ATE508124T1 - Verfahren zur herstellung von amorphem rabeprazole-natrium-salz - Google Patents

Verfahren zur herstellung von amorphem rabeprazole-natrium-salz

Info

Publication number: ATE508124T1
Authority: AT; Austria
Prior art keywords: group; hydrogen atom; sodium salt; methoxy group; rabeprazole sodium
Prior art date: 2003-03-24

Application number

AT04721289T

Other languages

English (en)

Inventor

Masahiko Tsujii

Yukio Morita

Original Assignee

Eisai R&D Man Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-24

Filing date

2004-03-17

Publication date

2011-05-15

2004-03-17 Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE508124T1 publication Critical patent/ATE508124T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
229960004157 rabeprazole Drugs 0.000 title 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 title 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
150000003462 sulfoxides Chemical class 0.000 abstract 2
125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
-1 3-methoxypropoxy group Chemical group 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
150000001342 alkaline earth metals Chemical class 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT04721289T 2003-03-24 2004-03-17 Verfahren zur herstellung von amorphem rabeprazole-natrium-salz ATE508124T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003081261		2003-03-24
PCT/JP2004/003525 WO2004085424A1 (ja)	2003-03-24	2004-03-17	スルホキシド誘導体またはその塩のアモルファスの製造方法

Publications (1)

Publication Number	Publication Date
ATE508124T1 true ATE508124T1 (de)	2011-05-15

Family

ID=33094891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04721289T ATE508124T1 (de)	2003-03-24	2004-03-17	Verfahren zur herstellung von amorphem rabeprazole-natrium-salz

Country Status (11)

Country	Link
US (2)	US20060178406A1 (de)
EP (1)	EP1607395B1 (de)
JP (1)	JP4787017B2 (de)
KR (1)	KR100714375B1 (de)
CN (1)	CN100364987C (de)
AT (1)	ATE508124T1 (de)
AU (1)	AU2004224042B2 (de)
CA (1)	CA2516600C (de)
DE (1)	DE602004032524D1 (de)
IL (1)	IL169791A (de)
WO (1)	WO2004085424A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI289557B (en) *	1999-06-17	2007-11-11	Takeda Chemical Industries Ltd	A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
MXPA05013316A (es)	2003-06-10	2006-03-17	Teva Pharma	Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol.
JP3921497B2 (ja)	2004-08-06	2007-05-30	エーザイ・アール・アンド・ディー・マネジメント株式会社	ベンズイミダゾール誘導体とアミンとの塩およびその製造方法
AR058440A1 (es) *	2005-08-02	2008-02-06	Medichem Sa	Procesos para la produccion de rabeprazol sodico amorfo
IT1392813B1 (it)	2009-02-06	2012-03-23	Dipharma Francis Srl	Forme cristalline di dexlansoprazolo
US9085556B2 (en)	2010-03-31	2015-07-21	Ranbaxy Laboraotories Limited	Salts of dexlansoprazole and their preparation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8301182D0 (sv) *	1983-03-04	1983-03-04	Haessle Ab	Novel compounds
FI90544C (fi) *	1986-11-13	1994-02-25	Eisai Co Ltd	Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
JPH0674272B2 (ja) *	1986-11-13	1994-09-21	エーザイ株式会社	ピリジン誘導体及びそれを含有する潰瘍治療剤
JPH08176113A (ja) *	1993-11-12	1996-07-09	Dainippon Pharmaceut Co Ltd	２−スルフィニルニコチンアミド誘導体及びその中間体並びにそれを有効成分とする消化性潰瘍治療薬
SE510666C2 (sv) *	1996-12-20	1999-06-14	Astra Ab	Nya Kristallmodifikationer
JP3926936B2 (ja) *	1998-11-16	2007-06-06	エーザイ・アール・アンド・ディー・マネジメント株式会社	スルホキシド誘導体・アセトン錯体およびその製造法
TWI289557B (en) *	1999-06-17	2007-11-11	Takeda Chemical Industries Ltd	A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
JP4536905B2 (ja) *	1999-06-17	2010-09-01	武田薬品工業株式会社	ベンズイミダゾール化合物の結晶
CA2290893C (en) *	1999-11-16	2007-05-01	Bernard Charles Sherman	Magnesium omeprazole
EP1706397A4 (de)	2000-05-15	2007-08-01	Ranbaxy Lab Ltd	Neue amorphe form von omeprazolsalzen
CA2417311C (en) *	2000-08-04	2012-07-10	Takeda Chemical Industries, Ltd.	Crystalline alkali metal salts of lansoprazole and their production and use
EP1515963B1 (de) *	2002-06-27	2007-02-14	Dr. Reddy's Laboratories Ltd.	Verfahren zur herstellung optisch reiner oder optisch angereicherter sulfoxidverbindungen einschliesslich amorphen esomeprazols und dessen salze
EP1552833B1 (de) *	2002-10-16	2016-12-28	Takeda Pharmaceutical Company Limited	Herstellung eines amorphen, optisch aktiven Isomers von Lansoprazol
US7507829B2 (en) *	2002-12-19	2009-03-24	Teva Pharmaceuticals Industries, Ltd	Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates

2004
- 2004-03-17 WO PCT/JP2004/003525 patent/WO2004085424A1/ja not_active Ceased
- 2004-03-17 DE DE602004032524T patent/DE602004032524D1/de not_active Expired - Lifetime
- 2004-03-17 CA CA2516600A patent/CA2516600C/en not_active Expired - Fee Related
- 2004-03-17 US US10/546,994 patent/US20060178406A1/en not_active Abandoned
- 2004-03-17 AU AU2004224042A patent/AU2004224042B2/en not_active Ceased
- 2004-03-17 CN CNB2004800055704A patent/CN100364987C/zh not_active Expired - Fee Related
- 2004-03-17 JP JP2005504007A patent/JP4787017B2/ja not_active Expired - Fee Related
- 2004-03-17 EP EP04721289A patent/EP1607395B1/de not_active Expired - Lifetime
- 2004-03-17 KR KR1020057015526A patent/KR100714375B1/ko not_active Expired - Fee Related
- 2004-03-17 AT AT04721289T patent/ATE508124T1/de not_active IP Right Cessation
2005
- 2005-07-20 IL IL169791A patent/IL169791A/en not_active IP Right Cessation
2007
- 2007-11-13 US US11/939,418 patent/US7754887B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL169791A (en)	2012-04-30
CA2516600A1 (en)	2004-10-07
US20060178406A1 (en)	2006-08-10
CA2516600C (en)	2011-04-05
KR100714375B1 (ko)	2007-05-02
US7754887B2 (en)	2010-07-13
IL169791A0 (en)	2007-07-04
CN1756751A (zh)	2006-04-05
JPWO2004085424A1 (ja)	2006-06-29
AU2004224042B2 (en)	2010-03-25
AU2004224042A1 (en)	2004-10-07
WO2004085424A1 (ja)	2004-10-07
DE602004032524D1 (de)	2011-06-16
JP4787017B2 (ja)	2011-10-05
EP1607395B1 (de)	2011-05-04
CN100364987C (zh)	2008-01-30
KR20050108360A (ko)	2005-11-16
EP1607395A4 (de)	2009-06-03
EP1607395A1 (de)	2005-12-21
US20080214828A1 (en)	2008-09-04

Legal Events

Date	Code	Title	Description
2011-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BG106622A (en)	2002-12-29	Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
TW200616994A (en)	2006-06-01	Novel thiophene derivatives
PT1129088E (pt)	2008-05-05	Forma cristalina de (r)-2-[[[3-metil-4-(2,2,2-trifluoroetoxi)- 2-piridinil]metil]sulfinil]-1h-benzimidazole
ATE419239T1 (de)	2009-01-15	Verfahren zur herstellung von 4-phenoxy chinolin derivaten
CA2289409A1 (en)	2000-05-16	Sulfoxide compounds and acetone complexes, and a process for producing the same
WO2004020430A3 (fr)	2004-04-22	Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
NO20082630L (no)	2008-09-16	Vann-opploslige benzoazepinforbindelser og farmasoytisk forbindelse
WO2009095792A3 (en)	2009-10-08	Substituted heteroarylamide diazepinopyrimidone derivatives
NO20071008L (no)	2007-02-21	Fremgangsmate for fremstilling av N-piperidino-1,5-difenylpyrazol-3-karboksamidderivater
TW200745077A (en)	2007-12-16	Thiophene compound having sulfonyl group and process for producing the same
ATE429429T1 (de)	2009-05-15	Pharmazeutisches verfahren und damit hergestellte verbindungen
MXPA05013631A (es)	2006-02-24	Derivado heterociclico de metilsulfona.
GEP20105071B (en)	2010-09-10	Processes for preparing 4-(phenoxy-5-methyl-pyrimidin-4-yloxy) piperidine-1-carboxylic acid derivatives and related compounds
DE602004032524D1 (de)	2011-06-16	Verfahren zur herstellung von amorphem rabeprazole-natrium-salz
ATE420875T1 (de)	2009-01-15	Verfahren zur herstellung von 5-(4-ä4-(5-cyano-3- indolyl)-butylü-1-piperazinyl)-benzofuran-2- carboxamid
ATE348811T1 (de)	2007-01-15	Verfahren zur herstellung von 2- aminomethylpyridin-derivaten
DK1325923T3 (da)	2007-04-02	Cephem-forbindelser og ESBL-detekterende reagenser indeholdende disse
ATE546432T1 (de)	2012-03-15	Verfahren zur herstellung von 2- aminomethylpyridin-derivate
TW200745038A (en)	2007-12-16	Improved process for the production of nitroguanidine derivative
ATE315568T1 (de)	2006-02-15	Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ
EE200300090A (et)	2004-12-15	Asendatud imidasopüridiinühendite valmistamise meetod
WO2007000505A3 (fr)	2007-11-15	Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique
ATE242235T1 (de)	2003-06-15	Verfahren zur herstellung von (s-(r,s))-g(b)- ((1-(1-oxo-3-(4-piperidinyl)propyl)-3- piperidinyl)carbonyl) amino)-3- pyridinpropansäurederivate
EP1650195A4 (de)	2008-09-17	Verfahren zur inhibierung der produktion von osteopontin
ATE311382T1 (de)	2005-12-15	Verfahren zur herstellung von 2-carbamoyl- pyridinen