CR10138A - 1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina - Google Patents

1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina

Info

Publication number
CR10138A
CR10138A CR10138A CR10138A CR10138A CR 10138 A CR10138 A CR 10138A CR 10138 A CR10138 A CR 10138A CR 10138 A CR10138 A CR 10138A CR 10138 A CR10138 A CR 10138A
Authority
CR
Costa Rica
Prior art keywords
receptors
hydroxitriptamine
sulfonyl
ligands
hydroxytryptamine
Prior art date
Application number
CR10138A
Other languages
English (en)
Inventor
E Mcdevitt Robert
Li Yanfang
J Robichaud Albert
D Heffernan Gavin
D Coghlan Richard
C Bernotas Ronald
Original Assignee
Exelixis Inc
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Wyeth Corp filed Critical Exelixis Inc
Publication of CR10138A publication Critical patent/CR10138A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

La presente invención se dirige a compuestos de Fórmula I: que son moduladores de los receptores 5-hidroxitriptamina-6 y 5-hidroxitriptamina-2A y que son inhibidores de retoma de norepinefrina. Los compuestos de la invención, y la composición farmacéutica de estos, son útiles en el tratamiento de trastornos relacionados con o asociados con los receptores 5-hidroxitriptamina-6 y 5-hidroxitriptamina-2A o con la inhibición de retoma de norepinefrina.
CR10138A 2006-01-13 2008-07-11 1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina CR10138A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75883306P 2006-01-13 2006-01-13

Publications (1)

Publication Number Publication Date
CR10138A true CR10138A (es) 2008-10-03

Family

ID=38179679

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10138A CR10138A (es) 2006-01-13 2008-07-11 1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina

Country Status (16)

Country Link
US (1) US7645752B2 (es)
EP (1) EP1973876A2 (es)
JP (1) JP2009523734A (es)
KR (1) KR20080114688A (es)
CN (1) CN101370775A (es)
AU (1) AU2007206016A1 (es)
BR (1) BRPI0706523A2 (es)
CA (1) CA2636007A1 (es)
CR (1) CR10138A (es)
EC (1) ECSP088620A (es)
IL (1) IL192695A0 (es)
MX (1) MX2008009022A (es)
NO (1) NO20083057L (es)
RU (1) RU2008127501A (es)
WO (1) WO2007084841A2 (es)
ZA (1) ZA200806071B (es)

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US7645752B2 (en) 2010-01-12
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ECSP088620A (es) 2008-08-29
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