ATE489109T1 - Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin - Google Patents

Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin

Info

Publication number: ATE489109T1
Authority: AT; Austria
Prior art keywords: imatinib; midostaurin; treatment; gastrointestinal stroma; tumors
Prior art date: 2003-09-19

Application number

AT04765359T

Other languages

English (en)

Inventor

Sasa Dimitrijevic

Jonathan Fletcher

Sandra SILBERMAN

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-19

Filing date

2004-09-17

Publication date

2010-12-15

2004-09-17 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE489109T1 publication Critical patent/ATE489109T1/de

Links

239000005517 L01XE01 - Imatinib Substances 0.000 title abstract 3
KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 title abstract 3
229960002411 imatinib Drugs 0.000 title abstract 3
BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical compound CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 title abstract 2
229950010895 midostaurin Drugs 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
230000002496 gastric effect Effects 0.000 title 1
206010051066 Gastrointestinal stromal tumour Diseases 0.000 abstract 2
201000011243 gastrointestinal stromal tumor Diseases 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04765359T 2003-09-19 2004-09-17 Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin ATE489109T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50424503P	2003-09-19	2003-09-19
PCT/EP2004/010467 WO2005027971A1 (en)	2003-09-19	2004-09-17	Treatment of gastrointestinal stromal tumors with imatinib and midostaurin

Publications (1)

Publication Number	Publication Date
ATE489109T1 true ATE489109T1 (de)	2010-12-15

Family

ID=34375467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04765359T ATE489109T1 (de)	2003-09-19	2004-09-17	Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin

Country Status (11)

Country	Link
US (1)	US20080096864A1 (de)
EP (1)	EP1667719B1 (de)
JP (1)	JP2007505859A (de)
CN (1)	CN100467064C (de)
AT (1)	ATE489109T1 (de)
AU (1)	AU2004273605B2 (de)
BR (1)	BRPI0414527A (de)
CA (1)	CA2538523A1 (de)
DE (1)	DE602004030265D1 (de)
MX (1)	MXPA06003056A (de)
WO (1)	WO2005027971A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4762150B2 (ja) *	2003-11-18	2011-08-31	ノバルティスアーゲー	Ｋｉｔの変異体の阻害剤
EP1799226A1 (de) *	2004-08-31	2007-06-27	Novartis AG	Verwendung von midostaurin zur behandlung von gastrointestinalem stromatumor
CN101171013A (zh) *	2005-05-02	2008-04-30	诺瓦提斯公司	嘧啶基氨基苯甲酰胺衍生物用于治疗全身性肥大细胞增多症的应用
DE602006013826D1 (de) *	2005-07-20	2010-06-02	Peter Valent	Zusammensetzungen zur behandlung von systemischer mastocytose
CA2629478C (en) *	2005-11-14	2013-10-15	Universitat Zurich	Staurosporine derivatives for use in alveolar rhabdomyosarcoma

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CO4940418A1 (es) *	1997-07-18	2000-07-24	Novartis Ag	Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
ITMI992711A1 (it) *	1999-12-27	2001-06-27	Novartis Ag	Composti organici
ATE321556T1 (de) *	2000-10-27	2006-04-15	Novartis Pharma Gmbh	Behandlung gastrointestinaler stroma-tumoren
AU2003214079B2 (en) *	2002-02-28	2007-05-31	Novartis Ag	N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine coated stents
JP4429732B2 (ja) *	2002-04-10	2010-03-10	バージニアコモンウェルスユニバーシティー	癌の処置におけるグリベック（ｓｔｉ５７１）とサイクリン依存性キナーゼインヒビター、とりわけフラボピリドールとの組合せ剤

2004
- 2004-09-17 CN CNB2004800270630A patent/CN100467064C/zh not_active Expired - Fee Related
- 2004-09-17 EP EP04765359A patent/EP1667719B1/de not_active Expired - Lifetime
- 2004-09-17 WO PCT/EP2004/010467 patent/WO2005027971A1/en not_active Ceased
- 2004-09-17 CA CA002538523A patent/CA2538523A1/en not_active Abandoned
- 2004-09-17 DE DE602004030265T patent/DE602004030265D1/de not_active Expired - Lifetime
- 2004-09-17 MX MXPA06003056A patent/MXPA06003056A/es not_active Application Discontinuation
- 2004-09-17 BR BRPI0414527-5A patent/BRPI0414527A/pt not_active IP Right Cessation
- 2004-09-17 AT AT04765359T patent/ATE489109T1/de not_active IP Right Cessation
- 2004-09-17 AU AU2004273605A patent/AU2004273605B2/en not_active Ceased
- 2004-09-17 JP JP2006526596A patent/JP2007505859A/ja active Pending
- 2004-09-17 US US10/572,259 patent/US20080096864A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE602004030265D1 (de)	2011-01-05
EP1667719B1 (de)	2010-11-24
WO2005027971A1 (en)	2005-03-31
US20080096864A1 (en)	2008-04-24
BRPI0414527A (pt)	2006-11-07
AU2004273605B2 (en)	2008-07-31
EP1667719A1 (de)	2006-06-14
JP2007505859A (ja)	2007-03-15
AU2004273605A1 (en)	2005-03-31
MXPA06003056A (es)	2006-05-31
CA2538523A1 (en)	2005-03-31
CN100467064C (zh)	2009-03-11
CN1852738A (zh)	2006-10-25

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Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties