ATE315568T1 - Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ - Google Patents

Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ

Info

Publication number
ATE315568T1
ATE315568T1 AT01982847T AT01982847T ATE315568T1 AT E315568 T1 ATE315568 T1 AT E315568T1 AT 01982847 T AT01982847 T AT 01982847T AT 01982847 T AT01982847 T AT 01982847T AT E315568 T1 ATE315568 T1 AT E315568T1
Authority
AT
Austria
Prior art keywords
type antibacterial
antibacterial compounds
carbapenem
producing carbapenem
salt
Prior art date
Application number
AT01982847T
Other languages
English (en)
Inventor
Katsuhiko Fujimoto
Takashi Kasai
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE315568T1 publication Critical patent/ATE315568T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01982847T 2000-11-20 2001-11-19 Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ ATE315568T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000352178 2000-11-20

Publications (1)

Publication Number Publication Date
ATE315568T1 true ATE315568T1 (de) 2006-02-15

Family

ID=18825114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01982847T ATE315568T1 (de) 2000-11-20 2001-11-19 Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ

Country Status (14)

Country Link
US (2) US7034150B2 (de)
EP (1) EP1338596B1 (de)
KR (1) KR100825243B1 (de)
CN (1) CN1247581C (de)
AT (1) ATE315568T1 (de)
AU (1) AU2002214325A1 (de)
CA (1) CA2429071A1 (de)
CY (1) CY1105598T1 (de)
DE (1) DE60116656T2 (de)
DK (1) DK1338596T3 (de)
ES (1) ES2256311T3 (de)
PT (1) PT1338596E (de)
TW (1) TWI290925B (de)
WO (1) WO2002040482A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2602097A1 (en) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited Process for producing carbapenem derivatives having 1-alkylpyrrolidine structure
CN101328178B (zh) * 2007-06-15 2010-10-13 山东轩竹医药科技有限公司 含有噻吩取代的巯基吡咯烷的培南衍生物
CN101357919B (zh) * 2007-06-22 2011-06-15 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺苯磺酰基的培南衍生物
CN101333219B (zh) * 2007-06-26 2010-10-13 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺苯烷基杂环的培南衍生物
CN101367812B (zh) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物
CN101343271B (zh) * 2007-07-13 2011-01-12 山东轩竹医药科技有限公司 含有异噁唑烷酮的培南衍生物
WO2011068543A1 (en) * 2009-12-04 2011-06-09 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
CN102002069A (zh) * 2010-11-12 2011-04-06 上海巴迪生物医药科技有限公司 一种合成培南类侧链的双环中间体的制备方法及其应用
ES2785313T3 (es) * 2013-01-15 2020-10-06 Merck Patent Gmbh Acilguanidinas para el tratamiento de la artrosis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
GB8809736D0 (en) * 1988-04-25 1988-06-02 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
JP3091297B2 (ja) * 1992-01-10 2000-09-25 住友製薬株式会社 ピロリジン誘導体およびその製造方法
EP0882728B1 (de) * 1995-12-21 2002-09-04 Sankyo Company Limited 1-methylcarbapenem-derivate
KR980008226A (ko) * 1996-07-05 1998-04-30 다케다 쿠니오 시각기능장애의 예방 및 치료제
JP2955276B2 (ja) 1997-06-19 1999-10-04 三共株式会社 １−メチルカルバペネム誘導体を含有する抗菌剤
WO1999002531A1 (en) * 1997-07-09 1999-01-21 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US6063931A (en) * 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
WO2004078195A1 (ja) * 2003-03-07 2004-09-16 Ajinomoto Co., Inc. 腸管細胞のインスリン産生細胞への変換誘導剤、及び糖尿病治療剤

Also Published As

Publication number Publication date
CN1247581C (zh) 2006-03-29
DE60116656T2 (de) 2006-09-21
WO2002040482A1 (en) 2002-05-23
CN1486316A (zh) 2004-03-31
KR20030097793A (ko) 2003-12-31
CA2429071A1 (en) 2002-05-23
DK1338596T3 (da) 2006-04-18
AU2002214325A1 (en) 2002-05-27
US20060009508A1 (en) 2006-01-12
EP1338596A1 (de) 2003-08-27
TWI290925B (en) 2007-12-11
EP1338596A4 (de) 2004-08-04
US7091363B2 (en) 2006-08-15
CY1105598T1 (el) 2010-07-28
US20030225055A1 (en) 2003-12-04
PT1338596E (pt) 2006-05-31
US7034150B2 (en) 2006-04-25
KR100825243B1 (ko) 2008-04-25
DE60116656D1 (de) 2006-04-06
HK1054745A1 (en) 2003-12-12
ES2256311T3 (es) 2006-07-16
EP1338596B1 (de) 2006-01-11

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