ATE491716T1 - Verfahren zur herstellung von drospirenon - Google Patents

Verfahren zur herstellung von drospirenon

Info

Publication number: ATE491716T1
Authority: AT; Austria
Prior art keywords: drospirenone; producing; producing drospirenone; antimineralocorticoid; progestogenic
Prior art date: 2004-12-06

Application number

AT05819134T

Other languages

English (en)

Inventor

Francesca Costantino

Roberto Lenna

Silvia Piuri

Original Assignee

Ind Chimica Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-06

Filing date

2005-11-14

Publication date

2011-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35840070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE491716(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-11-14 Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE491716T1 publication Critical patent/ATE491716T1/de

Links

METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 title abstract 2
METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 title abstract 2
229960004845 drospirenone Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
229940083712 aldosterone antagonist Drugs 0.000 abstract 1
230000002280 anti-androgenic effect Effects 0.000 abstract 1
230000001327 anti-mineralocorticoid effect Effects 0.000 abstract 1
230000002254 contraceptive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002394 mineralocorticoid antagonist Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000757 progestagenic effect Effects 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pens And Brushes (AREA)
Macromonomer-Based Addition Polymer (AREA)

AT05819134T 2004-12-06 2005-11-14 Verfahren zur herstellung von drospirenon ATE491716T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT002338A ITMI20042338A1 (it)	2004-12-06	2004-12-06	Processo per la preparazione di drospirenone
PCT/EP2005/055963 WO2006061309A1 (en)	2004-12-06	2005-11-14	Process for the preparation of drospirenone

Publications (1)

Publication Number	Publication Date
ATE491716T1 true ATE491716T1 (de)	2011-01-15

Family

ID=35840070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05819134T ATE491716T1 (de)	2004-12-06	2005-11-14	Verfahren zur herstellung von drospirenon

Country Status (20)

Country	Link
US (3)	US20080207575A1 (de)
EP (2)	EP1828222B9 (de)
JP (1)	JP5626616B2 (de)
CN (1)	CN101065396B (de)
AT (1)	ATE491716T1 (de)
BR (1)	BRPI0517752C1 (de)
CA (1)	CA2589928C (de)
CL (1)	CL2007001581A1 (de)
CY (1)	CY1111209T1 (de)
DE (1)	DE602005025396D1 (de)
DK (1)	DK1828222T3 (de)
ES (2)	ES2602823T3 (de)
IL (1)	IL183645A (de)
IT (1)	ITMI20042338A1 (de)
MX (1)	MX2007006701A (de)
PL (1)	PL1828222T3 (de)
PT (1)	PT1828222E (de)
SI (1)	SI1828222T1 (de)
WO (1)	WO2006061309A1 (de)
ZA (1)	ZA200705492B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2527356B1 (de)	2005-07-21	2018-01-03	Bayer Intellectual Property GmbH	Verfahren zur Herstellung von 3-Oxo-pregn-4-ene-21,17-carbolactonen mit metallfreier Oxidation von 17-(3-Hydroxypropyl)-3,17-dihydroxyandrostanen
DE502005004948D1 (de) *	2005-07-21	2008-09-18	Bayer Schering Pharma Ag	Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
US7319154B2 (en)	2005-07-21	2008-01-15	Bayer Schering Pharma Ag	Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
WO2008137050A2 (en) *	2007-05-01	2008-11-13	Sicor Inc.	A process for preparing drospirenone and intermediate thereof
DE102007027635A1 (de) *	2007-06-12	2008-12-18	Bayer Schering Pharma Aktiengesellschaft	17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007030596B3 (de) *	2007-06-28	2009-03-12	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
EP2019114B1 (de) *	2007-07-26	2010-12-15	Newchem S.p.A.	Herstellungsverfahren für Drospirenon
WO2009111574A2 (en) *	2008-03-05	2009-09-11	Evestra, Inc.	BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
US8222237B2 (en) *	2008-11-25	2012-07-17	Evestra, Inc.	Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
US8334375B2 (en) *	2009-04-10	2012-12-18	Evestra, Inc.	Methods for the preparation of drospirenone
ES2432063T3 (es)	2009-06-16	2013-11-29	Crystal Pharma, S.A.U.	Procedimiento para la obtención de 17-espirolactonas en esteroides
CN101775057B (zh) *	2010-02-09	2014-07-16	浙江仙琚制药股份有限公司	屈螺酮及其中间体的制备方法
CN101830959B (zh) *	2010-05-27	2012-07-18	杭州龙山化工有限公司	一种曲螺酮的合成方法
AR081670A1 (es)	2010-06-29	2012-10-10	Leon Farma Sa Lab	Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en)	2010-07-28	2022-06-07	Laboratorios Leon Farma Sa	Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en)	2010-07-28	2020-12-01	Laboratorios Leon Farma Sa	Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en)	2010-07-28	2017-03-28	Laboratorios Leon Farma Sa	Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
ES2419663T3 (es)	2010-08-03	2013-08-21	Newchem S.P.A.	Métodos para la preparación de Drospirenona y productos intermedios de la misma
CN102040650B (zh) *	2010-10-26	2014-03-26	西安科技大学	串联反应构建甾体-6β,7β-亚甲基结构的方法
WO2012107513A1 (en)	2011-02-10	2012-08-16	Crystal Pharma, S.A.U.	Process for obtaining drospirenone
ITMI20111383A1 (it) *	2011-07-25	2013-01-26	Ind Chimica Srl	Processo per la preparazione di drospirenone
PL2782924T3 (pl)	2011-11-22	2017-07-31	Industriale Chimica S.R.L.	Proces otrzymywania drospirenonu
EP2597101A1 (de)	2011-11-22	2013-05-29	Industriale Chimica S.R.L.	Verfahren zur Herstellung von Drospirenon
ITMI20120146A1 (it) *	2012-02-03	2013-08-04	Ind Chimica Srl	Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica
CN102887934B (zh) *	2012-09-20	2015-05-27	杭州福斯特药业有限公司	一种屈螺酮的制备方法
ITMI20130183A1 (it) *	2013-02-08	2014-08-09	Ind Chimica Srl	Processo per la preparazione di drospirenone.
WO2014128525A1 (en) *	2013-02-20	2014-08-28	Industriale Chimica S.R.L.	Process for the preparation of drospirenone
BR112015025816B1 (pt) *	2013-04-12	2021-02-02	Industriale Chimica S.R.L	processo para a preparação de drospirenona
WO2014174338A1 (en) *	2013-04-22	2014-10-30	Industriale Chimica S.R.L.	Process for preparing an intermediate useful in the production of drospirenone
CN104174341B (zh) *	2013-05-27	2017-09-26	乌鲁木齐益好天成新型节能材料有限公司	一种固相硅凝胶的制备方法
EP3108889A1 (de)	2015-06-23	2016-12-28	Philippe Perrin	Drospirenonbasiertes verhütungsmittel für einen weiblichen übergewichtigen patienten
RS65196B1 (sr)	2015-06-23	2024-03-29	Laboratorios Leon Farma Sa	Kontraceptivno sredstvo na bazi drospirenona za pacijentkinje sa viškom težine
CN105017362A (zh) *	2015-07-22	2015-11-04	浙江圃瑞药业有限公司	将表雄酮氧化为雄烷二酮的清洁生产方法
CN110407905B (zh) *	2019-08-22	2021-09-28	武汉九珑人福药业有限责任公司	一种屈螺酮及其中间体的制备方法
EP4134082A1 (de)	2021-08-12	2023-02-15	Chemo Research, S.L.	Verfahren zur behandlung von endometriose und zur bereitstellung einer wirksamen empfängnisverhütung
CN114437169B (zh) *	2022-01-25	2023-04-07	台州仙琚药业有限公司	一种屈螺酮关键中间体溴代物的合成方法
WO2023152658A1 (en)	2022-02-10	2023-08-17	Lupin Limited	Slow release drospirenone tablet composition
WO2023165988A1 (en)	2022-03-01	2023-09-07	Chemo Research, S.L.	Chewable oral contraceptive
CN115947773A (zh) *	2022-12-28	2023-04-11	台州仙琚药业有限公司	一种屈螺酮关键中间体的制备方法

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DE3042136A1 (de) *	1980-11-03	1982-06-09	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (de) *	1981-09-21	1985-08-28	Schering Aktiengesellschaft	3-Beta,7-beta,15-alpha-Trihydroxy-5-androsten-17-one, ihre 3,15-Trimethylessigsäure-Ester und ihre Herstellung
DE3916112A1 (de) *	1989-05-16	1990-11-22	Schering Ag	Dihydrospirorenon als antiandrogen
HU220871B1 (en) *	1993-12-17	2002-06-29	Upjohn Co	Process for oxidizing of 20-hydroxymethyl-pregn-4-en-3-on into 20-formyl-pregn-4-en-3-on
DE19633685C1 (de)	1996-08-12	1997-10-09	Schering Ag	Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
US20040034215A1 (en) *	2002-08-16	2004-02-19	White Michael J.	5-Androsten-3beta-ol steroid intermediates and processes for their preparation
EP1560841A1 (de) *	2002-11-06	2005-08-10	Pharmacia & Upjohn Company LLC	Verfahren zur herstellung von 7-carboxy substituierten steroiden
ITMI20040367A1 (it) *	2004-03-01	2004-06-01	Ind Chimica Srl	Processo per la preparazione di drospirenone
HUP0402466A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
HUP0402465A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
US7319154B2 (en) *	2005-07-21	2008-01-15	Bayer Schering Pharma Ag	Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes

2004
- 2004-12-06 IT IT002338A patent/ITMI20042338A1/it unknown
2005
- 2005-11-14 CA CA2589928A patent/CA2589928C/en not_active Expired - Lifetime
- 2005-11-14 WO PCT/EP2005/055963 patent/WO2006061309A1/en not_active Ceased
- 2005-11-14 PT PT05819134T patent/PT1828222E/pt unknown
- 2005-11-14 PL PL05819134T patent/PL1828222T3/pl unknown
- 2005-11-14 ES ES09159293.1T patent/ES2602823T3/es not_active Expired - Lifetime
- 2005-11-14 CN CN2005800407958A patent/CN101065396B/zh not_active Expired - Lifetime
- 2005-11-14 AT AT05819134T patent/ATE491716T1/de active
- 2005-11-14 DK DK05819134.7T patent/DK1828222T3/da active
- 2005-11-14 SI SI200531215T patent/SI1828222T1/sl unknown
- 2005-11-14 EP EP05819134A patent/EP1828222B9/de not_active Revoked
- 2005-11-14 BR BRPI0517752A patent/BRPI0517752C1/pt not_active IP Right Cessation
- 2005-11-14 DE DE602005025396T patent/DE602005025396D1/de not_active Expired - Lifetime
- 2005-11-14 MX MX2007006701A patent/MX2007006701A/es active IP Right Grant
- 2005-11-14 ES ES05819134T patent/ES2355982T3/es not_active Expired - Lifetime
- 2005-11-14 US US11/792,465 patent/US20080207575A1/en not_active Abandoned
- 2005-11-14 JP JP2007543825A patent/JP5626616B2/ja not_active Expired - Lifetime
- 2005-11-14 EP EP09159293.1A patent/EP2108652B1/de not_active Expired - Lifetime
2007
- 2007-06-01 CL CL2007001581A patent/CL2007001581A1/es unknown
- 2007-06-04 IL IL183645A patent/IL183645A/en active IP Right Grant
- 2007-07-05 ZA ZA200705492A patent/ZA200705492B/xx unknown
2010
- 2010-08-04 US US12/850,246 patent/US8227596B2/en not_active Expired - Lifetime
2011
- 2011-02-16 CY CY20111100198T patent/CY1111209T1/el unknown
2012
- 2012-05-30 US US13/483,229 patent/US20120264723A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BRPI0517752B8 (pt)	2019-02-19
DK1828222T3 (da)	2011-02-21
BRPI0517752A (pt)	2008-10-21
PL1828222T3 (pl)	2011-04-29
EP1828222B1 (de)	2010-12-15
CN101065396A (zh)	2007-10-31
IL183645A0 (en)	2007-09-20
CN101065396B (zh)	2012-05-23
BRPI0517752C1 (pt)	2021-05-25
CA2589928A1 (en)	2006-06-15
SI1828222T1 (sl)	2011-03-31
CA2589928C (en)	2013-07-02
MX2007006701A (es)	2007-11-09
EP2108652B1 (de)	2016-08-17
JP5626616B2 (ja)	2014-11-19
US20100331291A1 (en)	2010-12-30
CL2007001581A1 (es)	2008-01-04
EP2108652A2 (de)	2009-10-14
ES2602823T3 (es)	2017-02-22
US20080207575A1 (en)	2008-08-28
CY1111209T1 (el)	2015-06-11
DE602005025396D1 (de)	2011-01-27
EP1828222B9 (de)	2011-08-31
IL183645A (en)	2012-02-29
WO2006061309A1 (en)	2006-06-15
BRPI0517752B1 (pt)	2018-12-26
ES2355982T3 (es)	2011-04-01
ITMI20042338A1 (it)	2005-03-06
US8227596B2 (en)	2012-07-24
ZA200705492B (en)	2008-08-27
JP2008522962A (ja)	2008-07-03
PT1828222E (pt)	2011-01-31
US20120264723A1 (en)	2012-10-18
EP1828222A1 (de)	2007-09-05
EP2108652A3 (de)	2011-06-22

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2011-06-15

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