ATE502919T1 - Kupplungsmittel, deren aktive zwischenverbindungen und konjugate sowie die verwendung dieser konjugate für diagnostische zwecke - Google Patents
Kupplungsmittel, deren aktive zwischenverbindungen und konjugate sowie die verwendung dieser konjugate für diagnostische zweckeInfo
- Publication number
- ATE502919T1 ATE502919T1 AT03718910T AT03718910T ATE502919T1 AT E502919 T1 ATE502919 T1 AT E502919T1 AT 03718910 T AT03718910 T AT 03718910T AT 03718910 T AT03718910 T AT 03718910T AT E502919 T1 ATE502919 T1 AT E502919T1
- Authority
- AT
- Austria
- Prior art keywords
- mal
- conjugates
- new
- molecule
- iii
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 230000008878 coupling Effects 0.000 title 1
- 238000010168 coupling process Methods 0.000 title 1
- 238000005859 coupling reaction Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 5
- RUVRGYVESPRHSZ-UHFFFAOYSA-N 2-[2-(2-azaniumylethoxy)ethoxy]acetate Chemical group NCCOCCOCC(O)=O RUVRGYVESPRHSZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 abstract 2
- 230000021615 conjugation Effects 0.000 abstract 2
- 239000007822 coupling agent Substances 0.000 abstract 2
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 150000002576 ketones Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0202559A FR2836382B1 (fr) | 2002-02-28 | 2002-02-28 | Nouveaux agents de couplages, leurs conjugues, ainsi que l'utilisation de ces conjugues dans des methodes de diagnostic |
| PCT/FR2003/000619 WO2003072546A1 (fr) | 2002-02-28 | 2003-02-26 | Nouveaux agents de couplages, leurs intermédiaires actives, leurs conjugues, ainsi que l'utilisation de ces conjugues dans des méthodes de diagnostic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502919T1 true ATE502919T1 (de) | 2011-04-15 |
Family
ID=27676179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03718910T ATE502919T1 (de) | 2002-02-28 | 2003-02-26 | Kupplungsmittel, deren aktive zwischenverbindungen und konjugate sowie die verwendung dieser konjugate für diagnostische zwecke |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7132269B2 (de) |
| EP (1) | EP1478623B1 (de) |
| AT (1) | ATE502919T1 (de) |
| AU (1) | AU2003222944A1 (de) |
| DE (1) | DE60336455D1 (de) |
| FR (1) | FR2836382B1 (de) |
| WO (1) | WO2003072546A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7356711B1 (en) | 2002-05-30 | 2008-04-08 | Microsoft Corporation | Secure registration |
| FR2955111B1 (fr) | 2010-01-12 | 2013-05-31 | Biomerieux Sa | Procede de preparation de composes polybiotinyles |
| RU2012134974A (ru) | 2010-01-22 | 2014-02-27 | Ново Нордиск Хелс Кеа Аг | Стабилизированное соединение гормона роста |
| PL2525834T3 (pl) | 2010-01-22 | 2020-10-19 | Novo Nordisk Health Care Ag | Hormony wzrostu o przedłużonej skuteczności in-vivo |
| ES2841123T3 (es) | 2013-04-05 | 2021-07-07 | Formulacion Del Compuesto De La Hormona De Crecimiento | Formulación del compuesto de la hormona de crecimiento |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162505A (en) * | 1989-09-19 | 1992-11-10 | Centocor | Proteins modified with positively charged carriers and compositions prepared therefrom |
| US5329028A (en) * | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
| US6139819A (en) * | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
-
2002
- 2002-02-28 FR FR0202559A patent/FR2836382B1/fr not_active Expired - Fee Related
-
2003
- 2003-02-26 EP EP03718910A patent/EP1478623B1/de not_active Expired - Lifetime
- 2003-02-26 DE DE60336455T patent/DE60336455D1/de not_active Expired - Lifetime
- 2003-02-26 WO PCT/FR2003/000619 patent/WO2003072546A1/fr not_active Ceased
- 2003-02-26 AU AU2003222944A patent/AU2003222944A1/en not_active Abandoned
- 2003-02-26 US US10/505,746 patent/US7132269B2/en not_active Expired - Lifetime
- 2003-02-26 AT AT03718910T patent/ATE502919T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2836382A1 (fr) | 2003-08-29 |
| DE60336455D1 (de) | 2011-05-05 |
| WO2003072546A1 (fr) | 2003-09-04 |
| FR2836382B1 (fr) | 2004-08-13 |
| EP1478623A1 (de) | 2004-11-24 |
| US20050215771A1 (en) | 2005-09-29 |
| EP1478623B1 (de) | 2011-03-23 |
| US7132269B2 (en) | 2006-11-07 |
| AU2003222944A1 (en) | 2003-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |