ATE489613T1 - Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern - Google Patents

Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern

Info

Publication number
ATE489613T1
ATE489613T1 AT99909630T AT99909630T ATE489613T1 AT E489613 T1 ATE489613 T1 AT E489613T1 AT 99909630 T AT99909630 T AT 99909630T AT 99909630 T AT99909630 T AT 99909630T AT E489613 T1 ATE489613 T1 AT E489613T1
Authority
AT
Austria
Prior art keywords
probe
warmers
molecular pathology
independent slide
automated molecular
Prior art date
Application number
AT99909630T
Other languages
English (en)
Inventor
William Richards
Charles Lemme
Kimberly Christensen
Ethel Macrea
Original Assignee
Ventana Med Syst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Med Syst Inc filed Critical Ventana Med Syst Inc
Application granted granted Critical
Publication of ATE489613T1 publication Critical patent/ATE489613T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Laminated Bodies (AREA)
AT99909630T 1998-02-27 1999-02-26 Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern ATE489613T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7619898P 1998-02-27 1998-02-27
PCT/US1999/004181 WO1999044030A1 (en) 1998-02-27 1999-02-26 Automated molecular pathology apparatus having independent slide heaters

Publications (1)

Publication Number Publication Date
ATE489613T1 true ATE489613T1 (de) 2010-12-15

Family

ID=22130540

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99909630T ATE489613T1 (de) 1998-02-27 1999-02-26 Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern

Country Status (10)

Country Link
US (1) US6296809B1 (de)
EP (3) EP1056541B1 (de)
JP (5) JP3847559B2 (de)
CN (1) CN100403008C (de)
AT (1) ATE489613T1 (de)
AU (3) AU2883499A (de)
CA (2) CA2320750C (de)
DE (1) DE69942975D1 (de)
ES (1) ES2354598T3 (de)
WO (2) WO1999044030A1 (de)

Families Citing this family (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180061B1 (en) 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US20040191128A1 (en) * 1992-05-11 2004-09-30 Cytologix Corporation Slide stainer with heating
US6735531B2 (en) 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
JP3750772B2 (ja) * 1998-01-27 2006-03-01 富士写真フイルム株式会社 生化学分析装置
GB9803684D0 (en) * 1998-02-24 1998-04-15 Genevac Ltd Method and apparatus for controlling temperature during evaporation of samples
US6183693B1 (en) * 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US7188001B2 (en) * 1998-03-23 2007-03-06 Cepheid System and method for temperature control
US6495106B1 (en) * 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
US6620620B1 (en) * 1998-04-27 2003-09-16 Era Systems, Inc. Micro liquid evaporator
US6855552B2 (en) * 1998-09-03 2005-02-15 Ventana Medical Systems Automated immunohistochemical and in situ hybridization assay formulations
US7550298B2 (en) * 1998-09-03 2009-06-23 Ventana Medical Systems, Inc. Automated immunohistochemical and in situ hybridization assay formulations
US6649128B1 (en) * 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
US6544798B1 (en) * 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US7897106B2 (en) 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US6534008B1 (en) 1999-07-08 2003-03-18 Lee Angros In situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
WO2001022086A1 (en) * 1999-09-24 2001-03-29 Jonathan Cohen A high-throughput system for evaluating the clinical utility of molecular targets in tissue samples
US6403931B1 (en) 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
DE10006084B4 (de) * 2000-02-11 2009-01-02 Leica Biosystems Nussloch Gmbh Färbeautomat mit einer Heizstation
US6824738B1 (en) * 2000-04-14 2004-11-30 Discovery Partners International, Inc. System and method for treatment of samples on solid supports
DE10041227B4 (de) * 2000-08-22 2011-12-29 Leica Biosystems Nussloch Gmbh Vorrichtung zur Behandlung von Objekten
US6656685B2 (en) * 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
GB0117706D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Automated semi-solid matrix assay and liquid handler apparatus for the same
US7691598B2 (en) * 2001-03-30 2010-04-06 Nanoprobes, Inc. Method for detecting a target molecule by metal deposition
US7888060B2 (en) * 2001-03-30 2011-02-15 Nanoprobes, Inc. Method for detecting a target using enzyme directed deposition of elemental metal
US6662136B2 (en) * 2001-04-10 2003-12-09 International Business Machines Corporation Digital temperature sensor (DTS) system to monitor temperature in a memory subsystem
ES2400448T3 (es) * 2001-04-30 2013-04-10 Ventana Medical Systems, Inc. Reactivos y métodos para la hibridación automatizada in situ o para microarray
US7425306B1 (en) 2001-09-11 2008-09-16 Ventana Medical Systems, Inc. Slide heater
US7270785B1 (en) 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US6936474B2 (en) * 2001-11-05 2005-08-30 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
AU2002361618A1 (en) * 2001-11-13 2003-05-26 Chromavision Medical Systems, Inc. A system for tracking biological samples
US6998270B2 (en) * 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
US20040033163A1 (en) * 2001-11-26 2004-02-19 Lab Vision Corporation Automated tissue staining system and reagent container
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
DK1890127T3 (da) 2002-04-15 2013-09-23 Ventana Med Syst Inc Automatiseret objektglasfarvningssystem med høj kapacitet
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
ES2556242T3 (es) 2002-04-26 2016-01-14 Ventana Medical Systems, Inc. Aparato de patología molecular automatizado que tiene plataformas de portaobjetos fijas
US6833536B2 (en) 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
US20040126837A1 (en) * 2002-05-23 2004-07-01 Matthew Baker Pseudo-tissues and uses thereof
CA2489412A1 (en) * 2002-07-16 2004-01-22 Ventana Medical Systems, Inc. Tray for automated histochemical processing
KR20040023999A (ko) * 2002-09-12 2004-03-20 엘지전자 주식회사 의류건조기의 모터축 구조
US7584019B2 (en) * 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7875245B2 (en) * 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7850912B2 (en) * 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US20060073074A1 (en) * 2004-10-06 2006-04-06 Lars Winther Enhanced sample processing system and methods of biological slide processing
EP1625382A2 (de) * 2003-05-19 2006-02-15 Ventana Medical Systems, Inc. Elektrophoretische in-situ-gewebeanfärbung
WO2004111610A2 (en) 2003-06-12 2004-12-23 Accupath Diagnostic Laboratories, Inc. Method and system for the analysis of high density cells samples
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
US7501283B2 (en) 2003-08-11 2009-03-10 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US7767152B2 (en) 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US7744817B2 (en) 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
US7273591B2 (en) * 2003-08-12 2007-09-25 Idexx Laboratories, Inc. Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same
EP2489437A1 (de) * 2003-09-09 2012-08-22 BioGenex Laboratories Probenverarbeitungssystem
US7588733B2 (en) 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
US8012693B2 (en) * 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US8026106B1 (en) 2003-12-18 2011-09-27 Ventana Medical Systems, Inc. Removal of mercuric chloride crystals from fixed tissues
EP1697719B1 (de) * 2003-12-23 2018-09-19 Ventana Medical Systems, Inc. Verfahren und vorrichtung für effiziente dünnfilmfluid-bearbeitung auf ebenen flächen
CN1965223A (zh) * 2004-03-02 2007-05-16 丹麦达科有限公司 用于生物学着色仪的试剂传送系统、释放设备和容器
CN101006053A (zh) 2004-06-18 2007-07-25 比奥里波克斯公司 用于治疗炎症的吲哚
EP1771716A4 (de) * 2004-06-29 2012-04-25 Dako Denmark As Verfahren zur vorbehandlung und färbung einer trägervorrichtung für eine biologische probe
US7867443B2 (en) * 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
JP4806410B2 (ja) * 2004-07-23 2011-11-02 ベンタナ・メデイカル・システムズ・インコーポレーテツド 流体を生物学的試料に適用するための方法および装置
US7514041B2 (en) * 2004-07-28 2009-04-07 N-Solv Corporation Method and apparatus for testing heavy oil production processes
ATE501119T1 (de) 2005-01-19 2011-03-15 Biolipox Ab Entzündungshemmende indol-derivate
GB0501590D0 (en) * 2005-01-25 2005-03-02 Ceres Power Ltd Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode
WO2006116199A2 (en) * 2005-04-21 2006-11-02 Celerus Diagnostics, Inc. Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry
DE102005020426B4 (de) * 2005-04-29 2017-05-04 Leica Biosystems Nussloch Gmbh Eindeckautomat
WO2006127852A2 (en) * 2005-05-24 2006-11-30 Angros Lee H In situ heat induced antigen recovery and staining apparatus and method
CN100406874C (zh) * 2005-06-20 2008-07-30 北京源德生物医学工程有限公司 半自动微孔板单光子计数仪的门组件
EP1904670B1 (de) * 2005-06-28 2011-09-28 The Board of Regents of the University of Oklahoma Verfahren zur züchtung und entnahme von kohlenstoffnanoröhren
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
GB0521851D0 (en) * 2005-10-26 2005-12-07 Genial Genetic Solutions Ltd Biological apparatus
US9551635B2 (en) 2006-03-09 2017-01-24 Biogenex Laboratories Inc. Sample processing system
US8459509B2 (en) 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
CA2549614C (en) * 2006-06-07 2014-11-25 N-Solv Corporation Methods and apparatuses for sagd hydrocarbon production
CA2552482C (en) * 2006-07-19 2015-02-24 N-Solv Corporation Methods and apparatuses for enhanced in situ hydrocarbon production
US20090321263A1 (en) * 2006-09-22 2009-12-31 Fujifilm Corporation Clinical analysis apparatus
US7695929B2 (en) 2006-11-01 2010-04-13 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
US9116129B2 (en) 2007-05-08 2015-08-25 Idexx Laboratories, Inc. Chemical analyzer
ES2731432T3 (es) 2007-05-23 2019-11-15 Ventana Med Syst Inc Transportadores poliméricos para inmunohistoquímica e hibridación in situ
EP2165201B1 (de) * 2007-07-10 2012-02-29 Ventana Medical Systems, Inc. Vorrichtung und verfahren zur verarbeitung biologischer proben
US8440425B2 (en) * 2007-12-18 2013-05-14 Abbott Laboratories Method of preparing a biological specimen slide
EP2255310B1 (de) 2008-02-29 2019-02-20 Dako Denmark A/S Systeme und verfahren zur ortung und bereitstellung von arbeitsflussinformationen
US9802022B2 (en) * 2008-03-06 2017-10-31 Resmed Limited Humidification of respiratory gases
DK2995925T3 (da) 2008-06-05 2022-02-21 Ventana Med Syst Inc Sammensætning til histokemisk processering
EP2334827B1 (de) 2008-08-22 2015-03-11 Ventana Medical Systems, Inc. Verfahren zum chromogenen nachweis von zwei oder mehr zielmolekülen in einer einzelprobe
GB2477648B (en) 2008-08-29 2013-02-20 Lee H Angros In situ heat induced antigen recovery and staining apparatus and method
EP2350673B1 (de) * 2008-10-24 2022-05-11 Leica Biosystems Richmond, Inc. Modulares system für laborprotokolle und zugehörige verfahren
CN102209889B (zh) 2008-11-12 2015-05-13 文塔纳医疗系统公司 用于加热载持标本的载玻片的方法及设备
JP2012528569A (ja) 2009-05-29 2012-11-15 ヴェンタナ メディカル システムズ， インク． インサイツハイブリダイゼーションを使用した生物学試料の遺伝子コピー数のスコアリング法
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
DE102010010975B4 (de) 2009-09-14 2012-05-31 Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg Objektträgerhalter
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
KR101358549B1 (ko) * 2009-11-13 2014-02-05 벤타나 메디컬 시스템즈, 인코포레이티드 조절 가능한 체적 수용을 위한 박막 프로세싱 장치
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
WO2011096468A1 (ja) 2010-02-05 2011-08-11 株式会社ニチレイバイオサイエンス 免疫組織化学染色用前処理液及びその濃縮液
ES2606012T3 (es) 2010-02-26 2017-03-17 Ventana Medical Systems, Inc. Hibridación in situ con sondas PolyTag
CA2786853A1 (en) 2010-02-26 2011-09-01 Ventana Medical Systems, Inc. Cytogenic analysis of metaphase chromosomes
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
US10267769B2 (en) 2010-03-04 2019-04-23 Ventana Medical Systems, Inc. Processing system for processing specimens using acoustic energy
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
US9040310B2 (en) 2010-04-27 2015-05-26 Ventana Medical Systems, Inc. Antibody-nanoparticle conjugates and methods for making and using such conjugates
EP2564206A4 (de) 2010-04-29 2016-09-07 Leica Biosystems Richmond Inc Analysesystem zur ausführung von laborprotokollen und zugehörige verfahren
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
EP2752247A3 (de) * 2010-07-23 2016-08-31 Beckman Coulter, Inc. System oder Verfahren zur Aufnahme analytischer Einheiten
JP5393610B2 (ja) * 2010-07-28 2014-01-22 株式会社日立ハイテクノロジーズ 核酸分析装置
WO2012048154A1 (en) 2010-10-06 2012-04-12 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
DK2659000T3 (en) 2010-12-30 2016-08-29 Ventana Med Syst Inc ENHANCED DEPOSIT OF Chromogens USING pyrimidine
JP2014505248A (ja) 2011-01-10 2014-02-27 ヴェンタナ メディカル システムズ， インク． ヘマトキシリン染色法
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
US10295442B2 (en) 2011-02-28 2019-05-21 Dako Denmark A/S Two phase immiscible system for the pretreatment of embedded biological samples
CN103534359B (zh) 2011-03-14 2016-07-06 文塔纳医疗系统公司 分析染色体易位的方法及其系统
WO2012158988A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for valving on a sample processing device
BR112013029181B1 (pt) 2011-05-18 2020-11-03 Focus Diagnostics, Inc. método e sistema para o processamento de dispositivos de processamento de amostras
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
MX336625B (es) 2011-05-18 2016-01-26 3M Innovative Properties Co Sistemas y metodos para medicion volumetrica en dispositivo de procesamiento de muestra.
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
WO2013079606A1 (en) 2011-12-01 2013-06-06 Ventana Medical Systems, Inc. Automated dual stain of mirna and protein targets
EP2798355B1 (de) 2011-12-30 2018-09-12 Ventana Medical Systems, Inc. Automatisierte analyse von zirkulierenden tumorzellen
WO2013112891A1 (en) 2012-01-26 2013-08-01 Leica Biosystems Richmond, Inc. Methods and compositions for hematoxylin and eosin staining
EP2807272A1 (de) 2012-01-27 2014-12-03 Ventana Medical Systems, Inc. Vorrichtungen und verfahren zur erkennung von bioanalyten mit optisch enträtselbaren mustern
US10521644B2 (en) 2012-02-01 2019-12-31 Ventana Medical Systems, Inc. Lab color space silver and red in situ hybridization based techniques for detecting genes in tissue samples
US9909962B2 (en) 2012-03-09 2018-03-06 Leica Biosystems Richmond, Inc. Device and method for controlling the temperature in a moving fluid in a laboratory sample processing system
CN104245955B (zh) 2012-03-19 2018-03-16 文塔纳医疗系统公司 改进了对革兰氏阴性细菌的结晶紫‑碘复合物的脱色的革兰氏染色方法
BR112014026735B1 (pt) * 2012-04-27 2021-11-23 Cepheid Aparelho de processamento de amostra biológica, e, método para operar um aparelho de processamento de amostra
AU2013329655B2 (en) 2012-10-08 2017-01-12 Ventana Medical Systems, Inc. Methods, kits, and systems for clarifying pigmented samples
EP2917715B1 (de) 2012-11-06 2019-04-03 Biodot, Inc. Gesteuertes bedrucken einer zellprobe für karyotypisierung
WO2014079802A2 (en) 2012-11-20 2014-05-30 Ventana Medical Systems, Inc. Laser ablation inductively-coupled plasma mass spectral tissue diagnostics
EP2925450B1 (de) 2012-12-03 2017-09-13 Leica Biosystems Melbourne Pty Ltd Wärmemodul für eine probenverarbeitungsanordnung
JP5981665B2 (ja) * 2012-12-26 2016-08-31 ベンタナ メディカル システムズ， インコーポレイテッド 試薬を準備する標本処理システムおよび方法
CA2890956A1 (en) * 2012-12-26 2014-07-03 Ventana Medical Systems, Inc. Specimen processing systems and method for uniformly heating slides
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN103149070B (zh) * 2013-03-11 2014-10-08 黄石市第一医院 一种自动染片机
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
US10429279B2 (en) 2013-07-28 2019-10-01 Xmd, Llc Devices and cartridges for extracting bio-sample regions and molecules of interest
CN105793690B (zh) 2013-12-13 2020-01-03 文塔纳医疗系统公司 生物样本的自动化组织学处理及相关的技术
CN105980828B (zh) 2013-12-13 2021-12-17 文塔纳医疗系统公司 用于生物标本组织处理的染色试剂和其它液体及关联技术
EP3080577B1 (de) * 2013-12-13 2021-07-28 Ventana Medical Systems, Inc. Wärmeverwaltung im kontext der automatisierten histologischen verarbeitung biologischer proben und entsprechende technologie
ES2929493T3 (es) 2013-12-13 2022-11-29 Ventana Med Syst Inc Sistemas de procesamiento automatizados y procedimientos de procesamiento térmico de portaobjetos de microscopio
US9797916B2 (en) 2014-01-10 2017-10-24 Idexx Laboratories, Inc. Chemical analyzer
WO2015124703A1 (en) 2014-02-24 2015-08-27 Ventana Medical Systems, Inc. Quinone methide analog signal amplification
EP3617322A1 (de) 2014-02-24 2020-03-04 Ventana Medical Systems, Inc. Automatisierter rna-nachweis mit markierten 2-o-methyl-rns-oligonukleotidsonden und signalverstärkungssystemen
EP3152577B1 (de) 2014-06-06 2018-07-18 Ventana Medical Systems, Inc. Bedeutung der intratumoralen her2 heterogenität in brustkrebs und deren verwendung
EP3160648B1 (de) 2014-06-30 2024-04-03 Ventana Medical Systems, Inc. Probenverarbeitungssysteme, pipettenanordnungen und verfahren zur zubereitung von reagenzien
AU2015326827B2 (en) 2014-10-02 2019-11-07 Ventana Medical Systems, Inc. Polymers and conjugates comprising the same
AU2015373423A1 (en) 2014-12-30 2017-05-18 Ventana Medical Systems, Inc. Systems and methods for co-expression analysis in immunoscore computation
WO2016120195A1 (en) 2015-01-27 2016-08-04 Ventana Medical Systems, Inc. Methods for tissue sample fixation using an extended soak in aldehyde-based fixative solutions
WO2016120440A1 (en) 2015-01-29 2016-08-04 Ventana Medical Systems, Inc. Dot detection, color classification of dots and counting of color classified dots
WO2016120441A2 (en) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Quality metrics for automatic evaluation of dual ish images
WO2016120442A1 (en) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Foreground segmentation and nucleus ranking for scoring dual ish images
WO2016146616A1 (en) 2015-03-16 2016-09-22 Ventana Medical Systems, Inc. Control slides for immunohistochemistry generated from three-dimensional cell line cultures
AU2016248882B2 (en) * 2015-04-13 2020-04-30 Ventana Medical Systems, Inc. Thermochemical-based antibody inactivation methods and systems
AU2016261279B2 (en) 2015-05-10 2020-12-10 Ventana Medical Systems, Inc. Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays
WO2016189065A1 (en) 2015-05-26 2016-12-01 Ventana Medical Systems, Inc. Method and system for assessing stain quality for in-situ hybridization and immunohistochemistry
WO2017040349A1 (en) 2015-08-28 2017-03-09 Ventana Medical Systems, Inc. Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
CN105400693B (zh) * 2015-12-15 2017-06-06 上海海洋大学 平板等温核酸扩增芯片
CN105400692B (zh) * 2015-12-15 2017-06-27 上海海洋大学 等温核酸扩增装置及等温核酸扩增实验方法
JP6876062B2 (ja) 2016-01-26 2021-05-26 ヴェンタナ メディカル システムズ， インク． 自動ダイセクション、次世代シークエンシング、及び自動スライド染色装置を用いる、腫瘍のための予測診断ワークフロー
AU2017229370B2 (en) 2016-03-08 2021-03-11 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
WO2017218882A1 (en) 2016-06-16 2017-12-21 Nanocytomics, LLC Automated staining system
EP3475701B1 (de) 2016-06-28 2023-02-22 Ventana Medical Systems, Inc. Neue farben für chromogene ihc- und ish-färbung mit mehrfachfarbstoff-chinon-methid- und tyramid-konjugaten
CN121021395A (zh) 2016-06-28 2025-11-28 文塔纳医疗系统公司 点击化学用于ihc和ish测定中的信号扩增的应用
DE112016007190T5 (de) * 2016-08-30 2019-07-04 Aiham Z. S. Qdaisat Automatisiertes Objektträgerbetropfungssystem
WO2018055014A1 (en) 2016-09-23 2018-03-29 Ventana Medical Systems, Inc. Methods and systems for scoring extracellular matrix biomarkers in tumor samples
CN106370830A (zh) * 2016-11-14 2017-02-01 漯河医学高等专科学校 一种具有单独滑片加热器的分子病理学装置
EP3555634B1 (de) 2016-12-16 2023-09-06 Ventana Medical Systems, Inc. Reduzierung von pipettenrückständen
EP3555588B1 (de) 2016-12-19 2021-03-03 Ventana Medical Systems, Inc. Passives schwerkraftgesteuertes system zur behandlung eines abflusses in einem diagnosesystem
CN110121364A (zh) 2016-12-19 2019-08-13 文塔纳医疗系统公司 肽核酸缀合物
WO2018118786A1 (en) 2016-12-19 2018-06-28 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
EP3559672B1 (de) 2016-12-21 2021-10-13 Ventana Medical Systems, Inc. Verfahren und systeme zur zuführung von reagenzien
JP6877550B2 (ja) 2016-12-22 2021-05-26 ヴェンタナ メディカル システムズ， インク． 組織試料用の全自動核酸抽出方法
EP3559902B1 (de) 2016-12-22 2025-01-29 Ventana Medical Systems, Inc. Computerwertung auf der basis von primärfärbung und immunhistochemischen bildern
US10890523B2 (en) * 2017-01-19 2021-01-12 Agilent Technologies, Inc. Multi-temperature optical spectrometer modules, systems and methods of using the same
CN110383035B (zh) * 2017-03-16 2024-04-02 美国西门子医学诊断股份有限公司 用于诊断分析仪中的培育系统的热控制的系统和方法
EP3610451B1 (de) 2017-04-14 2021-09-29 Ventana Medical Systems, Inc. Lokale kachelbasierte registrierung und globale platzierung für stitching
CA3062732C (en) 2017-05-10 2023-08-01 Ventana Medical Systems, Inc. Stabilized two-part hematoxylin solution utilizing ph adjustment
EP3631410B1 (de) 2017-05-26 2024-08-28 Ventana Medical Systems, Inc. Berührungslose flüssigkeitsmischung auf einem objektträger
CN110785654A (zh) 2017-06-28 2020-02-11 文塔纳医疗系统公司 系统级校准
EP3659110A1 (de) 2017-07-24 2020-06-03 Ventana Medical Systems, Inc. Verfahren und systeme zur auswertung eines immunzelleninfiltrats in tumorproben
WO2019025533A1 (en) 2017-08-04 2019-02-07 Ventana Medical Systems, Inc. AUTOMATIC ASSAY ASSESSMENT AND NORMALIZATION FOR IMAGE PROCESSING
CN111602172B (zh) 2017-08-04 2023-09-26 文塔纳医疗系统公司 利用散射校正进行颜色解混
EP3714251B1 (de) 2017-11-21 2024-04-03 Ventana Medical Systems, Inc. Berührungsloses mischen mit modulierten luftstrahlen
EP3721406B1 (de) 2017-12-05 2024-01-24 Ventana Medical Systems, Inc. Verfahren zur berechnung der räumlichen heterogenität von tumoren und der heterogenität zwischen den markern
CN117038018A (zh) 2017-12-06 2023-11-10 文塔纳医疗系统公司 存储和检索数字病理学分析结果的方法
EP3721373B1 (de) 2017-12-07 2025-03-05 Ventana Medical Systems, Inc. Tieenlernsysteme und verfahren zur gemeinsamen zell- und regionklassifizierung auf biologischen bildern
WO2019120635A1 (en) 2017-12-18 2019-06-27 Ventana Medical Systems, Inc. Peptide nucleic acid conjugates
EP3729369A2 (de) 2017-12-24 2020-10-28 Ventana Medical Systems, Inc. Rechnerischer pathologieansatz zur retrospektiven analyse von auf gewebe basierenden begleitdiagnostischen klinischen studien
WO2019122057A2 (en) 2017-12-24 2019-06-27 Ventana Medical Systems, Inc. Eosin staining techniques
EP3729048B1 (de) 2017-12-24 2023-08-30 Ventana Medical Systems, Inc. Phenol-freie, säurefeste färbemittelzusammensetzung und deren verwendung
JP2021510894A (ja) 2018-01-11 2021-04-30 ベンタナ メディカル システムズ， インコーポレイテッド 曇り止めバーコード・リーダ
ES2965647T3 (es) 2018-01-31 2024-04-16 Ventana Med Syst Inc Procedimientos y sistemas para la evaluación de infiltrado de células inmunitarias en cáncer colorrectal en estadio III
EP3776337B1 (de) 2018-04-13 2024-09-11 Ventana Medical Systems, Inc. Systeme zur schätzung der zellform
CN112424825B (zh) 2018-05-15 2025-01-07 文塔纳医疗系统公司 染色聚集体中信号的定量
WO2019224153A1 (en) 2018-05-21 2019-11-28 Genentech, Inc. Her2 heterogeneity as a biomarker in cancer
EP3824288A1 (de) 2018-07-17 2021-05-26 Ventana Medical Systems, Inc. Materialien und verfahren zur detektion von fusionsproteinen
EP3830742B1 (de) 2018-07-27 2025-02-26 Ventana Medical Systems, Inc. Systeme zur automatisierten in-situ-hybridisierungsanalyse
EP3833435B1 (de) 2018-08-09 2025-09-24 F. Hoffmann-La Roche AG Bestimmung von morbus parkinson
CN112673258B (zh) 2018-09-13 2025-07-25 文塔纳医疗系统公司 用于检测ntrk融合蛋白的组织化学和细胞化学方法
JP7455816B2 (ja) 2018-09-20 2024-03-26 ヴェンタナ メディカル システムズ， インク． クマリン系架橋試薬
CN112789684B (zh) 2018-10-01 2025-05-09 文塔纳医疗系统公司 用于预测对pd-1轴导向疗法的应答的方法和系统
CN112823376B (zh) 2018-10-15 2025-09-05 文塔纳医疗系统公司 图像增强以实现改善的核检测和分割
WO2020081343A1 (en) 2018-10-15 2020-04-23 Ventana Medical Systems, Inc. Systems and methods for cell classification
JP7548903B2 (ja) 2018-11-20 2024-09-10 ヴェンタナ メディカル システムズ， インク． 形態学的特徴およびバイオマーカー発現のために細胞サンプルを調製および分析するための方法およびシステム
JP7411667B2 (ja) 2019-02-05 2024-01-11 ヴェンタナ メディカル システムズ， インク． ステージｉｖの結腸直腸がんにおける免疫細胞浸潤の評価のための方法及びシステム
CN113785184B (zh) 2019-05-14 2025-02-28 文塔纳医疗系统公司 包括生物学样品处理腔室的系统
EP4022287B1 (de) 2019-08-28 2025-07-30 Ventana Medical Systems, Inc. Systeme und verfahren zur beurteilung der fixierdauer und der qualität von proben mittels vibrationsspektroskopie
JP7644750B2 (ja) 2019-08-28 2025-03-12 ベンタナ メディカル システムズ， インコーポレイテッド 振動分光法による抗原回収および標的回収進行量の評価
WO2021173674A1 (en) 2020-02-26 2021-09-02 A2 Biotherapeutics, Inc. Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof
CN114207403B (zh) * 2020-03-11 2022-11-22 贵州美鑫达医疗科技有限公司 用于自动组织处理和染色的装置和组件及其使用
US20250130143A1 (en) * 2020-03-11 2025-04-24 Jin V. WU Devices and components for automated tissue processing and staining and uses thereof
EP4123309A4 (de) * 2020-03-17 2024-04-10 Hitachi High-Tech Corporation Automatische analysevorrichtung
CN115552248A (zh) 2020-05-07 2022-12-30 文塔纳医疗系统公司 用于评价肿瘤样品中egfr和egfr配体表达的组织化学系统和方法
WO2021224361A2 (en) 2020-05-08 2021-11-11 Ventana Medical Systems, Inc. Semi-synthesis and use of racemic hematoxylin
EP4153994B1 (de) 2020-05-20 2025-11-12 Roche Diagnostics Hematology, Inc. Verwendung von automatisierten plattformen zur herstellung von auf einem objektträger gedruckten biomarker- und romanowsky-gefärbten proben
ES3009236T3 (en) * 2020-05-27 2025-03-26 Agilent Technologies Inc Apparatus and method for processing biological samples
CN113804902B (zh) * 2020-06-16 2025-09-09 深圳迈瑞生物医疗电子股份有限公司 样本分析仪故障自诊断的方法及样本分析仪
US11977091B2 (en) 2020-07-10 2024-05-07 Idexx Laboratories Inc. Point-of-care medical diagnostic analyzer and devices, systems, and methods for medical diagnostic analysis of samples
EP4217393A1 (de) 2020-09-22 2023-08-02 Ventana Medical Systems, Inc. Vorhersage der reaktion auf epidermalen wachstumsfaktorrezeptorgerichtete therapien mit epiregulin und amphiregulin
CN112799444A (zh) * 2020-12-27 2021-05-14 北京工业大学 一种基于51单片机的血液寄生虫检测温控加热仪
EP4278181A1 (de) 2021-01-15 2023-11-22 Ventana Medical Systems, Inc. Lagerstabile haptene in käfigform
CN116868054A (zh) 2021-01-25 2023-10-10 文塔纳医疗系统公司 包括用一个或多个可检测部分标记的一种或多种生物标志物的染色生物学样本
JP2024516380A (ja) 2021-04-18 2024-04-15 ヴェンタナ メディカル システムズ， インク． 形態学的マーカー染色
KR102736858B1 (ko) * 2021-12-16 2024-12-04 (주)레보스케치 회전형 다채널 형광스캐너
JP2025506619A (ja) 2022-01-25 2025-03-13 ベンタナ メディカル システムズ， インコーポレイテッド メラニン色素組織を漂白するための材料および方法
EP4500183A1 (de) 2022-03-31 2025-02-05 Ventana Medical Systems, Inc. Verfahren und systeme zur vorhersage der reaktion auf pd-1-achsengerichtete therapeutika bei kolorektalen tumoren mit reparatur mangelhafter fehlanpassung
DE102022111890B3 (de) * 2022-05-12 2023-03-16 Dermagnostix GmbH Verfahren zur Deparaffinierung von Formalin-fixiertem Paraffin-eingebettetem Gewebe
EP4532111A2 (de) * 2022-06-03 2025-04-09 10X Genomics, Inc. Verfahren, systeme und vorrichtungen für probenschnittstelle
JP2025519560A (ja) 2022-06-09 2025-06-26 ベンタナ メディカル システムズ， インコーポレイテッド シッフ試薬のオンスライド合成
WO2024137817A1 (en) 2022-12-23 2024-06-27 Ventana Medical Systems, Inc. Materials and methods for evaluation of antigen presentation machinery components and uses thereof
CN120380313A (zh) 2022-12-23 2025-07-25 株式会社日立高新技术 载玻片冷却/加热装置及载玻片的冷却/加热方法
CN121844210A (zh) 2023-07-07 2026-04-10 文塔纳医疗系统公司 用于评估细胞中er、pr和ki-67生物标志物的共定位的明场三重免疫组织化学测定
WO2025038339A1 (en) 2023-08-16 2025-02-20 Ventana Medical Systems, Inc. Deep learning model to determine a fixation status of a morphologically stained biological specimen
WO2025166108A1 (en) 2024-02-01 2025-08-07 Ventana Medical Systems, Inc. Methods of generating digitally stained images from unstained biological samples
WO2026072715A1 (en) 2024-09-27 2026-04-02 Ventana Medical Systems, Inc. Compositions, kits, and methods for silver staining
CN119223966B (zh) * 2024-12-02 2025-02-25 星纯(常州)生物科技有限公司 一种无醇磁珠法病毒提取残留检测装置

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE373963B (de) 1973-06-14 1975-02-17 Janson Sven Olof
GB1445389A (en) * 1973-10-16 1976-08-11 Chemlab Mfg Ltd Sampling arrangements
US3853092A (en) 1973-10-25 1974-12-10 Corning Glass Works Apparatus for nutating and staining a microscope slide
US4043292A (en) * 1975-07-21 1977-08-23 Corning Glass Works Microscope slide staining apparatus having temperature control
US4092952A (en) 1977-08-19 1978-06-06 Wilkie Ronald N Automatic slide stainer
SE7801564L (sv) 1978-02-10 1979-08-11 Lkb Produkter Ab Anordning for infergning av biologiska preparat
DE2915248C3 (de) 1979-04-14 1982-01-14 Gise, Frhr. von, Hardo, Dr.med., 7400 Tübingen Einrichtung zum automatischen wahlweisen u. exakten Behandeln von Präparaten
AT364439B (de) * 1980-02-12 1981-10-27 List Hans Einrichtung zur anordnung an einer probeneingabeoeffnung eines analysengeraetes
US4647431A (en) 1980-05-31 1987-03-03 Fuji Photo Film Co., Ltd. Device for maintaining a constant temperature for chemical analysis
US4384193A (en) * 1981-06-09 1983-05-17 Immulok, Inc. Incubating device for specimen mounted on glass slides in immunoassays
US4430299A (en) 1981-06-18 1984-02-07 Coulter Electronics, Inc. Apparatus for monitoring chemical reactions
DK536881A (da) * 1981-12-04 1983-06-05 Radiometer As Proevebaeger
SE451164B (sv) * 1982-03-22 1987-09-07 Erik Ohlin Apparat och sett for serieutspedning av en provvetska
AT381794B (de) * 1984-02-02 1986-11-25 Avl Verbrennungskraft Messtech Analysengeraet zur messung fluessiger oder gasfoermiger proben
US4629862A (en) 1984-03-28 1986-12-16 Olympus Optical Company Ltd. Sample heater for use in microscopes
US4644807A (en) * 1985-02-21 1987-02-24 Dionex Corporation Fluid sample delivery apparatus
US4731335A (en) 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
JPH0640054B2 (ja) * 1985-09-20 1994-05-25 株式会社千代田製作所 電子顕微鏡標本作成用包埋装置
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
US4858155A (en) 1985-12-24 1989-08-15 Beckman Instruments, Inc. Reaction temperature control system
US4933146A (en) 1986-07-11 1990-06-12 Beckman Instruments, Inc. Temperature control apparatus for automated clinical analyzer
DE3773562D1 (de) * 1986-07-11 1991-11-14 Beckman Instruments Inc Probenhandhabungsvorrichtung.
US4888998A (en) * 1986-07-11 1989-12-26 Beckman Instruments, Inc. Sample handling system
US5154889A (en) 1986-08-07 1992-10-13 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
US4721680A (en) * 1986-08-11 1988-01-26 Multi-Technology, Inc. Methods of using micro pipette tips
FR2606885B1 (fr) * 1986-11-14 1989-08-04 Abx Sarl Dispositif de nettoyage d'une aiguille de prelevement d'un liquide
US4847208A (en) 1987-07-29 1989-07-11 Bogen Steven A Apparatus for immunohistochemical staining and method of rinsing a plurality of slides
GB8722902D0 (en) 1987-09-30 1987-11-04 Shandon Southern Prod Tissue &c processing
US4927765A (en) * 1988-02-29 1990-05-22 Pharmacia Eni Diagnostics, Inc. Automatic reagent dispenser
FI80147C (fi) * 1988-04-15 1990-04-10 Kone Oy Foerfarande foer foerverkligande av val av vaetska vid vaetskedosering i en analysator samt provtagningsanordning.
US5597733A (en) * 1988-07-25 1997-01-28 Precision Systems, Inc. Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer
JPH0718785B2 (ja) * 1988-09-19 1995-03-06 株式会社日立製作所 フローセル装置
US4865986A (en) 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
US4962041A (en) * 1988-10-06 1990-10-09 Medical Automation Specialities, Inc. Method and apparatus for automatic processing and analyzing of blood serum
FR2641436A1 (de) 1988-12-30 1990-07-06 Labo Electronique Physique
US5429803A (en) * 1991-04-18 1995-07-04 Lamina, Inc. Liquid specimen container and attachable testing modules
US5264182A (en) * 1989-04-12 1993-11-23 Olympus Optical Co., Ltd. Sample and reagent delivery device with a probe and probe supporting member for preventing contamination
US5093557A (en) 1989-05-16 1992-03-03 Microscience, Inc. Substrate heater and heating element
CA2017111C (en) * 1989-06-01 1995-10-31 Andreas Greter Pipetting insert
FR2649018B1 (fr) * 1989-06-30 1991-09-13 Degremont Dispositif pour l'introduction d'un liquide dans un milieu constitue par un materiau granulaire, en vue de la fluidisation de ce materiau
GB8919145D0 (en) 1989-08-23 1989-10-04 Royal Postgrad Med School Apparatus for the in situ hybridisation of slide-mounted cell samples
US5089229A (en) 1989-11-22 1992-02-18 Vettest S.A. Chemical analyzer
US4989623A (en) * 1989-12-01 1991-02-05 Akzo N.V. Apparatus and method for cleaning reagent delivery probes
CA2035067C (en) * 1990-02-22 1995-06-27 William M. Blough, Jr. Fluid mixing device
CA2076370A1 (en) 1990-03-02 1991-09-03 Thomas B. Green Analyzer transport device
US5595707A (en) 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US5075079A (en) * 1990-05-21 1991-12-24 Technicon Instruments Corporation Slide analysis system
US5207987A (en) 1990-05-21 1993-05-04 Pb Diagnostic Systems Inc. Temperature controlled chamber for diagnostic analyzer
US5425918A (en) 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
JP2530738Y2 (ja) * 1990-11-13 1997-03-26 株式会社明電舎 ノズル洗浄ポート
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5280156A (en) 1990-12-25 1994-01-18 Ngk Insulators, Ltd. Wafer heating apparatus and with ceramic substrate and dielectric layer having electrostatic chucking means
US5273905A (en) 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
US5246665A (en) 1991-06-03 1993-09-21 Abbott Laboratories Heat and air flow control for assay carrier
AU645915B2 (en) * 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
GB9123463D0 (en) 1991-11-05 1991-12-18 Hybaid Ltd Reaction temperature control device
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
FR2688313A1 (fr) * 1992-03-04 1993-09-10 Marteau D Autry Eric Filtration et identification automatique d'echantillons.
US5316452A (en) 1992-05-11 1994-05-31 Gilbert Corporation Dispensing assembly with interchangeable cartridge pumps
US5947167A (en) * 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5645114A (en) * 1992-05-11 1997-07-08 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5314825A (en) * 1992-07-16 1994-05-24 Schiapparelli Biosystems, Inc. Chemical analyzer
US5601141A (en) * 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5408891A (en) 1992-12-17 1995-04-25 Beckman Instruments, Inc. Fluid probe washing apparatus and method
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system
JP3323294B2 (ja) * 1993-09-14 2002-09-09 富士写真フイルム株式会社 点着チップおよびこの点着チップを用いた液体濃縮防止方法
US5439649A (en) * 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
JP3051626B2 (ja) 1993-12-09 2000-06-12 富士写真フイルム株式会社 インキュベータ
US5523056A (en) 1994-04-29 1996-06-04 Johnson & Johnson Clinical Diagnostics, Inc. Twin rotor incubator assembly
JP3387649B2 (ja) 1994-09-16 2003-03-17 富士写真フイルム株式会社 点着チップ
EP0843169B1 (de) * 1995-02-25 2003-03-19 Roche Diagnostics GmbH Vorrichtung zur Bearbeitung von Proben auf Objekträgern
US5645144A (en) * 1995-08-22 1997-07-08 A-Dec, Inc. Control mechanism for sliding panel
ES2245462T3 (es) * 1996-04-26 2006-01-01 Dade Behring Inc. Procedimiento y aparato para retratar muestras en un analizador quimico automatico.
US6183693B1 (en) 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6096271A (en) * 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
AU2003297813A1 (en) * 2002-12-09 2004-06-30 Glenn E. Elmore Method and apparatus for launching a surfacewave onto a single conductor transmission line
US20100128351A1 (en) * 2008-11-21 2010-05-27 3M Innovative Properties Company Curved sided cone structures for controlling gain and viewing angle in an optical film

Also Published As

Publication number Publication date
JP3847559B2 (ja) 2006-11-22
EP1056541A1 (de) 2000-12-06
JP4505547B2 (ja) 2010-07-21
AU2003255169A1 (en) 2003-11-13
JP2010091579A (ja) 2010-04-22
EP2284543A3 (de) 2015-05-27
EP1056541A4 (de) 2005-11-30
EP1073892A1 (de) 2001-02-07
EP1056541B1 (de) 2017-10-25
US6296809B1 (en) 2001-10-02
DE69942975D1 (de) 2011-01-05
CA2320750C (en) 2004-08-24
CA2320750A1 (en) 1999-09-02
WO1999044030A9 (en) 1999-12-16
ES2354598T3 (es) 2011-03-16
CA2321836A1 (en) 1999-09-02
JP2006304806A (ja) 2006-11-09
CA2321836C (en) 2004-09-28
JP2002504694A (ja) 2002-02-12
AU763354B2 (en) 2003-07-17
EP1073892B1 (de) 2010-11-24
CN1297529A (zh) 2001-05-30
EP2284543A2 (de) 2011-02-16
EP1073892A4 (de) 2005-10-12
JP2009216714A (ja) 2009-09-24
WO1999043434A1 (en) 1999-09-02
AU2883499A (en) 1999-09-15
CN100403008C (zh) 2008-07-16
JP4505538B2 (ja) 2010-07-21
JP4091960B2 (ja) 2008-05-28
WO1999044030A1 (en) 1999-09-02
AU2879699A (en) 1999-09-15
JP2002505089A (ja) 2002-02-19

Similar Documents

Publication Publication Date Title
DE69942975D1 (de) Automatisierter molekularer pathologieapparat mit unabhängigen objektträgerwärmern
JP3256818B2 (ja) 試料液体分析装置及び試料液体分析法
US5079959A (en) Analyzing system using sheath flow of sample
US5474744A (en) Automatic pipetting device with cleaning mechanism
AU645282B2 (en) Automated dispensing and diluting system
FI922477A0 (fi) Anordning och foerfarande foer rengoering av matningssonder foer reagens.
US20100051060A1 (en) Nozzle cleaning method, nozzle cleaning device, and automatic analyzer
DK160730B (da) Kontinuert stroemningsanlaeg for vaesker
IT1249433B (it) Procedimento per il dosaggio di analiti in campioni liquidi e relativaapparecchiatura.
JP2001504583A (ja) 流体サンプルの炭素分析装置
US3876374A (en) Method and apparatus for automated quantitative fluid analysis
US3826621A (en) Apparatus for transferring a liquid from one container to another
JPH05307043A (ja) 分取用チップの使用モードが選択可能な分注装置
US3401591A (en) Analytical cuvette and supply system wherein the cuvette inlet and outlet are located on the bottom of the cuvette
US4179932A (en) Supply apparatus
JPH11230970A (ja) 試料分注方法及び自動分析装置
EP0787990A4 (de) Automatischer analysevorrichtung
WO1996008725A1 (en) Method for analysis and device for carrying out the method
CA1123223A (en) Method and apparatus for photometric measurements in the visible and ultraviolet field of biological liquors and other liquids, adapted to prevent systematic errors due to pollution
JPH06213906A (ja) 自動試薬ノズル洗浄機構
JPH03230000A (ja) 液体の減圧吸引装置
JPH0110605Y2 (de)
JPS5925966B2 (ja) 液体比例配分方法及び装置
JPH0316060Y2 (de)
JPH019013Y2 (de)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties