ATE491806T1 - Signal-amplifikation mittels synthetischem zymogen - Google Patents

Signal-amplifikation mittels synthetischem zymogen

Info

Publication number
ATE491806T1
ATE491806T1 AT06011717T AT06011717T ATE491806T1 AT E491806 T1 ATE491806 T1 AT E491806T1 AT 06011717 T AT06011717 T AT 06011717T AT 06011717 T AT06011717 T AT 06011717T AT E491806 T1 ATE491806 T1 AT E491806T1
Authority
AT
Austria
Prior art keywords
zymogens
signal amplification
enzyme
substrate
synthetic zymogen
Prior art date
Application number
AT06011717T
Other languages
English (en)
Inventor
Gerard J Colpas
Shite Sebastian
Mitchell C Sanders
Original Assignee
Systagenix Wound Man Ip Co Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Systagenix Wound Man Ip Co Bv filed Critical Systagenix Wound Man Ip Co Bv
Application granted granted Critical
Publication of ATE491806T1 publication Critical patent/ATE491806T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/10—Enterobacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT06011717T 2003-09-02 2004-09-02 Signal-amplifikation mittels synthetischem zymogen ATE491806T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49984603P 2003-09-02 2003-09-02

Publications (1)

Publication Number Publication Date
ATE491806T1 true ATE491806T1 (de) 2011-01-15

Family

ID=34272880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06011717T ATE491806T1 (de) 2003-09-02 2004-09-02 Signal-amplifikation mittels synthetischem zymogen

Country Status (11)

Country Link
US (2) US8039228B2 (de)
EP (2) EP1670936A1 (de)
JP (3) JP2007503833A (de)
AT (1) ATE491806T1 (de)
AU (3) AU2004269425A1 (de)
CA (2) CA2564426C (de)
DE (1) DE602004030623D1 (de)
DK (1) DK1762626T3 (de)
ES (1) ES2357547T3 (de)
PT (1) PT1762626E (de)
WO (1) WO2005021780A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1576181B1 (de) 2002-01-31 2013-08-14 Systagenix Wound Management IP Co. BV. Verfahren zum nachweis pathogenenbakterien in wunden
CA2564426C (en) * 2003-09-02 2013-01-08 Expressive Constructs, Inc. A device for the detection of microorganisms using signal amplification
US8609358B2 (en) * 2003-11-03 2013-12-17 Systagenix Wound Management (Us), Inc. Methods, peptides and biosensors useful for detecting a broad spectrum of bacteria
CA2557623A1 (en) * 2003-11-03 2005-05-12 Ethicon, Inc. Detection of a microorganism by detecting modification of a peptide substrate and a biosensor for same
JP5089058B2 (ja) * 2006-03-01 2012-12-05 旭化成ファーマ株式会社 試料中の銅イオン濃度測定用酵素
AT509355B1 (de) * 2010-02-10 2012-04-15 Univ Graz Tech Testanordnung
EP2896963B1 (de) 2011-01-31 2019-01-30 Woundchek Laboratories B.V. Wundprognose
GB201116523D0 (en) 2011-09-23 2011-11-09 Systagenix Wound Man Ip Co Bv Wound prognosis
US9303063B2 (en) 2011-03-18 2016-04-05 Duke University Peptide compounds for suppressing inflammation
AU2012231268B2 (en) 2011-03-18 2017-02-02 Duke University Peptides for suppressing inflammation
US20130089858A1 (en) * 2011-09-16 2013-04-11 Winston Wong, JR. Molecular diagnostic assay device and method of use
KR101471932B1 (ko) * 2011-10-06 2014-12-11 주식회사 인지바이오 스크린 프린팅을 이용한 다중 진단 멤브레인 센서의 제조방법
WO2014146712A1 (en) * 2013-03-20 2014-09-25 Metgen Oy Method for saving energy in paper production
US20170127580A1 (en) * 2014-06-10 2017-05-04 Thomson Licensing Set top box having paste-in-hole tuner shield
EP3541935A4 (de) * 2016-11-16 2020-09-16 Universal Biosensors, Pty. Ltd. Spaltungsereignistransduktionsverfahren und produkte
CN106916797B (zh) * 2017-02-27 2019-12-17 中国科学院成都生物研究所 一种高活性漆酶突变体蛋白及其制备方法

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AU2684488A (en) * 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
JPH0480651A (ja) * 1990-07-23 1992-03-13 Kanzaki Paper Mfg Co Ltd 固定化酵素を用いるフロー型測定装置
JP3074361B2 (ja) * 1992-07-15 2000-08-07 セイコーインスツルメンツ株式会社 定量分析装置
ATE226642T1 (de) * 1994-07-07 2002-11-15 Tno Modifizierte proenzyme als substrate für proteolische enzyme
JPH08332077A (ja) * 1995-06-07 1996-12-17 Hitachi Ltd サンプルカップおよび生化学分析装置
JPH0923898A (ja) * 1995-07-13 1997-01-28 Nissui Pharm Co Ltd フェニルアラニンデアミナーゼ試験用反応シート
US20030096315A1 (en) * 2000-05-03 2003-05-22 Sanders Mitchell C. Device for detecting bacterial contamination and method of use
AU2001285200A1 (en) * 2000-08-22 2002-03-04 Cygene, Inc. Methods and compositions for ultra low copy number analyte detection
JP4830079B2 (ja) 2000-11-29 2011-12-07 国立感染症研究所長 プロテアーゼ活性の測定方法
WO2002082078A2 (en) * 2001-04-09 2002-10-17 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Activated enzyme-linked detection systems for detecting and quantifying nucleid acids, antigens antibodies and other analytes
JP2003169697A (ja) * 2001-12-05 2003-06-17 Fuji Electric Co Ltd 水中のリン酸計測方法と装置
CA2474130C (en) 2002-01-29 2011-04-05 Pyare Khanna Enzyme activation protease assay
EP1576181B1 (de) * 2002-01-31 2013-08-14 Systagenix Wound Management IP Co. BV. Verfahren zum nachweis pathogenenbakterien in wunden
WO2004047614A2 (en) 2002-11-26 2004-06-10 Expressive Constructs, Inc. Methods, biosensors and kits for detecting and identifying fungi
CA2514938A1 (en) 2003-01-31 2004-10-14 Ethicon, Inc. Method for detecting escherichia coli
CA2564426C (en) * 2003-09-02 2013-01-08 Expressive Constructs, Inc. A device for the detection of microorganisms using signal amplification
CA2557623A1 (en) 2003-11-03 2005-05-12 Ethicon, Inc. Detection of a microorganism by detecting modification of a peptide substrate and a biosensor for same

Also Published As

Publication number Publication date
ES2357547T3 (es) 2011-04-27
JP2007503833A (ja) 2007-03-01
WO2005021780A1 (en) 2005-03-10
CA2537529A1 (en) 2005-03-10
US20070196881A1 (en) 2007-08-23
AU2004269425A1 (en) 2005-03-10
AU2008203204A1 (en) 2008-08-07
DK1762626T3 (da) 2011-03-14
JP4991251B2 (ja) 2012-08-01
US7566564B2 (en) 2009-07-28
DE602004030623D1 (de) 2011-01-27
EP1762626B1 (de) 2010-12-15
US20070122873A1 (en) 2007-05-31
EP1762626A1 (de) 2007-03-14
CA2564426A1 (en) 2005-03-10
PT1762626E (pt) 2011-01-28
AU2011202044A1 (en) 2011-05-26
US8039228B2 (en) 2011-10-18
CA2564426C (en) 2013-01-08
JP2012120541A (ja) 2012-06-28
JP2007044052A (ja) 2007-02-22
EP1670936A1 (de) 2006-06-21

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