ATE494286T1 - Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren - Google Patents
Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitorenInfo
- Publication number
- ATE494286T1 ATE494286T1 AT05792113T AT05792113T ATE494286T1 AT E494286 T1 ATE494286 T1 AT E494286T1 AT 05792113 T AT05792113 T AT 05792113T AT 05792113 T AT05792113 T AT 05792113T AT E494286 T1 ATE494286 T1 AT E494286T1
- Authority
- AT
- Austria
- Prior art keywords
- monoamine
- inhibitors
- derivatives
- reuppost
- eurotransmitter
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical class C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Developing Agents For Electrophotography (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61405204P | 2004-09-30 | 2004-09-30 | |
| DKPA200401491 | 2004-09-30 | ||
| PCT/EP2005/054861 WO2006035034A1 (en) | 2004-09-30 | 2005-09-28 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE494286T1 true ATE494286T1 (de) | 2011-01-15 |
Family
ID=43448525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05792113T ATE494286T1 (de) | 2004-09-30 | 2005-09-28 | Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7696350B2 (de) |
| EP (2) | EP1797088B1 (de) |
| JP (1) | JP5001156B2 (de) |
| CN (1) | CN101023081A (de) |
| AT (1) | ATE494286T1 (de) |
| AU (1) | AU2005288914B2 (de) |
| BR (1) | BRPI0515261A (de) |
| CA (1) | CA2582297A1 (de) |
| DE (1) | DE602005025785D1 (de) |
| DK (1) | DK1797088T3 (de) |
| NZ (1) | NZ552919A (de) |
| PL (1) | PL1797088T3 (de) |
| RU (1) | RU2382040C2 (de) |
| WO (1) | WO2006035034A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070061846A (ko) * | 2004-09-30 | 2007-06-14 | 뉴로서치 에이/에스 | 신규한 크로멘-2-온 유도체 및 모노아민 신경전달물질재흡수 억제제로서의 이의 용도 |
| TW200800980A (en) * | 2006-02-17 | 2008-01-01 | Neurosearch As | Novel compounds |
| TW200836732A (en) * | 2006-12-20 | 2008-09-16 | Neurosearch As | Novel compounds |
| US20090312364A1 (en) * | 2006-12-20 | 2009-12-17 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CA2673315A1 (en) * | 2006-12-20 | 2008-06-26 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| TW200904815A (en) | 2007-05-09 | 2009-02-01 | Neurosearch As | Novel compounds |
| JP2010539075A (ja) * | 2007-09-10 | 2010-12-16 | ノイロサーチ アクティーゼルスカブ | フェノキサジン−３−オンの新規誘導体、並びにモノアミン神経伝達物質再取り込み阻害剤としてのその使用 |
| US20100286195A1 (en) * | 2007-09-10 | 2010-11-11 | Neurosearch A/S | Novel benzooxazol-and benzooxathiol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP2242754A1 (de) * | 2008-02-05 | 2010-10-27 | NeuroSearch A/S | Neue 9-azabicyclo[3.3.1]non-3-yloxychromen-2-onderivate und deren verwendung als monoaminneurotransmitter- wiederaufnahmeinhibitoren |
| BRPI0917802A2 (pt) | 2008-08-21 | 2016-03-01 | Neurosearch As | método para tratar um distúrbio de ansiedade, composição farmacêutica, uso do composto, uso de uma combinação, kit de partes, método para tratar, prevenir ou aliviar um distúrbio de ansiedade de um corpo de animal vivo, e, combinação |
| JP2012526744A (ja) | 2009-05-15 | 2012-11-01 | ノイロサーチ アクティーゼルスカブ | クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
| WO2011092061A1 (en) | 2010-01-29 | 2011-08-04 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2011117289A1 (en) | 2010-03-25 | 2011-09-29 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors |
| WO2012000881A1 (en) | 2010-07-02 | 2012-01-05 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP4241839A3 (de) * | 2019-08-06 | 2023-11-15 | Initiator Pharma A/S | Verbindung zur kombinationsbehandlung |
| CN120813353A (zh) * | 2023-01-03 | 2025-10-17 | 创始人制药股份有限公司 | 用于治疗勃起功能障碍的化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2189027B1 (de) * | 1972-06-21 | 1976-03-05 | Leurquin Laboratoires Fr | |
| DE69637097T2 (de) * | 1995-10-13 | 2007-09-20 | Neurosearch A/S | 8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung |
| EP0861242B1 (de) * | 1995-10-13 | 2001-05-30 | Aventis CropScience UK Limited | Heterozyclische fungizide |
| BR9707636A (pt) * | 1996-02-22 | 1999-07-27 | Neurosearch As | Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivo |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| AU2003243497A1 (en) | 2002-06-12 | 2003-12-31 | Millennium Pharmaceuticals, Inc. | Antagonists of melanin concentrating hormone receptor |
| US7538233B2 (en) * | 2003-09-05 | 2009-05-26 | Aventis Pharmaceuticals Inc. | Coumarins as iNOS inhibitors |
-
2005
- 2005-09-28 EP EP05792113A patent/EP1797088B1/de not_active Expired - Lifetime
- 2005-09-28 US US11/661,966 patent/US7696350B2/en active Active
- 2005-09-28 JP JP2007534018A patent/JP5001156B2/ja not_active Expired - Lifetime
- 2005-09-28 CA CA002582297A patent/CA2582297A1/en not_active Abandoned
- 2005-09-28 CN CNA2005800317650A patent/CN101023081A/zh active Pending
- 2005-09-28 EP EP10180549A patent/EP2284170A1/de not_active Withdrawn
- 2005-09-28 NZ NZ552919A patent/NZ552919A/en not_active IP Right Cessation
- 2005-09-28 RU RU2007106970/04A patent/RU2382040C2/ru not_active IP Right Cessation
- 2005-09-28 AT AT05792113T patent/ATE494286T1/de active
- 2005-09-28 BR BRPI0515261-5A patent/BRPI0515261A/pt not_active IP Right Cessation
- 2005-09-28 DE DE602005025785T patent/DE602005025785D1/de active Active
- 2005-09-28 WO PCT/EP2005/054861 patent/WO2006035034A1/en not_active Ceased
- 2005-09-28 DK DK05792113.2T patent/DK1797088T3/da active
- 2005-09-28 AU AU2005288914A patent/AU2005288914B2/en not_active Ceased
- 2005-09-28 PL PL05792113T patent/PL1797088T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2284170A1 (de) | 2011-02-16 |
| CA2582297A1 (en) | 2006-04-06 |
| RU2382040C2 (ru) | 2010-02-20 |
| US7696350B2 (en) | 2010-04-13 |
| PL1797088T3 (pl) | 2011-06-30 |
| DE602005025785D1 (de) | 2011-02-17 |
| BRPI0515261A (pt) | 2008-07-15 |
| AU2005288914A1 (en) | 2006-04-06 |
| RU2007106970A (ru) | 2008-11-10 |
| JP5001156B2 (ja) | 2012-08-15 |
| JP2008514676A (ja) | 2008-05-08 |
| AU2005288914B2 (en) | 2011-05-19 |
| EP1797088B1 (de) | 2011-01-05 |
| NZ552919A (en) | 2010-06-25 |
| WO2006035034A1 (en) | 2006-04-06 |
| EP1797088A1 (de) | 2007-06-20 |
| US20070232666A1 (en) | 2007-10-04 |
| CN101023081A (zh) | 2007-08-22 |
| DK1797088T3 (da) | 2011-04-04 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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