ATE496037T1 - Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel - Google Patents

Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel

Info

Publication number: ATE496037T1
Authority: AT; Austria
Prior art keywords: crystalline; füä1; ethylü; dibenzoäb; hydroxyethoxy
Prior art date: 1997-08-01

Application number

AT05011169T

Other languages

English (en)

Inventor

Evan William Snape

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-01

Filing date

1998-07-28

Publication date

2011-02-15

1998-07-28 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496037T1 publication Critical patent/ATE496037T1/de

Links

239000000164 antipsychotic agent Substances 0.000 title 1
150000008509 dibenzothiazepines Chemical class 0.000 title 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000003849 aromatic solvent Substances 0.000 abstract 1
239000002178 crystalline material Substances 0.000 abstract 1
GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 abstract 1
FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 abstract 1
OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 abstract 1
229940043265 methyl isobutyl ketone Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Liquid Crystal Substances (AREA)

AT05011169T 1997-08-01 1998-07-28 Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel ATE496037T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9716161.6A GB9716161D0 (en)	1997-08-01	1997-08-01	Process

Publications (1)

Publication Number	Publication Date
ATE496037T1 true ATE496037T1 (de)	2011-02-15

Family

ID=10816746

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98936529T ATE444959T1 (de)	1997-08-01	1998-07-28	Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel
AT05011169T ATE496037T1 (de)	1997-08-01	1998-07-28	Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98936529T ATE444959T1 (de)	1997-08-01	1998-07-28	Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel

Country Status (31)

Country	Link
US (2)	US6372734B1 (de)
EP (2)	EP1589008B1 (de)
JP (2)	JP2001512109A (de)
KR (1)	KR20010022241A (de)
CN (1)	CN1125058C (de)
AT (2)	ATE444959T1 (de)
AU (1)	AU739255B2 (de)
BG (1)	BG64796B1 (de)
BR (1)	BR9811061A (de)
CA (1)	CA2295792C (de)
CY (2)	CY2200162T2 (de)
CZ (1)	CZ299225B6 (de)
DE (4)	DE69841216D1 (de)
EE (1)	EE04550B1 (de)
ES (2)	ES2296568T3 (de)
GB (2)	GB9716161D0 (de)
HU (1)	HU228620B1 (de)
ID (1)	ID24219A (de)
IL (1)	IL133618A (de)
MY (1)	MY120999A (de)
NO (1)	NO20000484L (de)
NZ (1)	NZ501914A (de)
PL (1)	PL338384A1 (de)
PT (2)	PT1589008E (de)
RU (1)	RU2224754C2 (de)
SI (2)	SI1000043T1 (de)
SK (1)	SK287145B6 (de)
TR (1)	TR200000848T2 (de)
TW (1)	TW533207B (de)
WO (1)	WO1999006381A1 (de)
ZA (1)	ZA986904B (de)

Families Citing this family (30)

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IL164155A0 (en) *	2002-03-20	2005-12-18	Teva Pharma	Crystalline forms of quetiapine hemifumarate
CA2516646A1 (en) *	2003-02-22	2004-09-10	Teva Pharmaceutical Industries Ltd.	Synthesis of quetiapine and pharmaceutically acceptable salts thereof
WO2004078735A1 (en) *	2003-03-03	2004-09-16	Hetero Drugs Limited	Novel polymorphs of quetiapine fumarate
AU2003242982A1 (en) *	2003-04-07	2004-11-01	Hetero Drugs Limited	A novel crystalline form of dorzolamide hydrochloride
ES2223294B2 (es)	2003-08-08	2005-10-01	Vita Cientifica, S.L.	Procedimiento de preparacion de un compuesto farmaceuticamente activo.
US20060081361A1 (en) *	2004-09-13	2006-04-20	Gabbey Lawrence W	Oil cooler with integral filter
WO2006035293A1 (en) *	2004-09-27	2006-04-06	Ranbaxy Laboratories Limited	Polymorphic forms of quetiapine hemifumarate
WO2006056772A2 (en) *	2004-11-23	2006-06-01	Pliva Hrvatska D.O.O.	Salts of quetiapine
GB0425729D0 (en) *	2004-11-23	2004-12-22	Pliva Res & Dev Ltd	Heterocyclic compounds
ES2234447B1 (es) *	2005-03-07	2006-03-01	Union Quimico-Farmaceutica S.A.	Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
EP1869007A1 (de)	2005-04-14	2007-12-26	Teva Pharmaceutical Industries Ltd	Verfahren zur herstellung von quetiapinfumaraten
US20070072840A1 (en) *	2005-05-30	2007-03-29	Pandya Bhargav	Polymorphic forms of quetiapine
EP1928849A1 (de)	2005-09-30	2008-06-11	Fermion Oy	Neues kristallisationsverfahren für quetiapin-hemifumarat
US8044039B2 (en)	2005-10-28	2011-10-25	Fermion Oy	Quetiapine hemifumarate purification by crystallization
JP2009516707A (ja) *	2005-11-18	2009-04-23	アストラゼネカ・アクチエボラーグ	固形製剤
JP2009516708A (ja) *	2005-11-18	2009-04-23	アストラゼネカ・アクチエボラーグ	液体製剤
US20090069291A1 (en) *	2005-11-18	2009-03-12	Astrazeneca Ab	Salt Forms
EP1951257A4 (de) *	2005-11-18	2008-11-05	Astrazeneca Ab	Kristalline formen
US8389510B2 (en) *	2005-11-18	2013-03-05	Astrazeneca Ab	Crystalline forms
CZ300451B6 (cs) *	2006-07-03	2009-05-20	Farmak, A. S.	Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
WO2008066620A2 (en) *	2006-10-20	2008-06-05	Concert Pharmaceuticals Inc.	Dibenzothiazepine derivatives
EP1958617B1 (de)	2007-02-14	2010-09-08	Laboratorios Lesvi, S.L.	Pharmazeutische Zusammensetzungen mit Quetiapinfumarat
JP2009529062A (ja) *	2007-03-29	2009-08-13	テバファーマシューティカルインダストリーズリミティド	フマル酸クエチアピンを調製するための改良法
US8101597B2 (en) *	2007-05-07	2012-01-24	Actavis Group Ptc Ehf	Quetiapine salts and their polymorphs
US20090082334A1 (en) *	2007-09-25	2009-03-26	Protia, Llc	Deuterium-enriched quetiapine
WO2009071631A2 (en) *	2007-12-05	2009-06-11	Janssen Pharmaceutica Nv	Dibenzoazepine and dibenzooxazepine trpa1 agonists
PT2262486E (pt)	2008-08-01	2013-03-27	Tovarna Zdravil D D Novo Mesto Krka	Composição de quetiapina
US20100069356A1 (en) *	2008-09-17	2010-03-18	Auspex Pharmaceuticals, Inc.	Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors
JP2012519683A (ja)	2009-03-04	2012-08-30	ランバクシーラボラトリーズリミテッド	フマル酸クエチアピンの調製方法
DK2742152T3 (en)	2011-08-12	2017-07-31	Qiagen Gmbh	PROCEDURE FOR ISOLATING NUCLEIC ACIDS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE787249A (fr)	1971-08-05	1973-02-05	Squibb & Sons Inc	Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
GB8607684D0 (en) *	1986-03-27	1986-04-30	Ici America Inc	Thiazepine compounds
GB8705574D0 (en) *	1987-03-10	1987-04-15	Ici Plc	Preparation of thiazepine compound

1997
- 1997-08-01 GB GBGB9716161.6A patent/GB9716161D0/en active Pending
1998
- 1998-07-10 GB GBGB9814882.8A patent/GB9814882D0/en active Pending
- 1998-07-28 DE DE69841216T patent/DE69841216D1/de not_active Expired - Lifetime
- 1998-07-28 ES ES05011169T patent/ES2296568T3/es not_active Expired - Lifetime
- 1998-07-28 SI SI9830923T patent/SI1000043T1/sl unknown
- 1998-07-28 EE EEP200000062A patent/EE04550B1/xx not_active IP Right Cessation
- 1998-07-28 PT PT05011169T patent/PT1589008E/pt unknown
- 1998-07-28 DE DE05011169T patent/DE05011169T1/de active Pending
- 1998-07-28 US US09/463,452 patent/US6372734B1/en not_active Expired - Lifetime
- 1998-07-28 AT AT98936529T patent/ATE444959T1/de active
- 1998-07-28 PL PL98338384A patent/PL338384A1/xx not_active Application Discontinuation
- 1998-07-28 CA CA002295792A patent/CA2295792C/en not_active Expired - Fee Related
- 1998-07-28 WO PCT/GB1998/002260 patent/WO1999006381A1/en not_active Ceased
- 1998-07-28 AT AT05011169T patent/ATE496037T1/de active
- 1998-07-28 RU RU2000105271/04A patent/RU2224754C2/ru not_active IP Right Cessation
- 1998-07-28 TR TR2000/00848T patent/TR200000848T2/xx unknown
- 1998-07-28 DE DE69842104T patent/DE69842104D1/de not_active Expired - Lifetime
- 1998-07-28 SI SI9830929T patent/SI1589008T1/sl unknown
- 1998-07-28 IL IL13361898A patent/IL133618A/en not_active IP Right Cessation
- 1998-07-28 KR KR1020007000814A patent/KR20010022241A/ko not_active Ceased
- 1998-07-28 TW TW087112313A patent/TW533207B/zh not_active IP Right Cessation
- 1998-07-28 ES ES98936529T patent/ES2296575T3/es not_active Expired - Lifetime
- 1998-07-28 SK SK130-2000A patent/SK287145B6/sk not_active IP Right Cessation
- 1998-07-28 BR BR9811061-6A patent/BR9811061A/pt not_active Application Discontinuation
- 1998-07-28 AU AU85498/98A patent/AU739255B2/en not_active Ceased
- 1998-07-28 ID IDW20000029A patent/ID24219A/id unknown
- 1998-07-28 EP EP05011169A patent/EP1589008B1/de not_active Expired - Lifetime
- 1998-07-28 DE DE98936529T patent/DE98936529T1/de active Pending
- 1998-07-28 JP JP2000505140A patent/JP2001512109A/ja active Pending
- 1998-07-28 EP EP98936529A patent/EP1000043B1/de not_active Expired - Lifetime
- 1998-07-28 NZ NZ501914A patent/NZ501914A/en not_active IP Right Cessation
- 1998-07-28 HU HU0002663A patent/HU228620B1/hu not_active IP Right Cessation
- 1998-07-28 PT PT98936529T patent/PT1000043E/pt unknown
- 1998-07-28 CN CN98807572A patent/CN1125058C/zh not_active Expired - Fee Related
- 1998-07-28 CZ CZ20000341A patent/CZ299225B6/cs not_active IP Right Cessation
- 1998-07-29 MY MYPI98003471A patent/MY120999A/en unknown
- 1998-07-31 ZA ZA986904A patent/ZA986904B/xx unknown
2000
- 2000-01-31 NO NO20000484A patent/NO20000484L/no unknown
- 2000-02-22 BG BG104176A patent/BG64796B1/bg unknown
2002
- 2002-03-21 US US10/101,948 patent/US20020147186A1/en not_active Abandoned
2008
- 2008-03-04 CY CY20082200005T patent/CY2200162T2/el unknown
- 2008-03-04 CY CY20082200004T patent/CY2200161T2/el unknown
- 2008-12-09 JP JP2008313248A patent/JP2009102345A/ja active Pending

Also Published As

Publication number	Publication date
BG64796B1 (bg)	2006-04-28
DE05011169T1 (de)	2008-11-06
GB9716161D0 (en)	1997-10-08
DE98936529T1 (de)	2008-11-20
CY2200162T2 (el)	2010-07-28
HU228620B1 (en)	2013-04-29
TR200000848T2 (tr)	2000-08-21
NO20000484L (no)	2000-03-16
HK1081962A1 (en)	2006-05-26
GB9814882D0 (en)	1998-09-09
PT1000043E (pt)	2009-11-30
BR9811061A (pt)	2000-09-19
EP1000043A1 (de)	2000-05-17
ZA986904B (en)	1999-02-01
CN1265101A (zh)	2000-08-30
AU739255B2 (en)	2001-10-04
SI1589008T1 (sl)	2011-04-29
IL133618A (en)	2004-02-08
IL133618A0 (en)	2001-04-30
SK287145B6 (sk)	2010-01-07
RU2224754C2 (ru)	2004-02-27
CZ2000341A3 (cs)	2000-05-17
PL338384A1 (en)	2000-10-23
ES2296568T1 (es)	2008-05-01
CA2295792A1 (en)	1999-02-11
JP2001512109A (ja)	2001-08-21
CN1125058C (zh)	2003-10-22
EP1589008A1 (de)	2005-10-26
PT1589008E (pt)	2011-03-23
NZ501914A (en)	2001-09-28
HUP0002663A2 (hu)	2001-09-28
US6372734B1 (en)	2002-04-16
EP1000043B1 (de)	2009-10-07
DE69841216D1 (de)	2009-11-19
KR20010022241A (ko)	2001-03-15
EE04550B1 (et)	2005-10-17
ID24219A (id)	2000-07-13
ES2296575T3 (es)	2010-02-05
ATE444959T1 (de)	2009-10-15
JP2009102345A (ja)	2009-05-14
WO1999006381A1 (en)	1999-02-11
BG104176A (en)	2000-08-31
AU8549898A (en)	1999-02-22
SI1000043T1 (sl)	2010-01-29
EE200000062A (et)	2000-10-16
CA2295792C (en)	2007-04-17
NO20000484D0 (no)	2000-01-31
DE69842104D1 (de)	2011-03-03
ES2296568T3 (es)	2011-05-06
SK1302000A3 (en)	2000-06-12
ES2296575T1 (es)	2008-05-01
EP1589008B1 (de)	2011-01-19
HK1029992A1 (en)	2001-04-20
US20020147186A1 (en)	2002-10-10
CY2200161T2 (el)	2010-07-28
TW533207B (en)	2003-05-21
CZ299225B6 (cs)	2008-05-21
HUP0002663A3 (en)	2001-10-29
MY120999A (en)	2005-12-30

Legal Events

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2011-09-15

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Publication	Publication Date	Title
ATE444959T1 (de)	2009-10-15	Kristallines dibenzothiazepinderivat und seine verwendung als antipsychotisches mittel
ATE200279T1 (de)	2001-04-15	Herstellung von 3,4,4-trisubstituiertem piperidinyl-n-alkylcarboxylaten und zwischenverbindungen, verwendbar als opioid antagonisten
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AU697679B2 (en)	1998-10-15	Treatment of tinnitis using neuroprotective agents
NO931534L (no)	1993-11-15	Sulfonylbenzylsubstituerte benzo- og pyridopyridoner
TR199900477T2 (xx)	1999-06-21	Thiazolil-alanin art�� ihtiva eden yeni peptid t�revleri.
IL125002A0 (en)	1999-01-26	Novel substituted 4-(1H-benzimidazol-2-yl) [1,4] diazepanes useful for the treatment of allergic diseases
DE60009276D1 (de)	2004-04-29	Thiazolidindionderivat und seine verwendung als antidiabetikum
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DK0789658T3 (da)	1999-09-13	Styreindretning til at opnå optimal anvendelse af den energi, der frembringes af et fartøjs hovedenergikilde
DE69519219D1 (de)	2000-11-30	Verwendung von (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazoline]-2-carboxamid zur Behandlung von Keratopathie
DK0702009T3 (da)	1999-02-01	Fremgangsmåde til fremstilling af farmaceutisk aktive benzothiazepinderivater
AU7379794A (en)	1995-02-28	Aza-5,5-fused heterocyclic acids as leukotriene antagonists
KR970017938U (ko)	1997-05-23	유기성폐기물 처리용 발효처리기
DE59914948D1 (de)	2009-03-05	Verwendung von 1-(aminoalkyl)-3-chinoxalin-2-on-derivaten zur herstellung von als antioxidantien wirkenden zusammensetzungen
KR940022660U (ko)	1994-10-20	유기물 발효기용 탈취장치
HI et al.	1989	EXPERIENSE IN PURIFICATION OF DYEING WASTE WATER
ATE230413T1 (de)	2003-01-15	Pharmazeutisch verträgliche salze von 3-hydroxy- estr-5(10)-en-17-on-3-sulfat die als östrogene aktiv sind
DE69104646D1 (de)	1994-11-24	2-Fluorneplanocin A und seine Herstellung.
SI0874843T1 (en)	2002-12-31	Substituted 4-(1h-benzimidazol-2-yl) 1,4)diazepanes useful for the treatment of allergic diseases
SE9602476D0 (sv)	1996-06-24	Process for the preparation of organic salts of N'N -diacetylcystine
SE9602418D0 (sv)	1996-06-18	Process for the preparation of organic salts of N'N-diacetylcystine