ATE495766T1 - Herzmuskel-ähnliche zellschicht, dreidimensionales konstrukt, herzmuskel-ähnliches gewebe und verfahren zur herstellung - Google Patents
Herzmuskel-ähnliche zellschicht, dreidimensionales konstrukt, herzmuskel-ähnliches gewebe und verfahren zur herstellungInfo
- Publication number
- ATE495766T1 ATE495766T1 AT01945762T AT01945762T ATE495766T1 AT E495766 T1 ATE495766 T1 AT E495766T1 AT 01945762 T AT01945762 T AT 01945762T AT 01945762 T AT01945762 T AT 01945762T AT E495766 T1 ATE495766 T1 AT E495766T1
- Authority
- AT
- Austria
- Prior art keywords
- heart muscle
- tissue
- temperature
- production
- cultured
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3826—Muscle cells, e.g. smooth muscle cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2539/00—Supports and/or coatings for cell culture characterised by properties
- C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000221385 | 2000-07-21 | ||
| PCT/JP2001/005722 WO2002008387A1 (en) | 2000-07-21 | 2001-07-02 | Heart muscle-like cell sheet, three-dimensional construct, heart muscle-like tissue and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495766T1 true ATE495766T1 (de) | 2011-02-15 |
Family
ID=18715796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01945762T ATE495766T1 (de) | 2000-07-21 | 2001-07-02 | Herzmuskel-ähnliche zellschicht, dreidimensionales konstrukt, herzmuskel-ähnliches gewebe und verfahren zur herstellung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040009566A1 (de) |
| EP (2) | EP2275532B1 (de) |
| JP (2) | JP4679795B2 (de) |
| AT (1) | ATE495766T1 (de) |
| DE (1) | DE60143892D1 (de) |
| ES (2) | ES2357764T3 (de) |
| WO (1) | WO2002008387A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889417B2 (en) | 2000-07-21 | 2014-11-18 | Cellseed Inc. | Epidermal cultured cell sheet, multi-layered cultured skin sheet and processes for producing those sheets |
| DE60143892D1 (de) * | 2000-07-21 | 2011-03-03 | Cellseed Ind | Herzmuskel-ähnliche zellschicht, dreidimensionales konstrukt, herzmuskel-ähnliches gewebe und verfahren zur herstellung |
| JP5226923B2 (ja) * | 2002-04-15 | 2013-07-03 | 株式会社セルシード | 心筋細胞シートによる心筋症治療薬 |
| WO2004069295A1 (ja) | 2003-02-06 | 2004-08-19 | Cellseed Inc. | 角膜上皮形成用細胞シート、それらの製造方法及びそれらの利用方法 |
| AU2003207285A1 (en) * | 2003-02-06 | 2004-08-30 | Cellseed Inc. | High-density cell array board, process for producing the same and method of using the same |
| ES2475290T3 (es) * | 2003-02-06 | 2014-07-10 | Cellseed Inc. | Láminas celulares relacionadas con el segmento ocular anterior, estructuras tridimensionales, y procesos para producir las mismas |
| KR101228251B1 (ko) * | 2003-02-20 | 2013-01-30 | 가부시키가이샤 셀시드 | 재생 각막 내피 세포 시트, 제조 방법 및 그 이용 방법 |
| JP4756816B2 (ja) * | 2003-03-10 | 2011-08-24 | 株式会社アドバンス | 骨再生補綴物の製造方法 |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| WO2005001080A2 (en) | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
| WO2006071794A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
| US7349740B2 (en) * | 2003-07-28 | 2008-03-25 | Medtronic, Inc. | Myocardial stimulation |
| EP2266500B1 (de) * | 2003-08-01 | 2015-04-01 | CellSeed Inc. | Dreidimensional gewebe-struktur |
| EP1748064B1 (de) * | 2004-04-25 | 2019-04-17 | CellSeed Inc. | Kultivierte Periodontalverbindungzellage, Herstellungsverfahren sowie Verwendung davon |
| JP4303643B2 (ja) | 2004-06-01 | 2009-07-29 | 育男 森田 | 人工組織体およびその製造方法 |
| GB0425266D0 (en) * | 2004-11-16 | 2004-12-15 | Norton Healthcare Ltd | Pharmaceutical manufacturing process |
| US20060171930A1 (en) * | 2004-12-21 | 2006-08-03 | Agnieszka Seyda | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060166361A1 (en) * | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| JP2006223106A (ja) * | 2005-02-15 | 2006-08-31 | Fuji Photo Film Co Ltd | 細胞培養担体 |
| EP1857126B1 (de) * | 2005-02-28 | 2018-10-24 | CellSeed Inc. | Gezüchtete zellplatte, herstellungsverfahren und anwendungsverfahren dafür |
| US20080131476A1 (en) | 2005-02-28 | 2008-06-05 | Masato Kanzaki | Cultured Cell Sheet, Production Method and Tissue Repair Method Using Thereof |
| EP1728856B1 (de) | 2005-06-01 | 2009-05-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur optischen Bestimmung des dynamischen Verhaltens von kontrahierenden Zellen |
| US9249386B2 (en) * | 2005-06-06 | 2016-02-02 | Dai Nippon Printing Co., Ltd. | Substrate for cell transfer |
| WO2007050314A2 (en) * | 2005-10-24 | 2007-05-03 | Hosheng Tu | Medical device with living cell sheet |
| EP1991668A4 (de) | 2006-02-03 | 2011-06-15 | Harvard College | Entwickeltes zellwachstum auf polymerfolien und biotechnologische anwendungen davon |
| US20100196432A1 (en) * | 2006-10-10 | 2010-08-05 | Feinberg Adam W | Biopolymer structures |
| JP5424538B2 (ja) * | 2007-03-19 | 2014-02-26 | 株式会社セルシード | 移植用成熟誘導化樹状細胞、製造方法及びその利用方法 |
| WO2008143149A1 (ja) | 2007-05-11 | 2008-11-27 | Dai Nippon Printing Co., Ltd. | 寸法が保持された細胞シート、その製造方法、及びそのための細胞培養担体 |
| WO2008152983A1 (ja) * | 2007-06-08 | 2008-12-18 | National University Corporation Tokyo Medical And Dental University | モデル細胞チップ、モデル細胞チップによる薬効評価装置、および薬効評価方法 |
| US9068168B2 (en) * | 2007-09-26 | 2015-06-30 | President And Fellows Of Harvard College | Boundary conditions for the arrangement of cells and tissues |
| WO2010011407A2 (en) * | 2008-05-23 | 2010-01-28 | President And Fellows Of Harvard College | Methods of generating patterned soft substrates and uses thereof |
| WO2010044417A1 (ja) * | 2008-10-14 | 2010-04-22 | 株式会社セルシード | 温度応答性細胞培養器材、及びその製造方法 |
| JP5614928B2 (ja) * | 2008-12-05 | 2014-10-29 | 国立大学法人 東京医科歯科大学 | 心筋毒性検査装置、心筋毒性検査チップおよび心筋毒性検査方法 |
| US20100166822A1 (en) * | 2008-12-31 | 2010-07-01 | Howmedica Osteonics Corp. | Adhesive cartilage implant |
| WO2010101225A1 (ja) | 2009-03-04 | 2010-09-10 | 学校法人 東京女子医科大学 | 細胞シートを利用した細胞評価システム及びその利用方法 |
| WO2010127280A1 (en) | 2009-05-01 | 2010-11-04 | President And Fellows Of Harvard College | High throughput assays for determining contractile function and devices for use therein |
| WO2011058813A1 (ja) | 2009-11-13 | 2011-05-19 | Sawa Yoshiki | 心筋再生用細胞シート、製造方法及びその利用方法 |
| US20120308533A1 (en) | 2009-12-03 | 2012-12-06 | Osaka University | Adipocyte sheet, three-dimensional structure thereof, and method for producing the same |
| WO2012006320A1 (en) | 2010-07-06 | 2012-01-12 | President And Fellows Of Harvard College | Photosensitive cardiac rhythm modulation systems |
| US9617519B2 (en) | 2010-09-14 | 2017-04-11 | Tokyo Women's Medical University | Method for manufacturing multilayered cell sheet, multilayered cell sheet having vascular network obtained thereby, and method of use thereof |
| CN103180437B (zh) | 2010-09-14 | 2016-02-03 | 学校法人东京女子医科大学 | 细胞片叠层化物的制造方法、由该方法得到的具有血管网的细胞片叠层化物及其利用方法 |
| JP5367672B2 (ja) * | 2010-09-27 | 2013-12-11 | 株式会社セルシード | 心筋細胞シートによる心筋症治療薬 |
| JP5370376B2 (ja) | 2011-01-13 | 2013-12-18 | 横河電機株式会社 | 機器情報表示装置、機器情報表示プログラム、及び記録媒体 |
| JP5840855B2 (ja) | 2011-03-30 | 2016-01-06 | 学校法人東京女子医科大学 | 胚性幹細胞から心筋シートを製造する方法 |
| JP5816452B2 (ja) | 2011-03-31 | 2015-11-18 | 株式会社セルシード | 細胞シート移植治具及びその利用方法 |
| US9857356B2 (en) | 2011-12-09 | 2018-01-02 | President And Fellows Of Havard College | Muscle chips and methods of use thereof |
| JP5920741B2 (ja) | 2012-03-15 | 2016-05-18 | iHeart Japan株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| JP5990403B2 (ja) * | 2012-05-31 | 2016-09-14 | 株式会社 ジャパン・ティッシュ・エンジニアリング | 培養皿及び培養キット |
| WO2014015251A2 (en) | 2012-07-20 | 2014-01-23 | President And Fellows Of Harvard College | Tissue-engineered pumps and valves and uses thereof |
| JP6301098B2 (ja) * | 2013-10-02 | 2018-03-28 | テルモ株式会社 | シート状細胞培養物の剥離方法および製造方法ならびにこれらに用いる容器 |
| US10591458B2 (en) | 2014-02-18 | 2020-03-17 | President And Fellows Of Harvard College | Anisotropic muscular tissue devices with integrated electrical force readouts |
| JP6459458B2 (ja) * | 2014-03-03 | 2019-01-30 | ソニー株式会社 | 細胞評価装置 |
| US10603410B2 (en) | 2014-06-24 | 2020-03-31 | General Inc. | Complex of implant and cultured periodontal ligament cell sheet, method for manufacturing the same, and method for using the same |
| WO2016069142A2 (en) | 2014-09-24 | 2016-05-06 | President And Fellows Of Harvard College | Contractile function measuring devices, systems, and methods of use thereof |
| WO2017087759A1 (en) | 2015-11-18 | 2017-05-26 | President And Fellows Of Harvard College | Cartridge-based system for long term culture of cell clusters |
| JP2017140109A (ja) | 2016-02-08 | 2017-08-17 | テルモ株式会社 | 治療方法および医療用装置 |
| EP4349972B1 (de) | 2016-02-22 | 2026-04-08 | Osaka University | Verfahren zur herstellung von dreidimensionalem zellgewebe |
| JP7130198B2 (ja) * | 2017-06-29 | 2022-09-05 | 日本光電工業株式会社 | 積層化細胞シートの製造方法、及びそれにより作製される積層化細胞シート |
| US11111611B2 (en) | 2017-06-30 | 2021-09-07 | Board Of Regents, The University Of Texas System | Electrospun PNIPAAm/PCL fiber mats for aligned cell sheets |
| US11629318B2 (en) | 2017-10-20 | 2023-04-18 | President And Fellows Of Harvard College | Methods for producing mature adipocytes and methods of use thereof |
| CN112657051B (zh) * | 2020-12-25 | 2023-08-04 | 上海交通大学医学院附属上海儿童医学中心 | 一种基于共轭同轴静电纺丝技术的生物型心室辅助泵及其制备方法 |
| DE112022001103T5 (de) | 2021-02-17 | 2024-02-22 | Fukuoka University | Zellblattträger, Zellblattlaminate und Verfahren zu deren Herstellung |
| EP4667562A1 (de) | 2023-02-14 | 2025-12-24 | Toppan Holdings Inc. | Dreidimensionales hepatozytengewebe und verfahren zur herstellung davon |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4304866A (en) * | 1979-11-14 | 1981-12-08 | Massachusetts Institute Of Technology | Transplantable sheets of living keratinous tissue |
| JP2549151B2 (ja) | 1988-07-13 | 1996-10-30 | 株式会社東芝 | マンコンベヤ |
| JPH06104061B2 (ja) | 1989-02-10 | 1994-12-21 | 花王株式会社 | 細胞培養支持体材料 |
| US5543318A (en) * | 1991-06-12 | 1996-08-06 | Smith; David A. | Method of isolation, culture and proliferation of human atrial myocytes |
| JPH05192138A (ja) | 1992-01-22 | 1993-08-03 | Kao Corp | 皮膚細胞培養法及び培養皮膚 |
| US6099832A (en) * | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
| JP2000023191A (ja) | 1998-06-30 | 2000-01-21 | Aqueous Reserch:Kk | 動画像圧縮装置 |
| DE60143892D1 (de) * | 2000-07-21 | 2011-03-03 | Cellseed Ind | Herzmuskel-ähnliche zellschicht, dreidimensionales konstrukt, herzmuskel-ähnliches gewebe und verfahren zur herstellung |
-
2001
- 2001-07-02 DE DE60143892T patent/DE60143892D1/de not_active Expired - Lifetime
- 2001-07-02 EP EP10181984A patent/EP2275532B1/de not_active Expired - Lifetime
- 2001-07-02 JP JP2002513872A patent/JP4679795B2/ja not_active Expired - Fee Related
- 2001-07-02 EP EP01945762A patent/EP1302535B1/de not_active Expired - Lifetime
- 2001-07-02 ES ES01945762T patent/ES2357764T3/es not_active Expired - Lifetime
- 2001-07-02 ES ES10181984T patent/ES2385301T3/es not_active Expired - Lifetime
- 2001-07-02 AT AT01945762T patent/ATE495766T1/de not_active IP Right Cessation
- 2001-07-02 US US10/333,473 patent/US20040009566A1/en not_active Abandoned
- 2001-07-02 WO PCT/JP2001/005722 patent/WO2002008387A1/ja not_active Ceased
-
2010
- 2010-07-27 JP JP2010168577A patent/JP5086398B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5086398B2 (ja) | 2012-11-28 |
| ES2385301T3 (es) | 2012-07-20 |
| JP2011004750A (ja) | 2011-01-13 |
| JP4679795B2 (ja) | 2011-04-27 |
| DE60143892D1 (de) | 2011-03-03 |
| EP2275532A1 (de) | 2011-01-19 |
| ES2357764T3 (es) | 2011-04-29 |
| EP2275532B1 (de) | 2012-06-06 |
| EP1302535A1 (de) | 2003-04-16 |
| JPWO2002008387A1 (ja) | 2004-02-05 |
| US20040009566A1 (en) | 2004-01-15 |
| EP1302535B1 (de) | 2011-01-19 |
| WO2002008387A1 (en) | 2002-01-31 |
| EP1302535A4 (de) | 2007-08-29 |
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