ATE488498T1 - Verfahren zur herstellung von ace hemmern - Google Patents
Verfahren zur herstellung von ace hemmernInfo
- Publication number
- ATE488498T1 ATE488498T1 AT04731808T AT04731808T ATE488498T1 AT E488498 T1 ATE488498 T1 AT E488498T1 AT 04731808 T AT04731808 T AT 04731808T AT 04731808 T AT04731808 T AT 04731808T AT E488498 T1 ATE488498 T1 AT E488498T1
- Authority
- AT
- Austria
- Prior art keywords
- ace inhibitors
- amino acid
- activated
- producing
- producing ace
- Prior art date
Links
- 239000005541 ACE inhibitor Substances 0.000 title abstract 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001224 Uranium Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200300123A SI21507A (sl) | 2003-05-16 | 2003-05-16 | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| PCT/SI2004/000021 WO2004101515A1 (en) | 2003-05-16 | 2004-05-07 | A process for the preparation of compounds having an ace inhibitory action |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488498T1 true ATE488498T1 (de) | 2010-12-15 |
Family
ID=33448812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04731808T ATE488498T1 (de) | 2003-05-16 | 2004-05-07 | Verfahren zur herstellung von ace hemmern |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7671215B2 (de) |
| EP (1) | EP1628956B1 (de) |
| AT (1) | ATE488498T1 (de) |
| DE (1) | DE602004030112D1 (de) |
| RU (1) | RU2377236C2 (de) |
| SI (2) | SI21507A (de) |
| WO (1) | WO2004101515A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2468724T3 (en) * | 2006-12-21 | 2016-02-22 | Zealand Pharma As | Synthesis of pyrrolidine compounds |
| US20090076126A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched enalapril |
| CN102498098A (zh) | 2009-07-16 | 2012-06-13 | 艾博特公司 | 作为群多普利中间体的(2S，3aR，7aS)-八氢-1H-吲哚羧酸的合成方法 |
| EP2906536B1 (de) * | 2012-10-10 | 2018-03-14 | Piramal Enterprises Limited | Verbessertes verfahren zur herstellung eines perindopril-zwischenprodukts |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE289543C (de) | 1913-08-18 | |||
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| ATE174343T1 (de) * | 1991-02-27 | 1998-12-15 | Lacer Sa | Antihypertensive n-(alpha-substituiertes pyridyl)-carbonyldipeptide |
| DE4334936C1 (de) * | 1993-10-13 | 1995-06-22 | Karla Dr Lehmann | Arzneimittel zur optimierten Behandlung eines erhöhten Blutdrucks und zur Verhütung von Folgeerkrankungen |
| US5864040A (en) | 1996-01-11 | 1999-01-26 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| RU2119314C1 (ru) * | 1996-02-05 | 1998-09-27 | Московский научно-исследовательский институт глазных болезней им.Гельмгольца | Способ профилактики и лечения изъязвлений роговицы |
| GB9710612D0 (en) | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
| FR2771010B1 (fr) * | 1997-11-19 | 2003-08-15 | Adir | Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires |
| PL358618A1 (pl) | 2000-03-31 | 2004-08-09 | Pfizer Products Inc. | Nowe pochodne piperazyny |
| GB2375762B (en) | 2001-05-21 | 2003-10-01 | Fermenta Biotech Ltd | Stereospecific synthesis of 2-hydroxy-4-phenyl-butyric acid esters |
| WO2002094857A1 (en) * | 2001-05-23 | 2002-11-28 | The Curators Of The University Of Missouri | Inverse solid phase synthesis of peptides |
| AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
-
2003
- 2003-05-16 SI SI200300123A patent/SI21507A/sl not_active IP Right Cessation
-
2004
- 2004-05-07 US US10/556,986 patent/US7671215B2/en not_active Expired - Fee Related
- 2004-05-07 DE DE602004030112T patent/DE602004030112D1/de not_active Expired - Lifetime
- 2004-05-07 EP EP04731808A patent/EP1628956B1/de not_active Expired - Lifetime
- 2004-05-07 SI SI200431600T patent/SI1628956T1/sl unknown
- 2004-05-07 AT AT04731808T patent/ATE488498T1/de not_active IP Right Cessation
- 2004-05-07 WO PCT/SI2004/000021 patent/WO2004101515A1/en not_active Ceased
- 2004-05-07 RU RU2005139158/04A patent/RU2377236C2/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2005139158A (ru) | 2007-06-27 |
| WO2004101515A1 (en) | 2004-11-25 |
| SI21507A (sl) | 2004-12-31 |
| SI1628956T1 (sl) | 2011-03-31 |
| EP1628956B1 (de) | 2010-11-17 |
| US20070072919A1 (en) | 2007-03-29 |
| DE602004030112D1 (de) | 2010-12-30 |
| EP1628956A1 (de) | 2006-03-01 |
| US7671215B2 (en) | 2010-03-02 |
| RU2377236C2 (ru) | 2009-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |