BRPI0517752A - processo para a preparação de drospirenona - Google Patents

processo para a preparação de drospirenona

Info

Publication number
BRPI0517752A
BRPI0517752A BRPI0517752-9A BRPI0517752A BRPI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A
Authority
BR
Brazil
Prior art keywords
drospirenone
preparation
preparing
drospyrenone
antimineralocorticoid
Prior art date
Application number
BRPI0517752-9A
Other languages
English (en)
Inventor
Francesca Costantino
Roberto Lenna
Silvia Piuri
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35840070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0517752(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Publication of BRPI0517752A publication Critical patent/BRPI0517752A/pt
Publication of BRPI0517752B1 publication Critical patent/BRPI0517752B1/pt
Publication of BRPI0517752B8 publication Critical patent/BRPI0517752B8/pt
Publication of BRPI0517752C1 publication Critical patent/BRPI0517752C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pens And Brushes (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

PROCESSO PARA A PREPARAçãO DE DROSPIRENONA. Um processo é descrito para a preparação de drospirenona, um esterólde sintético com atividade progestogênica, antimineralocorticóidica e antiandrogênica, útil para preparação de composições farmacêuticas com ação contraceptiva; compreendendo a oxidação de 17<224>-(3-hidroxipropil) -6<225>, 7<225>; 15<225>, l6<225>-dimetileno-5<225>-androstano-3<225>, 5, 17<225>-triol.
BRPI0517752A 2004-12-06 2005-11-14 processo para a preparação de drospirenona BRPI0517752C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2004A002338 2004-12-06
IT002338A ITMI20042338A1 (it) 2004-12-06 2004-12-06 Processo per la preparazione di drospirenone
PCT/EP2005/055963 WO2006061309A1 (en) 2004-12-06 2005-11-14 Process for the preparation of drospirenone

Publications (4)

Publication Number Publication Date
BRPI0517752A true BRPI0517752A (pt) 2008-10-21
BRPI0517752B1 BRPI0517752B1 (pt) 2018-12-26
BRPI0517752B8 BRPI0517752B8 (pt) 2019-02-19
BRPI0517752C1 BRPI0517752C1 (pt) 2021-05-25

Family

ID=35840070

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517752A BRPI0517752C1 (pt) 2004-12-06 2005-11-14 processo para a preparação de drospirenona

Country Status (20)

Country Link
US (3) US20080207575A1 (pt)
EP (2) EP2108652B1 (pt)
JP (1) JP5626616B2 (pt)
CN (1) CN101065396B (pt)
AT (1) ATE491716T1 (pt)
BR (1) BRPI0517752C1 (pt)
CA (1) CA2589928C (pt)
CL (1) CL2007001581A1 (pt)
CY (1) CY1111209T1 (pt)
DE (1) DE602005025396D1 (pt)
DK (1) DK1828222T3 (pt)
ES (2) ES2602823T3 (pt)
IL (1) IL183645A (pt)
IT (1) ITMI20042338A1 (pt)
MX (1) MX2007006701A (pt)
PL (1) PL1828222T3 (pt)
PT (1) PT1828222E (pt)
SI (1) SI1828222T1 (pt)
WO (1) WO2006061309A1 (pt)
ZA (1) ZA200705492B (pt)

Families Citing this family (39)

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PT2527356T (pt) * 2005-07-21 2018-03-26 Bayer Ip Gmbh Processo para a produção de 3-oxo-pregn-4-eno-21,17-carbolactonas através da oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-diidroxiandrostanos
ES2311927T5 (es) * 2005-07-21 2014-09-08 Bayer Pharma Aktiengesellschaft Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
MX2008016571A (es) * 2007-05-01 2009-03-09 Sicor Inc Proceso para preparar drospirenona y su intermediarios.
DE102007027635A1 (de) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
RS51892B (sr) * 2007-07-26 2012-02-29 Newchem S.P.A. Proces pripreme drospirenona
EP2265629B1 (en) * 2008-03-05 2015-06-24 Evestra, Inc. Bismethylene-17 carbolactones and related uses
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) * 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
CN101775057B (zh) * 2010-02-09 2014-07-16 浙江仙琚制药股份有限公司 屈螺酮及其中间体的制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
ES2419663T3 (es) 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
CN102040650B (zh) * 2010-10-26 2014-03-26 西安科技大学 串联反应构建甾体-6β,7β-亚甲基结构的方法
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) * 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
ITMI20120146A1 (it) * 2012-02-03 2013-08-04 Ind Chimica Srl Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica
CA2856324C (en) 2011-11-22 2019-08-13 Industriale Chimica S.R.L. Process for the preparation of drospirenone
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
ITMI20130183A1 (it) * 2013-02-08 2014-08-09 Ind Chimica Srl Processo per la preparazione di drospirenone.
ES2651145T3 (es) 2013-02-20 2018-01-24 Industriale Chimica S.R.L. Proceso para la preparación de drospirenona
HUE032858T2 (en) 2013-04-12 2017-11-28 Ind Chimica Srl Method for producing drospirenone
WO2014174338A1 (en) * 2013-04-22 2014-10-30 Industriale Chimica S.R.L. Process for preparing an intermediate useful in the production of drospirenone
CN104174341B (zh) * 2013-05-27 2017-09-26 乌鲁木齐益好天成新型节能材料有限公司 一种固相硅凝胶的制备方法
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
JP6827962B2 (ja) 2015-06-23 2021-02-10 ラボラトリオス レオン ファーマ エスエー 過剰体重に影響される女性患者のためのドロスピレノン系避妊薬
CN105017362A (zh) * 2015-07-22 2015-11-04 浙江圃瑞药业有限公司 将表雄酮氧化为雄烷二酮的清洁生产方法
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
CN114437169B (zh) * 2022-01-25 2023-04-07 台州仙琚药业有限公司 一种屈螺酮关键中间体溴代物的合成方法
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
EP4486311A1 (en) 2022-03-01 2025-01-08 Chemo Research, S.L. Chewable oral contraceptive
CN115947773A (zh) * 2022-12-28 2023-04-11 台州仙琚药业有限公司 一种屈螺酮关键中间体的制备方法

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EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
ATE174601T1 (de) * 1993-12-17 1999-01-15 Upjohn Co Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
DE60308388T2 (de) * 2002-08-16 2007-09-20 Pharmacia & Upjohn Co. Llc, Kalamazoo 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung
US7196208B2 (en) * 2002-11-06 2007-03-27 Peter Guillaume Marie Wuts Processes for preparing 7-carboxy substituted steroids
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes

Also Published As

Publication number Publication date
EP2108652B1 (en) 2016-08-17
ATE491716T1 (de) 2011-01-15
DK1828222T3 (da) 2011-02-21
US8227596B2 (en) 2012-07-24
IL183645A0 (en) 2007-09-20
CA2589928C (en) 2013-07-02
BRPI0517752B1 (pt) 2018-12-26
IL183645A (en) 2012-02-29
CL2007001581A1 (es) 2008-01-04
SI1828222T1 (sl) 2011-03-31
DE602005025396D1 (de) 2011-01-27
EP2108652A3 (en) 2011-06-22
US20120264723A1 (en) 2012-10-18
CN101065396B (zh) 2012-05-23
ZA200705492B (en) 2008-08-27
ITMI20042338A1 (it) 2005-03-06
EP1828222B1 (en) 2010-12-15
JP2008522962A (ja) 2008-07-03
EP1828222B9 (en) 2011-08-31
ES2355982T3 (es) 2011-04-01
BRPI0517752C1 (pt) 2021-05-25
US20100331291A1 (en) 2010-12-30
JP5626616B2 (ja) 2014-11-19
WO2006061309A1 (en) 2006-06-15
PL1828222T3 (pl) 2011-04-29
MX2007006701A (es) 2007-11-09
ES2602823T3 (es) 2017-02-22
US20080207575A1 (en) 2008-08-28
PT1828222E (pt) 2011-01-31
EP2108652A2 (en) 2009-10-14
BRPI0517752B8 (pt) 2019-02-19
CN101065396A (zh) 2007-10-31
CY1111209T1 (el) 2015-06-11
EP1828222A1 (en) 2007-09-05
CA2589928A1 (en) 2006-06-15

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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