ATE514423T1 - Therapeutische verwendung von yessotoxin als wachstumshemmer für humane tumorzellen - Google Patents

Therapeutische verwendung von yessotoxin als wachstumshemmer für humane tumorzellen

Info

Publication number: ATE514423T1
Authority: AT; Austria
Prior art keywords: yessotoxin; tumor cells; therapeutic use; human tumor; growth inhibitor
Prior art date: 2003-07-25

Application number

AT07017630T

Other languages

English (en)

Inventor

Lopez Luis Miguel Botana

Rancano Amparo Alfonso

Vieytes Mercedes Rodriguez

Garcia Maria Isabel Loza

Original Assignee

Cifga S A Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-25

Filing date

2004-07-21

Publication date

2011-07-15

2004-07-21 Application filed by Cifga S A Lab filed Critical Cifga S A Lab

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE514423T1 publication Critical patent/ATE514423T1/de

Links

239000002463 yessotoxin Substances 0.000 title abstract 5
HCYDZFJGUKMTQB-AVHIVUAZSA-N yessotoxin Chemical compound C[C@H]([C@H]1O[C@H]2[C@@H](O)[C@@]3(C)O[C@H]4CC(=C)[C@H](O[C@@H]4C[C@@H]3O[C@@H]2C[C@@H]1O[C@@H]1C2)[C@](C)(O)\C=C\C(=C)CC=C)CC[C@]1(C)O[C@@]1(C)[C@H]2O[C@@H]2C[C@@H]3O[C@@H]4C[C@@H]5O[C@](C)(CCOS(O)(=O)=O)[C@@H](OS(O)(=O)=O)C[C@H]5O[C@H]4C[C@H]3O[C@H]2CC1 HCYDZFJGUKMTQB-AVHIVUAZSA-N 0.000 title abstract 4
QFTUOYVQWREZMQ-UHFFFAOYSA-N yessotoxin Natural products CC1CC2(C)OC3(C)CCC4OC5CC6OC7CC(OS(=O)(=O)O)C(C)(CCOS(=O)(=O)O)OC7CC6OC5CC4OC3CC2OC8CC9(C)OC%10CC%11OC(C(=C)CC%11OC%10(C)C(O)C9OC18)C(C)(O)C=CC(=C)CC=C QFTUOYVQWREZMQ-UHFFFAOYSA-N 0.000 title abstract 4
239000003966 growth inhibitor Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1
230000004913 activation Effects 0.000 abstract 3
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
230000000172 allergic effect Effects 0.000 abstract 2
208000006673 asthma Diseases 0.000 abstract 2
208000010668 atopic eczema Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
241000700159 Rattus Species 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
230000001086 cytosolic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229960001340 histamine Drugs 0.000 abstract 1
210000003630 histaminocyte Anatomy 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Transplantation (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

AT07017630T 2003-07-25 2004-07-21 Therapeutische verwendung von yessotoxin als wachstumshemmer für humane tumorzellen ATE514423T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES200301773A ES2235611B2 (es)	2003-07-25	2003-07-25	Metodo cuantitativo para la deteccion de yesotoxinas en productos pesqueros basado en la activacion que producen en las fosfodiesterasas.

Publications (1)

Publication Number	Publication Date
ATE514423T1 true ATE514423T1 (de)	2011-07-15

Family

ID=34112518

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT04742071T ATE393833T1 (de)	2003-07-25	2004-07-21	Quantitatives verfahren zum nachweis von yessotoxinen in fischprodukten auf grundlage der durch das toxin verursachten aktivierung zellulärer phosphodiesterase
AT07017630T ATE514423T1 (de)	2003-07-25	2004-07-21	Therapeutische verwendung von yessotoxin als wachstumshemmer für humane tumorzellen
AT07017631T ATE524174T1 (de)	2003-07-25	2004-07-21	Einsatz von yessotoxin bei der behandlung allergischer und asthmatischer leiden

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT04742071T ATE393833T1 (de)	2003-07-25	2004-07-21	Quantitatives verfahren zum nachweis von yessotoxinen in fischprodukten auf grundlage der durch das toxin verursachten aktivierung zellulärer phosphodiesterase

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT07017631T ATE524174T1 (de)	2003-07-25	2004-07-21	Einsatz von yessotoxin bei der behandlung allergischer und asthmatischer leiden

Country Status (12)

Country	Link
US (1)	US20110065138A1 (de)
EP (3)	EP1875907B1 (de)
JP (2)	JP2006528483A (de)
CN (1)	CN1852988A (de)
AT (3)	ATE393833T1 (de)
AU (3)	AU2004260895A1 (de)
BR (1)	BRPI0412832A (de)
CA (1)	CA2533600A1 (de)
DE (1)	DE602004013446D1 (de)
ES (4)	ES2235611B2 (de)
RU (1)	RU2389488C2 (de)
WO (1)	WO2005012543A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101382531B (zh) *	2008-10-08	2011-12-28	天津商业大学	利用电子鼻检测虾新鲜度的方法
ES2393696B2 (es) *	2012-09-07	2013-06-04	Universidade De Santiago De Compostela	Uso de la Yessotoxina y sus derivados para el tratamiento de gliomas
CN105198900A (zh) *	2015-09-22	2015-12-30	国家海洋环境检测中心	虾夷扇贝毒素ytx纯品的提取、制备方法
US10890573B2 (en)	2017-12-19	2021-01-12	International Business Machines Corporation	Facile methods to detect toxin in seafood
RU2716233C1 (ru) *	2018-11-13	2020-03-10	Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр питания, биотехнологии и безопасности пищи"	Способ количественного определения йессотоксинов в моллюсках

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5672509A (en) *	1993-08-25	1997-09-30	Pfizer Inc.	hPDE IV-C: a human phosphodiesterase IV isozyme
US5858694A (en) *	1997-05-30	1999-01-12	Cell Pathways, Inc.	Method for identifying compounds for inhibition of cancerous lesions
WO1999035283A1 (en) *	1997-12-15	1999-07-15	Beth Israel Deaconess Medical Center	Methods and reagents for modulating cell motility
RU2136278C1 (ru) *	1998-04-07	1999-09-10	Государственный научный центр вирусологии и биотехнологии "Вектор"	Противоопухолевое средство
PL205134B1 (pl) *	2000-03-27	2010-03-31	Scripps Research Inst	Pochodne glicylolizyny, preparat farmaceutyczny i zastosowanie pochodnych glicylolizyny
IT1318605B1 (it)	2000-06-30	2003-08-27	Uni Degli Studi Di Modena E Re	Procedimoento per il dosaggio di tossine dsp del gruppo delledinophysitossine e delle yessottossine.
US6977155B2 (en) *	2000-08-10	2005-12-20	Corning Incorporated	Arrays of biological membranes and methods and use thereof
AR033680A1 (es) *	2000-08-30	2004-01-07	Schering Corp	Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales
EP1251181A1 (de) *	2001-04-20	2002-10-23	Warner-Lambert Company	Nicht-rekombinante Zelllinien fähig zur überwiegende Expression der Subtyp B der zyklisch Nukleotide Phosphodiesterase (PDE4) und ihre Verwendung zum Screenen von PDE4 Subtyp-spezifische Modulatoren

2003
- 2003-07-25 ES ES200301773A patent/ES2235611B2/es not_active Expired - Fee Related
2004
- 2004-07-21 CN CNA200480021338XA patent/CN1852988A/zh active Pending
- 2004-07-21 CA CA002533600A patent/CA2533600A1/en not_active Abandoned
- 2004-07-21 AU AU2004260895A patent/AU2004260895A1/en not_active Abandoned
- 2004-07-21 AT AT04742071T patent/ATE393833T1/de not_active IP Right Cessation
- 2004-07-21 EP EP07017631A patent/EP1875907B1/de not_active Expired - Lifetime
- 2004-07-21 BR BRPI0412832-0A patent/BRPI0412832A/pt not_active Application Discontinuation
- 2004-07-21 JP JP2006520848A patent/JP2006528483A/ja active Pending
- 2004-07-21 WO PCT/ES2004/000343 patent/WO2005012543A2/es not_active Ceased
- 2004-07-21 EP EP07017630A patent/EP1875906B1/de not_active Expired - Lifetime
- 2004-07-21 US US10/566,050 patent/US20110065138A1/en not_active Abandoned
- 2004-07-21 ES ES07017630T patent/ES2368872T3/es not_active Expired - Lifetime
- 2004-07-21 DE DE602004013446T patent/DE602004013446D1/de not_active Expired - Lifetime
- 2004-07-21 RU RU2006101631/15A patent/RU2389488C2/ru not_active IP Right Cessation
- 2004-07-21 AT AT07017630T patent/ATE514423T1/de not_active IP Right Cessation
- 2004-07-21 AT AT07017631T patent/ATE524174T1/de not_active IP Right Cessation
- 2004-07-21 EP EP04742071A patent/EP1647599B1/de not_active Expired - Lifetime
- 2004-12-10 ES ES200402944A patent/ES2259894B2/es not_active Expired - Fee Related
- 2004-12-10 ES ES200402943A patent/ES2259266B2/es not_active Expired - Fee Related
2006
- 2006-03-27 JP JP2006084989A patent/JP2006325580A/ja active Pending
2010
- 2010-05-31 AU AU2010202232A patent/AU2010202232A1/en not_active Abandoned
- 2010-05-31 AU AU2010202237A patent/AU2010202237A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20110065138A1 (en)	2011-03-17
CN1852988A (zh)	2006-10-25
ES2259266B2 (es)	2008-06-01
RU2006101631A (ru)	2006-08-27
ES2259894B2 (es)	2008-11-16
EP1875907A3 (de)	2008-02-27
AU2010202237A1 (en)	2010-06-24
EP1875907A2 (de)	2008-01-09
ES2368872T3 (es)	2011-11-23
WO2005012543A2 (es)	2005-02-10
JP2006325580A (ja)	2006-12-07
RU2389488C2 (ru)	2010-05-20
ATE524174T1 (de)	2011-09-15
BRPI0412832A (pt)	2006-11-21
DE602004013446D1 (de)	2008-06-12
ES2259894A1 (es)	2006-10-16
AU2004260895A1 (en)	2005-02-10
EP1647599A2 (de)	2006-04-19
EP1875907B1 (de)	2011-09-14
CA2533600A1 (en)	2005-02-10
AU2010202232A1 (en)	2010-07-08
ES2259266A1 (es)	2006-09-16
EP1875906B1 (de)	2011-06-29
ES2235611A1 (es)	2005-07-01
WO2005012543A3 (es)	2005-03-17
JP2006528483A (ja)	2006-12-21
EP1647599B1 (de)	2008-04-30
ES2235611B2 (es)	2006-07-16
EP1875906A3 (de)	2008-02-27
ATE393833T1 (de)	2008-05-15
EP1875906A2 (de)	2008-01-09

Legal Events

Date	Code	Title	Description
2011-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE406351T1 (de)	2008-09-15	Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren
DK1583541T3 (da)	2011-04-11	Forbindelser og fremgangsmåder til at øge neurogenese
DE602004014117D1 (de)	2008-07-10	Thiazole zur verwendung als inhibitoren von protein-kinasen
DE60334651D1 (de)	2010-12-02	Nicotinamide und deren Verwendung als P38 Inhibitoren
CY1109763T1 (el)	2014-09-10	Υλικα και μεθοδος για τη θεραπεια διαταραχων πηξης
BR0314059A (pt)	2005-07-05	Compostos heterocìclicos
DE60233140D1 (de)	2009-09-10	Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
ATE441418T1 (de)	2009-09-15	Verwendung von treprostinil zur verbesserung der nierenfunktion
UY27872A1 (es)	2003-12-31	Inhibidores de caspasa y usos de los mismos.
DE602004031614D1 (de)	2011-04-14	Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs
DE50208008D1 (de)	2006-10-12	Tiotropiumsalze zur behandlung von entzündlichen erkrankungen
BRPI0512916A (pt)	2008-04-15	derivado de tienopirazol tendo atividade inibidora de pde 7
DE60219614D1 (de)	2007-05-31	3, 7 thiaprostansäurederivate als mittel zur verminderung des augeninnendruckes
ATE446102T1 (de)	2009-11-15	Behandlung von gewichtsverlust bei patienten mit entzündlichen darmerkrankungen mittels s. boulardii
ATE464895T1 (de)	2010-05-15	Verwendung von benzokondensierten heterocyclischen sulfamid-derivaten zur behandlung von depressionen
DK1478380T3 (da)	2006-11-27	Anvendelse af tyrosinkinase-inhibitorer til behandling af CNS-lidelser
ATE514423T1 (de)	2011-07-15	Therapeutische verwendung von yessotoxin als wachstumshemmer für humane tumorzellen
ZA200701850B (en)	2008-08-27	Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
ATE460166T1 (de)	2010-03-15	Chinazolinderivate und ihre verwendung bei der behandlung von thrombocythämie
ATE512146T1 (de)	2011-06-15	Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen
EA200701017A1 (ru)	2007-10-26	Применение рибозы-цистеина для лечения гипоксии
RU2008129782A (ru)	2010-01-27	Противовирусное соединение
PE20060618A1 (es)	2006-07-14	Derivados de triazolopiridinilsulfanilo como inhibidores de quinasa map p38
SE0100873D0 (sv)	2001-03-13	Method of treatment
ATE296631T1 (de)	2005-06-15	Verwendung von pde5 inhibitoren zur behandlung vorzeitiger ejakulation