ATE499098T1 - Verwendung von parp-1-hemmern - Google Patents

Verwendung von parp-1-hemmern

Info

Publication number: ATE499098T1
Authority: AT; Austria
Prior art keywords: parp; amount; tumor; patient; increase
Prior art date: 2005-11-25

Application number

AT06840026T

Other languages

English (en)

Inventor

Kathleen Scotto

Michael Mandola

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-25

Filing date

2006-11-27

Publication date

2011-03-15

2006-11-27 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE499098T1 publication Critical patent/ATE499098T1/de

Links

108010064218 Poly (ADP-Ribose) Polymerase-1 Proteins 0.000 title abstract 3
102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 3
XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 6
PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 abstract 6
229960000977 trabectedin Drugs 0.000 abstract 6
239000000203 mixture Substances 0.000 abstract 3
231100000433 cytotoxic Toxicity 0.000 abstract 2
230000001472 cytotoxic effect Effects 0.000 abstract 2
210000004881 tumor cell Anatomy 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000003013 cytotoxicity Effects 0.000 abstract 1
231100000135 cytotoxicity Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT06840026T 2005-11-25 2006-11-27 Verwendung von parp-1-hemmern ATE499098T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73953605P	2005-11-25	2005-11-25
PCT/US2006/061254 WO2007062413A2 (en)	2005-11-25	2006-11-27	Use of parp-1 inhibitors

Publications (1)

Publication Number	Publication Date
ATE499098T1 true ATE499098T1 (de)	2011-03-15

Family

ID=38068066

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06840026T ATE499098T1 (de)	2005-11-25	2006-11-27	Verwendung von parp-1-hemmern

Country Status (9)

Country	Link
US (1)	US20090170860A1 (de)
EP (1)	EP1962843B1 (de)
JP (1)	JP2009517403A (de)
AT (1)	ATE499098T1 (de)
AU (1)	AU2006318226A1 (de)
CA (1)	CA2630900A1 (de)
DE (1)	DE602006020335D1 (de)
ES (1)	ES2361566T3 (de)
WO (1)	WO2007062413A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
BR0115162A (pt) *	2000-11-06	2003-10-21	Pharma Mar Sa	Tratamentos antitumorais eficazes
GB0117402D0 (en) *	2001-07-17	2001-09-05	Pharma Mar Sa	New antitumoral derivatives of et-743
AU2004291037A1 (en) *	2003-11-14	2005-06-02	Pharma Mar, S.A.	Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
EP1827500B1 (de) *	2004-10-26	2009-05-06	Pharma Mar S.A., Sociedad Unipersonal	Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
ATE368461T1 (de)	2004-10-29	2007-08-15	Pharma Mar Sa	Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
US9486449B2 (en)	2007-10-09	2016-11-08	Malka COHEN-ARMON	Cancer therapy
WO2009047752A1 (en) *	2007-10-09	2009-04-16	Ramot At Tel-Aviv University Ltd.	Breast cancer therapy
US20100267732A1 (en) *	2007-10-19	2010-10-21	Pharma Mar, S.A.	Prognostic Molecular Markers for ET-743 Treatment
JP2013532683A (ja)	2010-07-27	2013-08-19	カディラヘルスケアリミティド	ポリ（ａｄｐリボース）ポリメラーゼ−１阻害剤としての、置換４−（４−フルオロ−３−（ピペラジン−１−カルボニル）ベンジル）フタラジン−１（２ｈ）−オン誘導体
ES2595240T3 (es)	2012-07-09	2016-12-28	Lupin Limited	Derivados de tetrahidroquinazolinona como inhibidores de PARP
HUE030613T2 (en)	2012-12-31	2017-05-29	Cadila Healthcare Ltd	Substituted phthalazin-1 (2H) -one derivatives as selective inhibitors of poly (ADP-ribose) polymerase-1
CN106853252B (zh) *	2015-12-09	2020-03-13	江苏恒瑞医药股份有限公司	曲贝替定药物组合物及其制备方法
WO2017181918A1 (zh) *	2016-04-18	2017-10-26	深圳市塔吉瑞生物医药有限公司	一种取代的酞嗪酮化合物及其药物组合物
KR20180097876A (ko) *	2017-02-24	2018-09-03	주식회사 온코크로스	1,5-이소퀴놀린디올을 포함하는 피부 노화 방지 및 주름 개선용 조성물
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물
EP3960177A1 (de) *	2020-08-26	2022-03-02	Anturec Pharmaceuticals GmbH	Zusammensetzung mit ttf-ngr zur verwendung in der behandlung von weichgewebesarkom

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6635677B2 (en) *	1999-08-13	2003-10-21	Case Western Reserve University	Methoxyamine combinations in the treatment of cancer
BR0115162A (pt) *	2000-11-06	2003-10-21	Pharma Mar Sa	Tratamentos antitumorais eficazes
ES2396334T3 (es) *	2003-05-28	2013-02-20	Eisai Inc.	Compuestos, métodos y composiciones farmacéuticas para la inhibición de PARP
GB0317466D0 (en) *	2003-07-25	2003-08-27	Univ Sheffield	Use
US20050187172A1 (en) *	2003-12-23	2005-08-25	Masferrer Jaime L.	Combination of a Cox-2 inhibitor and a DNA topoisomerase I inhibitor for treatment of neoplasia
PE20060285A1 (es) *	2004-03-30	2006-05-08	Aventis Pharma Inc	Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)

2006
- 2006-11-27 ES ES06840026T patent/ES2361566T3/es active Active
- 2006-11-27 AT AT06840026T patent/ATE499098T1/de not_active IP Right Cessation
- 2006-11-27 EP EP06840026A patent/EP1962843B1/de active Active
- 2006-11-27 DE DE602006020335T patent/DE602006020335D1/de active Active
- 2006-11-27 WO PCT/US2006/061254 patent/WO2007062413A2/en not_active Ceased
- 2006-11-27 JP JP2008542534A patent/JP2009517403A/ja active Pending
- 2006-11-27 AU AU2006318226A patent/AU2006318226A1/en not_active Abandoned
- 2006-11-27 US US12/094,744 patent/US20090170860A1/en not_active Abandoned
- 2006-11-27 CA CA002630900A patent/CA2630900A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE602006020335D1 (de)	2011-04-07
ES2361566T3 (es)	2011-06-20
EP1962843A2 (de)	2008-09-03
CA2630900A1 (en)	2007-05-31
WO2007062413A2 (en)	2007-05-31
WO2007062413A3 (en)	2007-12-27
JP2009517403A (ja)	2009-04-30
US20090170860A1 (en)	2009-07-02
EP1962843A4 (de)	2009-08-12
EP1962843B1 (de)	2011-02-23
AU2006318226A1 (en)	2007-05-31

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Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties