EE200000062A - Dibensotiasepiini kristalliline derivaat ja selle kasutamine antipsühhootilise agensina - Google Patents

Dibensotiasepiini kristalliline derivaat ja selle kasutamine antipsühhootilise agensina

Info

Publication number: EE200000062A
Authority: EE; Estonia
Prior art keywords: crystalline; füä1; ethylü; dibenzoäb; hydroxyethoxy
Prior art date: 1997-08-01

Application number

EEP200000062A

Other languages

English (en)

Inventor

William Snape Evan

Original Assignee

Zeneca Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-01

Filing date

1998-07-28

Publication date

2000-10-16

1998-07-28 Application filed by Zeneca Limited filed Critical Zeneca Limited

2000-10-16 Publication of EE200000062A publication Critical patent/EE200000062A/et

2005-10-17 Publication of EE04550B1 publication Critical patent/EE04550B1/et

Links

239000000164 antipsychotic agent Substances 0.000 title 1
150000008509 dibenzothiazepines Chemical class 0.000 title 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000003849 aromatic solvent Substances 0.000 abstract 1
239000002178 crystalline material Substances 0.000 abstract 1
GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 abstract 1
FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 abstract 1
OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 abstract 1
229940043265 methyl isobutyl ketone Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Glass Compositions (AREA)
Liquid Crystal Substances (AREA)

EEP200000062A 1997-08-01 1998-07-28 Dibensotiasepiini kristalliline derivaat, selle saamise protsess, selle kasutamine ravimitootmiseks ja seda sisaldav farmatseutiline kompositsioon EE04550B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9716161.6A GB9716161D0 (en)	1997-08-01	1997-08-01	Process
PCT/GB1998/002260 WO1999006381A1 (en)	1997-08-01	1998-07-28	A crystalline dibenzothiazepine derivative and its use as an antipsychotic agent

Publications (2)

Publication Number	Publication Date
EE200000062A true EE200000062A (et)	2000-10-16
EE04550B1 EE04550B1 (et)	2005-10-17

Family

ID=10816746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000062A EE04550B1 (et)	1997-08-01	1998-07-28	Dibensotiasepiini kristalliline derivaat, selle saamise protsess, selle kasutamine ravimitootmiseks ja seda sisaldav farmatseutiline kompositsioon

Country Status (31)

Country	Link
US (2)	US6372734B1 (et)
EP (2)	EP1000043B1 (et)
JP (2)	JP2001512109A (et)
KR (1)	KR20010022241A (et)
CN (1)	CN1125058C (et)
AT (2)	ATE496037T1 (et)
AU (1)	AU739255B2 (et)
BG (1)	BG64796B1 (et)
BR (1)	BR9811061A (et)
CA (1)	CA2295792C (et)
CY (2)	CY2200161T2 (et)
CZ (1)	CZ299225B6 (et)
DE (4)	DE98936529T1 (et)
EE (1)	EE04550B1 (et)
ES (2)	ES2296575T3 (et)
GB (2)	GB9716161D0 (et)
HU (1)	HU228620B1 (et)
ID (1)	ID24219A (et)
IL (1)	IL133618A (et)
MY (1)	MY120999A (et)
NO (1)	NO20000484L (et)
NZ (1)	NZ501914A (et)
PL (1)	PL338384A1 (et)
PT (2)	PT1589008E (et)
RU (1)	RU2224754C2 (et)
SI (2)	SI1589008T1 (et)
SK (1)	SK287145B6 (et)
TR (1)	TR200000848T2 (et)
TW (1)	TW533207B (et)
WO (1)	WO1999006381A1 (et)
ZA (1)	ZA986904B (et)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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AU2003235435A1 (en) *	2002-03-20	2003-10-08	Teva Pharmaceutical Industries Ltd.	Crystalline forms of quetiapine hemifumarate
EP1495008A1 (en) *	2003-02-22	2005-01-12	Teva Pharmaceutical Industries Limited	Synthesis of quetiapine and pharmaceutically acceptable salts thereof
TR200503401T1 (tr) *	2003-03-03	2008-03-21	Hetero Drugs Limited	Kuetiapin (Quetiapine) Fumarat'ın yeni polimorfları
US7053115B2 (en)	2003-04-07	2006-05-30	Hetero Drugs Limited	Crystalline form of dorzolamide hydrochloride
ES2223294B2 (es)	2003-08-08	2005-10-01	Vita Cientifica, S.L.	Procedimiento de preparacion de un compuesto farmaceuticamente activo.
US20060081361A1 (en) *	2004-09-13	2006-04-20	Gabbey Lawrence W	Oil cooler with integral filter
WO2006035293A1 (en) *	2004-09-27	2006-04-06	Ranbaxy Laboratories Limited	Polymorphic forms of quetiapine hemifumarate
WO2006056772A2 (en) *	2004-11-23	2006-06-01	Pliva Hrvatska D.O.O.	Salts of quetiapine
GB0425729D0 (en) *	2004-11-23	2004-12-22	Pliva Res & Dev Ltd	Heterocyclic compounds
ES2234447B1 (es) *	2005-03-07	2006-03-01	Union Quimico-Farmaceutica S.A.	Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
JP2008502707A (ja) *	2005-04-14	2008-01-31	テバファーマシューティカルインダストリーズリミティド	クエチアピンフマレートの調製方法
US20070072840A1 (en) *	2005-05-30	2007-03-29	Pandya Bhargav	Polymorphic forms of quetiapine
WO2007036599A1 (en)	2005-09-30	2007-04-05	Fermion Oy	New crystallization process of quetiapine hemifumarate
EP1948628A1 (en) *	2005-10-28	2008-07-30	Fermion Oy	Quetiapine hemifumarate purification by crystallization
WO2007062339A2 (en) *	2005-11-18	2007-05-31	Astrazeneca Ab	Liquid formulations
WO2007062336A2 (en) *	2005-11-18	2007-05-31	Astrazeneca Ab	Salt forms
EP1951257A4 (en) *	2005-11-18	2008-11-05	Astrazeneca Ab	CRYSTALLINE FORMS
US20090215744A1 (en) *	2005-11-18	2009-08-27	Astrazeneca Ab	Solid Formulations
US8389510B2 (en) *	2005-11-18	2013-03-05	Astrazeneca Ab	Crystalline forms
CZ300451B6 (cs) *	2006-07-03	2009-05-20	Farmak, A. S.	Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení
WO2008066620A2 (en) *	2006-10-20	2008-06-05	Concert Pharmaceuticals Inc.	Dibenzothiazepine derivatives
DE602007009036D1 (de)	2007-02-14	2010-10-21	Lesvi Laboratorios Sl	Pharmazeutische Zusammensetzungen mit Quetiapinfumarat
US20080241949A1 (en) *	2007-03-29	2008-10-02	Vinod Kumar Kansal	Process for preparing quetiapine fumarate
US8101597B2 (en) *	2007-05-07	2012-01-24	Actavis Group Ptc Ehf	Quetiapine salts and their polymorphs
US20090082334A1 (en) *	2007-09-25	2009-03-26	Protia, Llc	Deuterium-enriched quetiapine
CN101889000B (zh) *	2007-12-05	2012-11-28	詹森药业有限公司	二苯并氮杂和二苯并氧氮杂trpa1激动剂
EP2262486B1 (en)	2008-08-01	2013-01-02	KRKA, Tovarna Zdravil, D.D., Novo Mesto	Quetiapine composition
US20100069356A1 (en) *	2008-09-17	2010-03-18	Auspex Pharmaceuticals, Inc.	Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors
WO2010100623A1 (en)	2009-03-04	2010-09-10	Ranbaxy Laboratories Limited	Process for the preparation of quetiapine fumarate
EP2742152B1 (en)	2011-08-12	2017-04-12	Qiagen GmbH	Method for isolating nucleic acids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE787249A (fr)	1971-08-05	1973-02-05	Squibb & Sons Inc	Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
GB8607684D0 (en) *	1986-03-27	1986-04-30	Ici America Inc	Thiazepine compounds
GB8705574D0 (en) *	1987-03-10	1987-04-15	Ici Plc	Preparation of thiazepine compound

1997
- 1997-08-01 GB GBGB9716161.6A patent/GB9716161D0/en active Pending
1998
- 1998-07-10 GB GBGB9814882.8A patent/GB9814882D0/en active Pending
- 1998-07-28 SI SI9830929T patent/SI1589008T1/sl unknown
- 1998-07-28 JP JP2000505140A patent/JP2001512109A/ja active Pending
- 1998-07-28 CA CA002295792A patent/CA2295792C/en not_active Expired - Fee Related
- 1998-07-28 EE EEP200000062A patent/EE04550B1/et not_active IP Right Cessation
- 1998-07-28 PT PT05011169T patent/PT1589008E/pt unknown
- 1998-07-28 TW TW087112313A patent/TW533207B/zh not_active IP Right Cessation
- 1998-07-28 ES ES98936529T patent/ES2296575T3/es not_active Expired - Lifetime
- 1998-07-28 EP EP98936529A patent/EP1000043B1/en not_active Expired - Lifetime
- 1998-07-28 PL PL98338384A patent/PL338384A1/xx not_active Application Discontinuation
- 1998-07-28 AU AU85498/98A patent/AU739255B2/en not_active Ceased
- 1998-07-28 DE DE98936529T patent/DE98936529T1/de active Pending
- 1998-07-28 AT AT05011169T patent/ATE496037T1/de active
- 1998-07-28 SI SI9830923T patent/SI1000043T1/sl unknown
- 1998-07-28 EP EP05011169A patent/EP1589008B1/en not_active Expired - Lifetime
- 1998-07-28 ES ES05011169T patent/ES2296568T3/es not_active Expired - Lifetime
- 1998-07-28 PT PT98936529T patent/PT1000043E/pt unknown
- 1998-07-28 WO PCT/GB1998/002260 patent/WO1999006381A1/en not_active Ceased
- 1998-07-28 SK SK130-2000A patent/SK287145B6/sk not_active IP Right Cessation
- 1998-07-28 ID IDW20000029A patent/ID24219A/id unknown
- 1998-07-28 US US09/463,452 patent/US6372734B1/en not_active Expired - Lifetime
- 1998-07-28 RU RU2000105271/04A patent/RU2224754C2/ru not_active IP Right Cessation
- 1998-07-28 CN CN98807572A patent/CN1125058C/zh not_active Expired - Fee Related
- 1998-07-28 CZ CZ20000341A patent/CZ299225B6/cs not_active IP Right Cessation
- 1998-07-28 KR KR1020007000814A patent/KR20010022241A/ko not_active Ceased
- 1998-07-28 TR TR2000/00848T patent/TR200000848T2/xx unknown
- 1998-07-28 DE DE69841216T patent/DE69841216D1/de not_active Expired - Lifetime
- 1998-07-28 DE DE05011169T patent/DE05011169T1/de active Pending
- 1998-07-28 AT AT98936529T patent/ATE444959T1/de active
- 1998-07-28 BR BR9811061-6A patent/BR9811061A/pt not_active Application Discontinuation
- 1998-07-28 NZ NZ501914A patent/NZ501914A/en not_active IP Right Cessation
- 1998-07-28 DE DE69842104T patent/DE69842104D1/de not_active Expired - Lifetime
- 1998-07-28 IL IL13361898A patent/IL133618A/en not_active IP Right Cessation
- 1998-07-28 HU HU0002663A patent/HU228620B1/hu not_active IP Right Cessation
- 1998-07-29 MY MYPI98003471A patent/MY120999A/en unknown
- 1998-07-31 ZA ZA986904A patent/ZA986904B/xx unknown
2000
- 2000-01-31 NO NO20000484A patent/NO20000484L/no unknown
- 2000-02-22 BG BG104176A patent/BG64796B1/bg unknown
2002
- 2002-03-21 US US10/101,948 patent/US20020147186A1/en not_active Abandoned
2008
- 2008-03-04 CY CY20082200004T patent/CY2200161T2/el unknown
- 2008-03-04 CY CY20082200005T patent/CY2200162T2/el unknown
- 2008-12-09 JP JP2008313248A patent/JP2009102345A/ja active Pending

Also Published As

Publication number	Publication date
CN1265101A (zh)	2000-08-30
CZ299225B6 (cs)	2008-05-21
ES2296575T1 (es)	2008-05-01
PT1589008E (pt)	2011-03-23
CA2295792C (en)	2007-04-17
DE69842104D1 (de)	2011-03-03
HK1081962A1 (en)	2006-05-26
BR9811061A (pt)	2000-09-19
EP1000043B1 (en)	2009-10-07
EP1589008A1 (en)	2005-10-26
RU2224754C2 (ru)	2004-02-27
SK1302000A3 (en)	2000-06-12
IL133618A (en)	2004-02-08
IL133618A0 (en)	2001-04-30
PL338384A1 (en)	2000-10-23
BG64796B1 (bg)	2006-04-28
ES2296575T3 (es)	2010-02-05
AU739255B2 (en)	2001-10-04
NO20000484L (no)	2000-03-16
PT1000043E (pt)	2009-11-30
CN1125058C (zh)	2003-10-22
EP1589008B1 (en)	2011-01-19
ES2296568T1 (es)	2008-05-01
BG104176A (en)	2000-08-31
HUP0002663A2 (hu)	2001-09-28
CZ2000341A3 (cs)	2000-05-17
TR200000848T2 (tr)	2000-08-21
CA2295792A1 (en)	1999-02-11
ATE444959T1 (de)	2009-10-15
WO1999006381A1 (en)	1999-02-11
CY2200162T2 (el)	2010-07-28
KR20010022241A (ko)	2001-03-15
NO20000484D0 (no)	2000-01-31
US20020147186A1 (en)	2002-10-10
JP2009102345A (ja)	2009-05-14
US6372734B1 (en)	2002-04-16
JP2001512109A (ja)	2001-08-21
ID24219A (id)	2000-07-13
AU8549898A (en)	1999-02-22
EE04550B1 (et)	2005-10-17
ES2296568T3 (es)	2011-05-06
DE69841216D1 (de)	2009-11-19
GB9814882D0 (en)	1998-09-09
HK1029992A1 (en)	2001-04-20
DE05011169T1 (de)	2008-11-06
NZ501914A (en)	2001-09-28
GB9716161D0 (en)	1997-10-08
CY2200161T2 (el)	2010-07-28
MY120999A (en)	2005-12-30
SI1589008T1 (sl)	2011-04-29
SI1000043T1 (sl)	2010-01-29
HUP0002663A3 (en)	2001-10-29
ATE496037T1 (de)	2011-02-15
TW533207B (en)	2003-05-21
ZA986904B (en)	1999-02-01
HU228620B1 (en)	2013-04-29
DE98936529T1 (de)	2008-11-20
EP1000043A1 (en)	2000-05-17
SK287145B6 (sk)	2010-01-07

Legal Events

Date	Code	Title	Description
2005-10-17	GB1A	Change in the ownership or in the address of the owner
2005-10-17	HC1A	Change of owner name
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2017-03-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20160728

Publication	Publication Date	Title
EE200000062A (et)	2000-10-16	Dibensotiasepiini kristalliline derivaat ja selle kasutamine antipsühhootilise agensina
CO5200832A1 (es)	2002-09-27	Derivados de acidos heterociclicos, o una sal farmaceuticamente aceptable de los mismos, que son agentes antidiabeticos y antiobesidad
AU697679B2 (en)	1998-10-15	Treatment of tinnitis using neuroprotective agents
MY114393A (en)	2002-10-31	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivatives
NO962717D0 (no)	1996-06-27	Diaryl-5,6-kondenserte, heterosykliske syrer som leukotrienantagonister
AU4265596A (en)	1996-06-26	Heterocyclyl substituted hydroxyacetamide derivatives as fongicides
AU4009497A (en)	1998-02-10	Substituted pyrazolyl-pyrazole derivatives, process for their preparation nd their use as agents with a herbicidal effect
RU97117486A (ru)	1999-02-20	Средство для уничтожения пресноводных моллюсков
AU7379794A (en)	1995-02-28	Aza-5,5-fused heterocyclic acids as leukotriene antagonists
DE69411387D1 (de)	1998-08-06	Verfahren zur Herstellung von pharmazeutisch aktiven Benzothiazepinderivaten.
AU2001262746A1 (en)	2002-02-05	Process for the preparation of optically active thiazolidinone derivatives
ITRM940831A0 (it)	1994-12-23	"cerotto per assorbimento transcutaneo a rilascio controllato di fitoassociazione"
ITRM940832A0 (it)	1994-12-23	"cerotto per assorbimento transcutaneo a rilascio controllato di fitoassociazione"
AU2002339219A1 (en)	2003-04-07	Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents
SE9602418D0 (sv)	1996-06-18	Process for the preparation of organic salts of N'N-diacetylcystine
SE9602476D0 (sv)	1996-06-24	Process for the preparation of organic salts of N'N -diacetylcystine
ITRM940843A0 (it)	1994-12-23	"cerotto per assorbimento transcutaneo a rilascio controllato di fitoassociazione"
DK0868275T3 (da)	2000-06-19	Fremgangsmåde til fremstilling af til en brugs- eller forbrugsgenstand samt brugs- eller forbrugsgenstand af biologisk nedb
UY25977A1 (es)	2001-08-27	2-fenil-1- [4-(2-aminoetoxi)-bencil]- indoles como agentes estrogénicos
ITRM940839A0 (it)	1994-12-23	"cerotto per assorbimento transcutaneo a rilascio controllato di fitoassociazione eventualmente arricchita"
ITRM940842A0 (it)	1994-12-23	"cerotto per assorbimento transcutaneo a rilascio controllato di fitoassociazione eventualmente arricchita"