ATE508630T1 - Verfahren und gerät für das einfrieren und auftauen von biologischen proben - Google Patents

Verfahren und gerät für das einfrieren und auftauen von biologischen proben

Info

Publication number
ATE508630T1
ATE508630T1 AT03704956T AT03704956T ATE508630T1 AT E508630 T1 ATE508630 T1 AT E508630T1 AT 03704956 T AT03704956 T AT 03704956T AT 03704956 T AT03704956 T AT 03704956T AT E508630 T1 ATE508630 T1 AT E508630T1
Authority
AT
Austria
Prior art keywords
temperature
freezing
biological samples
sample
thawing biological
Prior art date
Application number
AT03704956T
Other languages
English (en)
Inventor
Meir Uri
Original Assignee
Core Dynamics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Core Dynamics Ltd filed Critical Core Dynamics Ltd
Application granted granted Critical
Publication of ATE508630T1 publication Critical patent/ATE508630T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/14Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A01N1/147Carriers for immersion in cryogenic fluid for slow freezing or vitrification
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/14Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142Apparatus
    • A01N1/144Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
    • A01N1/145Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/16Physical preservation processes
    • A01N1/162Temperature processes, e.g. following predefined temperature changes over time
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/54Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00Means for pre-treatment of biological substances
    • C12M45/20Heating; Cooling
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00Means for pre-treatment of biological substances
    • C12M45/22Means for packing or storing viable microorganisms
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D13/00Stationary devices, e.g. cold-rooms
    • F25D13/06Stationary devices, e.g. cold-rooms with conveyors carrying articles to be cooled through the cooling space
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/02Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25CPRODUCING, WORKING OR HANDLING ICE
    • F25C1/00Producing ice
    • F25C1/18Producing ice of a particular transparency or translucency, e.g. by injecting air
    • F25C1/20Producing ice of a particular transparency or translucency, e.g. by injecting air by agitation
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F25D3/11Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air with conveyors carrying articles to be cooled through the cooling space
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42Low-temperature sample treatment, e.g. cryofixation

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Combustion & Propulsion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
AT03704956T 2002-01-08 2003-01-08 Verfahren und gerät für das einfrieren und auftauen von biologischen proben ATE508630T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34564302P 2002-01-08 2002-01-08
US39157502P 2002-06-27 2002-06-27
PCT/IL2003/000026 WO2003056919A2 (en) 2002-01-08 2003-01-08 Methods and device for freezing and thawing biological samples

Publications (1)

Publication Number Publication Date
ATE508630T1 true ATE508630T1 (de) 2011-05-15

Family

ID=26994492

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03704956T ATE508630T1 (de) 2002-01-08 2003-01-08 Verfahren und gerät für das einfrieren und auftauen von biologischen proben

Country Status (5)

Country Link
US (1) US20040265831A1 (de)
EP (1) EP1476013B1 (de)
AT (1) ATE508630T1 (de)
AU (1) AU2003207952A1 (de)
WO (1) WO2003056919A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7331186B2 (en) 2002-06-27 2008-02-19 I.M.T. Interface Multigrad Technology Ltd Changing the temperature of a liquid sample and a receptacle useful therefor
ATE494777T1 (de) * 2003-10-09 2011-01-15 Core Dynamics Ltd Verfahren zum tiefgefrieren, auftauen und transplantieren von lebensfähigem knorpel
EP1711214A1 (de) 2004-02-02 2006-10-18 Interface Multigrad Technology (IMT) Ltd. Vorrichtung zum gerichteten kühlen von biomasse
JP4777908B2 (ja) 2004-02-02 2011-09-21 コア・ダイナミクス・リミテッド 生物学的材料ならびに生物学的材料の保存のための方法および溶液
ATE460947T1 (de) 2004-06-07 2010-04-15 Core Dynamics Ltd Verfahren zur sterilisation von biologischen präparaten
FI116946B (fi) * 2004-07-09 2006-04-13 Chip Man Technologies Oy Laitteisto solujen kuvaamiseksi
US8037696B2 (en) 2004-08-12 2011-10-18 Core Dynamics Limited Method and apparatus for freezing or thawing of a biological material
US8198085B2 (en) 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
GB0525115D0 (en) * 2005-12-09 2006-01-18 Oxford Biosensors Ltd Freeze drying of target substances
WO2007093978A1 (en) * 2006-02-13 2007-08-23 I.M.T. Interface Multigrad Technology Ltd. Frozen viable solid organs and method for freezing same
US8839527B2 (en) 2006-02-21 2014-09-23 Goji Limited Drying apparatus and methods and accessories for use therewith
EP2528414B1 (de) 2006-02-21 2016-05-11 Goji Limited Elektromagnetische Heizung
US10674570B2 (en) 2006-02-21 2020-06-02 Goji Limited System and method for applying electromagnetic energy
US8653482B2 (en) 2006-02-21 2014-02-18 Goji Limited RF controlled freezing
EP2544508B1 (de) 2006-07-10 2015-06-17 Goji Limited Verfahren zur Erhitzung von Nahrung
US9131543B2 (en) 2007-08-30 2015-09-08 Goji Limited Dynamic impedance matching in RF resonator cavity
KR101571584B1 (ko) 2008-11-10 2015-11-24 고지 엘티디. 에너지 제어 장치 및 방법
ES2620506T3 (es) * 2009-06-17 2017-06-28 Hiroshima University Disolución diluyente de esperma y método para inseminación artificial usando la misma
KR101663449B1 (ko) 2009-11-10 2016-10-06 고지 엘티디. 에너지를 제어하기 위한 장치 및 방법
WO2011098996A2 (en) 2010-02-09 2011-08-18 Core Dynamics Ltd. Improved method for changing the temperature of a biological specimen
KR101863971B1 (ko) 2010-05-03 2018-07-04 고지 엘티디. 모드 분석
CA3187726A1 (en) 2014-08-08 2016-02-11 Fremon Scientific, Inc. Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance
US20180324900A1 (en) 2017-05-04 2018-11-08 Fremon Scientific, Inc. Dry Heat Thawing of Biological Substances
WO2019217488A1 (en) 2018-05-07 2019-11-14 Fremon Scientific, Inc. Thawing biological substances
US11287185B1 (en) 2020-09-09 2022-03-29 Stay Fresh Technology, LLC Freeze drying with constant-pressure and constant-temperature phases
EP4412453A4 (de) * 2021-10-08 2025-01-22 TMRW Life Sciences, Inc. Systeme, vorrichtung und verfahren zur entnahme und/oder platzierung von probenbehältern

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131200A (en) * 1976-07-06 1978-12-26 Union Carbide Corporation Thermoplastic blood bag
CA2146098A1 (en) * 1995-01-12 1996-07-13 The Governors Of The University Of Alberta Bulk cryopreservation of biological materials and uses for cryopreserved and encapsulated biological materials
US5873254A (en) * 1996-09-06 1999-02-23 Interface Multigrad Technology Device and methods for multigradient directional cooling and warming of biological samples
EP1274301B1 (de) * 2000-04-17 2004-11-24 Organ Recovery Systems, Inc. Neues aufwärmverfahren für cryokonservierte proben
US20100143877A1 (en) * 2006-09-05 2010-06-10 Reproquest, Llc Composition for preserving reproductive cells and method of using

Also Published As

Publication number Publication date
WO2003056919A2 (en) 2003-07-17
WO2003056919A3 (en) 2003-11-27
AU2003207952A8 (en) 2003-07-24
AU2003207952A1 (en) 2003-07-24
EP1476013A2 (de) 2004-11-17
US20040265831A1 (en) 2004-12-30
EP1476013B1 (de) 2011-05-11

Similar Documents

Publication Publication Date Title
AU2003207952A8 (en) Methods and device for freezing and thawing biological samples
DK0922102T3 (da) Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf
ATE540319T1 (de) Verfahren für die bestimmung von fk506
ES2180782T3 (es) Procedimiento para la identificacion o el aislamiento de una molecula y moleculas identificadas de ese modo.
DK1112275T3 (da) Hidtil ukendte heteroaromatiske inhibitorer for fructose-1,6-bisphosphatase
DE69132352D1 (de) Protein-antagonisten der blut-koagulation und ihre verwendung
MXPA03003281A (es) Deteccion enzimatica no invasiva de estados asociados con la remodelacion de tejidos.
ATE512233T1 (de) Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten
DE69423346D1 (de) Schnelles verfahren fur die dns sequenzierung und diagnostische anwendungen
DE602004027074D1 (de) Probenahmesystem mit phosphataseinhibitor
PT1283907E (pt) Metodo para o diagnostico de cancros
DE69939312D1 (de) Verfahren zur identifizierung von induktoren und inhibitoren proteolytischer antikörper, zusammensetzungen sowie deren verwendungen
BR0209083A (pt) Métodos e reagentes para transplante celular
DE59907067D1 (de) Polymer-Werkstoff und Herstellungsverfahren, sowie System und Verfahren zur Materialüberprüfung von Polymer-Werkstoffen und Bauteilen
DE69534649D1 (de) Schlichtemittel für glasorgane, verwendungsverfahren und produkte daraus
ATE302945T1 (de) Verfahren zum überwachen von gas(en) in einer dielektrischen flüssigkeit
ATE282831T1 (de) Verfahren zur diagnose von sepsis unter bestimmung löslicher cytokeratinfragmente
DE60330099D1 (de) Verfahren und Anordnungen zur Herstellung, Feststellung und Übertragung von Identifikatoren
ATE296902T1 (de) Verfahren zur herstellung von mineralwolle, kobalt-basislegierungen für das verfahren und andere anwendungen
FR2774988B1 (fr) Procede de purification de la prpres a partir d'un echantillon biologique et ses applications
AU2003296085A1 (en) Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same
ATE197171T1 (de) Polyoxyalkylenblockcopolymere, verfahren zur herstellung und ihre verwendung als schmiermittel
ATE422555T1 (de) Test für niedrigmolekulares heparin, system und reagenz dafür
ATE532620T1 (de) Vorrichtung und verfahren zum temperieren von vorformlingen
DK1281083T3 (da) Fremgangsmåde til detektering af inflammation og inflammatoriske tilstande

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties