ATE489613T1 - Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern - Google Patents

Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern

Info

Publication number
ATE489613T1
ATE489613T1 AT99909630T AT99909630T ATE489613T1 AT E489613 T1 ATE489613 T1 AT E489613T1 AT 99909630 T AT99909630 T AT 99909630T AT 99909630 T AT99909630 T AT 99909630T AT E489613 T1 ATE489613 T1 AT E489613T1
Authority
AT
Austria
Prior art keywords
probe
warmers
molecular pathology
independent slide
automated molecular
Prior art date
Application number
AT99909630T
Other languages
English (en)
Inventor
William Richards
Charles Lemme
Kimberly Christensen
Ethel Macrea
Original Assignee
Ventana Med Syst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Med Syst Inc filed Critical Ventana Med Syst Inc
Application granted granted Critical
Publication of ATE489613T1 publication Critical patent/ATE489613T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Microscoopes, Condenser (AREA)
  • Laminated Bodies (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
AT99909630T 1998-02-27 1999-02-26 Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern ATE489613T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7619898P 1998-02-27 1998-02-27
PCT/US1999/004181 WO1999044030A1 (en) 1998-02-27 1999-02-26 Automated molecular pathology apparatus having independent slide heaters

Publications (1)

Publication Number Publication Date
ATE489613T1 true ATE489613T1 (de) 2010-12-15

Family

ID=22130540

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99909630T ATE489613T1 (de) 1998-02-27 1999-02-26 Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern

Country Status (10)

Country Link
US (1) US6296809B1 (de)
EP (3) EP2284543A3 (de)
JP (5) JP2002504694A (de)
CN (1) CN100403008C (de)
AT (1) ATE489613T1 (de)
AU (3) AU763354B2 (de)
CA (2) CA2321836C (de)
DE (1) DE69942975D1 (de)
ES (1) ES2354598T3 (de)
WO (2) WO1999043434A1 (de)

Families Citing this family (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040191128A1 (en) * 1992-05-11 2004-09-30 Cytologix Corporation Slide stainer with heating
US6180061B1 (en) 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US6735531B2 (en) 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
JP3750772B2 (ja) * 1998-01-27 2006-03-01 富士写真フイルム株式会社 生化学分析装置
GB9803684D0 (en) * 1998-02-24 1998-04-15 Genevac Ltd Method and apparatus for controlling temperature during evaporation of samples
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6183693B1 (en) * 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US7188001B2 (en) * 1998-03-23 2007-03-06 Cepheid System and method for temperature control
US6495106B1 (en) * 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
US6620620B1 (en) * 1998-04-27 2003-09-16 Era Systems, Inc. Micro liquid evaporator
US6855552B2 (en) * 1998-09-03 2005-02-15 Ventana Medical Systems Automated immunohistochemical and in situ hybridization assay formulations
US7550298B2 (en) * 1998-09-03 2009-06-23 Ventana Medical Systems, Inc. Automated immunohistochemical and in situ hybridization assay formulations
US6649128B1 (en) * 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
US6544798B1 (en) * 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6534008B1 (en) * 1999-07-08 2003-03-18 Lee Angros In situ heat induced antigen recovery and staining apparatus and method
US7897106B2 (en) 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) * 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
WO2001022086A1 (en) * 1999-09-24 2001-03-29 Jonathan Cohen A high-throughput system for evaluating the clinical utility of molecular targets in tissue samples
US6403931B1 (en) 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
DE10006084B4 (de) * 2000-02-11 2009-01-02 Leica Biosystems Nussloch Gmbh Färbeautomat mit einer Heizstation
US6824738B1 (en) * 2000-04-14 2004-11-30 Discovery Partners International, Inc. System and method for treatment of samples on solid supports
DE10041227B4 (de) * 2000-08-22 2011-12-29 Leica Biosystems Nussloch Gmbh Vorrichtung zur Behandlung von Objekten
US6656685B2 (en) * 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
GB0117706D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Automated semi-solid matrix assay and liquid handler apparatus for the same
US7888060B2 (en) * 2001-03-30 2011-02-15 Nanoprobes, Inc. Method for detecting a target using enzyme directed deposition of elemental metal
US7691598B2 (en) * 2001-03-30 2010-04-06 Nanoprobes, Inc. Method for detecting a target molecule by metal deposition
US6662136B2 (en) * 2001-04-10 2003-12-09 International Business Machines Corporation Digital temperature sensor (DTS) system to monitor temperature in a memory subsystem
WO2002088396A2 (en) * 2001-04-30 2002-11-07 Ventana Medical Systems, Inc. Reagents and methods for automated in situ or microarray hybridization
US7425306B1 (en) 2001-09-11 2008-09-16 Ventana Medical Systems, Inc. Slide heater
US7270785B1 (en) * 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US6936474B2 (en) * 2001-11-05 2005-08-30 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
AU2002361618A1 (en) * 2001-11-13 2003-05-26 Chromavision Medical Systems, Inc. A system for tracking biological samples
US20040033163A1 (en) * 2001-11-26 2004-02-19 Lab Vision Corporation Automated tissue staining system and reagent container
US6998270B2 (en) * 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
ES2425689T3 (es) * 2002-04-15 2013-10-16 Ventana Medical Systems, Inc. Sistema automatizado de coloración de placas portaobjetos con elevada velocidad de producción
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
WO2003091710A1 (en) * 2002-04-26 2003-11-06 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US6833536B2 (en) * 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
US20040126837A1 (en) * 2002-05-23 2004-07-01 Matthew Baker Pseudo-tissues and uses thereof
CA2489412A1 (en) * 2002-07-16 2004-01-22 Ventana Medical Systems, Inc. Tray for automated histochemical processing
KR20040023999A (ko) * 2002-09-12 2004-03-20 엘지전자 주식회사 의류건조기의 모터축 구조
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7875245B2 (en) * 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US20060073074A1 (en) * 2004-10-06 2006-04-06 Lars Winther Enhanced sample processing system and methods of biological slide processing
US8283176B2 (en) * 2004-06-29 2012-10-09 Dako Denmark A/S Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device
EP1625382A2 (de) * 2003-05-19 2006-02-15 Ventana Medical Systems, Inc. Elektrophoretische in-situ-gewebeanfärbung
ES2645437T3 (es) 2003-06-12 2017-12-05 Accupath Diagnostic Laboratories, Inc. Método y sistema para el análisis de muestras de células de alta densidad
US7642064B2 (en) * 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
US7744817B2 (en) 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US7767152B2 (en) 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
US7501283B2 (en) 2003-08-11 2009-03-10 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US7273591B2 (en) 2003-08-12 2007-09-25 Idexx Laboratories, Inc. Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same
EP2492681A1 (de) * 2003-09-09 2012-08-29 BioGenex Laboratories Probenverarbeitungssystem
US7588733B2 (en) 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US8026106B1 (en) 2003-12-18 2011-09-27 Ventana Medical Systems, Inc. Removal of mercuric chloride crystals from fixed tissues
US7615371B2 (en) 2003-12-23 2009-11-10 Ventana Medical Systems, Inc. Method and apparatus for treating a biological sample with a liquid reagent
JP2007526479A (ja) * 2004-03-02 2007-09-13 ダコ デンマーク アクティーゼルスカブ 生物学的染色装置のための試薬送達システム、分配デバイスおよび容器
KR20070028553A (ko) 2004-06-18 2007-03-12 바이올리폭스 에이비 염증 치료에 유용한 인돌
US7867443B2 (en) * 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7820381B2 (en) * 2004-07-23 2010-10-26 Ventana Medical Systems, Inc. Method and apparatus for applying fluids to a biological sample
US7514041B2 (en) * 2004-07-28 2009-04-07 N-Solv Corporation Method and apparatus for testing heavy oil production processes
AU2005325497A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
GB0501590D0 (en) * 2005-01-25 2005-03-02 Ceres Power Ltd Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode
CN101203762A (zh) * 2005-04-21 2008-06-18 塞莱勒斯诊断公司 用于自动快速免疫组织化学的方法和设备
DE102005020426B4 (de) * 2005-04-29 2017-05-04 Leica Biosystems Nussloch Gmbh Eindeckautomat
US8377377B2 (en) 2005-05-24 2013-02-19 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
CN101228429B (zh) 2005-05-24 2013-04-10 利·H·安格罗斯 原位热诱发的抗原修复及染色设备和方法
CN100406874C (zh) * 2005-06-20 2008-07-30 北京源德生物医学工程有限公司 半自动微孔板单光子计数仪的门组件
ATE526437T1 (de) * 2005-06-28 2011-10-15 Univ Oklahoma Verfahren zur züchtung und entnahme von kohlenstoffnanoröhren
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
GB0521851D0 (en) * 2005-10-26 2005-12-07 Genial Genetic Solutions Ltd Biological apparatus
US9551635B2 (en) 2006-03-09 2017-01-24 Biogenex Laboratories Inc. Sample processing system
US8459509B2 (en) 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
CA2549614C (en) * 2006-06-07 2014-11-25 N-Solv Corporation Methods and apparatuses for sagd hydrocarbon production
CA2552482C (en) * 2006-07-19 2015-02-24 N-Solv Corporation Methods and apparatuses for enhanced in situ hydrocarbon production
ATE551607T1 (de) * 2006-09-22 2012-04-15 Fujifilm Corp Klinisches analysegerät
EP2444807B1 (de) 2006-11-01 2014-06-11 Ventana Medical Systems, Inc. Mono- und dinitropyrazolhaptenkonjugate
US9116129B2 (en) 2007-05-08 2015-08-25 Idexx Laboratories, Inc. Chemical analyzer
ES2731432T3 (es) 2007-05-23 2019-11-15 Ventana Med Syst Inc Transportadores poliméricos para inmunohistoquímica e hibridación in situ
ES2435666T3 (es) * 2007-07-10 2013-12-20 Ventana Medical Systems, Inc. Aparato y método para el tratamiento de muestras biológicas
US8440425B2 (en) * 2007-12-18 2013-05-14 Abbott Laboratories Method of preparing a biological specimen slide
AU2009218872B2 (en) 2008-02-29 2015-01-15 Agilent Technologies, Inc. Systems and methods for tracking and providing workflow information
US9802022B2 (en) * 2008-03-06 2017-10-31 Resmed Limited Humidification of respiratory gases
ES2557594T3 (es) 2008-06-05 2016-01-27 Ventana Medical Systems, Inc. Método para el procesamiento histoquímico y el uso de una composición para el procesamiento histoquímico
DK2334827T3 (da) 2008-08-22 2015-06-15 Ventana Med Syst Inc Metode til kromogen påvisning af to eller flere målmolekyler i en enkelt prøve
EP2350673B1 (de) * 2008-10-24 2022-05-11 Leica Biosystems Richmond, Inc. Modulares system für laborprotokolle und zugehörige verfahren
EP2356423B1 (de) 2008-11-12 2024-08-07 Ventana Medical Systems, Inc. Verfahren und vorrichtungen zum erwärmen von präparate tragenden objektträgern
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
US20120141472A1 (en) 2009-05-29 2012-06-07 Shalini Singh Methods of scoring gene copy number in a biological sample using in situ hybridization
DE102010010975B4 (de) 2009-09-14 2012-05-31 Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg Objektträgerhalter
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
JP5611363B2 (ja) * 2009-11-13 2014-10-22 ベンタナ メディカル システムズ， インコーポレイテッド 調整可能な体積を収容する薄膜処理装置
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
ES2549170T3 (es) 2010-02-05 2015-10-23 Nichirei Biosciences Inc. Solución de pretratamiento para la tinción inmunohistoquímica y solución condensada de la misma
WO2011106583A1 (en) 2010-02-26 2011-09-01 Ventana Medical Systems, Inc. Polytag probes
US20120301885A1 (en) 2010-02-26 2012-11-29 Lei Tang Cytogenic analysis of metaphase chromosomes
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
AU2011222501B2 (en) 2010-03-04 2014-05-01 Ventana Medical Systems, Inc. Processing system for processing specimens using acoustic energy
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
WO2011139792A2 (en) 2010-04-27 2011-11-10 Ventana Medical Systems, Inc. Antibody-nanoparticle conjugates and methods for making and using such conjugates
EP2564206A4 (de) 2010-04-29 2016-09-07 Leica Biosystems Richmond Inc Analysesystem zur ausführung von laborprotokollen und zugehörige verfahren
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
JP2013535193A (ja) * 2010-07-23 2013-09-12 ベックマン コールター， インコーポレイテッド 分析装置を含むシステムおよび方法
JP5393610B2 (ja) * 2010-07-28 2014-01-22 株式会社日立ハイテクノロジーズ 核酸分析装置
EP2625502B1 (de) 2010-10-06 2018-09-05 Biocare Medical, LLC Verfahren und system zur effizienten verarbeitung biologischer proben
SG10201804238TA (en) 2010-12-30 2018-06-28 Ventana Med Syst Inc Enhanced deposition of chromogens utilizing pyrimidine analogs
US20130302852A1 (en) 2011-01-10 2013-11-14 Ventana Medical Systems, Inc. Hematoxylin Staining Method
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
AU2012222963B2 (en) 2011-02-28 2016-09-22 Agilent Technologies, Inc. Two phase immiscible system for the pretreatment of embedded biological samples
EP2686438B1 (de) 2011-03-14 2018-04-18 Ventana Medical Systems, Inc. Verfahren zur analyse von chromosomen-translokationen und system dafür
MX336651B (es) 2011-05-18 2016-01-27 3M Innovative Properties Co Sistemas y metodos de distribucion en dispositivo de procesamiento de muestra.
KR20140022399A (ko) 2011-05-18 2014-02-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
JP6235462B2 (ja) 2011-05-18 2017-11-22 スリーエム イノベイティブ プロパティズ カンパニー 試料処理装置内で材料の選択された体積の存在を検出するためのシステム及び方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
WO2013079606A1 (en) 2011-12-01 2013-06-06 Ventana Medical Systems, Inc. Automated dual stain of mirna and protein targets
WO2013101989A1 (en) 2011-12-30 2013-07-04 Ventana Medical Systems, Inc. Automated analysis of circulating tumor cells
EP2807490B1 (de) 2012-01-26 2017-09-13 Leica Biosystems Richmond, Inc. Verfahren für hämatoxylin- und eosinanfärbung
EP2807272A1 (de) 2012-01-27 2014-12-03 Ventana Medical Systems, Inc. Vorrichtungen und verfahren zur erkennung von bioanalyten mit optisch enträtselbaren mustern
EP2810213B1 (de) 2012-02-01 2020-01-22 Ventana Medical Systems, Inc. System zur gendetektion in gewebeproben
EP2823281B1 (de) 2012-03-09 2018-11-28 Leica Biosystems Richmond, Inc. Vorrichtung und verfahren zur regelung der temperatur in einer strömenden flüssigkeit in einem laborprobenverarbeitungssystem
CN104245955B (zh) 2012-03-19 2018-03-16 文塔纳医疗系统公司 改进了对革兰氏阴性细菌的结晶紫‑碘复合物的脱色的革兰氏染色方法
KR102145460B1 (ko) * 2012-04-27 2020-08-18 세페이드 이질적 처리 모듈을 갖는 장치
AU2013329655B2 (en) 2012-10-08 2017-01-12 Ventana Medical Systems, Inc. Methods, kits, and systems for clarifying pigmented samples
US11181448B2 (en) 2012-11-06 2021-11-23 Biodot, Inc. Controlled printing of a cell sample for karyotyping
WO2014079802A2 (en) 2012-11-20 2014-05-30 Ventana Medical Systems, Inc. Laser ablation inductively-coupled plasma mass spectral tissue diagnostics
EP2925450B1 (de) * 2012-12-03 2017-09-13 Leica Biosystems Melbourne Pty Ltd Wärmemodul für eine probenverarbeitungsanordnung
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
BR112015015469A2 (pt) * 2012-12-26 2017-07-11 Ventana Med Syst Inc aparelho de processamento de lâmina e método para processar um espécime portado em uma lâmina
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
BR112015015413A2 (pt) * 2012-12-26 2017-07-11 Ventana Med Syst Inc aparelho de aquecimento de lâmina, método para aquecer um espécime biológico conduzido em uma lâmina e sistema para aquecer uma lâmina portadora de espécime
CN103149070B (zh) * 2013-03-11 2014-10-08 黄石市第一医院 一种自动染片机
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
US10429279B2 (en) 2013-07-28 2019-10-01 Xmd, Llc Devices and cartridges for extracting bio-sample regions and molecules of interest
CA2932492C (en) 2013-12-13 2020-05-12 Ventana Medical Systems, Inc. Staining reagents and other liquids for histological processing of biological specimens and associated technology
CN105829862B (zh) 2013-12-13 2021-11-09 文塔纳医疗系统公司 热处理显微镜载玻片的自动化处理系统及方法
CA2932803C (en) * 2013-12-13 2020-09-08 Ventana Medical Systems, Inc. Thermal management in the context of automated histological processing of biological specimens and associated technology
CN111089980B (zh) 2013-12-13 2023-08-15 文塔纳医疗系统公司 生物样本的自动化组织学处理及相关的技术
WO2015106008A1 (en) 2014-01-10 2015-07-16 Idexx Laboratories, Inc. Chemical analyzer
JP6825915B2 (ja) 2014-02-24 2021-02-03 ヴェンタナ メディカル システムズ， インク． 標識された２’−ｏ−メチルｒｎａオリゴヌクレオチドプローブ及びシグナル増幅系を使用する自動ｒｎａ検出
DK3111224T3 (en) 2014-02-24 2019-03-18 Ventana Med Syst Inc Quinonmethidanalog-signal gain
ES2688079T3 (es) 2014-06-06 2018-10-30 Ventana Medical Systems, Inc. Significación de la heterogeneidad de HER2 intratumoral en el cáncer de mama y usos de la misma
EP3160648B1 (de) * 2014-06-30 2024-04-03 Ventana Medical Systems, Inc. Probenverarbeitungssysteme, pipettenanordnungen und verfahren zur zubereitung von reagenzien
AU2015326827B2 (en) 2014-10-02 2019-11-07 Ventana Medical Systems, Inc. Polymers and conjugates comprising the same
CA2966555C (en) 2014-12-30 2023-06-13 Ventana Medical Systems, Inc. Systems and methods for co-expression analysis in immunoscore computation
AU2016212229B2 (en) 2015-01-27 2019-06-06 Ventana Medical Systems, Inc. Methods for tissue sample fixation using an extended soak in aldehyde-based fixative solutions
WO2016120440A1 (en) 2015-01-29 2016-08-04 Ventana Medical Systems, Inc. Dot detection, color classification of dots and counting of color classified dots
WO2016120441A2 (en) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Quality metrics for automatic evaluation of dual ish images
WO2016120442A1 (en) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Foreground segmentation and nucleus ranking for scoring dual ish images
WO2016146616A1 (en) 2015-03-16 2016-09-22 Ventana Medical Systems, Inc. Control slides for immunohistochemistry generated from three-dimensional cell line cultures
JP6811721B2 (ja) * 2015-04-13 2021-01-13 ベンタナ メディカル システムズ， インコーポレイテッド 熱化学に基づく抗体不活性化法およびシステム
CN107980095A (zh) 2015-05-10 2018-05-01 文塔纳医疗系统公司 用于在自动化多重组织组织染色测定期间使碱性磷酸酶和过氧化物酶同时失活的组合物和方法
WO2016189065A1 (en) 2015-05-26 2016-12-01 Ventana Medical Systems, Inc. Method and system for assessing stain quality for in-situ hybridization and immunohistochemistry
WO2017040349A1 (en) 2015-08-28 2017-03-09 Ventana Medical Systems, Inc. Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
CN105400692B (zh) * 2015-12-15 2017-06-27 上海海洋大学 等温核酸扩增装置及等温核酸扩增实验方法
CN105400693B (zh) * 2015-12-15 2017-06-06 上海海洋大学 平板等温核酸扩增芯片
AU2017211236B2 (en) 2016-01-26 2023-04-20 Ventana Medical Systems, Inc. Predictive diagnostic workflow for tumors using automated dissection, next generation sequencing, and automated slide stainers
AU2017229370B2 (en) 2016-03-08 2021-03-11 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
WO2017218882A1 (en) 2016-06-16 2017-12-21 Nanocytomics, LLC Automated staining system
CN121021395A (zh) 2016-06-28 2025-11-28 文塔纳医疗系统公司 点击化学用于ihc和ish测定中的信号扩增的应用
CN116840465A (zh) 2016-06-28 2023-10-03 文塔纳医疗系统公司 用多染料醌甲基化物和酪酰胺缀合物的显色ihc和ish染色的新颜色
DE112016007190T5 (de) * 2016-08-30 2019-07-04 Aiham Z. S. Qdaisat Automatisiertes Objektträgerbetropfungssystem
EP3516397A1 (de) 2016-09-23 2019-07-31 Ventana Medical Systems, Inc. Verfahren und systeme zur bewertung extrazellulärer matrixbiomarker in tumorproben
CN106370830A (zh) * 2016-11-14 2017-02-01 漯河医学高等专科学校 一种具有单独滑片加热器的分子病理学装置
EP3555634B1 (de) 2016-12-16 2023-09-06 Ventana Medical Systems, Inc. Reduzierung von pipettenrückständen
CN110337588B (zh) 2016-12-19 2023-02-17 文塔纳医疗系统公司 用于定量免疫组织化学的方法和系统
EP3555588B1 (de) 2016-12-19 2021-03-03 Ventana Medical Systems, Inc. Passives schwerkraftgesteuertes system zur behandlung eines abflusses in einem diagnosesystem
JP7048617B2 (ja) 2016-12-19 2022-04-05 ヴェンタナ メディカル システムズ， インク． ペプチド核酸コンジュゲート
WO2018119199A1 (en) 2016-12-21 2018-06-28 Ventana Medical Systems, Inc. Methods, systems and solid compositions for reagent delivery
JP6877550B2 (ja) 2016-12-22 2021-05-26 ヴェンタナ メディカル システムズ， インク． 組織試料用の全自動核酸抽出方法
JP6968177B2 (ja) 2016-12-22 2021-11-17 ベンタナ メディカル システムズ， インコーポレイテッド 一次染色および免疫組織化学画像に基づくコンピュータ採点
US10890523B2 (en) * 2017-01-19 2021-01-12 Agilent Technologies, Inc. Multi-temperature optical spectrometer modules, systems and methods of using the same
CN110383035B (zh) * 2017-03-16 2024-04-02 美国西门子医学诊断股份有限公司 用于诊断分析仪中的培育系统的热控制的系统和方法
EP3610451B1 (de) 2017-04-14 2021-09-29 Ventana Medical Systems, Inc. Lokale kachelbasierte registrierung und globale platzierung für stitching
JP6940626B2 (ja) 2017-05-10 2021-09-29 ヴェンタナ メディカル システムズ， インク． ｐＨ調整を利用する安定化した２パートヘマトキシリン溶液
EP3631410B1 (de) 2017-05-26 2024-08-28 Ventana Medical Systems, Inc. Berührungslose flüssigkeitsmischung auf einem objektträger
EP3646006B1 (de) 2017-06-28 2024-10-23 Ventana Medical Systems, Inc. Kalibrierung auf systemebene
WO2019020556A1 (en) 2017-07-24 2019-01-31 Ventana Medical Systems, Inc. METHODS AND SYSTEMS FOR ASSESSING INFILTRAT OF IMMUNE CELLS IN TUMOR SAMPLES
CN111602172B (zh) 2017-08-04 2023-09-26 文塔纳医疗系统公司 利用散射校正进行颜色解混
EP4300424A3 (de) 2017-08-04 2024-03-06 Ventana Medical Systems, Inc. Automatische assay-beurteilung und normalisierung für bildverarbeitung
CN111356912B (zh) 2017-11-21 2023-09-05 文塔纳医疗系统公司 使用调制气体射流的非接触式混合
JP7231631B2 (ja) 2017-12-05 2023-03-01 ベンタナ メディカル システムズ， インコーポレイテッド 腫瘍空間異質性およびインターマーカ異質性の計算方法
EP3721372A1 (de) 2017-12-06 2020-10-14 Ventana Medical Systems, Inc. Verfahren zum speichern und abrufen von digitalen pathologieanalyseergebnissen
EP3721373B1 (de) 2017-12-07 2025-03-05 Ventana Medical Systems, Inc. Tieenlernsysteme und verfahren zur gemeinsamen zell- und regionklassifizierung auf biologischen bildern
WO2019120635A1 (en) 2017-12-18 2019-06-27 Ventana Medical Systems, Inc. Peptide nucleic acid conjugates
JP7341144B2 (ja) 2017-12-24 2023-09-08 ヴェンタナ メディカル システムズ， インク． フェノール非含有抗酸染色組成物およびその使用
CN111492224A (zh) 2017-12-24 2020-08-04 文塔纳医疗系统公司 伊红染色技术
EP3729369A2 (de) 2017-12-24 2020-10-28 Ventana Medical Systems, Inc. Rechnerischer pathologieansatz zur retrospektiven analyse von auf gewebe basierenden begleitdiagnostischen klinischen studien
JP2021510894A (ja) 2018-01-11 2021-04-30 ベンタナ メディカル システムズ， インコーポレイテッド 曇り止めバーコード・リーダ
DK3746790T3 (da) 2018-01-31 2023-12-11 Ventana Med Syst Inc Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer
EP3776337B1 (de) 2018-04-13 2024-09-11 Ventana Medical Systems, Inc. Systeme zur schätzung der zellform
JP7214756B2 (ja) 2018-05-15 2023-01-30 ベンタナ メディカル システムズ， インコーポレイテッド ステイン集合体における信号の定量
WO2019224153A1 (en) 2018-05-21 2019-11-28 Genentech, Inc. Her2 heterogeneity as a biomarker in cancer
EP3824288A1 (de) 2018-07-17 2021-05-26 Ventana Medical Systems, Inc. Materialien und verfahren zur detektion von fusionsproteinen
US12020493B2 (en) 2018-07-27 2024-06-25 Ventana Medical Systems, Inc. Systems for automated in situ hybridization analysis
EP3833435B1 (de) 2018-08-09 2025-09-24 F. Hoffmann-La Roche AG Bestimmung von morbus parkinson
CN112673258B (zh) 2018-09-13 2025-07-25 文塔纳医疗系统公司 用于检测ntrk融合蛋白的组织化学和细胞化学方法
WO2020058339A1 (en) 2018-09-20 2020-03-26 Ventana Medical Systems, Inc. Coumarin-based crosslinking reagents
CN112789684B (zh) 2018-10-01 2025-05-09 文塔纳医疗系统公司 用于预测对pd-1轴导向疗法的应答的方法和系统
WO2020081340A1 (en) 2018-10-15 2020-04-23 Ventana Medical Systems, Inc. Image enhancement to enable improved nuclei detection and segmentation
JP7228031B2 (ja) 2018-10-15 2023-02-22 ベンタナ メディカル システムズ， インコーポレイテッド 細胞の分類のためのシステムおよび方法
EP3884259A1 (de) 2018-11-20 2021-09-29 Ventana Medical Systems, Inc. Verfahren und systeme zur herstellung und analyse von zellulären proben für morphologische merkmale und biomarkerexpression
JP7411667B2 (ja) 2019-02-05 2024-01-11 ヴェンタナ メディカル システムズ， インク． ステージｉｖの結腸直腸がんにおける免疫細胞浸潤の評価のための方法及びシステム
CN120063863A (zh) 2019-05-14 2025-05-30 文塔纳医疗系统公司 包括生物学样品处理腔室的系统
JP7644750B2 (ja) 2019-08-28 2025-03-12 ベンタナ メディカル システムズ， インコーポレイテッド 振動分光法による抗原回収および標的回収進行量の評価
WO2021037875A1 (en) 2019-08-28 2021-03-04 Ventana Medical Systems, Inc. Systems and methods for assessing specimen fixation duration and quality using vibrational spectroscopy
EP4110823A1 (de) 2020-02-26 2023-01-04 A2 Biotherapeutics, Inc. Gegen mage-a3-peptid-mhc-komplexe gerichtete polypeptide und verfahren zu deren verwendung
US20250130143A1 (en) * 2020-03-11 2025-04-24 Jin V. WU Devices and components for automated tissue processing and staining and uses thereof
CN114207403B (zh) * 2020-03-11 2022-11-22 贵州美鑫达医疗科技有限公司 用于自动组织处理和染色的装置和组件及其使用
WO2021186902A1 (ja) * 2020-03-17 2021-09-23 株式会社日立ハイテク 自動分析装置
EP4147054A1 (de) 2020-05-07 2023-03-15 Ventana Medical Systems, Inc. Histochemische systeme und verfahren zur beurteilung der egfr- und egfr-ligandexpression in tumorproben
CN115552214A (zh) 2020-05-08 2022-12-30 文塔纳医疗系统公司 外消旋苏木精的半合成和用途
CN115698710A (zh) 2020-05-20 2023-02-03 罗氏血液诊断股份有限公司 使用自动化平台制备打印在载玻片上的生物标志物和罗曼诺夫斯基型染色的样品
AU2021281387B2 (en) * 2020-05-27 2026-03-12 Agilent Technologies, Inc. Apparatus and method for processing biological samples
CN113804902B (zh) * 2020-06-16 2025-09-09 深圳迈瑞生物医疗电子股份有限公司 样本分析仪故障自诊断的方法及样本分析仪
EP4179290A2 (de) 2020-07-10 2023-05-17 Idexx Laboratories, Inc. Medizinischer diagnostischer analysator am versorgungsort sowie vorrichtungen, systeme und verfahren zur medizinischen diagnostischen analyse von proben
JP2023542343A (ja) 2020-09-22 2023-10-06 ヴェンタナ メディカル システムズ， インク． エピレグリンおよびアンフィレグリンを用いた上皮増殖因子受容体指向性療法に対する応答の予測
CN112799444A (zh) * 2020-12-27 2021-05-14 北京工业大学 一种基于51单片机的血液寄生虫检测温控加热仪
EP4278181A1 (de) 2021-01-15 2023-11-22 Ventana Medical Systems, Inc. Lagerstabile haptene in käfigform
JP2024507677A (ja) 2021-01-25 2024-02-21 ベンタナ メディカル システムズ， インコーポレイテッド １つ又は複数の検出可能部分で標識された１つ又は複数のバイオマーカーを含む染色された生物学的検体
JP2024516380A (ja) 2021-04-18 2024-04-15 ヴェンタナ メディカル システムズ， インク． 形態学的マーカー染色
KR102736858B1 (ko) * 2021-12-16 2024-12-04 (주)레보스케치 회전형 다채널 형광스캐너
EP4468864A1 (de) 2022-01-25 2024-12-04 Ventana Medical Systems, Inc. Materialien und verfahren zum bleichen von melaninpigmentierten geweben
JP2025513724A (ja) 2022-03-31 2025-04-30 ヴェンタナ メディカル システムズ， インク． ミスマッチ修復が欠損した結腸直腸腫瘍におけるｐｄ－１軸指向治療薬に対する応答を予測するための方法およびシステム
DE102022111890B3 (de) * 2022-05-12 2023-03-16 Dermagnostix GmbH Verfahren zur Deparaffinierung von Formalin-fixiertem Paraffin-eingebettetem Gewebe
EP4532111A2 (de) * 2022-06-03 2025-04-09 10X Genomics, Inc. Verfahren, systeme und vorrichtungen für probenschnittstelle
EP4519362A2 (de) 2022-06-09 2025-03-12 Ventana Medical Systems, Inc. Synthese eines schiff reagens auf objektträgern
EP4641164A1 (de) 2022-12-23 2025-10-29 Hitachi High-Tech Corporation Vorrichtung zum kühlen/erhitzen von schiebeglas und verfahren zum kühlen/erhitzen von schiebeglas
JP2026502116A (ja) 2022-12-23 2026-01-21 ヴェンタナ メディカル システムズ， インク． 抗原提示機構の構成要素を評価するための材料および方法ならびにそれらの使用
WO2025014787A1 (en) 2023-07-07 2025-01-16 Ventana Medical Systems, Inc. Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells
CN121693762A (zh) 2023-08-16 2026-03-17 文塔纳医疗系统公司 用以确定形态学染色的生物学样本的固定状态的深度学习模型
WO2025166108A1 (en) 2024-02-01 2025-08-07 Ventana Medical Systems, Inc. Methods of generating digitally stained images from unstained biological samples
CN119223966B (zh) * 2024-12-02 2025-02-25 星纯(常州)生物科技有限公司 一种无醇磁珠法病毒提取残留检测装置

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE373963B (de) 1973-06-14 1975-02-17 Janson Sven Olof
GB1445389A (en) * 1973-10-16 1976-08-11 Chemlab Mfg Ltd Sampling arrangements
US3853092A (en) 1973-10-25 1974-12-10 Corning Glass Works Apparatus for nutating and staining a microscope slide
US4043292A (en) 1975-07-21 1977-08-23 Corning Glass Works Microscope slide staining apparatus having temperature control
US4092952A (en) 1977-08-19 1978-06-06 Wilkie Ronald N Automatic slide stainer
SE7801564L (sv) 1978-02-10 1979-08-11 Lkb Produkter Ab Anordning for infergning av biologiska preparat
DE2915248C3 (de) 1979-04-14 1982-01-14 Gise, Frhr. von, Hardo, Dr.med., 7400 Tübingen Einrichtung zum automatischen wahlweisen u. exakten Behandeln von Präparaten
AT364439B (de) * 1980-02-12 1981-10-27 List Hans Einrichtung zur anordnung an einer probeneingabeoeffnung eines analysengeraetes
US4647431A (en) 1980-05-31 1987-03-03 Fuji Photo Film Co., Ltd. Device for maintaining a constant temperature for chemical analysis
US4384193A (en) * 1981-06-09 1983-05-17 Immulok, Inc. Incubating device for specimen mounted on glass slides in immunoassays
US4430299A (en) 1981-06-18 1984-02-07 Coulter Electronics, Inc. Apparatus for monitoring chemical reactions
DK536881A (da) * 1981-12-04 1983-06-05 Radiometer As Proevebaeger
SE451164B (sv) * 1982-03-22 1987-09-07 Erik Ohlin Apparat och sett for serieutspedning av en provvetska
AT381794B (de) * 1984-02-02 1986-11-25 Avl Verbrennungskraft Messtech Analysengeraet zur messung fluessiger oder gasfoermiger proben
US4629862A (en) * 1984-03-28 1986-12-16 Olympus Optical Company Ltd. Sample heater for use in microscopes
US4644807A (en) * 1985-02-21 1987-02-24 Dionex Corporation Fluid sample delivery apparatus
US4731335A (en) 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
JPH0640054B2 (ja) * 1985-09-20 1994-05-25 株式会社千代田製作所 電子顕微鏡標本作成用包埋装置
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
US4858155A (en) 1985-12-24 1989-08-15 Beckman Instruments, Inc. Reaction temperature control system
US4888998A (en) * 1986-07-11 1989-12-26 Beckman Instruments, Inc. Sample handling system
EP0253519B1 (de) * 1986-07-11 1991-10-09 Beckman Instruments, Inc. Probenhandhabungsvorrichtung
US4933146A (en) 1986-07-11 1990-06-12 Beckman Instruments, Inc. Temperature control apparatus for automated clinical analyzer
US5154889A (en) 1986-08-07 1992-10-13 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
US4721680A (en) * 1986-08-11 1988-01-26 Multi-Technology, Inc. Methods of using micro pipette tips
FR2606885B1 (fr) * 1986-11-14 1989-08-04 Abx Sarl Dispositif de nettoyage d'une aiguille de prelevement d'un liquide
US4847208A (en) 1987-07-29 1989-07-11 Bogen Steven A Apparatus for immunohistochemical staining and method of rinsing a plurality of slides
GB8722902D0 (en) 1987-09-30 1987-11-04 Shandon Southern Prod Tissue &c processing
US4927765A (en) * 1988-02-29 1990-05-22 Pharmacia Eni Diagnostics, Inc. Automatic reagent dispenser
FI80147C (fi) * 1988-04-15 1990-04-10 Kone Oy Foerfarande foer foerverkligande av val av vaetska vid vaetskedosering i en analysator samt provtagningsanordning.
US5597733A (en) * 1988-07-25 1997-01-28 Precision Systems, Inc. Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer
JPH0718785B2 (ja) * 1988-09-19 1995-03-06 株式会社日立製作所 フローセル装置
US4865986A (en) 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
US4962041A (en) * 1988-10-06 1990-10-09 Medical Automation Specialities, Inc. Method and apparatus for automatic processing and analyzing of blood serum
FR2641436A1 (de) 1988-12-30 1990-07-06 Labo Electronique Physique
US5429803A (en) * 1991-04-18 1995-07-04 Lamina, Inc. Liquid specimen container and attachable testing modules
US5264182A (en) * 1989-04-12 1993-11-23 Olympus Optical Co., Ltd. Sample and reagent delivery device with a probe and probe supporting member for preventing contamination
US5093557A (en) 1989-05-16 1992-03-03 Microscience, Inc. Substrate heater and heating element
CA2017111C (en) * 1989-06-01 1995-10-31 Andreas Greter Pipetting insert
FR2649018B1 (fr) * 1989-06-30 1991-09-13 Degremont Dispositif pour l'introduction d'un liquide dans un milieu constitue par un materiau granulaire, en vue de la fluidisation de ce materiau
GB8919145D0 (en) 1989-08-23 1989-10-04 Royal Postgrad Med School Apparatus for the in situ hybridisation of slide-mounted cell samples
US5089229A (en) 1989-11-22 1992-02-18 Vettest S.A. Chemical analyzer
US4989623A (en) * 1989-12-01 1991-02-05 Akzo N.V. Apparatus and method for cleaning reagent delivery probes
CA2035067C (en) * 1990-02-22 1995-06-27 William M. Blough, Jr. Fluid mixing device
US5595707A (en) * 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
CA2076370A1 (en) 1990-03-02 1991-09-03 Thomas B. Green Analyzer transport device
US5075079A (en) * 1990-05-21 1991-12-24 Technicon Instruments Corporation Slide analysis system
US5207987A (en) 1990-05-21 1993-05-04 Pb Diagnostic Systems Inc. Temperature controlled chamber for diagnostic analyzer
US5425918A (en) 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
JP2530738Y2 (ja) * 1990-11-13 1997-03-26 株式会社明電舎 ノズル洗浄ポート
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
EP0493089B1 (de) 1990-12-25 1998-09-16 Ngk Insulators, Ltd. Heizungsapparat für eine Halbleiterscheibe und Verfahren zum Herstellen desselben
US5273905A (en) * 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
US5246665A (en) 1991-06-03 1993-09-21 Abbott Laboratories Heat and air flow control for assay carrier
CA2218875C (en) * 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
GB9123463D0 (en) 1991-11-05 1991-12-18 Hybaid Ltd Reaction temperature control device
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
FR2688313A1 (fr) * 1992-03-04 1993-09-10 Marteau D Autry Eric Filtration et identification automatique d'echantillons.
US5947167A (en) * 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5316452A (en) 1992-05-11 1994-05-31 Gilbert Corporation Dispensing assembly with interchangeable cartridge pumps
US5645114A (en) * 1992-05-11 1997-07-08 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5314825A (en) * 1992-07-16 1994-05-24 Schiapparelli Biosystems, Inc. Chemical analyzer
US5601141A (en) * 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5408891A (en) 1992-12-17 1995-04-25 Beckman Instruments, Inc. Fluid probe washing apparatus and method
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system
JP3323294B2 (ja) * 1993-09-14 2002-09-09 富士写真フイルム株式会社 点着チップおよびこの点着チップを用いた液体濃縮防止方法
US5439649A (en) * 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
JP3051626B2 (ja) 1993-12-09 2000-06-12 富士写真フイルム株式会社 インキュベータ
US5523056A (en) 1994-04-29 1996-06-04 Johnson & Johnson Clinical Diagnostics, Inc. Twin rotor incubator assembly
JP3387649B2 (ja) * 1994-09-16 2003-03-17 富士写真フイルム株式会社 点着チップ
EP0729021A1 (de) * 1995-02-25 1996-08-28 Roche Diagnostics GmbH Vorrichtung zur Bearbeitung von Proben auf Objektträgern
US5645144A (en) * 1995-08-22 1997-07-08 A-Dec, Inc. Control mechanism for sliding panel
EP0835452B1 (de) * 1996-04-26 2005-08-10 Dade Behring Inc. Verfahren und vorrichtung zur vorbehandlung von proben in einem chemischen analysator
US6096271A (en) * 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
US6183693B1 (en) 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
EP1579527B1 (de) * 2002-12-09 2012-04-25 Corridor Systems, Inc. Verfahren und vorrichtung zum einspeisen einer oberflächenwelle auf eine einzelleiter-übertragungsleitung
US20100128351A1 (en) * 2008-11-21 2010-05-27 3M Innovative Properties Company Curved sided cone structures for controlling gain and viewing angle in an optical film

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ES2354598T3 (es) 2011-03-16
AU2879699A (en) 1999-09-15
CN100403008C (zh) 2008-07-16
AU763354B2 (en) 2003-07-17
WO1999043434A1 (en) 1999-09-02
JP2006304806A (ja) 2006-11-09
AU2883499A (en) 1999-09-15
EP1073892A4 (de) 2005-10-12
EP2284543A3 (de) 2015-05-27
WO1999044030A9 (en) 1999-12-16
AU2003255169A1 (en) 2003-11-13
WO1999044030A1 (en) 1999-09-02
JP2002504694A (ja) 2002-02-12
EP2284543A2 (de) 2011-02-16
US6296809B1 (en) 2001-10-02
JP4505538B2 (ja) 2010-07-21
CA2321836A1 (en) 1999-09-02
EP1073892B1 (de) 2010-11-24
EP1073892A1 (de) 2001-02-07
JP2010091579A (ja) 2010-04-22
JP4505547B2 (ja) 2010-07-21
JP4091960B2 (ja) 2008-05-28
JP2009216714A (ja) 2009-09-24
EP1056541B1 (de) 2017-10-25
CA2321836C (en) 2004-09-28
JP2002505089A (ja) 2002-02-19
EP1056541A1 (de) 2000-12-06
EP1056541A4 (de) 2005-11-30
JP3847559B2 (ja) 2006-11-22
CN1297529A (zh) 2001-05-30
CA2320750C (en) 2004-08-24
CA2320750A1 (en) 1999-09-02

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