ATE510850T1 - Verfahren zum hochdurchsatzscreening von auf cpg basierenden immunagonisten und -antagonisten - Google Patents
Verfahren zum hochdurchsatzscreening von auf cpg basierenden immunagonisten und -antagonistenInfo
- Publication number
- ATE510850T1 ATE510850T1 AT01971181T AT01971181T ATE510850T1 AT E510850 T1 ATE510850 T1 AT E510850T1 AT 01971181 T AT01971181 T AT 01971181T AT 01971181 T AT01971181 T AT 01971181T AT E510850 T1 ATE510850 T1 AT E510850T1
- Authority
- AT
- Austria
- Prior art keywords
- murine
- tlr8
- tlr7
- tlr9
- well
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 3
- 238000013537 high throughput screening Methods 0.000 title 1
- 241001529936 Murinae Species 0.000 abstract 12
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 abstract 6
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 abstract 6
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 abstract 5
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 abstract 5
- 102100039390 Toll-like receptor 7 Human genes 0.000 abstract 5
- 102100033110 Toll-like receptor 8 Human genes 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000000556 agonist Substances 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- -1 CpG nucleic acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23303500P | 2000-09-15 | 2000-09-15 | |
| US26365701P | 2001-01-23 | 2001-01-23 | |
| US29172601P | 2001-05-17 | 2001-05-17 | |
| US30021001P | 2001-06-22 | 2001-06-22 | |
| PCT/US2001/029229 WO2002022809A2 (en) | 2000-09-15 | 2001-09-17 | PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE510850T1 true ATE510850T1 (de) | 2011-06-15 |
Family
ID=27499675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01971181T ATE510850T1 (de) | 2000-09-15 | 2001-09-17 | Verfahren zum hochdurchsatzscreening von auf cpg basierenden immunagonisten und -antagonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6943240B2 (de) |
| EP (1) | EP1366077B1 (de) |
| JP (1) | JP2005500806A (de) |
| AT (1) | ATE510850T1 (de) |
| AU (1) | AU2001291096A1 (de) |
| CA (1) | CA2419894A1 (de) |
| DK (1) | DK1366077T3 (de) |
| WO (1) | WO2002022809A2 (de) |
Families Citing this family (143)
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| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
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| EP1366077B1 (de) | 2011-05-25 |
| JP2005500806A (ja) | 2005-01-13 |
| WO2002022809A9 (en) | 2003-03-20 |
| CA2419894A1 (en) | 2002-03-21 |
| US7820379B2 (en) | 2010-10-26 |
| DK1366077T3 (da) | 2011-09-12 |
| US6943240B2 (en) | 2005-09-13 |
| EP1366077A2 (de) | 2003-12-03 |
| US20050181422A1 (en) | 2005-08-18 |
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