BRPI0517752B8 - processo para a preparação de drospirenona - Google Patents

processo para a preparação de drospirenona

Info

Publication number
BRPI0517752B8
BRPI0517752B8 BRPI0517752A BRPI0517752A BRPI0517752B8 BR PI0517752 B8 BRPI0517752 B8 BR PI0517752B8 BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 B8 BRPI0517752 B8 BR PI0517752B8
Authority
BR
Brazil
Prior art keywords
drospirenone
preparation
antimineralocorticoid
progestogenic
androstane
Prior art date
Application number
BRPI0517752A
Other languages
English (en)
Inventor
Francesca Costantino
Roberto Lenna
Silvia Piuri
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35840070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0517752(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Publication of BRPI0517752A publication Critical patent/BRPI0517752A/pt
Publication of BRPI0517752B1 publication Critical patent/BRPI0517752B1/pt
Publication of BRPI0517752B8 publication Critical patent/BRPI0517752B8/pt
Publication of BRPI0517752C1 publication Critical patent/BRPI0517752C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pens And Brushes (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

processo para a preparação de drospirenona. um processo é descrito para a preparação de drospirenona, um esterólde sintético com atividade progestogênica, antimineralocorticóidica e antiandrogênica, útil para preparação de composições farmacêuticas com ação contraceptiva; compreendendo a oxidação de 17alfa-(3-hidroxipropil) -6beta, 7beta; 15beta, 16beta-dimetileno-5beta-androstano-3beta, 5, 17beta-triol.
BRPI0517752A 2004-12-06 2005-11-14 processo para a preparação de drospirenona BRPI0517752C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2004A002338 2004-12-06
IT002338A ITMI20042338A1 (it) 2004-12-06 2004-12-06 Processo per la preparazione di drospirenone
PCT/EP2005/055963 WO2006061309A1 (en) 2004-12-06 2005-11-14 Process for the preparation of drospirenone

Publications (4)

Publication Number Publication Date
BRPI0517752A BRPI0517752A (pt) 2008-10-21
BRPI0517752B1 BRPI0517752B1 (pt) 2018-12-26
BRPI0517752B8 true BRPI0517752B8 (pt) 2019-02-19
BRPI0517752C1 BRPI0517752C1 (pt) 2021-05-25

Family

ID=35840070

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517752A BRPI0517752C1 (pt) 2004-12-06 2005-11-14 processo para a preparação de drospirenona

Country Status (20)

Country Link
US (3) US20080207575A1 (pt)
EP (2) EP1828222B9 (pt)
JP (1) JP5626616B2 (pt)
CN (1) CN101065396B (pt)
AT (1) ATE491716T1 (pt)
BR (1) BRPI0517752C1 (pt)
CA (1) CA2589928C (pt)
CL (1) CL2007001581A1 (pt)
CY (1) CY1111209T1 (pt)
DE (1) DE602005025396D1 (pt)
DK (1) DK1828222T3 (pt)
ES (2) ES2355982T3 (pt)
IL (1) IL183645A (pt)
IT (1) ITMI20042338A1 (pt)
MX (1) MX2007006701A (pt)
PL (1) PL1828222T3 (pt)
PT (1) PT1828222E (pt)
SI (1) SI1828222T1 (pt)
WO (1) WO2006061309A1 (pt)
ZA (1) ZA200705492B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038504T2 (hu) * 2005-07-21 2018-10-29 Bayer Ip Gmbh Eljárás 3-oxo-pregn-4-én-21,17-karbolaktonok elõállítására 17-(3-hidroxipropil)-3,17,dihidroxiandrosztánok fémmentes oxidációjával
PT1746101E (pt) * 2005-07-21 2008-10-27 Bayer Schering Pharma Ag Processo para o fabrico de 3-oxo-pregn-4-eno-21,17-carbolactonas por meio de oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-di-hidroxiandrostanos
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
WO2008137050A2 (en) * 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
DE102007027635A1 (de) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
EP2019114B1 (en) * 2007-07-26 2010-12-15 Newchem S.p.A. Process for the preparation of Drospirenone
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
EP2367808A4 (en) * 2008-11-25 2012-05-09 Evestra Inc PROGESTATIVE 3- (6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-EN-17a-YL) PROPIONIC ACID g-LACTONE
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
CN101775057B (zh) * 2010-02-09 2014-07-16 浙江仙琚制药股份有限公司 屈螺酮及其中间体的制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2415778B1 (en) 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
CN102040650B (zh) * 2010-10-26 2014-03-26 西安科技大学 串联反应构建甾体-6β,7β-亚甲基结构的方法
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) * 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
WO2013076118A1 (en) 2011-11-22 2013-05-30 Industriale Chimica S.R.L. Process for the preparation of drospirenone
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
ITMI20120146A1 (it) * 2012-02-03 2013-08-04 Ind Chimica Srl Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
ITMI20130183A1 (it) * 2013-02-08 2014-08-09 Ind Chimica Srl Processo per la preparazione di drospirenone.
EP2958929B1 (en) 2013-02-20 2017-09-13 Industriale Chimica S.R.L. Process for the preparation of drospirenone
PT2984100T (pt) * 2013-04-12 2017-07-14 Ind Chimica Srl Processo para a preparação de drospirenona
WO2014174338A1 (en) * 2013-04-22 2014-10-30 Industriale Chimica S.R.L. Process for preparing an intermediate useful in the production of drospirenone
CN104174341B (zh) * 2013-05-27 2017-09-26 乌鲁木齐益好天成新型节能材料有限公司 一种固相硅凝胶的制备方法
DK3313408T3 (da) 2015-06-23 2024-01-29 Laboratorios Leon Farma Sa Drospirenon-baseret svangerskabsforebyggende middel til en kvindelig patient, som lider af overvægt
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
CN105017362A (zh) * 2015-07-22 2015-11-04 浙江圃瑞药业有限公司 将表雄酮氧化为雄烷二酮的清洁生产方法
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
CN114437169B (zh) * 2022-01-25 2023-04-07 台州仙琚药业有限公司 一种屈螺酮关键中间体溴代物的合成方法
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
AR128632A1 (es) 2022-03-01 2024-05-29 Chemo Res S L Anticonceptivo oral masticable de drospirenona
CN115947773A (zh) * 2022-12-28 2023-04-11 台州仙琚药业有限公司 一种屈螺酮关键中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
RU2131437C1 (ru) * 1993-12-17 1999-06-10 Фармация Энд Апджон Компани Способ получения бисноральдегида
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
BR0313523A (pt) * 2002-08-16 2005-06-28 Upjohn Co Intermediários do esteróide 5-androsten-3(beta)-ol e processos para a sua preparação
CA2504745A1 (en) * 2002-11-06 2004-05-27 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes

Also Published As

Publication number Publication date
DE602005025396D1 (de) 2011-01-27
CN101065396B (zh) 2012-05-23
MX2007006701A (es) 2007-11-09
DK1828222T3 (da) 2011-02-21
CY1111209T1 (el) 2015-06-11
BRPI0517752A (pt) 2008-10-21
ATE491716T1 (de) 2011-01-15
US8227596B2 (en) 2012-07-24
EP2108652B1 (en) 2016-08-17
ES2602823T3 (es) 2017-02-22
PL1828222T3 (pl) 2011-04-29
ZA200705492B (en) 2008-08-27
IL183645A (en) 2012-02-29
EP1828222B9 (en) 2011-08-31
CL2007001581A1 (es) 2008-01-04
JP5626616B2 (ja) 2014-11-19
BRPI0517752B1 (pt) 2018-12-26
ES2355982T3 (es) 2011-04-01
EP2108652A3 (en) 2011-06-22
US20080207575A1 (en) 2008-08-28
EP1828222A1 (en) 2007-09-05
BRPI0517752C1 (pt) 2021-05-25
EP1828222B1 (en) 2010-12-15
ITMI20042338A1 (it) 2005-03-06
EP2108652A2 (en) 2009-10-14
US20100331291A1 (en) 2010-12-30
CN101065396A (zh) 2007-10-31
JP2008522962A (ja) 2008-07-03
US20120264723A1 (en) 2012-10-18
CA2589928C (en) 2013-07-02
WO2006061309A1 (en) 2006-06-15
SI1828222T1 (sl) 2011-03-31
IL183645A0 (en) 2007-09-20
PT1828222E (pt) 2011-01-31
CA2589928A1 (en) 2006-06-15

Similar Documents

Publication Publication Date Title
BRPI0517752C1 (pt) processo para a preparação de drospirenona
ITMI20040367A1 (it) Processo per la preparazione di drospirenone
NO20032805L (no) Blandinger med ostrogen-syklodekstrinkomplekser
TR200002774T2 (tr) Alzheimer hastalığının tedavisi için steroit sapogenler ve bunların türevleri
HUP0104718A3 (en) Micronized eplerenone compositions, process for their preparation and use thereof for the preparation of pharmaceutical compositions
HUP0202500A3 (en) Use of a pharmaceutical combination of ethinylestradiol and drospirenone for producing pharmaceutical compositions having contraceptive activity
BRPI0512993A (pt) uso de um antagonista de pr, kit farmaceuticamente últil, e, método de contracepção em uma fêmea em idade de parto
BR0308660A (pt) C-17 espirolactonização e 6,7 oxidação de esteróides
BR9814136A (pt) Conjunto contraceptivo, processos de fabricação do mesmo e de tratamento de sangramento, usos de anti-progestogênio, de progestogênio e de anti-progestogênio, e, de um composto.
BR9908605A (pt) Kit anticoncepcional, uso de um composto esteróide, e, processo de contracepção
BR0116127A (pt) Composto, composição farmacêutica, uso de um composto, e, conjunto para a contracepção masculina
DE60133396D1 (de) Modifizierte zellen und ihre verwendungen, insbesondere zur herstellung von steroidderivate
HUP0301190A3 (en) 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity, pharmaceutical compositions containing them and their use
AR061251A1 (es) Proceso para la preparacion de drospirenona y una composicion farmaceutrica
ITMI20051516A1 (it) Derivati 17 alfa-sostituti dell'estradiolo ad attivita' cicatrizzante
BR0113357A (pt) Composição oral
RU2002130065A (ru) Состав, обладающий контрацептивной активностью
MX356791B (es) Procedimiento para la preparacion de drospirenona.
ECSP993196A (es) Composiciones de isotretinoina y proceso para su produccion
DOP2010000130A (es) Combinacion de un gestageno y un estrogeno y uno o varios excipientes/portadores farmaceuticamente aceptables para ser aplicada como anticonceptivo para la anticoncepcion oral sin lactosa
BR8001820U (pt) Conjunto multianelar para construir pastas e similares
GB0113724D0 (en) Open-and-shut briefs, velcro-surface fastening at both ends of the saddle

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS. (CO) REFERENTE A RPI 2503 DE 26/12/2018, QUANTO A MONTAGEM DO CONJUNTO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/11/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 14/11/2025