TR200000848T2 - Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması. - Google Patents

Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması.

Info

Publication number
TR200000848T2
TR200000848T2 TR2000/00848T TR200000848T TR200000848T2 TR 200000848 T2 TR200000848 T2 TR 200000848T2 TR 2000/00848 T TR2000/00848 T TR 2000/00848T TR 200000848 T TR200000848 T TR 200000848T TR 200000848 T2 TR200000848 T2 TR 200000848T2
Authority
TR
Turkey
Prior art keywords
crystalline
ethyl
thiazepine
dibenzo
hydroxyethoxy
Prior art date
Application number
TR2000/00848T
Other languages
English (en)
Inventor
William Snape Evan
Original Assignee
Zeneca Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Limited filed Critical Zeneca Limited
Publication of TR200000848T2 publication Critical patent/TR200000848T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

Kristalin 11-(4-[2-(2-hidroksietoksi) etil]-1- piperazinil)-dibenzo[b,f] [1,4] tiazepin (I), etil esetat, izobütil asetat, metil izo-bütilketon ya da tert-bütil eter gibi aromatik olmayan bir çözgenden hareketle tercihen sudan arik bir ortamda 11-(4-[2-(2-hidroksietoksi) etil]-1- piperazinil)-dibenzo[b,f] [1,4] tiazepini kristallestirmek suretiyle hazirlanabilir. Elde edilen kristalin maddeyi fumarat gibi farmasötik açidan geçerli bir tuza dönüstürmek mümkündür. Kristalin 11-(4-[2-(2-hidroksietoksi) etil]-1- piperazinil)-dibenzo[b,f] [1,4] tiazepin psikozlari tedavi etmek için kullanilabilir.
TR2000/00848T 1997-08-01 1998-07-28 Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması. TR200000848T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9716161.6A GB9716161D0 (en) 1997-08-01 1997-08-01 Process

Publications (1)

Publication Number Publication Date
TR200000848T2 true TR200000848T2 (tr) 2000-08-21

Family

ID=10816746

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00848T TR200000848T2 (tr) 1997-08-01 1998-07-28 Bir kristalin dibenzotiazepin türevi ve bunun antipsikotik bir ajan olarak kullanılması.

Country Status (31)

Country Link
US (2) US6372734B1 (tr)
EP (2) EP1589008B1 (tr)
JP (2) JP2001512109A (tr)
KR (1) KR20010022241A (tr)
CN (1) CN1125058C (tr)
AT (2) ATE444959T1 (tr)
AU (1) AU739255B2 (tr)
BG (1) BG64796B1 (tr)
BR (1) BR9811061A (tr)
CA (1) CA2295792C (tr)
CY (2) CY2200162T2 (tr)
CZ (1) CZ299225B6 (tr)
DE (4) DE98936529T1 (tr)
EE (1) EE04550B1 (tr)
ES (2) ES2296568T3 (tr)
GB (2) GB9716161D0 (tr)
HU (1) HU228620B1 (tr)
ID (1) ID24219A (tr)
IL (1) IL133618A (tr)
MY (1) MY120999A (tr)
NO (1) NO20000484L (tr)
NZ (1) NZ501914A (tr)
PL (1) PL338384A1 (tr)
PT (2) PT1000043E (tr)
RU (1) RU2224754C2 (tr)
SI (2) SI1000043T1 (tr)
SK (1) SK287145B6 (tr)
TR (1) TR200000848T2 (tr)
TW (1) TW533207B (tr)
WO (1) WO1999006381A1 (tr)
ZA (1) ZA986904B (tr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4414237B2 (ja) * 2002-03-20 2010-02-10 テバ ファーマシューティカル インダストリーズ リミティド ケチアピンヘミフマレートの結晶形
WO2004076431A1 (en) * 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
AU2003216705A1 (en) * 2003-03-03 2004-09-28 Hetero Drugs Limited Novel polymorphs of quetiapine fumarate
WO2004089957A1 (en) 2003-04-07 2004-10-21 Hetero Drugs Limited A novel crystalline form of dorzolamide hydrochloride
ES2223294B2 (es) 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
US20060081361A1 (en) * 2004-09-13 2006-04-20 Gabbey Lawrence W Oil cooler with integral filter
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
JP2008502707A (ja) 2005-04-14 2008-01-31 テバ ファーマシューティカル インダストリーズ リミティド クエチアピンフマレートの調製方法
US20070072840A1 (en) * 2005-05-30 2007-03-29 Pandya Bhargav Polymorphic forms of quetiapine
US8044038B2 (en) * 2005-09-30 2011-10-25 Fermion Oy Crystallization process of quetiapine hemifumarate
WO2007048870A1 (en) * 2005-10-28 2007-05-03 Fermion Oy Quetiapine hemifumarate purification by crystallization
EP1951257A4 (en) * 2005-11-18 2008-11-05 Astrazeneca Ab CRYSTALLINE FORMS
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
JP2009516708A (ja) * 2005-11-18 2009-04-23 アストラゼネカ・アクチエボラーグ 液体製剤
WO2007062338A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Solid formulations
EP1951694A4 (en) * 2005-11-18 2010-09-22 Astrazeneca Ab FORMS OF SALTS
CZ300451B6 (cs) * 2006-07-03 2009-05-20 Farmak, A. S. Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
WO2008066620A2 (en) * 2006-10-20 2008-06-05 Concert Pharmaceuticals Inc. Dibenzothiazepine derivatives
EP1958617B1 (en) 2007-02-14 2010-09-08 Laboratorios Lesvi, S.L. Pharmaceutical compositions containing quetiapine fumarate
US20080241949A1 (en) * 2007-03-29 2008-10-02 Vinod Kumar Kansal Process for preparing quetiapine fumarate
WO2009004480A2 (en) * 2007-05-07 2009-01-08 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
US20090082334A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched quetiapine
US8461145B2 (en) * 2007-12-05 2013-06-11 Janssen Pharmaceutica Nv Dibenzoazepine and dibenzooxazepine TRPA1 agonists
DE202009018024U1 (de) 2008-08-01 2010-12-09 Krka Tovarna Zdravil, D.D., Novo Mesto Quetiapin-Zusammensetzung
WO2010033270A1 (en) * 2008-09-17 2010-03-25 Auspex Pharmaceuticals, Inc. Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
JP6096774B2 (ja) 2011-08-12 2017-03-15 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 核酸を単離するための方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8705574D0 (en) * 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound

Also Published As

Publication number Publication date
IL133618A (en) 2004-02-08
IL133618A0 (en) 2001-04-30
BG104176A (en) 2000-08-31
TW533207B (en) 2003-05-21
WO1999006381A1 (en) 1999-02-11
RU2224754C2 (ru) 2004-02-27
BG64796B1 (bg) 2006-04-28
GB9814882D0 (en) 1998-09-09
PT1000043E (pt) 2009-11-30
PL338384A1 (en) 2000-10-23
CY2200162T2 (el) 2010-07-28
ZA986904B (en) 1999-02-01
HUP0002663A3 (en) 2001-10-29
DE69841216D1 (de) 2009-11-19
EP1000043B1 (en) 2009-10-07
EP1589008B1 (en) 2011-01-19
DE69842104D1 (de) 2011-03-03
SK287145B6 (sk) 2010-01-07
SI1589008T1 (sl) 2011-04-29
US20020147186A1 (en) 2002-10-10
GB9716161D0 (en) 1997-10-08
NO20000484L (no) 2000-03-16
CY2200161T2 (el) 2010-07-28
CZ299225B6 (cs) 2008-05-21
HUP0002663A2 (hu) 2001-09-28
ES2296568T3 (es) 2011-05-06
NZ501914A (en) 2001-09-28
ES2296575T3 (es) 2010-02-05
EP1000043A1 (en) 2000-05-17
SI1000043T1 (sl) 2010-01-29
JP2001512109A (ja) 2001-08-21
HK1029992A1 (en) 2001-04-20
CN1265101A (zh) 2000-08-30
HK1081962A1 (en) 2006-05-26
CA2295792C (en) 2007-04-17
CA2295792A1 (en) 1999-02-11
US6372734B1 (en) 2002-04-16
ES2296575T1 (es) 2008-05-01
CZ2000341A3 (cs) 2000-05-17
ATE496037T1 (de) 2011-02-15
EE04550B1 (et) 2005-10-17
ES2296568T1 (es) 2008-05-01
AU739255B2 (en) 2001-10-04
AU8549898A (en) 1999-02-22
KR20010022241A (ko) 2001-03-15
MY120999A (en) 2005-12-30
CN1125058C (zh) 2003-10-22
DE98936529T1 (de) 2008-11-20
EP1589008A1 (en) 2005-10-26
JP2009102345A (ja) 2009-05-14
ATE444959T1 (de) 2009-10-15
SK1302000A3 (en) 2000-06-12
EE200000062A (et) 2000-10-16
ID24219A (id) 2000-07-13
PT1589008E (pt) 2011-03-23
NO20000484D0 (no) 2000-01-31
BR9811061A (pt) 2000-09-19
DE05011169T1 (de) 2008-11-06
HU228620B1 (en) 2013-04-29

Similar Documents

Publication Publication Date Title
MY120999A (en) Crystalline dibenzothiazephine derivative and its use as an antipsychotic agent
NO174421C (no) Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelsen 11-(4-(2-(2-hydroksyetoksy)etyl)-1-piperazinyl)-dibenzo(b,f)(1,4)tiazepin
HUP9902194A2 (hu) Dibenzo-[b,f][1,4]tiazepin-származékot tartalmazó gyógyászati készítmények
NZ219788A (en) 11-(4-(2-(2-hydroxyethoxy) ethyl)-1-piperazinyl)-dibenzo (b,f)(1,4) thiazepine; and preparations
BR1100931A (pt) Compostos derivados de aril-heteroaril carbinóis, processos para a preparação dos compostos, composições farmacêuticas, e, uso dos compostos derivados de aril-heteroaril carbinóis
BR9808069A (pt) Novos compostos, seus usos e preparações
AU7554987A (en) Solutions of oxazaphosphorins having improved stability and process for the preparation thereof
DE3762860D1 (de) 2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
AR017213A1 (es) Un proceso para preparar un hidrato de la sal del acido maleico de la 5-[4-[2-(n-metil-n-(2-piridil)amino)-etoxi]bencil]tiazolidin-2,4-diona
AU658175B2 (en) Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
EE03565B1 (et) 3-hüdroksü-5-[2-(dimetüülamino)etüül]-2,3-dihüdro-2-(4-metoksüfenüül)-1,5-bensotiasep iin-4(5H)-ooni, selle derivaatide ja farmakoloogiliste ühendite valmistamise meetod
NO970240D0 (no) Streptogramin-derivater, deres fermstilling og farmasöytiske preparater inneholdende derivatene
AU667428C (en) Transparent clear cosmetic stick composition containing sodium salts of methyl carboxyl derivatives of ethoxylated lauryl alcohol
DK118886D0 (da) Pyrrolo(1,2-a)azepinon-derivater, deres fremstilling og farmaceutiske praeparater deraf
ES2119718A1 (es) Nueva locion topica para depilar el vello de las personas, procedimiento para su preparacion y aplicaciones.