ATE499362T1 - 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind - Google Patents

3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind

Info

Publication number: ATE499362T1
Authority: AT; Austria
Prior art keywords: inhibitors; receptor tyrosine; tyrosine kinases; tec family; ones useful
Prior art date: 2005-08-29

Application number

AT06813771T

Other languages

English (en)

Inventor

Jean-Damien Charrier

Sharn Ramaya

Steven Durrant

Juan-Miguel Jimenez

Julian Golec

Michael Mortimore

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-29

Filing date

2006-08-25

Publication date

2011-03-15

2006-08-25 Application filed by Vertex Pharma filed Critical Vertex Pharma

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE499362T1 publication Critical patent/ATE499362T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
102000037979 non-receptor tyrosine kinases Human genes 0.000 title 1
108091008046 non-receptor tyrosine kinases Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
102000001253 Protein Kinase Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1

Classifications

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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
AIDS & HIV (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Otolaryngology (AREA)

AT06813771T 2005-08-29 2006-08-25 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind ATE499362T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71245705P	2005-08-29	2005-08-29
PCT/US2006/033282 WO2007027528A2 (en)	2005-08-29	2006-08-25	3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases

Publications (1)

Publication Number	Publication Date
ATE499362T1 true ATE499362T1 (de)	2011-03-15

Family

ID=37565557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06813771T ATE499362T1 (de)	2005-08-29	2006-08-25	3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind

Country Status (10)

Country	Link
US (1)	US7786120B2 (de)
EP (1)	EP1919905B1 (de)
JP (2)	JP5112317B2 (de)
CN (1)	CN101291926A (de)
AT (1)	ATE499362T1 (de)
AU (1)	AU2006285145A1 (de)
CA (1)	CA2620631A1 (de)
DE (1)	DE602006020293D1 (de)
ES (1)	ES2361338T3 (de)
WO (1)	WO2007027528A2 (de)

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ATE548363T1 (de) *	2005-08-29	2012-03-15	Vertex Pharma	3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
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AU2009265813B2 (en)	2008-07-02	2014-04-10	F. Hoffmann-La Roche Ag	Novel phenylpyrazinones as kinase inhibitors
AR082590A1 (es)	2010-08-12	2012-12-19	Hoffmann La Roche	Inhibidores de la tirosina-quinasa de bruton
WO2013153539A1 (en)	2012-04-13	2013-10-17	Glenmark Pharmaceuticals S.A.	Tricyclic compounds as tec kinase inhibitors

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2006
- 2006-08-25 DE DE602006020293T patent/DE602006020293D1/de active Active
- 2006-08-25 US US11/510,126 patent/US7786120B2/en not_active Expired - Fee Related
- 2006-08-25 WO PCT/US2006/033282 patent/WO2007027528A2/en not_active Ceased
- 2006-08-25 ES ES06813771T patent/ES2361338T3/es active Active
- 2006-08-25 AT AT06813771T patent/ATE499362T1/de not_active IP Right Cessation
- 2006-08-25 AU AU2006285145A patent/AU2006285145A1/en not_active Abandoned
- 2006-08-25 CN CNA2006800393748A patent/CN101291926A/zh active Pending
- 2006-08-25 CA CA002620631A patent/CA2620631A1/en not_active Abandoned
- 2006-08-25 EP EP06813771A patent/EP1919905B1/de not_active Not-in-force
- 2006-08-25 JP JP2008529133A patent/JP5112317B2/ja not_active Expired - Fee Related
2012
- 2012-06-20 JP JP2012138966A patent/JP2012184260A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
ES2361338T3 (es)	2011-06-16
JP2009507790A (ja)	2009-02-26
CA2620631A1 (en)	2007-03-08
US20070185125A1 (en)	2007-08-09
US7786120B2 (en)	2010-08-31
JP2012184260A (ja)	2012-09-27
EP1919905B1 (de)	2011-02-23
EP1919905A2 (de)	2008-05-14
JP5112317B2 (ja)	2013-01-09
CN101291926A (zh)	2008-10-22
DE602006020293D1 (de)	2011-04-07
WO2007027528A3 (en)	2007-05-03
WO2007027528A2 (en)	2007-03-08
AU2006285145A1 (en)	2007-03-08

Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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ATE450530T1 (de)	2009-12-15	Zusammensetzungen zur verwendung als protein- kinase-inhibitoren
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ATE542814T1 (de)	2012-02-15	Pyrazinkinaseinhibitoren
ATE435858T1 (de)	2009-07-15	Prodrugs von als erk-proteinkinase-inhibitoren wirkenden pyrrolylpyrimidinen
ATE499362T1 (de)	2011-03-15	3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind