ATE500324T1 - Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen - Google Patents

Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen

Info

Publication number
ATE500324T1
ATE500324T1 AT03812536T AT03812536T ATE500324T1 AT E500324 T1 ATE500324 T1 AT E500324T1 AT 03812536 T AT03812536 T AT 03812536T AT 03812536 T AT03812536 T AT 03812536T AT E500324 T1 ATE500324 T1 AT E500324T1
Authority
AT
Austria
Prior art keywords
eopa
activity
heopa
application
endooligopeptidase
Prior art date
Application number
AT03812536T
Other languages
English (en)
Inventor
Antonio Camargo
Mirian Hayashi
Fernanda Portaro
Juliano Guerreiro
Original Assignee
Antonio Camargo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BR0305688A external-priority patent/BR0305688A/pt
Application filed by Antonio Camargo filed Critical Antonio Camargo
Application granted granted Critical
Publication of ATE500324T1 publication Critical patent/ATE500324T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03812536T 2002-12-09 2003-12-08 Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen ATE500324T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BR0205000 2002-12-09
BR0305688A BR0305688A (pt) 2003-12-05 2003-12-05 Processo para a determinação da estrutura primária do rna mensageiro codificante para a endooligopeptidase a humana (heopa) [genbank acc n°af217798] e da sua sequência protéica [genbank acc n° aaf24516], para a determinação do gene da eopa humana, e para a produção da eopa humana recombinante; processo de geração de anticorpos anti-heopa; processo de padronização e utilização de substratos sintéticos para a determinação das propriedades bioquìmicas e proteolìticas da heopa; processo de identificação e produção de inibidores da eopa, obtenção de anticorpos com atividade inibitória sobre a atividade catalìtica e sobre a interação com oligopeptìdeos; método de identificação dessa proteìna em patologias congênitas, infecciosas e degenerativas do sistema nervoso central, e método de determinação do papel da eopa em processos imunológicos; método de diagnóstico imuno-quìmico e/ou enzimático, para a prevenção, evolução de patologias, prognóstico ou tratamento de doenças congênitas, infecciosas e degenerativas do sistema nervoso central; uso das propriedades de interação de ligantes com o centro ativo da eopa atuando quer como inibidores da sua ação enzimática e/ou alterando a sua associação com outras proteìnas intracelulares, úteis no tratamento de patologias neurológicas, psiquiátricas e degenerativas
PCT/BR2003/000189 WO2004053052A2 (en) 2002-12-09 2003-12-08 HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA)

Publications (1)

Publication Number Publication Date
ATE500324T1 true ATE500324T1 (de) 2011-03-15

Family

ID=37719837

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03812536T ATE500324T1 (de) 2002-12-09 2003-12-08 Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen

Country Status (8)

Country Link
US (2) US20070031830A1 (de)
EP (1) EP1578953B1 (de)
JP (1) JP5272114B2 (de)
AT (1) ATE500324T1 (de)
AU (1) AU2003302901A1 (de)
CA (1) CA2507811C (de)
DE (1) DE60336265D1 (de)
WO (1) WO2004053052A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985555B2 (en) 2004-06-25 2011-07-26 Washington University Markers for brain damage
KR101666228B1 (ko) * 2007-09-28 2016-10-13 인트렉손 코포레이션 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도
BRPI1004231A2 (pt) * 2010-11-09 2013-03-12 Universidade Federal De São Paulo- Unifesp mÉtodo e kit para diagnàstico de condiÇÕes neuropsiquiÁtricas, mÉtodo para avaliaÇço de tratamentos de condiÇÕes neuropsiquiÁtricas e mÉtodo de identificaÇço de fÁrmacos potencialmente éteis no tratamento de condiÇÕes neuropsiquiÁtricas
US10115661B2 (en) 2013-02-08 2018-10-30 Qualcomm Incorporated Substrate-less discrete coupled inductor structure
KR102453739B1 (ko) * 2013-03-29 2022-10-11 애플 인크. 셀 방식 네트워크에서의 인터넷에의 연결 확립

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171790B1 (en) * 1998-05-01 2001-01-09 Incyte Pharmaceuticals, Inc. Human protease associated proteins
US6406891B1 (en) * 1998-09-28 2002-06-18 Board Of Regents, The University Of Texas System Dual RT procedure for cDNA synthesis
JP5058403B2 (ja) * 2000-06-27 2012-10-24 シスメックス株式会社 Ｃｋ−ｍｂ活性測定法およびｃｋ−ｍｂ活性測定試薬
JP2002065266A (ja) * 2000-08-28 2002-03-05 Teijin Ltd 気道特異的トリプシン様酵素およびその利用法

Also Published As

Publication number Publication date
JP5272114B2 (ja) 2013-08-28
EP1578953A4 (de) 2007-08-08
WO2004053052A2 (en) 2004-06-24
EP1578953B1 (de) 2011-03-02
EP1578953A2 (de) 2005-09-28
AU2003302901A1 (en) 2004-06-30
CA2507811A1 (en) 2004-06-24
CA2507811C (en) 2013-11-05
US20070031830A1 (en) 2007-02-08
WO2004053052A3 (en) 2006-08-03
AU2003302901A8 (en) 2004-06-30
JP2006524983A (ja) 2006-11-09
DE60336265D1 (de) 2011-04-14
US20090017042A1 (en) 2009-01-15

Similar Documents

Publication Publication Date Title
WO2007070671A3 (en) Therapeutic methods for inhibiting tumor growth with dll4 antagonists
EE200000697A (et) Lahustuv T-raku retseptor
EA200700210A1 (ru) ВАРИАНТЫ ОБЛАСТИ Fc
NO2011003I1 (no) Dimensk fusjonsprotein bestående av de ligandbindende cfomener av de ekstacellulære deler av human type I interieukm-1 reseptor (IL-1R1) og IL-1 reseptor hjelpeprotein bundet (IL-I-RAcP) bundet i tinje til Fc-delen av humant IgG
IL195338A (en) An antibody comprising an FC variant containing amino acid replaces d or e at position 239, a medicament containing it and its use
WO2006002161A3 (en) Modulators of odorant receptors
NO20074374L (no) Fremgangsmate for fremstilling av polypeptidblandinger ved anvendelse av hydrogenolyse
DK1572967T3 (da) IL-1-receptorbaserede antagonister og fremgangsmåder til fremstilling og anvendelse deraf
ATE465171T1 (de) Neue chemokine bindende peptide, die die biologische aktivität dieser chemokine modulieren
DE502005009389D1 (de) Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern
WO2005087811A3 (en) Estrogen receptors and methods of use
MXPA05011085A (es) Composiciones y metodos relacionados a stop-1.
DE602005019495D1 (de) Ligand für den Formylpeptidrezeptorähnlichen- 2 (FPRL2) G Protein gekoppelten Rezeptor und dessen Anwendung
ATE500324T1 (de) Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen
DK1234025T3 (da) Humane enzymer fra metalloproteasefamilien
ATE373717T1 (de) Pde8a und seine verwendung
DE60332579D1 (de) Prozess zur Immobilisierung von Polypeptiden über die Carboxylgruppe des C-terminus
DE60330680D1 (de) Transferrin-fusionsproteinbibliotheken
ATE466880T1 (de) Cytokinpolypeptidvarianten
EP1572931A4 (de) Verfahren und zusammensetzungen zur modulation und zum nachweis von wisp-aktivität
ATE455849T1 (de) Rekombinante carboxypeptidase b und ihre aufreinigung
DE60032161D1 (de) P-glycoproteine und ihre verwendungen
SE9801530D0 (sv) Method for screening
AU2003260546A8 (en) Device for the presentation of peptides or proteins, method for the preparation and use thereof
GB0426960D0 (en) TGR-3 like protein receptor

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties