ATE502013T1 - Pyridonderivate als inhibitoren von p38a-mapk - Google Patents
Pyridonderivate als inhibitoren von p38a-mapkInfo
- Publication number
- ATE502013T1 ATE502013T1 AT08752572T AT08752572T ATE502013T1 AT E502013 T1 ATE502013 T1 AT E502013T1 AT 08752572 T AT08752572 T AT 08752572T AT 08752572 T AT08752572 T AT 08752572T AT E502013 T1 ATE502013 T1 AT E502013T1
- Authority
- AT
- Austria
- Prior art keywords
- mapk
- inhibitors
- pyridone derivatives
- pyridone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91584507P | 2007-05-03 | 2007-05-03 | |
| PCT/JP2008/058689 WO2008140066A2 (en) | 2007-05-03 | 2008-05-02 | Pyridone derivatives as p38a mapk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502013T1 true ATE502013T1 (de) | 2011-04-15 |
Family
ID=39865639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08752572T ATE502013T1 (de) | 2007-05-03 | 2008-05-02 | Pyridonderivate als inhibitoren von p38a-mapk |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8173684B2 (de) |
| EP (1) | EP2155683B8 (de) |
| JP (1) | JP2010526026A (de) |
| KR (1) | KR20100016563A (de) |
| CN (1) | CN101675034A (de) |
| AR (1) | AR066421A1 (de) |
| AT (1) | ATE502013T1 (de) |
| CA (1) | CA2686091A1 (de) |
| DE (1) | DE602008005581D1 (de) |
| ES (1) | ES2363109T3 (de) |
| MX (1) | MX2009011769A (de) |
| PL (1) | PL2155683T3 (de) |
| PT (1) | PT2155683E (de) |
| TW (1) | TW200904421A (de) |
| WO (1) | WO2008140066A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2296653B1 (de) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Verbindungen und verfahren zur behandlung von entzündungserkrankungen und fibrotischen erkrankungen |
| JP5744021B2 (ja) | 2010-06-30 | 2015-07-01 | 富士フイルム株式会社 | 新規なニコチンアミド誘導体またはその塩 |
| US20130269064A1 (en) * | 2010-11-23 | 2013-10-10 | Syngenta Participations Ag | Insecticidal compounds |
| DK2799431T3 (en) | 2011-12-28 | 2018-03-26 | Fujifilm Corp | Hitherto unknown nicotinamide derivatives or salts thereof |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| CN104961803B (zh) * | 2015-07-08 | 2017-11-28 | 中国人民解放军军事医学科学院基础医学研究所 | 一种治疗心肌缺血再灌注损伤的多肽药物 |
| CN104961804B (zh) * | 2015-07-08 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | p38α拮抗肽突变体及其应用 |
| CN116570594A (zh) | 2016-06-23 | 2023-08-11 | 马里兰大学巴尔的摩分校 | 选择性p38α特异性MAPK抑制剂 |
| EP3824906A1 (de) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antikörperformulierungen |
| CN107033134B (zh) * | 2017-05-03 | 2020-02-21 | 贵州大学 | 含吡啶盐和1,3,4-噁二唑基的双酰胺类化合物及其制备方法及应用 |
| JP7594787B2 (ja) | 2018-12-07 | 2024-12-05 | ユニバーシティ オブ メリーランド、ボルチモア | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
| JP7646643B2 (ja) * | 2019-10-04 | 2025-03-17 | アンスティトゥート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシャルシュ・メディカル・（インセルム） | 新規なピリジン－２（１ｈ）オン誘導体、その調製、及び疼痛を処置するためのその使用 |
| CN116406355B (zh) | 2020-05-18 | 2026-05-15 | Gen1E生命科学公司 | P38α促分裂原活化蛋白激酶抑制剂 |
| AU2021370893B2 (en) | 2020-10-29 | 2024-03-07 | Gen1E Lifesciences Inc. | Crystalline 5-(dimethylamino) -n- (4-(morpholinomethyl)phenyl) naphthalene-1-sulfonamide di-hydrochloride di-hydrate |
| NZ804686A (en) | 2021-03-23 | 2026-03-27 | Gen1E Lifesciences Inc | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
| US7713998B2 (en) | 2004-11-10 | 2010-05-11 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic compound and pharmaceutical use thereof |
| AP2007004244A0 (en) * | 2005-05-10 | 2007-12-31 | Intermune Inc | Method of modulating stress-activated protein kinase system |
| TW200745034A (en) * | 2005-09-01 | 2007-12-16 | Astellas Pharma Inc | New compounds |
-
2008
- 2008-04-30 TW TW097115812A patent/TW200904421A/zh unknown
- 2008-05-02 ES ES08752572T patent/ES2363109T3/es active Active
- 2008-05-02 WO PCT/JP2008/058689 patent/WO2008140066A2/en not_active Ceased
- 2008-05-02 AT AT08752572T patent/ATE502013T1/de active
- 2008-05-02 AR ARP080101864A patent/AR066421A1/es unknown
- 2008-05-02 PL PL08752572T patent/PL2155683T3/pl unknown
- 2008-05-02 EP EP08752572A patent/EP2155683B8/de not_active Not-in-force
- 2008-05-02 JP JP2009546541A patent/JP2010526026A/ja not_active Withdrawn
- 2008-05-02 MX MX2009011769A patent/MX2009011769A/es active IP Right Grant
- 2008-05-02 KR KR1020097023816A patent/KR20100016563A/ko not_active Withdrawn
- 2008-05-02 PT PT08752572T patent/PT2155683E/pt unknown
- 2008-05-02 CN CN200880014625A patent/CN101675034A/zh active Pending
- 2008-05-02 DE DE602008005581T patent/DE602008005581D1/de active Active
- 2008-05-02 US US12/597,926 patent/US8173684B2/en not_active Expired - Fee Related
- 2008-05-02 CA CA002686091A patent/CA2686091A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2686091A1 (en) | 2008-11-20 |
| PT2155683E (pt) | 2011-04-11 |
| EP2155683B1 (de) | 2011-03-16 |
| EP2155683A2 (de) | 2010-02-24 |
| EP2155683B8 (de) | 2011-09-21 |
| WO2008140066A2 (en) | 2008-11-20 |
| WO2008140066A3 (en) | 2008-12-31 |
| AR066421A1 (es) | 2009-08-19 |
| TW200904421A (en) | 2009-02-01 |
| US8173684B2 (en) | 2012-05-08 |
| CN101675034A (zh) | 2010-03-17 |
| JP2010526026A (ja) | 2010-07-29 |
| US20100063098A1 (en) | 2010-03-11 |
| KR20100016563A (ko) | 2010-02-12 |
| MX2009011769A (es) | 2009-11-13 |
| PL2155683T3 (pl) | 2011-08-31 |
| DE602008005581D1 (de) | 2011-04-28 |
| ES2363109T3 (es) | 2011-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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