ATE515698T1 - Nanopartikelsonden mit raman-spektroskopischen fingerabdrücken zum analytnachweis - Google Patents

Nanopartikelsonden mit raman-spektroskopischen fingerabdrücken zum analytnachweis

Info

Publication number
ATE515698T1
ATE515698T1 AT03736550T AT03736550T ATE515698T1 AT E515698 T1 ATE515698 T1 AT E515698T1 AT 03736550 T AT03736550 T AT 03736550T AT 03736550 T AT03736550 T AT 03736550T AT E515698 T1 ATE515698 T1 AT E515698T1
Authority
AT
Austria
Prior art keywords
reagents
raman
specific binding
probes
detection
Prior art date
Application number
AT03736550T
Other languages
English (en)
Inventor
Chad Mirkin
Yun-Wei Cao
Rongchao Jin
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern filed Critical Univ Northwestern
Application granted granted Critical
Publication of ATE515698T1 publication Critical patent/ATE515698T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT03736550T 2002-05-07 2003-05-07 Nanopartikelsonden mit raman-spektroskopischen fingerabdrücken zum analytnachweis ATE515698T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37853802P 2002-05-07 2002-05-07
US38363002P 2002-05-28 2002-05-28
US10/172,428 US20030211488A1 (en) 2002-05-07 2002-06-14 Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
PCT/US2003/014100 WO2003095973A2 (en) 2002-05-07 2003-05-07 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection

Publications (1)

Publication Number Publication Date
ATE515698T1 true ATE515698T1 (de) 2011-07-15

Family

ID=29407691

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03736550T ATE515698T1 (de) 2002-05-07 2003-05-07 Nanopartikelsonden mit raman-spektroskopischen fingerabdrücken zum analytnachweis

Country Status (7)

Country Link
US (2) US20030211488A1 (de)
EP (1) EP1499889B1 (de)
JP (1) JP2005524849A (de)
AT (1) ATE515698T1 (de)
AU (1) AU2003237180B2 (de)
CA (1) CA2483697C (de)
WO (1) WO2003095973A2 (de)

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
EP2000803A1 (de) 1998-11-30 2008-12-10 Nanosphere, Inc. Nanoteilchen mit Polymerschalen
JP2004501340A (ja) * 2000-01-13 2004-01-15 ナノスフェアー　インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
WO2002004681A2 (en) * 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7160577B2 (en) 2002-05-02 2007-01-09 Micron Technology, Inc. Methods for atomic-layer deposition of aluminum oxides in integrated circuits
US7589029B2 (en) 2002-05-02 2009-09-15 Micron Technology, Inc. Atomic layer deposition and conversion
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
ATE420357T1 (de) * 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
EP1387169B1 (de) * 2002-08-02 2006-05-24 Sony Deutschland GmbH Verfahren zur Bindung hydophiler Substanzen an hydrophile Makromoleküle und Immobilisierung derselben auf hydrophoben Oberflächen
US7810380B2 (en) * 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US8020433B2 (en) * 2003-03-25 2011-09-20 Tearlab Research, Inc. Systems and methods for a sample fluid collection device
ATE534748T1 (de) * 2002-12-12 2011-12-15 Nanosphere Inc Direkter snp-nachweis mit nichtamplifizierter dna
WO2005001143A2 (en) * 2003-02-27 2005-01-06 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
US7019828B2 (en) * 2003-03-12 2006-03-28 Intel Corporation Chemical enhancement in surface enhanced raman scattering using lithium salts
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
WO2005001113A2 (en) * 2003-06-27 2005-01-06 Thomas Jefferson University Methods for detecting nucleic acid variations
WO2005031301A2 (en) * 2003-07-10 2005-04-07 Parallax Biosystems, Inc. Raman signature probes and their use in the detection and imaging of molecular processes and structures
GB0319949D0 (en) * 2003-08-26 2003-09-24 Univ Strathclyde Nucleic acid sequence identification
US20050064435A1 (en) * 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
WO2005040755A2 (en) * 2003-10-20 2005-05-06 The Regents Of The University Of California Nanoscale transduction systems for detecting molecular interactions
US20070128608A1 (en) * 2003-12-19 2007-06-07 Kankyo Engineering Co., Ltd. Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US7361410B2 (en) * 2003-12-29 2008-04-22 Intel Corporation External modification of composite organic inorganic nanoclusters comprising raman active organic compound
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
US20050147976A1 (en) * 2003-12-29 2005-07-07 Xing Su Methods for determining nucleotide sequence information
US20080076119A9 (en) * 2003-12-29 2008-03-27 Lei Sun Composite organic inorganic nanoclusters
US20050148100A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods and devices for using Raman-active probe constructs to assay biological samples
US20050148098A1 (en) * 2003-12-30 2005-07-07 Xing Su Methods for using raman spectroscopy to obtain a protein profile of a biological sample
AU2004312893B2 (en) 2003-12-31 2010-06-17 President And Fellows Of Harvard College Assay device and method
WO2005069006A1 (en) * 2004-01-06 2005-07-28 Bwt Property Inc. Novel antibody mediated surface enhanced raman scattering (sers) immunoassay and multiplexing schemes
US7422696B2 (en) * 2004-02-20 2008-09-09 Northwestern University Multicomponent nanorods
US20050225758A1 (en) * 2004-03-23 2005-10-13 Knopp Kevin J Raman optical identification tag
DE102004015272A1 (de) * 2004-03-29 2005-11-03 Infineon Technologies Ag Biosensor-Anordnung zum Erfassen von Biomolekülen und Verfahren zum Erfassen von Biomolekülen
US7351591B2 (en) 2004-03-30 2008-04-01 Intel Corporation Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
US20050221507A1 (en) * 2004-03-30 2005-10-06 Intel Corporation Method to detect molecular binding by surface-enhanced Raman spectroscopy
EP1582599A1 (de) * 2004-03-31 2005-10-05 Takara Bio Inc. Verfahren zur Mikroperlenreinigung
US7226794B2 (en) * 2004-04-14 2007-06-05 Agilent Technologies, Inc. Surface-enhanced Raman spectroscopy for biosensor systems and methods for determining the presence of biomolecules
SG185329A1 (en) * 2004-04-23 2012-11-29 Becton Dickinson Co Surface enhanced spectroscopy-active composite nanoparticles
US20060057613A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant S. aureus from methicillin sensitive S. aureus in a mixed culture
US20070048797A1 (en) * 2004-08-11 2007-03-01 Xing Su Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules
US7776547B2 (en) * 2004-08-26 2010-08-17 Intel Corporation Cellular analysis using Raman surface scanning
US20060046311A1 (en) * 2004-08-26 2006-03-02 Intel Corporation Biomolecule analysis using Raman surface scanning
US7588988B2 (en) 2004-08-31 2009-09-15 Micron Technology, Inc. Method of forming apparatus having oxide films formed using atomic layer deposition
WO2006030993A1 (en) * 2004-09-14 2006-03-23 Jin-Ho Choy Information code system using dna sequences
WO2006037036A2 (en) * 2004-09-27 2006-04-06 Purdue Research Foundation Quantitative proteomics with isotopic substituted raman active labeling
US7285427B2 (en) * 2004-10-06 2007-10-23 General Electric Company Raman-active particles and methods of making and using them
US7393692B2 (en) * 2004-10-18 2008-07-01 Real-Time Analyzers, Inc. SERS method for rapid pharmacokinetic analysis of drugs in saliva
US7393691B2 (en) * 2004-10-18 2008-07-01 Real-Time Analyzers, Inc. SERS method and apparatus for rapid extraction and analysis of drugs in saliva
NZ554892A (en) * 2004-10-21 2010-01-29 Englebienne & Associates Stable metal/conductive polymer composite colloids and methods for making and using the same
US7738096B2 (en) 2004-10-21 2010-06-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
US7583379B2 (en) * 2005-07-28 2009-09-01 University Of Georgia Research Foundation Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
US20100291537A1 (en) * 2004-11-16 2010-11-18 Glauco Souza Methods and compositions related to phage-nanoparticle assemblies
US8129199B2 (en) * 2004-12-13 2012-03-06 University of South Caroliina Surface enhanced Raman spectroscopy using shaped gold nanoparticles
US7485471B1 (en) * 2004-12-17 2009-02-03 Intel Corporation Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
US20060134806A1 (en) * 2004-12-20 2006-06-22 General Electric Company Method of separating unattached Raman-active tag from bioassay or other reaction mixture
US20060147941A1 (en) * 2004-12-30 2006-07-06 Intel Corporation Methods and apparatus for SERS assay of biological analytes
US7687409B2 (en) 2005-03-29 2010-03-30 Micron Technology, Inc. Atomic layer deposited titanium silicon oxide films
US7662729B2 (en) 2005-04-28 2010-02-16 Micron Technology, Inc. Atomic layer deposition of a ruthenium layer to a lanthanide oxide dielectric layer
US7572695B2 (en) 2005-05-27 2009-08-11 Micron Technology, Inc. Hafnium titanium oxide films
JP2006349462A (ja) * 2005-06-15 2006-12-28 Canon Inc 表面増強ラマン分光分析用治具及びその製造方法
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US20070134815A1 (en) * 2005-07-11 2007-06-14 Danielle Chamberlin Sensitivity enhancement of POCT devices using gold and silver nanoparticles on substrates containing nanostructures or nanoparticles that interact with labeling particles
US7927948B2 (en) 2005-07-20 2011-04-19 Micron Technology, Inc. Devices with nanocrystals and methods of formation
US7575978B2 (en) * 2005-08-04 2009-08-18 Micron Technology, Inc. Method for making conductive nanoparticle charge storage element
ATE489482T1 (de) * 2005-08-19 2010-12-15 Nanosphere Inc Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
US7410910B2 (en) 2005-08-31 2008-08-12 Micron Technology, Inc. Lanthanum aluminum oxynitride dielectric films
US7410763B2 (en) * 2005-09-01 2008-08-12 Intel Corporation Multiplex data collection and analysis in bioanalyte detection
KR100650522B1 (ko) * 2005-09-15 2006-11-27 재단법인서울대학교산학협력재단 표면증강 라만 산란법에 의해 표지된 마이크로 비드와유전전기영동력을 이용한 새로운 초고속 검색 방법
US20070072309A1 (en) * 2005-09-29 2007-03-29 General Electric Company Analytical compositions including nanometer-sized transducers, methods to make thereof, and devices therefrom
JPWO2007049508A1 (ja) * 2005-10-24 2009-04-30 株式会社アイ・ピー・ビー 長鎖ｄｎａ塩基配列解析装置及び方法
US20090298197A1 (en) * 2005-11-15 2009-12-03 Oxonica Materials Inc. Sers-based methods for detection of bioagents
US20070155022A1 (en) * 2005-12-30 2007-07-05 Mineo Yamakawa Degenerate binding detection and protein identification using Raman spectroscopy nanoparticle labels
DE102006000775A1 (de) * 2006-01-04 2007-07-12 Julius-Maximilians-Universität Würzburg Bildgebendes Diagnoseverfahren
US20090155811A1 (en) * 2006-01-27 2009-06-18 Oxonica, Inc. Lateral Flow Immunoassay With Encapsulated Detection Modality
ES2493990T3 (es) * 2006-02-08 2014-09-12 Becton Dickinson And Company Ensayos con nanoetiquetas SERS
WO2008097328A2 (en) * 2006-06-23 2008-08-14 Northwestern University Asymmetric functionalized nanoparticles and methods of use
EP2620771B1 (de) * 2006-07-24 2017-08-30 Becton Dickinson and Company Testpartikelkonzentrationsvorrichtung und -verfahren
US20090047673A1 (en) * 2006-08-22 2009-02-19 Cary Robert B Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
US7502106B2 (en) * 2006-09-21 2009-03-10 Honeywell International Inc. SERS analyzer
US7727776B2 (en) * 2006-10-24 2010-06-01 Honeywell International Inc. Core-shell nanoparticles for detection based on SERS
WO2008062479A2 (en) 2006-11-21 2008-05-29 Jawaharlal Nehru Centre For Advanced Scientific Research A high sensitivity assay for molecular typing of biological sample, probes and a kit thereof
US7763511B2 (en) * 2006-12-29 2010-07-27 Intel Corporation Dielectric barrier for nanocrystals
US7869030B2 (en) * 2007-01-03 2011-01-11 Research Foundation Of State University Of New York Aggregates of plural transition metal nanoparticles and plural cyanine dye molecules
US8343627B2 (en) 2007-02-20 2013-01-01 Research Foundation Of State University Of New York Core-shell nanoparticles with multiple cores and a method for fabricating them
US20090017562A1 (en) * 2007-03-13 2009-01-15 Iowa State University Research Foundation, Inc. Raman-active reagents
MX2009009994A (es) 2007-03-20 2009-10-19 Becton Dickinson Co Ensayos que usan particulas activas para espectroscopia raman mejorada por superficie (sers).
EP1992938A1 (de) * 2007-05-14 2008-11-19 Koninklijke Philips Electronics N.V. Verbesserte Verfahren zum SE(R)RS-Nachweis unter Verwendung mehrerer Marker
US8367506B2 (en) 2007-06-04 2013-02-05 Micron Technology, Inc. High-k dielectrics with gold nano-particles
US20120164717A1 (en) * 2007-07-18 2012-06-28 Joseph Irudayaraj Identity profiling of cell surface markers
AU2008289383A1 (en) * 2007-07-24 2009-02-26 Northwestern University Coated colloidal materials
EP2040075A1 (de) 2007-09-24 2009-03-25 Julius-Maximilians-Universität Würzburg Verbindungen und Marker für oberflächenverstärkte Raman-Streuung
ITPO20070023A1 (it) 2007-09-26 2009-03-27 Hospitex Diagnostics S R L Metodo e dispositivo per l'analisi multipla ad alta sensibilita di campioni biologici
US7829735B2 (en) * 2007-10-26 2010-11-09 Northwestern University Universal phosphoramidite for preparation of modified biomolecules and surfaces
US8153827B2 (en) * 2007-12-27 2012-04-10 Purdue Research Foundation Reagents for biomolecular labeling, detection and quantification employing Raman spectroscopy
CA2709456A1 (en) * 2007-12-31 2009-07-16 The Regents Of The University Of California Sers-based, single step, real-time detection of protein kinase and/or phosphatase activity
EP2245186A4 (de) * 2008-01-14 2011-08-24 Ultrapid Nanodiagnostics Inc Schnelltest mit einer sonde für genetische sequenzen
US20100105024A1 (en) * 2008-01-14 2010-04-29 Transgenex Nanobiotech, Inc. Rapid test including genetic sequence probe
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
US20090253121A1 (en) * 2008-04-04 2009-10-08 Micah Halpern Method for amt-rflp dna fingerprinting
WO2009137059A1 (en) 2008-05-05 2009-11-12 Los Alamos National Security, Llc Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
KR101153748B1 (ko) * 2008-05-07 2012-06-14 재단법인서울대학교산학협력재단 바이오센서로 유용한 새로운 형태의 금／은 코어쉘 복합체
US20160266104A1 (en) * 2008-05-07 2016-09-15 Korea Research Institute Of Chemical Technology Heterodimeric core-shell nanoparticle in which raman-active molecules are located at a binding portion of a nanoparticle heterodimer, use thereof, and method for preparing same
EP2352999A4 (de) * 2008-10-15 2012-12-26 Univ Cornell Erweitertes biomolekulares nachweisverfahren auf on-chip-sers-basis anhand von elektrokinetisch aktiven mikrowellen
US7879625B1 (en) 2008-12-03 2011-02-01 The United States Of America As Represented By The Secretary Of The Navy Preparation of SERS substrates on silica-coated magnetic microspheres
US20110171749A1 (en) * 2009-03-02 2011-07-14 Board Of Trustees Of Michigan State University Nanoparticle tracer-based electrochemical dna sensor for detection of pathogens-amplification by a universal nano-tracer (aunt)
JP5391744B2 (ja) * 2009-03-09 2014-01-15 住友ベークライト株式会社 アレイ用基板
US20100291599A1 (en) * 2009-05-18 2010-11-18 Bruker Optics, Inc. Large area scanning apparatus for analyte quantification by surface enhanced raman spectroscopy and method of use
WO2010144053A1 (en) * 2009-06-12 2010-12-16 Agency For Science, Technology And Research Method for determining protein-nucleic acid interaction
US9575061B2 (en) * 2009-10-20 2017-02-21 Vanderbilt University Liquid drop diagnostic assays
DE102009050287B4 (de) 2009-10-20 2012-07-05 Friedrich-Schiller-Universität Jena SERS-Substrat
AU2010328768B2 (en) * 2009-12-11 2014-01-16 Korea Research Institute Of Chemical Technology A dimeric core-shell nanostructure labeled with a raman active molecule localized at an interparticle junction, use thereof, and method for preparing the same
EP2516995B1 (de) * 2009-12-22 2016-10-26 Agency For Science, Technology And Research Nachweis von analyten auf sers-basis
US8416609B2 (en) 2010-02-15 2013-04-09 Micron Technology, Inc. Cross-point memory cells, non-volatile memory arrays, methods of reading a memory cell, methods of programming a memory cell, methods of writing to and reading from a memory cell, and computer systems
FR2963106A1 (fr) * 2010-07-21 2012-01-27 Ecole Polytechnique Dgar Procede et dispositif d'analyse d'interactions moleculaires, et leurs utilisations
KR101229991B1 (ko) 2010-10-06 2013-02-05 단국대학교 산학협력단 광섬유 기반 ｌｓｐｒ 및 ｓｅｒｓ신호의 동시 측정 센서 시스템
EP2699698B9 (de) 2011-04-20 2020-07-15 Mesa Biotech, Inc. Oszillierende amplifikationsreaktion für nukleinsäuren
GB201207821D0 (en) * 2012-04-05 2012-06-13 Renishaw Diagnostics Ltd Dye sets for surface enhanced resonant raman spectroscopy
KR101460439B1 (ko) * 2012-05-14 2014-11-12 서울대학교산학협력단 나노프로브 및 이를 이용한 표적 물질 검출방법
CN102692405B (zh) * 2012-06-07 2015-05-27 中国科学院合肥物质科学研究院 米粒状氟化物/银复合纳米材料、制备方法及应用
CA2882003C (en) * 2012-08-17 2020-11-10 Japan Science And Technology Agency Method and apparatus for analyzing biomolecules using raman spectroscopy
US9512468B2 (en) 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
JP6602202B2 (ja) * 2012-12-11 2019-11-06 アール． ザメツニク，コリン 造影剤としての、増加した表面増強ラマン散乱特性を有する封入色素コーティング貴金属ナノ粒子
JP2016528510A (ja) 2013-08-21 2016-09-15 ミカルティス エヌブイＭｙｃａｒｔｉｓ Ｎｖ 不均質表面官能化
WO2015183758A1 (en) * 2014-05-28 2015-12-03 University Of Houston System Nanoporous gold and silver nanoparticles and substrates for molecular and biomolecular sensing
CN104142375B (zh) * 2014-08-20 2016-01-20 中华人民共和国潍坊出入境检验检疫局 一种利用霉菌代谢产物建立指纹图谱以及利用指纹图谱鉴定霉菌菌种的方法
US11536707B2 (en) 2014-09-23 2022-12-27 Tearlab Research, Inc. Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest
EP3001183B1 (de) * 2014-09-25 2019-02-13 Centre National De La Recherche Scientifique (Cnrs) Nachweis von Analyten unter Verwendung von Nanopartikeln als Lichtstreuungsverstärker
US10105080B1 (en) * 2014-10-24 2018-10-23 Verily Life Sciences Llc Interstitial fluid sampling above microneedle array
JP2016156807A (ja) * 2015-02-23 2016-09-01 株式会社堀場製作所 分析方法及び分析装置
AU2016253147B2 (en) 2015-04-24 2021-07-22 Mesa Biotech, Inc. Fluidic test cassette
WO2016194879A1 (ja) * 2015-05-29 2016-12-08 京セラ株式会社 検出方法、および検出装置
WO2016205678A1 (en) * 2015-06-19 2016-12-22 Emory University Methods of measuring cell purity for making quality control determinations and related compositions
US10301667B2 (en) * 2015-11-18 2019-05-28 University Of Florida Research Foundation, Inc. Devices for detecting target biological molecules from cells and viruses
CN106596927B (zh) * 2016-12-26 2018-10-19 中国科学院长春光学精密机械与物理研究所 一种光纤生物探针及其制备方法与全血检测方法
US20210140953A1 (en) 2017-03-10 2021-05-13 Universität Duisburg-Essen Efficient ligand exchange of a detergent bilayer on the surface of metal nanoparticles for molecular functionalization and assembly, corresponding functionalized nanoparticles and nanoparticle assemblies, and their use in plasmonic applications including surface-enhanced raman spectroscopy
US10156658B1 (en) * 2017-06-06 2018-12-18 Saudi Arabian Oil Company Detecting a tracer in a hydrocarbon reservoir
JP2020525038A (ja) * 2017-06-30 2020-08-27 コリア リサーチ インスティテュート オブ ケミカル テクノロジー 敗血症診断用キット及びそれを用いた診断方法
CN110554018A (zh) * 2018-05-31 2019-12-10 上海市刑事科学技术研究院 检测水溶液中4-溴甲卡西酮的表面增强拉曼材料及其制备方法
CN110951833B (zh) * 2018-09-26 2022-03-29 中国农业大学 一种同时检测多种喷施雾滴飘失或沉积检测试剂盒及检测方法
JP7719500B2 (ja) * 2019-04-03 2025-08-06 アトナープ株式会社 分析ユニットを有する装置
GB201907007D0 (en) * 2019-05-17 2019-07-03 Nano Biosols Ltd A simple method and kit for quantifying gold nanoparticles in a liquid sample
CN110455754B (zh) * 2019-07-15 2022-03-18 深圳大学 一种dna探针及制作方法
CN110749585B (zh) * 2019-09-11 2022-04-01 亳州市新健康科技有限公司 一种基于表面增强拉曼技术的生物传感器及制备方法
CN110646399B (zh) * 2019-09-29 2021-08-13 吉林大学 基于sers的高通量蛋白检测芯片
CN110702665B (zh) * 2019-11-14 2022-03-22 济南大学 一种纸基耦合增强拉曼传感器制备及其在大田软海绵酸检测中的应用
WO2021193589A1 (ja) * 2020-03-23 2021-09-30 積水化学工業株式会社 検査方法、検査キット及び検査システム
GB202017378D0 (en) * 2020-11-02 2020-12-16 Univ Birmingham Single point variant detection
KR20230118570A (ko) * 2020-11-11 2023-08-11 노틸러스 서브시디어리, 인크. 강화된 결합 및 검출 특성을 갖는 친화성 시약
CN112698020B (zh) * 2020-11-12 2022-08-26 中山大学 基于DNA-AuNP编码的交叉响应系统的多峰耦合分析方法
CN113189078B (zh) * 2021-03-04 2024-04-16 吉林大学 一种靶向药物的高通量筛选方法
CN113433100B (zh) * 2021-05-25 2022-09-27 上海市公共卫生临床中心 基于dna合成银纳米团簇与色氨酸光化学反应的血浆色氨酸和白蛋白联合检测方法
US11796517B2 (en) 2021-11-09 2023-10-24 Saudi Arabian Oil Company Multifunctional magnetic tags for mud logging
US12110448B2 (en) 2021-11-09 2024-10-08 Saudi Arabian Oil Company Multifunctional fluorescent tags for subterranean applications
US12140582B2 (en) 2021-11-09 2024-11-12 Saudi Arabian Oil Company Multifunctional polysaccharide-based mud logging barcode tracers
US11999855B2 (en) 2021-12-13 2024-06-04 Saudi Arabian Oil Company Fluorescent dye molecules having hydrophilicity and hydrophobicity for tracer applications
US11725139B2 (en) 2021-12-13 2023-08-15 Saudi Arabian Oil Company Manipulating hydrophilicity of conventional dye molecules for water tracer applications
US12440821B2 (en) 2021-12-13 2025-10-14 Saudi Arabian Oil Company Method for tracing subterranean formations with oil-soluble organic molecular tracers and extracting them of from oil phases
US12253467B2 (en) 2021-12-13 2025-03-18 Saudi Arabian Oil Company Determining partition coefficients of tracer analytes
US12000278B2 (en) 2021-12-16 2024-06-04 Saudi Arabian Oil Company Determining oil and water production rates in multiple production zones from a single production well
US20230236208A1 (en) * 2022-01-26 2023-07-27 Dawatek, Inc. Raman testing system and methods of detecting pathogens
CN114624223B (zh) * 2022-03-15 2025-02-18 山东农业大学 一种基于嵌入特异性核酸酶dna水凝胶的表面增强拉曼光谱传感器检测链霉素的方法
WO2023205784A2 (en) * 2022-04-21 2023-10-26 Emory University Heteromultivalent nucleic acid functionalized materials to detect mutations and use in diagnostic applications
KR102726244B1 (ko) * 2022-05-26 2024-11-06 단국대학교 산학협력단 광섬유 다발을 이용한 디지털 국소화 표면 플라즈몬 공명 센서 및 제작 방법
CN115112629B (zh) * 2022-06-07 2025-02-18 中国工程物理研究院激光聚变研究中心 基于谐振腔的多通道病毒检测sers芯片及其制备方法
US12188350B2 (en) 2022-06-08 2025-01-07 Saudi Arabian Oil Company Fluorescent dye oil tracer compositions
CN115792239B (zh) * 2022-07-22 2025-11-14 暨南大学 一种表面增强拉曼效应与CRISPR/Cas12a联用的蛋白检测方法
CN115855928A (zh) * 2023-02-27 2023-03-28 合肥工业大学 基于核酸宏阵列和双功能分子的汞离子检测方法及试剂盒
WO2024220599A2 (en) * 2023-04-20 2024-10-24 The Trustees Of Columbia University In The City Of New York Genome-wide qpcr
CN119000634B (zh) * 2024-07-24 2025-03-11 苏州方格尔生物科技有限公司 一种基于拉曼增强光谱的大肠杆菌检测试剂、检测方法及试剂盒

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4256834A (en) * 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4261968A (en) * 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4650770A (en) * 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US4713348A (en) * 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US5288609A (en) * 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5514602A (en) * 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5360895A (en) * 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
GB8800702D0 (en) 1988-01-13 1988-02-10 Nycomed As Test method & reagent kit therefor
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
DE3901458A1 (de) * 1989-01-19 1990-07-26 Behringwerke Ag Verwendung von zwei- oder dreiwertigen kationen in immunchemischen tests
US5266498A (en) * 1989-10-27 1993-11-30 Abbott Laboratories Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal
US5376556A (en) * 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
US5460831A (en) * 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
WO1992008133A1 (en) * 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5294369A (en) * 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
US5203989A (en) * 1991-01-30 1993-04-20 Reidy James J Portable air-water generator
WO1993010564A1 (en) * 1991-11-22 1993-05-27 The Regents Of The University Of California Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers
US5225064A (en) * 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
US5306403A (en) * 1992-08-24 1994-04-26 Martin Marietta Energy Systems, Inc. Raman-based system for DNA sequencing-mapping and other separations
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5637508A (en) * 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
US5384265A (en) * 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5681943A (en) * 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
EP0630974A3 (de) 1993-06-25 1995-11-15 Clinical Diagnostic Syst Verfahren und Testkit zum Nachweis von anorganischen Orthophosphat bei der Amplifizierung von Zielnukleinsäuren.
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH07227299A (ja) 1994-02-14 1995-08-29 Kyoto Daiichi Kagaku:Kk Ｄｎａの特定塩基配列の検出方法及びその装置
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6025202A (en) * 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
US5609907A (en) * 1995-02-09 1997-03-11 The Penn State Research Foundation Self-assembled metal colloid monolayers
GB9517955D0 (en) * 1995-07-25 1995-11-08 Univ Strathclyde Nucleotide sequence detection and analysis
US5814516A (en) * 1995-10-13 1998-09-29 Lockheed Martin Energy Systems, Inc. Surface enhanced Raman gene probe and methods thereof
IL126544A (en) * 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO1998004740A1 (en) 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6242264B1 (en) * 1996-09-04 2001-06-05 The Penn State Research Foundation Self-assembled metal colloid monolayers having size and density gradients
US5830986A (en) * 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6149868A (en) * 1997-10-28 2000-11-21 The Penn State Research Foundation Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5972615A (en) * 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
EP2000803A1 (de) 1998-11-30 2008-12-10 Nanosphere, Inc. Nanoteilchen mit Polymerschalen
US6277489B1 (en) * 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
EP1198591B1 (de) * 1999-06-25 2011-03-16 Nanosphere, Inc. Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
JP2004501340A (ja) * 2000-01-13 2004-01-15 ナノスフェアー　インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
CA2402955C (en) 2000-03-28 2010-03-09 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO2002004681A2 (en) 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
EP1362121A2 (de) 2000-08-11 2003-11-19 Nanosphere, Inc. Nanopartikel verbunden mit oligonukleotiden und verwendungen davon
US7829348B2 (en) * 2000-09-22 2010-11-09 Iowa State University Research Foundation, Inc. Raman-active reagents and the use thereof
WO2002046483A2 (en) * 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
ATE506075T1 (de) 2000-12-08 2011-05-15 Curagen Corp Verfahren zur bestimmung und behandlung von tuberöse-sklerose komplex assoziierten erkrankungen
WO2002046472A2 (en) 2000-12-08 2002-06-13 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
ATE431853T1 (de) 2001-03-28 2009-06-15 Nanosphere Inc Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
AU2002367709A1 (en) 2001-04-26 2003-10-27 Nanosphere, Inc. Oligonucleotide-modified romp polymers and co-polymers
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7110585B2 (en) * 2001-08-03 2006-09-19 Nanosphere, Inc. Nanoparticle imaging system and method
AU2002363062B2 (en) 2001-10-09 2007-03-22 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
ATE403751T1 (de) * 2001-11-09 2008-08-15 Nanosphere Inc Biokonjugat-nanopartikelsonden
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
ATE420357T1 (de) 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
AU2003296014B2 (en) * 2002-11-26 2010-06-03 University Of Maryland Biotechnology Institute High-sensitivity assays for pathogen detection using metal-enhanced fluorescence
ATE534748T1 (de) 2002-12-12 2011-12-15 Nanosphere Inc Direkter snp-nachweis mit nichtamplifizierter dna
US7361410B2 (en) * 2003-12-29 2008-04-22 Intel Corporation External modification of composite organic inorganic nanoclusters comprising raman active organic compound

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