ATE511547T1 - Verfahren zur herstellung von beta-lactam- verbindungen - Google Patents

Verfahren zur herstellung von beta-lactam- verbindungen

Info

Publication number
ATE511547T1
ATE511547T1 AT08717556T AT08717556T ATE511547T1 AT E511547 T1 ATE511547 T1 AT E511547T1 AT 08717556 T AT08717556 T AT 08717556T AT 08717556 T AT08717556 T AT 08717556T AT E511547 T1 ATE511547 T1 AT E511547T1
Authority
AT
Austria
Prior art keywords
side chain
lactam compounds
producing beta
chain ester
phenylglycine
Prior art date
Application number
AT08717556T
Other languages
English (en)
Inventor
Van Der Does
Harold Moody
Van Dooren
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE511547T1 publication Critical patent/ATE511547T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
AT08717556T 2007-03-09 2008-03-10 Verfahren zur herstellung von beta-lactam- verbindungen ATE511547T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07103850 2007-03-09
PCT/EP2008/052809 WO2008110527A1 (en) 2007-03-09 2008-03-10 Process for the preparation of beta-lactam compounds

Publications (1)

Publication Number Publication Date
ATE511547T1 true ATE511547T1 (de) 2011-06-15

Family

ID=38325288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08717556T ATE511547T1 (de) 2007-03-09 2008-03-10 Verfahren zur herstellung von beta-lactam- verbindungen

Country Status (10)

Country Link
US (1) US8497088B2 (de)
EP (1) EP2121960B1 (de)
JP (1) JP2010520752A (de)
KR (1) KR101444492B1 (de)
CN (1) CN101631872B (de)
AT (1) ATE511547T1 (de)
BR (1) BRPI0808685A2 (de)
ES (1) ES2365831T3 (de)
MX (1) MX2009009526A (de)
WO (1) WO2008110527A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20180318T1 (hr) 2008-12-23 2018-03-23 Dsm Sinochem Pharmaceuticals Netherlands B.V. Mutant penicilin g acilaze
WO2011073166A2 (en) 2009-12-14 2011-06-23 Dsm Ip Assets B.V. Production process for cephradine
US20140200342A1 (en) 2011-06-23 2014-07-17 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a pencillin g acylase
EP2723881A2 (de) 2011-06-23 2014-04-30 DSM Sinochem Pharmaceuticals Netherlands B.V. Neues kristallines cefoperazon-zwischenprodukt
RU2537845C2 (ru) * 2012-04-25 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессиональногообразования "Московский государственный университет имени М.В. Ломоносова " (МГУ) Способ синтеза пептидов, в том числе бета-лактамных антибиотиков, при использовании варианта пенициллинацилазы
CN103805671B (zh) * 2013-11-11 2015-08-26 华北制药河北华民药业有限责任公司 一种制备头孢氨苄的方法
CN103757085B (zh) * 2013-11-28 2016-06-15 湖南福来格生物技术有限公司 头孢克洛及其合成方法
CN103805672B (zh) * 2014-02-25 2016-05-25 华北制药集团先泰药业有限公司 一种酶法制备氨苄西林的工艺
CN103937866B (zh) * 2014-05-12 2016-07-06 联邦制药(内蒙古)有限公司 一种改进的氨苄西林的制备方法
KR20170058941A (ko) * 2014-09-22 2017-05-29 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 페닐글리신 메틸에스테르의 염
CN106187795A (zh) * 2016-07-05 2016-12-07 南京红杉生物科技有限公司 一种d‑苯甘氨酸甲酯的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2086250C (en) 1990-07-04 2001-05-29 Svend Gunnar Kaasgaard Process for preparation of beta-lactams
JPH05148199A (ja) 1991-11-28 1993-06-15 Ajinomoto Co Inc アミノ酸エステルの製造法
CN1034177C (zh) * 1993-12-02 1997-03-05 山东新华制药厂 头孢氨苄的制备方法
US6060268A (en) * 1995-07-18 2000-05-09 Gist-Brocades B.V. Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer
CN1165616C (zh) * 1995-07-18 2004-09-08 吉斯特·布罗卡迪斯股份有限公司 一种改进的固定化青霉素g酰基转移酶
TW555855B (en) 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
JP2000512860A (ja) * 1997-04-22 2000-10-03 ギスト ブロカデス ベスローテン フェンノートシャップ β―ラクタム抗生物質を調製する方法
EP1333278B1 (de) * 2002-02-01 2004-03-10 MTM molecular tools in medicine Verfahren zur Prognose gastrointestinaler Tumoren
WO2006003671A1 (en) * 2004-07-02 2006-01-12 Srinivasa Reddy Battula A process for resolution of methylamino(2-chlorophenyl)acetate

Also Published As

Publication number Publication date
MX2009009526A (es) 2009-09-16
KR101444492B1 (ko) 2014-09-24
EP2121960B1 (de) 2011-06-01
EP2121960A1 (de) 2009-11-25
HK1138623A1 (en) 2010-08-27
US20110104748A1 (en) 2011-05-05
CN101631872B (zh) 2014-07-16
CN101631872A (zh) 2010-01-20
WO2008110527A1 (en) 2008-09-18
US8497088B2 (en) 2013-07-30
BRPI0808685A2 (pt) 2014-08-19
JP2010520752A (ja) 2010-06-17
ES2365831T3 (es) 2011-10-11
KR20090121310A (ko) 2009-11-25

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