ATE513916T1 - Deletionsmutante von neisseria glycosyltransferase für die oligosaccharidebiosynthese, und deren gene - Google Patents

Deletionsmutante von neisseria glycosyltransferase für die oligosaccharidebiosynthese, und deren gene

Info

Publication number
ATE513916T1
ATE513916T1 AT05076067T AT05076067T ATE513916T1 AT E513916 T1 ATE513916 T1 AT E513916T1 AT 05076067 T AT05076067 T AT 05076067T AT 05076067 T AT05076067 T AT 05076067T AT E513916 T1 ATE513916 T1 AT E513916T1
Authority
AT
Austria
Prior art keywords
beta
glycosyltransferases
mimic
glycosyltransferase
neisseria
Prior art date
Application number
AT05076067T
Other languages
English (en)
Inventor
Emil C Gotschlich
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of ATE513916T1 publication Critical patent/ATE513916T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
AT05076067T 1994-09-26 1995-09-25 Deletionsmutante von neisseria glycosyltransferase für die oligosaccharidebiosynthese, und deren gene ATE513916T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/312,387 US5545553A (en) 1994-09-26 1994-09-26 Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them

Publications (1)

Publication Number Publication Date
ATE513916T1 true ATE513916T1 (de) 2011-07-15

Family

ID=23211210

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05076067T ATE513916T1 (de) 1994-09-26 1995-09-25 Deletionsmutante von neisseria glycosyltransferase für die oligosaccharidebiosynthese, und deren gene
AT95934548T ATE435290T1 (de) 1994-09-26 1995-09-25 Glycosyltransferasen für die biosynthese von oligosacchariden und dafür kodierende gene

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95934548T ATE435290T1 (de) 1994-09-26 1995-09-25 Glycosyltransferasen für die biosynthese von oligosacchariden und dafür kodierende gene

Country Status (10)

Country Link
US (9) US5545553A (de)
EP (2) EP0784688B1 (de)
JP (2) JP3756182B2 (de)
KR (1) KR100465892B1 (de)
AT (2) ATE513916T1 (de)
CA (2) CA2200973A1 (de)
DE (1) DE69535975D1 (de)
ES (1) ES2371440T3 (de)
MX (1) MX9702351A (de)
WO (1) WO1996010086A1 (de)

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JP3756182B2 (ja) 2006-03-15
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AU714684B2 (en) 2000-01-06
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US5545553A (en) 1996-08-13
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US6342382B1 (en) 2002-01-29
EP0784688A1 (de) 1997-07-23
US20040043464A1 (en) 2004-03-04
US8268596B2 (en) 2012-09-18
US5798233A (en) 1998-08-25
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US5945322A (en) 1999-08-31
US6780624B2 (en) 2004-08-24
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US20100316675A1 (en) 2010-12-16
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