ATE514425T1 - Heterocyclische derivate zur verwendung als modulatoren der opioid-rezeptoren - Google Patents
Heterocyclische derivate zur verwendung als modulatoren der opioid-rezeptorenInfo
- Publication number
- ATE514425T1 ATE514425T1 AT03719805T AT03719805T ATE514425T1 AT E514425 T1 ATE514425 T1 AT E514425T1 AT 03719805 T AT03719805 T AT 03719805T AT 03719805 T AT03719805 T AT 03719805T AT E514425 T1 ATE514425 T1 AT E514425T1
- Authority
- AT
- Austria
- Prior art keywords
- modulators
- opioid receptors
- heterocyclic derivatives
- opioid
- disorders
- Prior art date
Links
- 102000003840 Opioid Receptors Human genes 0.000 title abstract 2
- 108090000137 Opioid Receptors Proteins 0.000 title abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37640602P | 2002-04-29 | 2002-04-29 | |
| US10/400,006 US7041681B2 (en) | 2002-04-29 | 2003-03-26 | Compounds as opioid receptor modulators |
| PCT/US2003/011872 WO2003092688A2 (en) | 2002-04-29 | 2003-04-17 | Heterocyclic derivatives as opioid modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE514425T1 true ATE514425T1 (de) | 2011-07-15 |
Family
ID=29406753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03719805T ATE514425T1 (de) | 2002-04-29 | 2003-04-17 | Heterocyclische derivate zur verwendung als modulatoren der opioid-rezeptoren |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US7041681B2 (de) |
| EP (2) | EP1499313B1 (de) |
| JP (1) | JP4969039B2 (de) |
| KR (2) | KR101287409B1 (de) |
| CN (2) | CN101255131B (de) |
| AT (1) | ATE514425T1 (de) |
| AU (3) | AU2003223664A1 (de) |
| BR (1) | BRPI0309708B1 (de) |
| CA (3) | CA2753371C (de) |
| CY (1) | CY1111858T1 (de) |
| DK (1) | DK1499313T3 (de) |
| ES (2) | ES2366471T3 (de) |
| HR (2) | HRP20130893A2 (de) |
| HU (1) | HUE031331T2 (de) |
| IL (2) | IL164910A (de) |
| MX (1) | MXPA04011947A (de) |
| NO (3) | NO332722B1 (de) |
| NZ (2) | NZ561795A (de) |
| PL (2) | PL219912B1 (de) |
| PT (1) | PT1499313E (de) |
| RU (1) | RU2332411C2 (de) |
| SI (1) | SI1499313T1 (de) |
| WO (1) | WO2003092688A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041681B2 (en) * | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
| KR101166342B1 (ko) | 2004-03-15 | 2012-07-18 | 얀센 파마슈티카 엔.브이. | 아편계 약물 수용체 조절자로서의 신규의 화합물 |
| ES2535048T3 (es) * | 2005-03-14 | 2015-05-04 | Janssen Pharmaceutica Nv | Proceso para la preparación de moduladores de opioides |
| DE102005050497A1 (de) * | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Difluorphenol-Derivate und ihre Verwendung |
| US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| JP2010500372A (ja) * | 2006-08-09 | 2010-01-07 | スミスクライン ビーチャム コーポレーション | オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物 |
| TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| AU2010313392B2 (en) * | 2009-10-30 | 2015-07-09 | Janssen Pharmaceutica Nv | Pyrazines as delta opioid receptor modulators |
| US8642622B2 (en) | 2010-06-16 | 2014-02-04 | Bristol-Myers Squibb Company | Piperidinyl compound as a modulator of chemokine receptor activity |
| US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
| CA2996281C (en) * | 2015-08-31 | 2022-03-08 | Regents Of The University Of Minnesota | Opioid receptor modulators and use thereof |
| CN109563133B (zh) * | 2016-09-27 | 2020-09-11 | 四川科伦博泰生物医药股份有限公司 | 多酰胺化合物及其用途 |
| CN106866463B (zh) * | 2017-01-24 | 2018-08-28 | 富乐马鸿凯（大连）医药有限公司 | 艾沙度林中间体的制备方法 |
| CA3018321A1 (en) | 2017-09-25 | 2019-03-25 | Apotex Inc. | Novel crystalline form of eluxadoline |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE584914A (de) | 1958-11-24 | |||
| CH543479A (de) | 1970-05-06 | 1973-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Phenyläthylaminderivaten |
| GB2146026A (en) | 1983-09-07 | 1985-04-11 | Tanabe Seiyaku Co | Peptides and process for preparing the same |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| JPH05339240A (ja) | 1992-06-04 | 1993-12-21 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロイソキノリンアミド誘導体 |
| SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
| FR2735776B1 (fr) | 1995-06-22 | 1997-07-18 | Synthelabo | Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique |
| GB9609976D0 (en) * | 1996-05-13 | 1996-07-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| US6451806B2 (en) * | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
| US6916905B2 (en) | 2000-03-24 | 2005-07-12 | The United States Of America As Represented By The Department Of Health And Human Services | Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use |
| AU2479702A (en) * | 2000-10-30 | 2002-05-15 | Janssen Pharmaceutica Nv | Tripeptidyl peptidase inhibitors |
| US7041681B2 (en) * | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
| ES2535048T3 (es) * | 2005-03-14 | 2015-05-04 | Janssen Pharmaceutica Nv | Proceso para la preparación de moduladores de opioides |
-
2003
- 2003-03-26 US US10/400,006 patent/US7041681B2/en not_active Expired - Lifetime
- 2003-04-17 JP JP2004500872A patent/JP4969039B2/ja not_active Expired - Fee Related
- 2003-04-17 PL PL396160A patent/PL219912B1/pl unknown
- 2003-04-17 CN CN2008100865985A patent/CN101255131B/zh not_active Expired - Lifetime
- 2003-04-17 DK DK03719805.8T patent/DK1499313T3/da active
- 2003-04-17 AU AU2003223664A patent/AU2003223664A1/en not_active Abandoned
- 2003-04-17 ES ES03719805T patent/ES2366471T3/es not_active Expired - Lifetime
- 2003-04-17 AT AT03719805T patent/ATE514425T1/de active
- 2003-04-17 CN CN038151995A patent/CN1665501B/zh not_active Expired - Lifetime
- 2003-04-17 HR HRP20130893AA patent/HRP20130893A2/hr not_active Application Discontinuation
- 2003-04-17 HR HRP20041014AA patent/HRP20041014B1/hr not_active IP Right Cessation
- 2003-04-17 PL PL374053A patent/PL211163B1/pl unknown
- 2003-04-17 CA CA2753371A patent/CA2753371C/en not_active Expired - Lifetime
- 2003-04-17 CA CA2483662A patent/CA2483662C/en not_active Expired - Lifetime
- 2003-04-17 KR KR1020047017395A patent/KR101287409B1/ko not_active Expired - Lifetime
- 2003-04-17 ES ES10180687.5T patent/ES2608840T3/es not_active Expired - Lifetime
- 2003-04-17 PT PT03719805T patent/PT1499313E/pt unknown
- 2003-04-17 WO PCT/US2003/011872 patent/WO2003092688A2/en not_active Ceased
- 2003-04-17 SI SI200332038T patent/SI1499313T1/sl unknown
- 2003-04-17 BR BRPI0309708A patent/BRPI0309708B1/pt not_active IP Right Cessation
- 2003-04-17 NZ NZ561795A patent/NZ561795A/en not_active IP Right Cessation
- 2003-04-17 EP EP03719805A patent/EP1499313B1/de not_active Expired - Lifetime
- 2003-04-17 KR KR1020137005624A patent/KR101377078B1/ko not_active Expired - Fee Related
- 2003-04-17 CA CA2883629A patent/CA2883629A1/en not_active Abandoned
- 2003-04-17 NZ NZ575640A patent/NZ575640A/en not_active IP Right Cessation
- 2003-04-17 MX MXPA04011947A patent/MXPA04011947A/es active IP Right Grant
- 2003-04-17 HU HUE10180687A patent/HUE031331T2/hu unknown
- 2003-04-17 EP EP10180687.5A patent/EP2275105B1/de not_active Expired - Lifetime
- 2003-04-17 RU RU2004131829/04A patent/RU2332411C2/ru active
-
2004
- 2004-10-28 IL IL164910A patent/IL164910A/en active IP Right Grant
- 2004-11-25 NO NO20045159A patent/NO332722B1/no not_active IP Right Cessation
-
2005
- 2005-03-14 US US11/079,573 patent/US7202381B2/en not_active Expired - Lifetime
- 2005-10-04 US US11/242,763 patent/US7659402B2/en not_active Expired - Lifetime
-
2009
- 2009-03-17 IL IL197642A patent/IL197642A/en active IP Right Grant
- 2009-11-05 AU AU2009233679A patent/AU2009233679B2/en not_active Expired
-
2011
- 2011-05-20 AU AU2011202364A patent/AU2011202364B2/en not_active Expired
- 2011-09-22 CY CY20111100920T patent/CY1111858T1/el unknown
-
2012
- 2012-07-09 NO NO20120788A patent/NO335607B1/no not_active IP Right Cessation
-
2014
- 2014-04-24 NO NO20140530A patent/NO20140530L/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1111858T1 (el) | Ετεροκυκλικα παραγωγα ως διαμορφωτες υποδοχεα οπιοειδων | |
| ATE349434T1 (de) | Lactamderivaten zur verwendung als humane 11cby rezeptorantagonisten | |
| CY1110362T1 (el) | Ν-(2-αρυλαιθυλο)βενζυλαμινες ως ανταγωνιστες του 5-ητ6 υποδοχεα | |
| NO20072965L (no) | Potentiatorer av glutamatreceptorer | |
| CY1111469T1 (el) | ΧΡΗΣΗ ΠΑΡΑΓΩΓΩΝ 3-ΦΑΙΝΥΛΘΕΙΟ-1Η-ΙΝΔΟΛΗ-1-ΟΞΙΚΟΥ ΟΞΕΟΣ ΩΣ ΡΥΘΜΙΣΤΕΣ ΤΗΣ ΔΡΑΣΗΣ ΤΟΥ ΥΠΟΔΟΧΕΑ CRTh2 | |
| CY1109416T1 (el) | Συμπυκνωμενες ετεροκυκλικες ενωσεις ως ρυθμιστες υποδοχεα σεροτονινης | |
| EA200301142A1 (ru) | Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6 | |
| CY1105705T1 (el) | Παραγωγα ινδολυλαλκυλαμινης σαν συνδετηρες 5-υδροξυτρυπταμινης-6 | |
| DE60230683D1 (de) | 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat | |
| ATE356623T1 (de) | 5-ht3-rezeptorantagonisten und verwendungsverfahren | |
| CY1108837T1 (el) | ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5 | |
| GEP20084494B (en) | New heterocyclic carboxylic acid amide derivatives | |
| DE60131001D1 (de) | Oxazolylarylpropionsäure derivate und ihre verwendung als ppar agonisten | |
| DE602006017837D1 (de) | Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors | |
| DE60231568D1 (de) | Verwendung von Pyrrolederivaten gegen Angstzustände | |
| UA87962C2 (ru) | Соединения как модуляторы опиоидного рецептора | |
| EA200600416A1 (ru) | Производные циклопропила в качестве антагонистов рецептора nk3 | |
| ATE487481T1 (de) | N-(4-oxo-3,4-dihydrochinazolin-2-yl)butanamide als androgenrezeptormodulatoren | |
| ATE362368T1 (de) | Substituierte piperidin- und piperazin-derivative als melanocortin-4 receptor modulatoren | |
| DE602005019090D1 (de) | Pyrrolidin-2-on-Derivate zur Verwendung als DP1-Rezeptoragonisten | |
| CY1117548T1 (el) | Ν-(2-αρυλαιθυλο)βενζυλαμινες ως ανταγωνιστες του 5-ηt6 υποδοχεα |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1499313 Country of ref document: EP |