ATE486940T1 - Abgeschwächte salmonella sp12 mutante als antigen-träger. - Google Patents
Abgeschwächte salmonella sp12 mutante als antigen-träger.Info
- Publication number
- ATE486940T1 ATE486940T1 AT08075560T AT08075560T ATE486940T1 AT E486940 T1 ATE486940 T1 AT E486940T1 AT 08075560 T AT08075560 T AT 08075560T AT 08075560 T AT08075560 T AT 08075560T AT E486940 T1 ATE486940 T1 AT E486940T1
- Authority
- AT
- Austria
- Prior art keywords
- cell
- nucleic acid
- acid molecule
- antigen
- carrier
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98116827 | 1998-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486940T1 true ATE486940T1 (de) | 2010-11-15 |
Family
ID=8232583
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99946122T ATE403728T1 (de) | 1998-09-04 | 1999-09-03 | Attenuierte salmonella spi2 mutante als antigen- träger |
| AT08075560T ATE486940T1 (de) | 1998-09-04 | 1999-09-03 | Abgeschwächte salmonella sp12 mutante als antigen-träger. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99946122T ATE403728T1 (de) | 1998-09-04 | 1999-09-03 | Attenuierte salmonella spi2 mutante als antigen- träger |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6936425B1 (de) |
| EP (2) | EP1970449B1 (de) |
| JP (1) | JP2002524077A (de) |
| AT (2) | ATE403728T1 (de) |
| AU (1) | AU5860599A (de) |
| BR (1) | BR9914479A (de) |
| CA (1) | CA2341349C (de) |
| CY (1) | CY1109387T1 (de) |
| DE (2) | DE69942925D1 (de) |
| DK (1) | DK1108034T3 (de) |
| ES (2) | ES2356863T3 (de) |
| PT (1) | PT1108034E (de) |
| WO (1) | WO2000014240A2 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG119177A1 (en) * | 1994-12-09 | 2006-02-28 | Imp College Innovations Ltd | Identification of genes |
| ATE403728T1 (de) | 1998-09-04 | 2008-08-15 | Emergent Product Dev Uk Ltd | Attenuierte salmonella spi2 mutante als antigen- träger |
| AU2003204710B2 (en) * | 1999-05-10 | 2006-08-03 | Microscience Limited | Attenuated microorganisms for the treatment of infection |
| GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
| EP1640013A3 (de) * | 2000-03-17 | 2007-02-21 | Pharmacia & Upjohn Company LLC | Inaktivierte Salmonella Impfstoffe |
| BR0109322A (pt) | 2000-03-17 | 2002-12-10 | Upjohn Co | Materiais e métodos de vacina de salmonella |
| GB0105924D0 (en) * | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| DE60216099D1 (de) * | 2001-05-17 | 2006-12-28 | Creatogen Ag | Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben |
| US8029777B2 (en) | 2004-08-13 | 2011-10-04 | Marshall Barry J | Helicobacter system and uses thereof |
| CA2576280A1 (en) | 2004-08-13 | 2006-02-16 | Barry J. Marshall | Helicobacter pylori-based delivery system |
| RU2296560C2 (ru) * | 2004-08-25 | 2007-04-10 | Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потебителей и благополучия человека (ФГУН ГНЦ ВБ "ВЕКТОР" Роспотребнадзора) | Суппозитории для иммунопрофилактики вирусных инфекций |
| CN1276076C (zh) * | 2004-12-14 | 2006-09-20 | 华东理工大学 | 一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用 |
| US20070134814A1 (en) * | 2005-12-09 | 2007-06-14 | Kajander E O | Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease |
| EP2517723B1 (de) | 2006-09-18 | 2019-11-06 | The Board of Trustees of The University of Arkansas | Zusammensetzungen und Verfahren zur Verstärkung von Immunreaktionen |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| WO2009025888A2 (en) | 2007-05-10 | 2009-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety |
| US20100317084A1 (en) * | 2007-05-10 | 2010-12-16 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens |
| WO2008153772A2 (en) * | 2007-05-25 | 2008-12-18 | Emergent Product Development Gaithersburg Inc. | Chlamydia vaccine comprising htra polypeptides |
| US8465755B2 (en) * | 2007-10-05 | 2013-06-18 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against enteric pathogens |
| BRPI0818736A2 (pt) * | 2007-10-30 | 2017-06-13 | Univ Arkansas | composições e métodos para intensificar imunorrepostas à bactéria flagelada |
| WO2009059298A2 (en) | 2007-11-01 | 2009-05-07 | Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancinc immune responses to eimeria |
| RU2392003C2 (ru) * | 2008-04-02 | 2010-06-20 | ФГОУ ВПО Курская государственная сельскохозяйственная академия им. профессора И.И. Иванова | Способ получения сальмонеллезной вакцины |
| US8703153B2 (en) | 2008-06-16 | 2014-04-22 | Prokarium Ltd. | Salmonella vectored vaccines against Chlamydia and methods of use |
| WO2010017383A1 (en) | 2008-08-06 | 2010-02-11 | Emergent Product Development Uk Limited | Vaccines against clostridium difficile and methods of use |
| WO2010045620A1 (en) | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| US20120064114A1 (en) * | 2008-10-21 | 2012-03-15 | Emergent Product Development United Kingdom | Use of e. coli surface antigen 3 sequences for the export of heterologous antigens |
| JP4575498B2 (ja) * | 2009-02-20 | 2010-11-04 | 株式会社東芝 | 磁気記録媒体の製造方法 |
| US9163219B2 (en) * | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
| WO2010141143A2 (en) * | 2009-04-21 | 2010-12-09 | Vivocure, Inc. | Engineered avirulent bacteria strains and use in medical treatments |
| US8518658B1 (en) * | 2009-04-27 | 2013-08-27 | University Of South Florida | ATP-bioluminescence immunoassay |
| WO2010135563A1 (en) | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
| US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
| CN102811734B (zh) | 2010-01-21 | 2016-02-10 | 阿肯色大学评议会 | 增强免疫应答的疫苗载体和方法 |
| WO2011091291A1 (en) | 2010-01-22 | 2011-07-28 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | BACTERIUM COMPRISING A REGULATED rfaH NUCLEIC ACID |
| US9598697B2 (en) | 2010-05-28 | 2017-03-21 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium to decrease tumor growth |
| CA2800830C (en) | 2010-06-09 | 2020-09-08 | The Board Of Trustees Of The University Of Arkansas | Vaccine and methods to reduce campylobacter infection |
| US8481052B2 (en) | 2011-05-17 | 2013-07-09 | Cj Cheiljedang Corporation | Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same |
| RU2510839C2 (ru) * | 2012-05-03 | 2014-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Вакцина ассоциированная против сальмонеллеза, эшерихиоза и вирусной геморрагической болезни кроликов |
| RU2496518C1 (ru) * | 2012-05-03 | 2013-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Способ изготовления вакцины ассоциированной против сальмонеллеза, эшерихиоза и вирусной геморрагической болезни кроликов |
| US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
| JP6216371B2 (ja) * | 2012-05-23 | 2017-10-18 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ＹｅｒｓｉｎｉａｐｅｓｔｉｓＦ１−Ｖ融合タンパク質を発現するＳａｌｍｏｎｅｌｌａＴｙｐｈｉＴｙ２１ａおよびその使用 |
| WO2014043518A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
| HUE047484T2 (hu) | 2013-02-14 | 2020-04-28 | Univ Arkansas | Készítmények és eljárások eimeria elleni immunválasz fokozására vagy eimeria-fertõzés korlátozására |
| US10376571B2 (en) | 2013-03-15 | 2019-08-13 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
| WO2014144965A1 (en) | 2013-03-15 | 2014-09-18 | Husseiny Elsayed Mohamed I | Attenuated salmonella bacteria and methods of using |
| US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
| US10987432B2 (en) * | 2013-09-05 | 2021-04-27 | The University Of Hong Kong | Therapeutic delivery and expression system, methods and uses thereof |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR20190015712A (ko) | 2016-05-03 | 2019-02-14 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| EP4045672A4 (de) * | 2019-10-18 | 2023-11-22 | University of Virginia Patent Foundation | Zusammensetzungen und verfahren für die erzeugung verbesserter immunantworten und schnelle antikörperproduktion |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| GB202019767D0 (en) | 2020-12-15 | 2021-01-27 | Chain Biotechnology Ltd | Compostitions and methods |
| WO2022271976A1 (en) * | 2021-06-24 | 2022-12-29 | Elanco Us Inc. | Attenuated salmonella, vaccines, and delivery platform |
| CN114292339B (zh) * | 2022-01-05 | 2022-08-09 | 武汉科前生物股份有限公司 | 鞭毛素突变体与非洲猪瘟抗原的融合蛋白及其应用 |
| CN114703214A (zh) * | 2022-03-03 | 2022-07-05 | 南京吉芮康生物科技研究院有限公司 | 一种抗丢失时空可控表达的新型质粒及其应用 |
| AU2023346467A1 (en) * | 2022-09-21 | 2025-03-27 | Prokarium Limited | Salmonella strain with chromosomally integrated landing pad |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US232165A (en) * | 1880-09-14 | Mechanical musical instrument | ||
| US1449502A (en) * | 1921-04-23 | 1923-03-27 | James G Diffendaffer | Restraining device |
| US1476164A (en) * | 1922-02-21 | 1923-12-04 | Michael J Manahan | Door and window shade and curtain clamp |
| US1903387A (en) * | 1930-08-20 | 1933-04-04 | Eaton Mfg Co | Automobile heater |
| US2103863A (en) * | 1936-12-28 | 1937-12-28 | Woodall Industries Inc | Visor construction |
| US2728467A (en) * | 1954-01-28 | 1955-12-27 | Glicker Herman | Parking tower structure |
| US4440859A (en) * | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4704362A (en) * | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| YU44186B (en) * | 1978-12-22 | 1990-04-30 | Biogen Nv | Process for obtaining recombinant dnk molecules |
| US4530901A (en) * | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US5210035A (en) * | 1980-05-19 | 1993-05-11 | Board Of Trustees Of Leland Stanford Jr. University | Non-reventing live vaccines |
| US4837151A (en) * | 1980-05-19 | 1989-06-06 | The Board Of Trustees Of The Leland Stanford Junior University, Stanford University | Live vaccines comprising two mutations and foreign antigen |
| US4550081A (en) * | 1980-05-19 | 1985-10-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Non-reverting salmonella |
| US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4582800A (en) * | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| US4757006A (en) * | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4677063A (en) * | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US5643579A (en) * | 1984-11-01 | 1997-07-01 | American Home Products Corporation | Oral vaccines |
| US4810648A (en) * | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| US5397697A (en) | 1989-01-10 | 1995-03-14 | Ciba-Geigy Corporation | Identification of plant-responsive genes of bacteria |
| FR2664614B1 (fr) | 1990-07-11 | 1992-10-16 | Pasteur Institut | Sequences nucleiques issues du genome de salmonella typhi, et leurs utilisations notamment pour le diagnostic in vitro de la presence de bacteries du genre salmonella dans les produits alimentaires. |
| SE9101433D0 (sv) | 1991-05-13 | 1991-05-13 | Marianne Hansson | Recombinant dna sequence and its use |
| AU2509592A (en) | 1991-08-22 | 1993-03-16 | Washington University | Polynucleotide probes for salmonella |
| AU2778992A (en) | 1991-10-07 | 1993-05-03 | Idaho Research Foundation Inc., The | Genetic construct for selection of homologous recombinants on a single selective medium |
| AU3130893A (en) | 1991-11-15 | 1993-06-15 | Board Of Regents, The University Of Texas System | Membrane expression of heterologous genes |
| US5356797A (en) * | 1991-11-15 | 1994-10-18 | Board Of Regents, The University Of Texas | Membrane expression of heterologous genes |
| WO1994011024A1 (en) | 1992-11-06 | 1994-05-26 | Regents Of The University Of Minnesota | Composition protective against p. multocida pasteurellosis infection |
| WO1994026933A1 (en) | 1993-05-13 | 1994-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Genetic footprinting: insertional mutagenesis and genetic selection |
| AU3958895A (en) | 1994-10-18 | 1996-05-06 | Board Of Regents, The University Of Texas System | Membrane expression of heterologous genes |
| SG119177A1 (en) * | 1994-12-09 | 2006-02-28 | Imp College Innovations Ltd | Identification of genes |
| US5700683A (en) | 1995-02-17 | 1997-12-23 | Pathogenesis Corporation | Virulence-attenuating genetic deletions deleted from mycobacterium BCG |
| WO1997014800A1 (en) | 1995-10-16 | 1997-04-24 | Smithkline Beecham Plc | Novel saliva binding protein |
| AU7738396A (en) | 1995-11-14 | 1997-06-05 | General Hospital Corporation, The | Salmonella secreted proteins and uses thereof |
| US6030624A (en) | 1996-08-16 | 2000-02-29 | Uab Research Foundation | Mucosal immunogens for novel vaccines |
| GB9621091D0 (en) * | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| WO1998035562A1 (en) | 1997-02-14 | 1998-08-20 | Merck & Co., Inc. | Polynucleotide vaccine formulations |
| US6455323B1 (en) | 1997-07-03 | 2002-09-24 | Pharmacia & Upjohn Company | Anti-bacterial methods and materials |
| GB9804809D0 (en) | 1998-03-06 | 1998-04-29 | Wallis Timothy S | Attenuated salmonella:materials and methods relating thereto |
| US6585975B1 (en) * | 1998-04-30 | 2003-07-01 | Acambis, Inc. | Use of Salmonella vectors for vaccination against helicobacter infection |
| ATE403728T1 (de) * | 1998-09-04 | 2008-08-15 | Emergent Product Dev Uk Ltd | Attenuierte salmonella spi2 mutante als antigen- träger |
| BR9915165A (pt) * | 1998-11-09 | 2001-12-04 | Microscience Ltd | Genes e proteìnas de virulência e uso dos mesmos |
| GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
| EP1226254A2 (de) | 1999-11-05 | 2002-07-31 | L'Unité de Recherche en Biologie Moléculaire (URBM) des Facultés Universitaires Notre Dame de la Paix (FUNDP) | Virulenzgene, proteine, und ihre verwendung |
| JP2003520034A (ja) * | 1999-12-23 | 2003-07-02 | ヴィマックス リミテッド | ビルレンス遺伝子、タンパク質、およびそれらの用途 |
| GB0011108D0 (en) | 2000-05-08 | 2000-06-28 | Microscience Ltd | Virulence gene and protein and their use |
| GB0127657D0 (en) | 2001-11-19 | 2002-01-09 | Microscience Ltd | Virulence genes and proteins and their use |
| US7449178B2 (en) * | 2002-04-05 | 2008-11-11 | Merial Limited | Attenuated gram negative bacteria |
-
1999
- 1999-09-03 AT AT99946122T patent/ATE403728T1/de active
- 1999-09-03 DK DK99946122T patent/DK1108034T3/da active
- 1999-09-03 EP EP08075560A patent/EP1970449B1/de not_active Expired - Lifetime
- 1999-09-03 ES ES08075560T patent/ES2356863T3/es not_active Expired - Lifetime
- 1999-09-03 EP EP99946122A patent/EP1108034B1/de not_active Expired - Lifetime
- 1999-09-03 AT AT08075560T patent/ATE486940T1/de not_active IP Right Cessation
- 1999-09-03 ES ES99946122T patent/ES2313792T3/es not_active Expired - Lifetime
- 1999-09-03 AU AU58605/99A patent/AU5860599A/en not_active Abandoned
- 1999-09-03 WO PCT/EP1999/006514 patent/WO2000014240A2/en not_active Ceased
- 1999-09-03 BR BR9914479-4A patent/BR9914479A/pt not_active Application Discontinuation
- 1999-09-03 PT PT99946122T patent/PT1108034E/pt unknown
- 1999-09-03 DE DE69942925T patent/DE69942925D1/de not_active Expired - Lifetime
- 1999-09-03 US US09/763,620 patent/US6936425B1/en not_active Expired - Fee Related
- 1999-09-03 CA CA2341349A patent/CA2341349C/en not_active Expired - Fee Related
- 1999-09-03 JP JP2000568983A patent/JP2002524077A/ja active Pending
- 1999-09-03 DE DE69939264T patent/DE69939264D1/de not_active Expired - Lifetime
-
2004
- 2004-01-23 US US10/763,883 patent/US7700104B2/en not_active Expired - Lifetime
-
2007
- 2007-08-17 US US11/840,928 patent/US7955600B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 CY CY20081101270T patent/CY1109387T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1970449A1 (de) | 2008-09-17 |
| CA2341349C (en) | 2013-12-10 |
| AU5860599A (en) | 2000-03-27 |
| EP1108034A2 (de) | 2001-06-20 |
| US20080075739A1 (en) | 2008-03-27 |
| EP1970449B1 (de) | 2010-11-03 |
| ES2313792T3 (es) | 2009-03-01 |
| DE69939264D1 (de) | 2008-09-18 |
| US7955600B2 (en) | 2011-06-07 |
| JP2002524077A (ja) | 2002-08-06 |
| US20040203039A1 (en) | 2004-10-14 |
| US7700104B2 (en) | 2010-04-20 |
| WO2000014240A2 (en) | 2000-03-16 |
| WO2000014240A3 (en) | 2000-08-03 |
| BR9914479A (pt) | 2001-06-26 |
| EP1108034B1 (de) | 2008-08-06 |
| US6936425B1 (en) | 2005-08-30 |
| CA2341349A1 (en) | 2000-03-16 |
| CY1109387T1 (el) | 2014-07-02 |
| ES2356863T3 (es) | 2011-04-13 |
| DE69942925D1 (de) | 2010-12-16 |
| ATE403728T1 (de) | 2008-08-15 |
| PT1108034E (pt) | 2008-11-14 |
| DK1108034T3 (da) | 2008-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69942925D1 (de) | Abgeschwächte Salmonella SP12 Mutante als Antigen-Träger. | |
| ATE219948T1 (de) | Rekombinante impfstoffe die immunogene attenuierte rpos-positiv phentotyp bakterien enthalten | |
| ATE453403T1 (de) | Wirtszelle enthaltend ein rekombinantes virus, welches ein antigen exprimiert und ein rekombinantes virus, welches ein immunstimulatorisches molekül exprimiert | |
| NZ316787A (en) | Methods and compositions for the selective modification of nucleic acids | |
| HUP0301659A2 (hu) | Kukorica cellulóz-szintetázok és alkalmazásuk | |
| KR937000640A (ko) | 생 백신 | |
| EP0837928A4 (de) | Zusammensetzungen aus rekombinierten poxvirus-cytomegalovirus und ihre verwendung | |
| NO960839L (no) | Bakterieeksporterte proteiner og acellulære vaksiner som er basert på disse | |
| CY1107656T1 (el) | Εξασθενημενοι μικροοργανισμοι για την αντιμετωπιση μολυνσης | |
| ATE401406T1 (de) | Hühner-anaemie-virus mutante, impfstoffe, und verwendungen basiert auf virusprotein vp3, oder dafür kodierende virus-sequenzen | |
| DK0892054T3 (da) | Clostridium perfringens-vaccine | |
| NO924576D0 (no) | Kloning og ekspresjon av gener som koder for arabinan-nedbrytende enzymer av sopp-opprinnelse | |
| Roberts et al. | Comparison of abilities of Salmonella enterica serovar typhimurium aroA aroD and aroA htrA mutants to act as live vectors | |
| AU3532089A (en) | A pasteurella vaccine | |
| IE810618L (en) | Pasteurella vaccines | |
| ATE181104T1 (de) | Isoliertes pctd plasmid aus chlamydia trachomatis von serotyp d, dessen genen und davon kodierten proteine, rekombinante plasmide für die expression von deren genen als fusionsproteine in einem keterologen system, und ihre verwendung als impfstoff- und/oder diagnostiekformulierung | |
| WO2001012657A3 (en) | Methods and means for selenoprotein expression | |
| DE69941099D1 (de) | Spezifische Nukleinsäuren und Polypeptide aus krankheitserregenden Stämmen von Neisseria | |
| IT1317849B1 (it) | Mezzi e metodi per l'espressione di proteine omologhe ed eterologhe inceppi di rhodococcus. | |
| PT729509E (pt) | Vacina contra papeira contendo uma estirpe do virus jerryl-lynn | |
| DK0869184T3 (da) | Vaccine til immunisering mod TBE-virusinfektioner samt en fremgangsmåde til fremstilling deraf | |
| DK230890A (da) | Dna-fragment, der koder for et pasteurella multocida-toxin eller for en subsekvens eller analog deraf, ekspressionsvektor, der omfatter dna-fragmentet, mikroorganisme, der udtrykker dette, fremgangsmaade til fremstilling af et pasteurella-multocida-toxin, diagnostisk middel samt anvendelse heraf, vaccine indeholdende et pasteurella-multocida-toxinderivat, anvendelse af pasteurella multocida-t m.m. | |
| WO2002057457A3 (en) | Human proteins 55562 and 21617, and methods of use thereof | |
| EA200000618A1 (ru) | Вакцина для иммунизации позвоночных против заболеваний, вызываемых патогеном, вакцина для профилактики или лечения позвоночного от бруцеллеза, аттенюированный или авирулентный вариант штамма в. abortus rb51, способ профилактики или лечения позвоночного при риске заболевания или страдающего от патогенного микроорганизма (варианты), способ профилактики или лечения позвоночного при риске заболевания или страдающего от бруцеллеза | |
| WO1996002272A3 (en) | Treatment of autoimmune diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |