ATE472544T1 - Als via-rezeptor-antagonisten verwendbare indole - Google Patents

Als via-rezeptor-antagonisten verwendbare indole

Info

Publication number
ATE472544T1
ATE472544T1 AT07847501T AT07847501T ATE472544T1 AT E472544 T1 ATE472544 T1 AT E472544T1 AT 07847501 T AT07847501 T AT 07847501T AT 07847501 T AT07847501 T AT 07847501T AT E472544 T1 ATE472544 T1 AT E472544T1
Authority
AT
Austria
Prior art keywords
indoles
usable
receptor antagonists
via receptor
antagonists
Prior art date
Application number
AT07847501T
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Raffaello Masciadri
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38983746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE472544(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE472544T1 publication Critical patent/ATE472544T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07847501T 2006-12-08 2007-11-29 Als via-rezeptor-antagonisten verwendbare indole ATE472544T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125663 2006-12-08
PCT/EP2007/062984 WO2008068184A1 (en) 2006-12-08 2007-11-29 Indoles which act as via receptor antagonists

Publications (1)

Publication Number Publication Date
ATE472544T1 true ATE472544T1 (de) 2010-07-15

Family

ID=38983746

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07847501T ATE472544T1 (de) 2006-12-08 2007-11-29 Als via-rezeptor-antagonisten verwendbare indole

Country Status (21)

Country Link
US (4) US7799923B2 (de)
EP (1) EP2089381B1 (de)
JP (1) JP2010511660A (de)
KR (1) KR101050558B1 (de)
CN (1) CN101541786A (de)
AR (1) AR064137A1 (de)
AT (1) ATE472544T1 (de)
AU (1) AU2007328994B2 (de)
BR (1) BRPI0720441A2 (de)
CA (1) CA2671324A1 (de)
CL (1) CL2007003503A1 (de)
DE (1) DE602007007512D1 (de)
ES (1) ES2345132T3 (de)
IL (1) IL198683A0 (de)
MX (1) MX2009005541A (de)
NO (1) NO20091832L (de)
PE (1) PE20081380A1 (de)
RU (1) RU2009120443A (de)
TW (1) TW200829570A (de)
WO (1) WO2008068184A1 (de)
ZA (1) ZA200903499B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008068183A1 (en) * 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Indoles
WO2008068184A1 (en) * 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Indoles which act as via receptor antagonists
PE20081401A1 (es) * 2006-12-28 2008-10-24 Hoffmann La Roche Derivados de indol como antagonistas de receptores vasopresina
EP2199967A1 (de) * 2008-12-08 2010-06-23 Electronics and Telecommunications Research Institute Vorrichtung zur Bereitstellung digitaler Inhalte mittels DMB-Kanal und Verfahren dafür
EP2956441A4 (de) * 2013-02-18 2016-11-02 Scripps Research Inst Modulatoren der vasopressin-rezeptoren mit therapeutischem potenzial
GB201521059D0 (en) * 2015-11-30 2016-01-13 Isis Innovation Inhibitors of metallo-beta-lactamases
JP2022530474A (ja) * 2019-04-26 2022-06-29 ジェネロス バイオファーマ リミテッド 複素環含有化合物、その使用及びそれを含む組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5924990B2 (ja) * 1979-11-21 1984-06-13 協和醗酵工業株式会社 新規なピペリジン誘導体
TW199153B (de) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
ATE216580T1 (de) * 1993-07-16 2002-05-15 Merck & Co Inc Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten
CO5150201A1 (es) 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
US6911448B2 (en) 2000-05-12 2005-06-28 Solvay Pharmaceuticals B.V. Piperazine and piperidine compounds
AU2003301436A1 (en) 2002-10-17 2004-05-04 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
BRPI0612988A2 (pt) 2005-07-14 2010-12-14 Hoffmann La Roche derivados de indol-3-il-carbonil-espiro-piperidina como antagonistas de receptor v1a
PT1912976E (pt) * 2005-07-21 2009-01-07 Hoffmann La Roche Derivados de indol-3-il-carboni-piperidin-benzimidazole como antagonistas dos receptores v1a
ATE488519T1 (de) * 2005-09-28 2010-12-15 Hoffmann La Roche Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten
WO2008068184A1 (en) * 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Indoles which act as via receptor antagonists

Also Published As

Publication number Publication date
BRPI0720441A2 (pt) 2014-01-07
AU2007328994B2 (en) 2012-03-08
ZA200903499B (en) 2010-03-31
WO2008068184A1 (en) 2008-06-12
MX2009005541A (es) 2009-06-05
AU2007328994A1 (en) 2008-06-12
US8071622B2 (en) 2011-12-06
US20080269290A1 (en) 2008-10-30
ES2345132T3 (es) 2010-09-15
IL198683A0 (en) 2010-02-17
EP2089381B1 (de) 2010-06-30
CN101541786A (zh) 2009-09-23
CL2007003503A1 (es) 2008-07-04
KR101050558B1 (ko) 2011-07-19
RU2009120443A (ru) 2011-01-20
AR064137A1 (es) 2009-03-18
US20080139548A1 (en) 2008-06-12
PE20081380A1 (es) 2008-09-18
JP2010511660A (ja) 2010-04-15
DE602007007512D1 (de) 2010-08-12
CA2671324A1 (en) 2008-06-12
TW200829570A (en) 2008-07-16
US20080139617A1 (en) 2008-06-12
KR20090078368A (ko) 2009-07-17
EP2089381A1 (de) 2009-08-19
US20080139618A1 (en) 2008-06-12
NO20091832L (no) 2009-07-07
US7799923B2 (en) 2010-09-21

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