MA30284B1 - Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu - Google Patents

Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu

Info

Publication number
MA30284B1
MA30284B1 MA31246A MA31246A MA30284B1 MA 30284 B1 MA30284 B1 MA 30284B1 MA 31246 A MA31246 A MA 31246A MA 31246 A MA31246 A MA 31246A MA 30284 B1 MA30284 B1 MA 30284B1
Authority
MA
Morocco
Prior art keywords
compounds
opioid receptor
azabicyclo
receptor antagonists
octane compounds
Prior art date
Application number
MA31246A
Other languages
English (en)
Inventor
Daniel Long
Timothy J Church
John R Jacobsen
Lan Jiang
Daisuke Roland Saito
Ioanna Stergiades
Dyke Priscilla Van
Sean Dalziel
Leticia Preza
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30284(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MA30284B1 publication Critical patent/MA30284B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne de nouveaux composés de 8-azabicyclo[3.2.1]octane de formule (I) où R1, R2, R3, A et G sont tels que définis dans la description, ou un sel ou solvate pharmaceutiquement acceptable de ceux-ci, lesdits composés étant des antagonistes du récepteur opioïde mu. L'invention décrit également des compositions pharmaceutiques contenant de tels composés, des procédés d'utilisation de tels composés visant à traiter des pathologies associées à l'activité du récepteur opioïde mu, ainsi que des procédés et des intermédiaires utiles pour la préparation de ces composés.
MA31246A 2006-03-01 2008-09-17 Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu MA30284B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30

Publications (1)

Publication Number Publication Date
MA30284B1 true MA30284B1 (fr) 2009-03-02

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31246A MA30284B1 (fr) 2006-03-01 2008-09-17 Composes de 8-azabicyclo[3.2.1]octane en tant qu'antagonistes du recepteur opioide mu

Country Status (24)

Country Link
US (11) US7622508B2 (fr)
EP (1) EP2001876B1 (fr)
JP (2) JP5086280B2 (fr)
KR (1) KR101376479B1 (fr)
AR (1) AR059690A1 (fr)
AT (1) ATE509928T1 (fr)
AU (1) AU2007224213B2 (fr)
BR (1) BRPI0708490B8 (fr)
CA (1) CA2646409C (fr)
CY (1) CY1111747T1 (fr)
DK (1) DK2001876T3 (fr)
HR (1) HRP20110590T1 (fr)
IL (1) IL193690A (fr)
MA (1) MA30284B1 (fr)
MX (1) MX2008011165A (fr)
MY (1) MY145633A (fr)
NZ (1) NZ570764A (fr)
PE (1) PE20071311A1 (fr)
PL (1) PL2001876T3 (fr)
PT (1) PT2001876E (fr)
RU (1) RU2423362C2 (fr)
SI (1) SI2001876T1 (fr)
TW (1) TWI379832B (fr)
WO (1) WO2007103187A2 (fr)

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MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2009029253A1 (fr) * 2007-08-27 2009-03-05 Theravance, Inc. Composés d'hétéroarylalkyl-8-azabicyclo[3.2.1]octane comme antagonistes des récepteurs opioïdes mu
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ES2390195T3 (es) * 2007-08-27 2012-11-07 Theravance, Inc. Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
US7947710B2 (en) * 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
EP2423210A1 (fr) 2010-08-25 2012-02-29 Bayer CropScience AG Dérivés d'hétéroarylpipéridine et -pipérazine comme fongicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
UA112534C2 (uk) 2010-10-27 2016-09-26 Байєр Інтеллектуал Проперті Гмбх Похідні гетероарилпіперидину, проміжні сполуки, композиція для боротьби із шкідливими фітопатогенними грибами та спосіб її виготовлення
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KR101848116B1 (ko) 2011-02-01 2018-04-11 바이엘 인텔렉쳐 프로퍼티 게엠베하 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체
JP5959646B2 (ja) 2011-09-15 2016-08-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 殺菌剤としてのピペリジンピラゾール類
DK2921495T3 (en) 2011-12-27 2018-07-16 Bayer Ip Gmbh HETEROARYLPIPERIDINE AND PIPERAZINE DERIVATIVES AS FUNGICIDES
EP3082816B1 (fr) 2013-12-20 2019-03-20 Indivior UK Limited Compositions de naloxone intranasales et leurs procédés de préparation et d'utilisation
HRP20200432T1 (hr) 2015-04-02 2020-06-12 Theravance Biopharma R&D Ip, Llc Oblik za kombinacijsko doziranje antagonista mu opioidnog receptora i opioidnog sredstva
BR112020015712A2 (pt) 2018-02-05 2020-12-08 Alkermes, Inc. Compostos para tratamento de dor
KR20230154789A (ko) * 2020-11-06 2023-11-09 액티노젠 메디컬 리미티드 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정

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JP2010509227A (ja) 2006-11-07 2010-03-25 ネクター セラピューティックス エイエル，コーポレイション オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与
TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
US7947710B2 (en) 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2009029253A1 (fr) 2007-08-27 2009-03-05 Theravance, Inc. Composés d'hétéroarylalkyl-8-azabicyclo[3.2.1]octane comme antagonistes des récepteurs opioïdes mu
ES2390195T3 (es) 2007-08-27 2012-11-07 Theravance, Inc. Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu

Also Published As

Publication number Publication date
DK2001876T3 (da) 2011-08-29
US20160176863A1 (en) 2016-06-23
RU2423362C2 (ru) 2011-07-10
BRPI0708490B1 (pt) 2019-07-30
TW200800981A (en) 2008-01-01
HK1125935A1 (en) 2009-08-21
JP2009528371A (ja) 2009-08-06
BRPI0708490A2 (pt) 2011-05-31
US20190308966A1 (en) 2019-10-10
US20130158060A1 (en) 2013-06-20
ATE509928T1 (de) 2011-06-15
AR059690A1 (es) 2008-04-23
NZ570764A (en) 2011-08-26
IL193690A (en) 2013-02-28
JP2012211193A (ja) 2012-11-01
US20230183232A1 (en) 2023-06-15
US8927573B2 (en) 2015-01-06
US20190119267A1 (en) 2019-04-25
US20210024515A1 (en) 2021-01-28
IL193690A0 (en) 2009-08-03
US7622508B2 (en) 2009-11-24
WO2007103187A2 (fr) 2007-09-13
AU2007224213A1 (en) 2007-09-13
MX2008011165A (es) 2008-09-15
WO2007103187A3 (fr) 2007-11-01
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
US20150291579A1 (en) 2015-10-15
US8664242B2 (en) 2014-03-04
PL2001876T3 (pl) 2011-10-31
PE20071311A1 (es) 2007-12-29
US11548887B2 (en) 2023-01-10
TWI379832B (en) 2012-12-21
US20140288112A1 (en) 2014-09-25
SI2001876T1 (sl) 2011-09-30
US9663509B2 (en) 2017-05-30
MY145633A (en) 2012-03-15
US20100035921A1 (en) 2010-02-11
US20170349578A1 (en) 2017-12-07
US10081626B2 (en) 2018-09-25
CA2646409C (fr) 2015-11-10
US10745394B2 (en) 2020-08-18
AU2007224213B2 (en) 2012-06-14
KR101376479B1 (ko) 2014-03-27
BRPI0708490B8 (pt) 2021-05-25
HRP20110590T1 (hr) 2011-09-30
RU2008138875A (ru) 2010-04-10
US10377751B2 (en) 2019-08-13
US9206172B2 (en) 2015-12-08
EP2001876A2 (fr) 2008-12-17
US20070219278A1 (en) 2007-09-20
EP2001876B1 (fr) 2011-05-18
CA2646409A1 (fr) 2007-09-13
CY1111747T1 (el) 2015-10-07
JP5086280B2 (ja) 2012-11-28
US8263618B2 (en) 2012-09-11

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