ATE439357T1 - Indolylderivate als liver-x-rezeptormodulatoren - Google Patents

Indolylderivate als liver-x-rezeptormodulatoren

Info

Publication number: ATE439357T1
Authority: AT; Austria
Prior art keywords: liver; receptor modulators; indolyl derivatives; indolyl; derivatives
Prior art date: 2004-05-03

Application number

AT05751959T

Other languages

English (en)

Inventor

Henrietta Dehmlow

Bernd Kuhn

Narendra Panday

Hasane Ratni

Tanja Schulz-Gasch

Matthew Wright

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-03

Filing date

2005-04-26

Publication date

2009-08-15

2005-04-26 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-08-15 Application granted granted Critical

2009-08-15 Publication of ATE439357T1 publication Critical patent/ATE439357T1/de

Links

-1 INDOLYL Chemical class 0.000 title 1
102000004311 liver X receptors Human genes 0.000 title 1
108090000865 liver X receptors Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT05751959T 2004-05-03 2005-04-26 Indolylderivate als liver-x-rezeptormodulatoren ATE439357T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04101889		2004-05-03
PCT/EP2005/004454 WO2005105791A1 (en)	2004-05-03	2005-04-26	Indolyl derivatives as liver-x-receptor modulators

Publications (1)

Publication Number	Publication Date
ATE439357T1 true ATE439357T1 (de)	2009-08-15

Family

ID=34970495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05751959T ATE439357T1 (de)	2004-05-03	2005-04-26	Indolylderivate als liver-x-rezeptormodulatoren

Country Status (26)

Country	Link
US (2)	US7173048B2 (de)
EP (1)	EP1756096B1 (de)
JP (1)	JP4682192B2 (de)
KR (1)	KR100893449B1 (de)
CN (1)	CN1950365A (de)
AR (1)	AR049497A1 (de)
AT (1)	ATE439357T1 (de)
AU (1)	AU2005238176B2 (de)
BR (1)	BRPI0510599A (de)
CA (1)	CA2564563C (de)
DE (1)	DE602005015962D1 (de)
DK (1)	DK1756096T3 (de)
ES (1)	ES2329489T3 (de)
HR (1)	HRP20090533T1 (de)
IL (1)	IL178767A0 (de)
MX (1)	MXPA06012683A (de)
MY (1)	MY139571A (de)
NO (1)	NO20065503L (de)
NZ (1)	NZ550447A (de)
PL (1)	PL1756096T3 (de)
PT (1)	PT1756096E (de)
RU (1)	RU2368612C2 (de)
SI (1)	SI1756096T1 (de)
TW (1)	TWI287537B (de)
WO (1)	WO2005105791A1 (de)
ZA (1)	ZA200608886B (de)

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US20070219206A1 (en) *	2005-11-04	2007-09-20	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
US20070244128A1 (en) *	2005-11-04	2007-10-18	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
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US8399666B2 (en) *	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
ES2581765T3 (es)	2006-08-24	2016-09-07	University Of Tennessee Research Foundation	Acilanilidas sustituidas y métodos de uso de las mismas
JP5275236B2 (ja)	2006-09-29	2013-08-28	スミスクラインビーチャムコーポレーション	置換されたインドール化合物
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US7910583B2 (en) *	2007-05-04	2011-03-22	Bristol-Myers Squibb Company	[6,6] and [6,7]-bicyclic GPR119 G protein-coupled receptor agonists
ES2388315T3 (es)	2007-05-04	2012-10-11	Bristol-Myers Squibb Company	Agonistas [6,5]-bicíclicos de receptores GPR119 acoplados a la proteína G
EA016595B1 (ru) *	2007-07-17	2012-06-29	Бристол-Маерс Сквибб Компани	Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения
KR100918814B1 (ko) *	2007-10-04	2009-09-25	건국대학교 산학협력단	인쇄방법을 이용한 세라믹 전자부품 고속제조방법
TW200920369A (en) *	2007-10-26	2009-05-16	Amira Pharmaceuticals Inc	5-lipoxygenase activating protein (flap) inhibitor
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TW201006821A (en)	2008-07-16	2010-02-16	Bristol Myers Squibb Co	Pyridone and pyridazone analogues as GPR119 modulators
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
SG184168A1 (en)	2010-04-08	2012-10-30	Bristol Myers Squibb Co	Pyrimidinylpiperidinyloxypyridinone analogues as gpr119 modulators
US8940716B2 (en)	2010-05-06	2015-01-27	Bristol-Myers Squibb Company	Bicyclic heteroaryl compounds as GPR119 modulators
US8729084B2 (en)	2010-05-06	2014-05-20	Bristol-Myers Squibb Company	Benzofuranyl analogues as GPR119 modulators
RU2598842C2 (ru) *	2011-01-20	2016-09-27	Мерк Шарп Энд Домэ Корп.	Антагонисты рецептора минералокортикоидов
WO2013173198A1 (en)	2012-05-16	2013-11-21	Bristol-Myers Squibb Company	Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators
US9622992B2 (en)	2012-07-13	2017-04-18	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10987334B2 (en)	2012-07-13	2021-04-27	University Of Tennessee Research Foundation	Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10314807B2 (en)	2012-07-13	2019-06-11	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
LT2872482T (lt)	2012-07-13	2020-12-28	Oncternal Therapeutics, Inc.	Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi
US9744149B2 (en)	2012-07-13	2017-08-29	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en)	2012-07-13	2018-05-15	Gtx, Inc.	Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10258596B2 (en)	2012-07-13	2019-04-16	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
WO2014139388A1 (en) *	2013-03-14	2014-09-18	Merck Sharp & Dohme Corp.	Novel indole derivatives useful as anti-diabetic agents
WO2015061272A1 (en)	2013-10-22	2015-04-30	Bristol-Myers Squibb Company	Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
WO2015106164A1 (en)	2014-01-10	2015-07-16	Rgenix, Inc.	Lxr agonists and uses thereof
EP3402477A4 (de)	2016-01-11	2019-08-21	The Rockefeller University	Verfahren zur behandlung von erkrankungen im zusammenhang mit aus myeloid abgeleiteten suppressorzellen
CN106187899B (zh) *	2016-06-28	2019-07-16	绍兴文理学院	一种氟代氮杂芳烃的合成方法
JP7072557B2 (ja)	2016-07-22	2022-05-20	ブリストル－マイヤーズスクイブカンパニー	グルコキナーゼ活性化剤およびその使用方法
CA3078981A1 (en)	2017-11-21	2019-05-31	Rgenix, Inc.	Polymorphs and uses thereof
TWI748194B (zh) *	2018-06-28	2021-12-01	德商菲尼克斯Ｆｘｒ有限責任公司	含有雙環核心部分之新穎lxr調節劑
US20200085810A1 (en)	2018-07-26	2020-03-19	Hoffmann-La Roche Inc.	Compounds for use in treating kidney disorders
CN110305141B (zh) *	2019-07-18	2022-01-11	深圳市三启药物开发有限公司	一种螺(3,3’-异丙基吡咯烷氧化吲哚)类肝x受体调节剂及其制备方法和应用
TWI888447B (zh)	2019-12-13	2025-07-01	美商因思博納公司	金屬鹽及其用途
CN115028655B (zh) *	2022-05-20	2024-01-16	上海大学	一种2-三氟甲基-3-碘-吲哚类化合物及其制备方法

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2005
- 2005-04-26 DE DE602005015962T patent/DE602005015962D1/de not_active Expired - Lifetime
- 2005-04-26 BR BRPI0510599-4A patent/BRPI0510599A/pt not_active IP Right Cessation
- 2005-04-26 MX MXPA06012683A patent/MXPA06012683A/es active IP Right Grant
- 2005-04-26 EP EP05751959A patent/EP1756096B1/de not_active Expired - Lifetime
- 2005-04-26 AT AT05751959T patent/ATE439357T1/de active
- 2005-04-26 DK DK05751959T patent/DK1756096T3/da active
- 2005-04-26 KR KR1020067023014A patent/KR100893449B1/ko not_active Expired - Fee Related
- 2005-04-26 HR HR20090533T patent/HRP20090533T1/xx unknown
- 2005-04-26 SI SI200530765T patent/SI1756096T1/sl unknown
- 2005-04-26 JP JP2007511949A patent/JP4682192B2/ja not_active Expired - Fee Related
- 2005-04-26 CA CA2564563A patent/CA2564563C/en not_active Expired - Fee Related
- 2005-04-26 CN CNA2005800142069A patent/CN1950365A/zh active Pending
- 2005-04-26 PT PT05751959T patent/PT1756096E/pt unknown
- 2005-04-26 ES ES05751959T patent/ES2329489T3/es not_active Expired - Lifetime
- 2005-04-26 NZ NZ550447A patent/NZ550447A/en not_active IP Right Cessation
- 2005-04-26 RU RU2006142746/04A patent/RU2368612C2/ru not_active IP Right Cessation
- 2005-04-26 AU AU2005238176A patent/AU2005238176B2/en not_active Ceased
- 2005-04-26 WO PCT/EP2005/004454 patent/WO2005105791A1/en not_active Ceased
- 2005-04-26 PL PL05751959T patent/PL1756096T3/pl unknown
- 2005-04-27 US US11/115,942 patent/US7173048B2/en not_active Expired - Fee Related
- 2005-04-28 MY MYPI20051897A patent/MY139571A/en unknown
- 2005-04-29 AR ARP050101717A patent/AR049497A1/es unknown
- 2005-04-29 TW TW094113966A patent/TWI287537B/zh not_active IP Right Cessation
2006
- 2006-10-19 IL IL178767A patent/IL178767A0/en unknown
- 2006-10-25 ZA ZA200608886A patent/ZA200608886B/en unknown
- 2006-11-29 NO NO20065503A patent/NO20065503L/no not_active Application Discontinuation
- 2006-12-11 US US11/636,925 patent/US7485652B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU2006142746A (ru)	2008-06-10
PT1756096E (pt)	2009-10-16
ZA200608886B (en)	2008-06-25
NO20065503L (no)	2007-01-24
KR100893449B1 (ko)	2009-04-17
US20070099916A1 (en)	2007-05-03
DE602005015962D1 (de)	2009-09-24
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