ATE511547T1 - Verfahren zur herstellung von beta-lactam- verbindungen - Google Patents
Verfahren zur herstellung von beta-lactam- verbindungenInfo
- Publication number
- ATE511547T1 ATE511547T1 AT08717556T AT08717556T ATE511547T1 AT E511547 T1 ATE511547 T1 AT E511547T1 AT 08717556 T AT08717556 T AT 08717556T AT 08717556 T AT08717556 T AT 08717556T AT E511547 T1 ATE511547 T1 AT E511547T1
- Authority
- AT
- Austria
- Prior art keywords
- side chain
- lactam compounds
- producing beta
- chain ester
- phenylglycine
- Prior art date
Links
- -1 BETA-LACTAM COMPOUNDS Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 3
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07103850 | 2007-03-09 | ||
| PCT/EP2008/052809 WO2008110527A1 (en) | 2007-03-09 | 2008-03-10 | Process for the preparation of beta-lactam compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE511547T1 true ATE511547T1 (de) | 2011-06-15 |
Family
ID=38325288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08717556T ATE511547T1 (de) | 2007-03-09 | 2008-03-10 | Verfahren zur herstellung von beta-lactam- verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8497088B2 (de) |
| EP (1) | EP2121960B1 (de) |
| JP (1) | JP2010520752A (de) |
| KR (1) | KR101444492B1 (de) |
| CN (1) | CN101631872B (de) |
| AT (1) | ATE511547T1 (de) |
| BR (1) | BRPI0808685A2 (de) |
| ES (1) | ES2365831T3 (de) |
| MX (1) | MX2009009526A (de) |
| WO (1) | WO2008110527A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE036302T2 (hu) | 2008-12-23 | 2018-07-30 | Dsm Sinochem Pharm Nl Bv | Mutáns penicillin-G-acilázok |
| CN102656274B (zh) | 2009-12-14 | 2014-10-15 | 中化帝斯曼制药有限公司荷兰公司 | 生产头孢拉定的方法 |
| EP2723882B1 (de) | 2011-06-23 | 2019-05-01 | Centrient Pharmaceuticals Netherlands B.V. | Verfahren zur herstellung von 3 '-thiosubstituierten cephalosporinen unter verwendung einer penicillin-g-acylase |
| EP2723881A2 (de) | 2011-06-23 | 2014-04-30 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Neues kristallines cefoperazon-zwischenprodukt |
| RU2537845C2 (ru) * | 2012-04-25 | 2015-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессиональногообразования "Московский государственный университет имени М.В. Ломоносова " (МГУ) | Способ синтеза пептидов, в том числе бета-лактамных антибиотиков, при использовании варианта пенициллинацилазы |
| CN103805671B (zh) * | 2013-11-11 | 2015-08-26 | 华北制药河北华民药业有限责任公司 | 一种制备头孢氨苄的方法 |
| CN103757085B (zh) * | 2013-11-28 | 2016-06-15 | 湖南福来格生物技术有限公司 | 头孢克洛及其合成方法 |
| CN103805672B (zh) * | 2014-02-25 | 2016-05-25 | 华北制药集团先泰药业有限公司 | 一种酶法制备氨苄西林的工艺 |
| CN103937866B (zh) * | 2014-05-12 | 2016-07-06 | 联邦制药(内蒙古)有限公司 | 一种改进的氨苄西林的制备方法 |
| JP2017528495A (ja) * | 2014-09-22 | 2017-09-28 | デーエスエム シノケム ファーマシューティカルズ ネーデルランド ベースローテン フェンノートシャップＤｓｍ Ｓｉｎｏｃｈｅｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｎｅｔｈｅｒｌａｎｄｓ Ｂ．Ｖ． | フェニルグリシンメチルエステルの塩 |
| CN106187795A (zh) * | 2016-07-05 | 2016-12-07 | 南京红杉生物科技有限公司 | 一种d‑苯甘氨酸甲酯的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0537255B1 (de) * | 1990-07-04 | 2006-02-15 | DSM IP Assets B.V. | Verfahren zur herstellung von beta-lactamen |
| JPH05148199A (ja) | 1991-11-28 | 1993-06-15 | Ajinomoto Co Inc | アミノ酸エステルの製造法 |
| CN1034177C (zh) * | 1993-12-02 | 1997-03-05 | 山东新华制药厂 | 头孢氨苄的制备方法 |
| EP0839192B1 (de) * | 1995-07-18 | 2008-12-10 | DSM IP Assets B.V. | Eine verbesserte immobilisierte penicillin g acylase |
| US6060268A (en) * | 1995-07-18 | 2000-05-09 | Gist-Brocades B.V. | Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer |
| TW555855B (en) * | 1996-07-26 | 2003-10-01 | Bristol Myers Squibb Co | Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase |
| BR9804858A (pt) * | 1997-04-22 | 1999-08-24 | Gist Brocades Bv | M-todo de prepara-Æo de antibiÄtico b-lactam |
| EP1333278B1 (de) * | 2002-02-01 | 2004-03-10 | MTM molecular tools in medicine | Verfahren zur Prognose gastrointestinaler Tumoren |
| WO2006003671A1 (en) * | 2004-07-02 | 2006-01-12 | Srinivasa Reddy Battula | A process for resolution of methylamino(2-chlorophenyl)acetate |
-
2008
- 2008-03-10 KR KR1020097018774A patent/KR101444492B1/ko active Active
- 2008-03-10 US US12/528,695 patent/US8497088B2/en active Active
- 2008-03-10 BR BRPI0808685-0A patent/BRPI0808685A2/pt not_active Application Discontinuation
- 2008-03-10 MX MX2009009526A patent/MX2009009526A/es active IP Right Grant
- 2008-03-10 ES ES08717556T patent/ES2365831T3/es active Active
- 2008-03-10 EP EP08717556A patent/EP2121960B1/de active Active
- 2008-03-10 CN CN200880007729.4A patent/CN101631872B/zh active Active
- 2008-03-10 AT AT08717556T patent/ATE511547T1/de active
- 2008-03-10 WO PCT/EP2008/052809 patent/WO2008110527A1/en not_active Ceased
- 2008-03-10 JP JP2009552220A patent/JP2010520752A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101631872A (zh) | 2010-01-20 |
| WO2008110527A1 (en) | 2008-09-18 |
| JP2010520752A (ja) | 2010-06-17 |
| KR101444492B1 (ko) | 2014-09-24 |
| BRPI0808685A2 (pt) | 2014-08-19 |
| EP2121960B1 (de) | 2011-06-01 |
| MX2009009526A (es) | 2009-09-16 |
| ES2365831T3 (es) | 2011-10-11 |
| US20110104748A1 (en) | 2011-05-05 |
| US8497088B2 (en) | 2013-07-30 |
| EP2121960A1 (de) | 2009-11-25 |
| CN101631872B (zh) | 2014-07-16 |
| HK1138623A1 (en) | 2010-08-27 |
| KR20090121310A (ko) | 2009-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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