ATE537265T1 - Verfahren zur vitaminherstellung - Google Patents
Verfahren zur vitaminherstellungInfo
- Publication number
- ATE537265T1 ATE537265T1 AT09004155T AT09004155T ATE537265T1 AT E537265 T1 ATE537265 T1 AT E537265T1 AT 09004155 T AT09004155 T AT 09004155T AT 09004155 T AT09004155 T AT 09004155T AT E537265 T1 ATE537265 T1 AT E537265T1
- Authority
- AT
- Austria
- Prior art keywords
- geranylgeraniol
- microorganism
- farnesol
- producing vitamins
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01Q—ANTENNAS, i.e. RADIO AERIALS
- H01Q1/00—Details of, or arrangements associated with, antennas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9195198P | 1998-07-06 | 1998-07-06 | |
| US9196498P | 1998-07-06 | 1998-07-06 | |
| US9198398P | 1998-07-06 | 1998-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE537265T1 true ATE537265T1 (de) | 2011-12-15 |
Family
ID=27377004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08003596T ATE490332T1 (de) | 1998-07-06 | 1999-07-06 | Verfahren zur vitaminherstellung |
| AT09004155T ATE537265T1 (de) | 1998-07-06 | 1999-07-06 | Verfahren zur vitaminherstellung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08003596T ATE490332T1 (de) | 1998-07-06 | 1999-07-06 | Verfahren zur vitaminherstellung |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP2100963B1 (de) |
| JP (1) | JP4579415B2 (de) |
| CN (1) | CN1330621A (de) |
| AT (2) | ATE490332T1 (de) |
| AU (1) | AU4863099A (de) |
| CA (2) | CA2331343C (de) |
| DE (1) | DE69943009D1 (de) |
| DK (3) | DK2100963T3 (de) |
| ES (2) | ES2379212T3 (de) |
| MX (2) | MX276941B (de) |
| WO (1) | WO2000001650A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2305825B1 (de) | 1998-07-06 | 2015-01-14 | DCV Inc. doing business as Bio-Technical Resourses | Verfahren zur Vitaminherstellung |
| PT1190068E (pt) | 1999-04-15 | 2006-06-30 | Calgene Llc | Sequencias de acidos nucleicos para proteinas envolvidas na sintese de tocoferol |
| DE60126587D1 (de) * | 2000-03-02 | 2007-03-29 | Toudai Tlo Ltd | Verfahren zum screening nach substanzen, die spezifisch den "nicht-mevalonat"-pfad inhibieren |
| US6872815B1 (en) | 2000-10-14 | 2005-03-29 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| EP2292776A1 (de) | 2000-07-31 | 2011-03-09 | Danisco US Inc. | Manipulation der in der Mevalonsäure- und Isoprenoid-Biosynthese verantwortlichen Gene zur Herstellung von geänderten Merkmalen in Transgenen Organismen |
| EP1356033B1 (de) | 2000-08-07 | 2009-10-28 | Monsanto Technology LLC | Am methyl-d-erythriol phosphat reaktionsweg beteiligte gene |
| JP2003088368A (ja) * | 2001-09-18 | 2003-03-25 | Toyota Motor Corp | プレニルアルコールの製造方法 |
| CN1491282A (zh) * | 2000-12-28 | 2004-04-21 | 丰田自动车株式会社 | 异戊二烯醇的制备方法 |
| JP4013535B2 (ja) * | 2000-12-28 | 2007-11-28 | トヨタ自動車株式会社 | 微生物によるプレニルアルコールの高生産方法 |
| JP2002253284A (ja) * | 2000-12-28 | 2002-09-10 | Toyota Motor Corp | 微生物によるゲラニルゲラニオール及びその類縁化合物の製造方法 |
| EP1354956A4 (de) | 2000-12-28 | 2004-10-27 | Toyota Motor Co Ltd | Verfahren zur herstellung von prenylalkohol |
| JP3838033B2 (ja) * | 2000-12-28 | 2006-10-25 | トヨタ自動車株式会社 | プレニルアルコールの製造方法 |
| AU2002257237B8 (en) | 2001-05-09 | 2008-06-05 | Monsanto Technology Llc | Tyra genes and uses thereof |
| US7161061B2 (en) | 2001-05-09 | 2007-01-09 | Monsanto Technology Llc | Metabolite transporters |
| KR100704072B1 (ko) * | 2001-06-06 | 2007-04-05 | 디에스엠 아이피 어셋츠 비.브이. | 개선된 이소프레노이드 제조 방법 |
| US7244877B2 (en) | 2001-08-17 | 2007-07-17 | Monsanto Technology Llc | Methyltransferase from cotton and uses thereof |
| WO2003034812A2 (en) | 2001-10-25 | 2003-05-01 | Monsanto Technology Llc | Aromatic methyltransferases and uses thereof |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| BR0308740A (pt) | 2002-03-19 | 2007-01-09 | Monsanto Technology Llc | ácidos nucléicos e polipeptìdeos de homogentisado prenil transferase ("hpt"), e empregos destes |
| CA2487144C (en) | 2002-06-21 | 2012-06-12 | Dsm Ip Assets B.V. | Increased carotenoid production by inhibition of squalene biosynthesis |
| AU2003268083A1 (en) | 2002-08-05 | 2004-02-23 | Monsanto Technology, Llc | Tocopherol biosynthesis related genes and uses thereof |
| ES2305501T3 (es) * | 2002-09-27 | 2008-11-01 | Dsm Ip Assets B.V. | Gen escualeno sintasa (sqs). |
| JP4926061B2 (ja) | 2004-05-21 | 2012-05-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | イソプレノイド化合物の産生を促進する方法 |
| CA2574593C (en) | 2004-07-27 | 2016-07-05 | The Regents Of The University Of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| CN101218352B (zh) | 2005-03-18 | 2013-09-04 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| JP4824985B2 (ja) * | 2005-10-13 | 2011-11-30 | 株式会社Adeka | ファルネシル二リン酸の製造方法 |
| US8691555B2 (en) | 2006-09-28 | 2014-04-08 | Dsm Ip Assests B.V. | Production of carotenoids in oleaginous yeast and fungi |
| CN104212844A (zh) | 2007-06-01 | 2014-12-17 | 索拉兹米公司 | 在微生物中生产油 |
| CA3044405C (en) | 2007-09-20 | 2021-10-19 | Amyris, Inc. | Production of isoprenoids |
| JP5174430B2 (ja) * | 2007-11-06 | 2013-04-03 | 花王株式会社 | 2−フェニルエチルアルコールの製造方法 |
| CA2737195A1 (en) * | 2008-09-15 | 2010-03-18 | The Goodyear Tire & Rubber Company | Conversion of prenyl derivatives to isoprene |
| US7883882B2 (en) * | 2008-11-28 | 2011-02-08 | Solazyme, Inc. | Renewable chemical production from novel fatty acid feedstocks |
| WO2011150410A2 (en) | 2010-05-28 | 2011-12-01 | Solazyme, Inc. | Tailored oils produced from recombinant heterotrophic microorganisms |
| NZ708078A (en) | 2010-06-02 | 2017-01-27 | Evolva Nutrition Inc | Recombinant production of steviol glycosides |
| ES2909143T3 (es) | 2010-11-03 | 2022-05-05 | Corbion Biotech Inc | Microbios de Chlorella o Prototheca modificados genéticamente y aceite producido a partir de estos |
| US9249436B2 (en) | 2011-02-02 | 2016-02-02 | Solazyme, Inc. | Tailored oils produced from recombinant oleaginous microorganisms |
| EP2705138B1 (de) | 2011-05-06 | 2017-03-22 | TerraVia Holdings, Inc. | Genetisch modifizierte mikroorganismen zur verstoffwechselung von xylose |
| DK2707475T3 (en) * | 2011-05-09 | 2016-01-11 | Amyris Inc | Preparation of Acetyl-Coenzyme α-Derived Compounds |
| BR122021015508B1 (pt) | 2011-08-08 | 2022-03-29 | Evolva Sa | Método para produzir um glicosídeo de esteviol alvo |
| SG11201406711TA (en) | 2012-04-18 | 2014-11-27 | Solazyme Inc | Tailored oils |
| MY190346A (en) | 2013-02-06 | 2022-04-15 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| EP2954061B1 (de) | 2013-02-11 | 2023-11-22 | Evolva SA | Effiziente herstellung von steviolglycosiden in rekombinanten wirtszellen |
| EP2993993A2 (de) | 2013-04-26 | 2016-03-16 | Solazyme, Inc. | Öle mit niedrigem gehalt an mehrfach ungesättigten fettsäuren und verwendungen davon |
| SG11201602638SA (en) | 2013-10-04 | 2016-05-30 | Solazyme Inc | Tailored oils |
| BR112017000414A2 (pt) | 2014-07-10 | 2017-11-07 | Terravia Holdings Inc | genes cetoacil-acp sintase e utilizações dos mesmos |
| JP2017528125A (ja) | 2014-08-11 | 2017-09-28 | エヴォルヴァ エスアー.Evolva Sa. | 組み換え宿主におけるステビオールグリコシドの産生 |
| WO2016038095A2 (en) | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN108337892B (zh) | 2015-01-30 | 2022-06-24 | 埃沃尔瓦公司 | 在重组宿主中生产甜菊醇糖苷 |
| CN115851470B (zh) | 2015-03-16 | 2025-09-02 | 帝斯曼知识产权资产管理有限公司 | Udp-糖基转移酶 |
| WO2017025362A1 (en) | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN105153102A (zh) * | 2015-09-30 | 2015-12-16 | 宜春大海龟生命科学有限公司 | 以混合生育酚为原料制备α-生育酚的方法 |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN109312378A (zh) | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
| EP3535406A1 (de) | 2016-11-07 | 2019-09-11 | Evolva SA | Herstellung von steviolglycosiden in rekombinanten wirten |
| CN111699247A (zh) | 2017-12-07 | 2020-09-22 | 齐默尔根公司 | 通过发酵产生(6e)-8-羟基香叶醇的经改造的生物合成途径 |
| EP3728212A1 (de) | 2017-12-21 | 2020-10-28 | Zymergen Inc. | Nepetalactol-oxidoreduktasen, nepetalactol-synthasen und nebalacton produzierende mikroben |
| CN109609579B (zh) * | 2018-12-31 | 2022-04-05 | 陕西师范大学 | 一种产β-胡萝卜素的基因工程菌及其构建方法 |
| CN109884216A (zh) * | 2019-04-10 | 2019-06-14 | 西南医科大学 | 一种高效液相色谱测定载药胶束中法尼醛含量的方法 |
| CN110903190B (zh) * | 2019-12-09 | 2022-07-12 | 万华化学集团股份有限公司 | 一种维生素a及维生素a酯的制备方法 |
| CN110950791B (zh) * | 2019-12-09 | 2021-12-14 | 万华化学集团股份有限公司 | 一种维生素a及维生素a酯制备方法 |
| WO2021130057A1 (en) * | 2019-12-23 | 2021-07-01 | Dsm Ip Assets B.V. | Dehydrogenation process |
| CN113621631A (zh) * | 2021-08-11 | 2021-11-09 | 昆明理工大学 | 一种甲羟戊酸激酶基因rkmk及其应用 |
| CN113969288B (zh) * | 2021-10-29 | 2024-09-17 | 湖北冠众通科技有限公司 | 一种产法尼醇基因工程菌及其构建方法与应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE810299A (fr) * | 1974-01-29 | 1974-05-16 | Procede de fabrication de composes contenant un noyau chromane. | |
| US3862988A (en) | 1974-05-23 | 1975-01-28 | Eastman Kodak Co | 4,8 Dimethyl- 12-oxotridecanal |
| US3917710A (en) | 1974-05-23 | 1975-11-04 | Eastman Kodak Co | Preparation of phytone via the addition of dimethylketene to 4,8-dimethyl-12-oxotridecanal |
| GB1479272A (en) * | 1974-12-23 | 1977-07-13 | Kuraray Co | Process for preparing a stereospecific farnesol |
| US4225734A (en) | 1978-08-08 | 1980-09-30 | The Regents Of The University Of California | Process for producing symmetrical olefins |
| US4743546A (en) | 1985-02-13 | 1988-05-10 | Biotechnica International, Inc. | Controlled gene excision |
| US4871721A (en) | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
| US5589372A (en) | 1990-09-26 | 1996-12-31 | E. R. Squibb & Sons, Inc. | Squalene synthetase |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5475029A (en) | 1993-07-08 | 1995-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Farnesyl compounds as cholesterol lowering agents |
| JP3657298B2 (ja) | 1994-11-08 | 2005-06-08 | 株式会社クラレ | ゲラニルゲラニオ−ルの製造方法 |
| US5556990A (en) | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| JP3120684B2 (ja) | 1995-02-14 | 2000-12-25 | トヨタ自動車株式会社 | ゲラニルゲラニル二リン酸を合成する変異型ファルネシル二リン酸合成酵素及びそれをコードするdna |
| JP3151371B2 (ja) * | 1995-03-10 | 2001-04-03 | 麒麟麦酒株式会社 | カロチノイド生産量の増量に有用なdna鎖 |
| CA2192253A1 (en) | 1995-12-07 | 1997-06-08 | Susan Ferro-Novick | Geranylgeranyl diphosphate synthase proteins, nucleic acid molecules and uses thereof |
| JP2000507087A (ja) * | 1995-12-22 | 2000-06-13 | ギスト ブロカデス ベスローテン ファンノートシャップ | ファフィア株を形質転換する改良法、そのようにして得られた形質転換したファフィア株及び前記方法における組換えdna |
| US5744341A (en) * | 1996-03-29 | 1998-04-28 | University Of Maryland College Park | Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes |
| EP0955363A3 (de) * | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | DNS Sequenzen kodierend für Enzyme für die Herstellung von Isoprenoiden |
-
1999
- 1999-07-06 EP EP09004155A patent/EP2100963B1/de not_active Expired - Lifetime
- 1999-07-06 AU AU48630/99A patent/AU4863099A/en not_active Abandoned
- 1999-07-06 WO PCT/US1999/015264 patent/WO2000001650A1/en not_active Ceased
- 1999-07-06 DK DK09004155.9T patent/DK2100963T3/da active
- 1999-07-06 CA CA2331343A patent/CA2331343C/en not_active Expired - Lifetime
- 1999-07-06 AT AT08003596T patent/ATE490332T1/de not_active IP Right Cessation
- 1999-07-06 JP JP2000558056A patent/JP4579415B2/ja not_active Expired - Lifetime
- 1999-07-06 DK DK08003596.7T patent/DK1947189T3/da active
- 1999-07-06 CA CA2831321A patent/CA2831321C/en not_active Expired - Lifetime
- 1999-07-06 ES ES09004155T patent/ES2379212T3/es not_active Expired - Lifetime
- 1999-07-06 DK DK10180179T patent/DK2305825T3/en active
- 1999-07-06 ES ES10180179.3T patent/ES2534937T3/es not_active Expired - Lifetime
- 1999-07-06 MX MXPA04002408 patent/MX276941B/es unknown
- 1999-07-06 EP EP99932295A patent/EP1095002A4/de not_active Withdrawn
- 1999-07-06 CN CN99810559A patent/CN1330621A/zh active Pending
- 1999-07-06 EP EP08003596A patent/EP1947189B1/de not_active Expired - Lifetime
- 1999-07-06 MX MXPA01000216 patent/MX219130B/es unknown
- 1999-07-06 AT AT09004155T patent/ATE537265T1/de active
- 1999-07-06 DE DE69943009T patent/DE69943009D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1330621A (zh) | 2002-01-09 |
| DK2305825T3 (en) | 2015-03-02 |
| EP1095002A4 (de) | 2005-08-03 |
| JP2002519049A (ja) | 2002-07-02 |
| MXPA01000216A (es) | 2002-10-17 |
| WO2000001650A1 (en) | 2000-01-13 |
| MX276941B (es) | 2010-06-28 |
| DK1947189T3 (da) | 2011-03-14 |
| CA2331343C (en) | 2014-01-14 |
| CA2831321A1 (en) | 2000-01-13 |
| EP1947189B1 (de) | 2010-12-01 |
| MX219130B (es) | 2004-02-10 |
| DE69943009D1 (de) | 2011-01-13 |
| EP2100963B1 (de) | 2011-12-14 |
| CA2331343A1 (en) | 2000-01-13 |
| JP4579415B2 (ja) | 2010-11-10 |
| EP1947189A2 (de) | 2008-07-23 |
| EP1947189A3 (de) | 2008-10-08 |
| DK2100963T3 (da) | 2012-04-02 |
| ES2534937T3 (es) | 2015-04-30 |
| EP2100963A1 (de) | 2009-09-16 |
| CA2831321C (en) | 2018-05-15 |
| AU4863099A (en) | 2000-01-24 |
| ES2379212T3 (es) | 2012-04-23 |
| EP1095002A1 (de) | 2001-05-02 |
| ATE490332T1 (de) | 2010-12-15 |
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