PL396160A1 - Pochodna heterocykliczna i jej zastosowanie - Google Patents

Pochodna heterocykliczna i jej zastosowanie

Info

Publication number: PL396160A1
Authority: PL; Poland
Prior art keywords: application; heterocyclic derivative; opioid; disorders; antagonists
Prior art date: 2002-04-29

Application number

PL396160A

Other languages

English (en)

Other versions

PL219912B1 (pl

Inventor

Henry J. Breslin

Wei He

Robert W. Kavash

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2003-04-17

Publication date

2012-01-16

2003-04-17 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2012-01-16 Publication of PL396160A1 publication Critical patent/PL396160A1/pl

2015-07-31 Publication of PL219912B1 publication Critical patent/PL219912B1/pl

Links

125000000623 heterocyclic group Chemical group 0.000 title 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
102000003840 Opioid Receptors Human genes 0.000 abstract 1
108090000137 Opioid Receptors Proteins 0.000 abstract 1
208000027520 Somatoform disease Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
208000027753 pain disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL396160A 2002-04-29 2003-04-17 Pochodna heterocykliczna i jej zastosowanie PL219912B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37640602P	2002-04-29	2002-04-29
US10/400,006 US7041681B2 (en)	2002-04-29	2003-03-26	Compounds as opioid receptor modulators

Publications (2)

Publication Number	Publication Date
PL396160A1 true PL396160A1 (pl)	2012-01-16
PL219912B1 PL219912B1 (pl)	2015-07-31

Family

ID=29406753

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL396160A PL219912B1 (pl)	2002-04-29	2003-04-17	Pochodna heterocykliczna i jej zastosowanie
PL374053A PL211163B1 (pl)	2002-04-29	2003-04-17	Pochodna heterocykliczna i związek pośredni

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL374053A PL211163B1 (pl)	2002-04-29	2003-04-17	Pochodna heterocykliczna i związek pośredni

Country Status (23)

Country	Link
US (3)	US7041681B2 (pl)
EP (2)	EP1499313B1 (pl)
JP (1)	JP4969039B2 (pl)
KR (2)	KR101287409B1 (pl)
CN (2)	CN101255131B (pl)
AT (1)	ATE514425T1 (pl)
AU (3)	AU2003223664A1 (pl)
BR (1)	BRPI0309708B1 (pl)
CA (3)	CA2753371C (pl)
CY (1)	CY1111858T1 (pl)
DK (1)	DK1499313T3 (pl)
ES (2)	ES2366471T3 (pl)
HR (2)	HRP20130893A2 (pl)
HU (1)	HUE031331T2 (pl)
IL (2)	IL164910A (pl)
MX (1)	MXPA04011947A (pl)
NO (3)	NO332722B1 (pl)
NZ (2)	NZ561795A (pl)
PL (2)	PL219912B1 (pl)
PT (1)	PT1499313E (pl)
RU (1)	RU2332411C2 (pl)
SI (1)	SI1499313T1 (pl)
WO (1)	WO2003092688A2 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7041681B2 (en) *	2002-04-29	2006-05-09	Janssen Pharmaceutica N.V.	Compounds as opioid receptor modulators
KR101166342B1 (ko)	2004-03-15	2012-07-18	얀센 파마슈티카 엔.브이.	아편계 약물 수용체 조절자로서의 신규의 화합물
ES2535048T3 (es) *	2005-03-14	2015-05-04	Janssen Pharmaceutica Nv	Proceso para la preparación de moduladores de opioides
DE102005050497A1 (de) *	2005-10-21	2007-04-26	Bayer Healthcare Ag	Difluorphenol-Derivate und ihre Verwendung
US7601844B2 (en)	2006-01-27	2009-10-13	Bristol-Myers Squibb Company	Piperidinyl derivatives as modulators of chemokine receptor activity
US7615556B2 (en)	2006-01-27	2009-11-10	Bristol-Myers Squibb Company	Piperazinyl derivatives as modulators of chemokine receptor activity
JP2010500372A (ja) *	2006-08-09	2010-01-07	スミスクラインビーチャムコーポレーション	オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物
TWI433838B (zh)	2008-06-25	2014-04-11	必治妥美雅史谷比公司	作為趨化因子受體活性調節劑之六氫吡啶衍生物
AU2010313392B2 (en) *	2009-10-30	2015-07-09	Janssen Pharmaceutica Nv	Pyrazines as delta opioid receptor modulators
US8642622B2 (en)	2010-06-16	2014-02-04	Bristol-Myers Squibb Company	Piperidinyl compound as a modulator of chemokine receptor activity
US9675587B2 (en)	2013-03-14	2017-06-13	Allergan Holdings Unlimited Company	Opioid receptor modulator dosage formulations
CA2996281C (en) *	2015-08-31	2022-03-08	Regents Of The University Of Minnesota	Opioid receptor modulators and use thereof
CN109563133B (zh) *	2016-09-27	2020-09-11	四川科伦博泰生物医药股份有限公司	多酰胺化合物及其用途
CN106866463B (zh) *	2017-01-24	2018-08-28	富乐马鸿凯（大连）医药有限公司	艾沙度林中间体的制备方法
CA3018321A1 (en)	2017-09-25	2019-03-25	Apotex Inc.	Novel crystalline form of eluxadoline

Family Cites Families (13)

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BE584914A (pl)	1958-11-24
CH543479A (de)	1970-05-06	1973-10-31	Hoffmann La Roche	Verfahren zur Herstellung von Phenyläthylaminderivaten
GB2146026A (en)	1983-09-07	1985-04-11	Tanabe Seiyaku Co	Peptides and process for preparing the same
US5159081A (en)	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
JPH05339240A (ja)	1992-06-04	1993-12-21	Yamanouchi Pharmaceut Co Ltd	テトラヒドロイソキノリンアミド誘導体
SE9402880D0 (sv)	1994-08-30	1994-08-30	Astra Ab	New peptide derivatives
FR2735776B1 (fr)	1995-06-22	1997-07-18	Synthelabo	Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
GB9609976D0 (en) *	1996-05-13	1996-07-17	Lilly Industries Ltd	Pharmaceutical compounds
US6451806B2 (en) *	1999-09-29	2002-09-17	Adolor Corporation	Methods and compositions involving opioids and antagonists thereof
US6916905B2 (en)	2000-03-24	2005-07-12	The United States Of America As Represented By The Department Of Health And Human Services	Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use
AU2479702A (en) *	2000-10-30	2002-05-15	Janssen Pharmaceutica Nv	Tripeptidyl peptidase inhibitors
US7041681B2 (en) *	2002-04-29	2006-05-09	Janssen Pharmaceutica N.V.	Compounds as opioid receptor modulators
ES2535048T3 (es) *	2005-03-14	2015-05-04	Janssen Pharmaceutica Nv	Proceso para la preparación de moduladores de opioides

2003
- 2003-03-26 US US10/400,006 patent/US7041681B2/en not_active Expired - Lifetime
- 2003-04-17 JP JP2004500872A patent/JP4969039B2/ja not_active Expired - Fee Related
- 2003-04-17 PL PL396160A patent/PL219912B1/pl unknown
- 2003-04-17 CN CN2008100865985A patent/CN101255131B/zh not_active Expired - Lifetime
- 2003-04-17 DK DK03719805.8T patent/DK1499313T3/da active
- 2003-04-17 AU AU2003223664A patent/AU2003223664A1/en not_active Abandoned
- 2003-04-17 ES ES03719805T patent/ES2366471T3/es not_active Expired - Lifetime
- 2003-04-17 AT AT03719805T patent/ATE514425T1/de active
- 2003-04-17 CN CN038151995A patent/CN1665501B/zh not_active Expired - Lifetime
- 2003-04-17 HR HRP20130893AA patent/HRP20130893A2/hr not_active Application Discontinuation
- 2003-04-17 HR HRP20041014AA patent/HRP20041014B1/hr not_active IP Right Cessation
- 2003-04-17 PL PL374053A patent/PL211163B1/pl unknown
- 2003-04-17 CA CA2753371A patent/CA2753371C/en not_active Expired - Lifetime
- 2003-04-17 CA CA2483662A patent/CA2483662C/en not_active Expired - Lifetime
- 2003-04-17 KR KR1020047017395A patent/KR101287409B1/ko not_active Expired - Lifetime
- 2003-04-17 ES ES10180687.5T patent/ES2608840T3/es not_active Expired - Lifetime
- 2003-04-17 PT PT03719805T patent/PT1499313E/pt unknown
- 2003-04-17 WO PCT/US2003/011872 patent/WO2003092688A2/en not_active Ceased
- 2003-04-17 SI SI200332038T patent/SI1499313T1/sl unknown
- 2003-04-17 BR BRPI0309708A patent/BRPI0309708B1/pt not_active IP Right Cessation
- 2003-04-17 NZ NZ561795A patent/NZ561795A/en not_active IP Right Cessation
- 2003-04-17 EP EP03719805A patent/EP1499313B1/en not_active Expired - Lifetime
- 2003-04-17 KR KR1020137005624A patent/KR101377078B1/ko not_active Expired - Fee Related
- 2003-04-17 CA CA2883629A patent/CA2883629A1/en not_active Abandoned
- 2003-04-17 NZ NZ575640A patent/NZ575640A/en not_active IP Right Cessation
- 2003-04-17 MX MXPA04011947A patent/MXPA04011947A/es active IP Right Grant
- 2003-04-17 HU HUE10180687A patent/HUE031331T2/hu unknown
- 2003-04-17 EP EP10180687.5A patent/EP2275105B1/en not_active Expired - Lifetime
- 2003-04-17 RU RU2004131829/04A patent/RU2332411C2/ru active
2004
- 2004-10-28 IL IL164910A patent/IL164910A/en active IP Right Grant
- 2004-11-25 NO NO20045159A patent/NO332722B1/no not_active IP Right Cessation
2005
- 2005-03-14 US US11/079,573 patent/US7202381B2/en not_active Expired - Lifetime
- 2005-10-04 US US11/242,763 patent/US7659402B2/en not_active Expired - Lifetime
2009
- 2009-03-17 IL IL197642A patent/IL197642A/en active IP Right Grant
- 2009-11-05 AU AU2009233679A patent/AU2009233679B2/en not_active Expired
2011
- 2011-05-20 AU AU2011202364A patent/AU2011202364B2/en not_active Expired
- 2011-09-22 CY CY20111100920T patent/CY1111858T1/el unknown
2012
- 2012-07-09 NO NO20120788A patent/NO335607B1/no not_active IP Right Cessation
2014
- 2014-04-24 NO NO20140530A patent/NO20140530L/no unknown

Also Published As

Publication number	Publication date
PT1499313E (pt)	2011-08-24
NO20045159L (no)	2004-11-25
CA2483662C (en)	2011-12-06
AU2011202364B2 (en)	2012-09-20
NO332722B1 (no)	2012-12-27
KR101377078B1 (ko)	2014-03-25
MXPA04011947A (es)	2005-07-26
NO335607B1 (no)	2015-01-12
AU2011202364A1 (en)	2011-06-09
JP2005530749A (ja)	2005-10-13
HRP20041014A2 (en)	2005-06-30
DK1499313T3 (da)	2011-10-03
ES2608840T3 (es)	2017-04-17
NO20120788L (no)	2004-11-25
IL197642A (en)	2015-04-30
IL197642A0 (en)	2009-12-24
PL219912B1 (pl)	2015-07-31
NO20140530L (no)	2004-11-25
HRP20130893A2 (hr)	2014-02-28
CN101255131A (zh)	2008-09-03
ES2366471T3 (es)	2011-10-20
ATE514425T1 (de)	2011-07-15
KR20040104663A (ko)	2004-12-10
KR20130041301A (ko)	2013-04-24
RU2332411C2 (ru)	2008-08-27
IL164910A0 (en)	2005-12-18
CN1665501B (zh)	2010-10-06
HRP20041014B1 (hr)	2013-10-11
US20060030558A1 (en)	2006-02-09
RU2004131829A (ru)	2005-05-27
PL211163B1 (pl)	2012-04-30
KR101287409B1 (ko)	2013-07-19
CA2883629A1 (en)	2003-11-13
WO2003092688A2 (en)	2003-11-13
AU2009233679A1 (en)	2009-11-26
EP1499313A2 (en)	2005-01-26
CA2753371C (en)	2015-06-30
HUE031331T2 (hu)	2017-07-28
US7202381B2 (en)	2007-04-10
PL374053A1 (pl)	2005-09-19
WO2003092688A3 (en)	2004-08-19
NZ561795A (en)	2009-04-30
JP4969039B2 (ja)	2012-07-04
US20050187252A1 (en)	2005-08-25
CA2483662A1 (en)	2003-11-13
BR0309708A (pt)	2005-02-15
AU2003223664A1 (en)	2003-11-17
US7041681B2 (en)	2006-05-09
US20040010014A1 (en)	2004-01-15
IL164910A (en)	2011-07-31
EP1499313B1 (en)	2011-06-29
EP2275105A1 (en)	2011-01-19
SI1499313T1 (sl)	2011-10-28
CY1111858T1 (el)	2015-11-04
BRPI0309708B1 (pt)	2017-03-21
AU2009233679B2 (en)	2011-05-26
US7659402B2 (en)	2010-02-09
CN101255131B (zh)	2012-12-05
CN1665501A (zh)	2005-09-07
EP2275105B1 (en)	2016-10-05
CA2753371A1 (en)	2003-11-13
NZ575640A (en)	2010-10-29

Publication	Publication Date	Title
IL197642A0 (en)	2009-12-24	Heterocyclic derivatives as opioid modulators
IL161074A0 (en)	2004-08-31	Lactam derivatives as antagonists for human 11cby receptors
IL182957A0 (en)	2007-08-19	Potentiators of glutamate receptors
IL157651A0 (en)	2004-03-28	N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor
MY135333A (en)	2008-03-31	Modulators of the glucocorticoid receptor
IS6922A (is)	2003-08-20	Heterófjölhringjaefnasambönd og notkun þeirra semmetabótrópísk mótlyf gegn glútamat viðtökum
NO20034122L (no)	2003-09-16	Sammensmeltede pyridinderivater for anvendelse som vanilloidreseptorantagonister for behandling av smerte
EA200301142A1 (ru)	2004-02-26	Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6
DE60313478D1 (de)	2007-06-06	N-substituierte hydromorphone und ihre anwendung
WO2004022528A3 (en)	2004-05-21	Arylglycine derivatives and their use as glycine transport inhibitors
DE60230683D1 (de)	2009-02-12	3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
DE60022050D1 (de)	2005-09-22	Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems
CY1108837T1 (el)	2014-07-02	ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5
ATE486071T1 (de)	2010-11-15	Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors
MX2007011280A (es)	2007-11-15	Dipirazoles como farmacos del sistema nervioso central.
UA87962C2 (ru)	2009-09-10	Соединения как модуляторы опиоидного рецептора
EA200600416A1 (ru)	2006-08-25	Производные циклопропила в качестве антагонистов рецептора nk3
ZA200400824B (en)	2004-07-20	Pyridin-2-yl-methlyamine derivatives for treating opioid dependence.
SE0303419D0 (sv)	2003-12-17	New use 11