2002/029372 patent/WO2003022785A2/en not_active Ceased
- 2002-09-12 RU RU2004110928/04A patent/RU2308451C2/ru not_active IP Right Cessation
- 2002-09-12 CN CNA2008101102755A patent/CN101353324A/zh active Pending
- 2002-09-12 CN CNB02817593XA patent/CN1272322C/zh not_active Expired - Lifetime
- 2002-09-12 US US10/243,434 patent/US6825351B2/en not_active Expired - Lifetime
- 2002-09-12 BR BR0212443-2A patent/BR0212443A/pt not_active IP Right Cessation
- 2002-09-12 CN CNB2006100054539A patent/CN100412062C/zh not_active Expired - Lifetime
- 2002-09-12 IL IL16011502A patent/IL160115A0/xx unknown
- 2002-09-12 AT AT02775823T patent/ATE486850T1/de not_active IP Right Cessation
-
2004
- 2004-01-29 IL IL160115A patent/IL160115A/en unknown
- 2004-01-29 ZA ZA200400750A patent/ZA200400750B/en unknown
- 2004-03-10 NO NO20041012A patent/NO20041012L/no not_active Application Discontinuation
- 2004-10-06 US US10/959,823 patent/US7135570B2/en not_active Expired - Lifetime
-
2006
- 2006-11-14 US US11/598,955 patent/US7452994B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030114679A1 (en) | 2003-06-19 |
| JP2005508316A (ja) | 2005-03-31 |
| US20050080267A1 (en) | 2005-04-14 |
| EP1487795A2 (de) | 2004-12-22 |
| CN1817864A (zh) | 2006-08-16 |
| PL372705A1 (en) | 2005-07-25 |
| NO20041012L (no) | 2004-03-10 |
| EP1487795B1 (de) | 2010-11-03 |
| HUP0600777A2 (en) | 2007-01-29 |
| DE60238218D1 (de) | 2010-12-16 |
| MXPA04002356A (es) | 2004-06-29 |
| HK1074044A1 (en) | 2005-10-28 |
| CN101353324A (zh) | 2009-01-28 |
| CA2456614A1 (en) | 2003-03-20 |
| NZ531482A (en) | 2007-04-27 |
| BR0212443A (pt) | 2005-03-15 |
| RU2004110928A (ru) | 2005-10-10 |
| JP4431389B2 (ja) | 2010-03-10 |
| WO2003022785A3 (en) | 2004-09-30 |
| US7452994B2 (en) | 2008-11-18 |
| EP1487795A4 (de) | 2005-02-09 |
| IL160115A (en) | 2010-12-30 |
| KR20040044909A (ko) | 2004-05-31 |
| US6825351B2 (en) | 2004-11-30 |
| WO2003022785A2 (en) | 2003-03-20 |
| CN100412062C (zh) | 2008-08-20 |
| IL160115A0 (en) | 2004-06-20 |
| CN1608052A (zh) | 2005-04-20 |
| RU2308451C2 (ru) | 2007-10-20 |
| US20070060757A1 (en) | 2007-03-15 |
| US7135570B2 (en) | 2006-11-14 |
| ZA200400750B (en) | 2005-04-06 |
| CN1272322C (zh) | 2006-08-30 |
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