ATE517097T1 - Thiazol- und oxazolsubstituierte arylamide - Google Patents
Thiazol- und oxazolsubstituierte arylamideInfo
- Publication number
- ATE517097T1 ATE517097T1 AT07822118T AT07822118T ATE517097T1 AT E517097 T1 ATE517097 T1 AT E517097T1 AT 07822118 T AT07822118 T AT 07822118T AT 07822118 T AT07822118 T AT 07822118T AT E517097 T1 ATE517097 T1 AT E517097T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazole
- oxazole substituted
- substituted arylamides
- arylamides
- oxazole
- Prior art date
Links
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85828306P | 2006-11-09 | 2006-11-09 | |
| PCT/EP2007/061771 WO2008055840A1 (en) | 2006-11-09 | 2007-10-31 | Thiazole and oxazole-substituted arylamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517097T1 true ATE517097T1 (de) | 2011-08-15 |
Family
ID=39149180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07822118T ATE517097T1 (de) | 2006-11-09 | 2007-10-31 | Thiazol- und oxazolsubstituierte arylamide |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7786110B2 (de) |
| EP (1) | EP2091927B1 (de) |
| JP (1) | JP5084839B2 (de) |
| KR (2) | KR101165936B1 (de) |
| CN (1) | CN101528717B (de) |
| AR (1) | AR063601A1 (de) |
| AT (1) | ATE517097T1 (de) |
| AU (1) | AU2007316681B2 (de) |
| BR (1) | BRPI0718714B8 (de) |
| CA (1) | CA2668399C (de) |
| CL (1) | CL2007003192A1 (de) |
| ES (1) | ES2367455T3 (de) |
| IL (1) | IL198301A (de) |
| MX (1) | MX2009004900A (de) |
| PE (1) | PE20081475A1 (de) |
| TW (1) | TW200829584A (de) |
| WO (1) | WO2008055840A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101528717B (zh) | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| US8501933B2 (en) * | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
| CA2703915C (en) * | 2007-10-31 | 2015-02-24 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| ES2541662T3 (es) * | 2007-12-17 | 2015-07-23 | F. Hoffmann-La Roche Ag | Derivados arilamida sustituidos con triazol y utilización de los mismos como antagonistas de receptores purinérgicos P2X3 y/o P2X2/3 |
| CA2708791C (en) * | 2007-12-17 | 2016-06-21 | F. Hoffmann-La Roche Ag | Imidazole-substituted arylamides and uses thereof as p2x receptor antagonists |
| WO2009077371A1 (en) * | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists |
| DK2234976T3 (da) * | 2007-12-17 | 2013-06-24 | Hoffmann La Roche | Nye pyrazol-substituerede arylamider |
| CA2715835C (en) | 2008-02-29 | 2017-03-21 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| JP5608655B2 (ja) * | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | Ｐ２ｘ３受容体活性のモジュレーター |
| WO2010069794A1 (en) | 2008-12-16 | 2010-06-24 | F. Hoffmann-La Roche Ag | Thiadiazole-substituted arylamides |
| CN102438989B (zh) * | 2009-06-22 | 2015-05-27 | 霍夫曼-拉罗奇有限公司 | 噁唑酮和吡咯烷酮取代的芳基酰胺 |
| SG177308A1 (en) | 2009-06-22 | 2012-02-28 | Hoffmann La Roche | Novel biphenyl and phenyl-pyridine amides |
| WO2011153359A1 (en) * | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US8698952B2 (en) | 2011-10-31 | 2014-04-15 | Lg Innotek Co., Ltd. | Camera module |
| WO2014086746A1 (de) * | 2012-12-07 | 2014-06-12 | Bayer Cropscience Ag | N-(isoxazol-3-yl)-arylcarbonsäureamide und ihre verwendung als herbizide |
| EP2905282A1 (de) * | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituierte Thiazole oder Oxazole als P2X7-Rezeptorantagonisten |
| EP3230281B1 (de) | 2014-12-09 | 2021-05-26 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl-substituierte benzamide |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| KR20160138877A (ko) | 2015-05-26 | 2016-12-06 | (주)펠리테크 | 마이크로파를 이용한 세라믹 발열 하이브리드 건조기 |
| AU2017327539B2 (en) | 2016-09-15 | 2020-12-24 | Boehringer Ingelheim International Gmbh | Heteroaryl carboxamide compounds as inhibitors of RIPK2 |
| RU2019112740A (ru) * | 2016-09-30 | 2020-11-02 | АСАНА БАЙОСАЙЕНСИЗ, ЭлЭлСи | P2x3 и/или p2x2/3 соединения и способы |
| WO2020002090A1 (de) | 2018-06-25 | 2020-01-02 | Bayer Aktiengesellschaft | Substituierte thiazolylpyrrolone sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| EP3757103A1 (de) * | 2019-06-27 | 2020-12-30 | Bayer AG | Analoga von 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluor-methyl)pyrimidin-5-yl]ethyl}benzamid zur behandlung von neurogenen krankheiten |
| WO2022063205A1 (zh) * | 2020-09-24 | 2022-03-31 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281217B2 (en) | 1999-03-25 | 2001-08-28 | Dingwei Tim Yu | Class of piperazino substituted thiazoles |
| EP1194421B1 (de) | 1999-06-30 | 2005-10-12 | H. Lundbeck A/S | Selektive npy (y5) antagonisten |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EP1736478B1 (de) | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren |
| SK286630B6 (sk) | 2001-01-22 | 2009-02-05 | Merck & Co., Inc. | Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| AU2002359376B2 (en) * | 2001-11-08 | 2008-01-10 | Elan Pharmaceuticals, Inc. | N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| WO2003105770A2 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| CN1678326A (zh) | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷 |
| TW200500375A (en) | 2002-06-28 | 2005-01-01 | Idenix Cayman Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| LT1576138T (lt) | 2002-11-15 | 2017-06-26 | Idenix Pharmaceuticals Llc | 2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| AU2004224825A1 (en) | 2003-03-26 | 2004-10-07 | Crc For Asthma Limited | Therapeutic and prophylactic compositions and uses therefor |
| CA2522476A1 (en) | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
| ATE355273T1 (de) * | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
| WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| US20050075309A1 (en) | 2003-07-25 | 2005-04-07 | Richard Storer | Purine nucleoside analogues for treating Flaviviridae including hepatitis C |
| CA2557372C (en) * | 2004-03-05 | 2013-01-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
| EP2038264B1 (de) | 2006-06-29 | 2016-10-26 | F.Hoffmann-La Roche Ag | Tetrazolsubstituierte arylamide |
| CN101528717B (zh) | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
| JP2011502148A (ja) | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
-
2007
- 2007-10-31 CN CN2007800394586A patent/CN101528717B/zh active Active
- 2007-10-31 AU AU2007316681A patent/AU2007316681B2/en not_active Ceased
- 2007-10-31 KR KR1020127002496A patent/KR101165936B1/ko active Active
- 2007-10-31 MX MX2009004900A patent/MX2009004900A/es active IP Right Grant
- 2007-10-31 JP JP2009535681A patent/JP5084839B2/ja active Active
- 2007-10-31 WO PCT/EP2007/061771 patent/WO2008055840A1/en not_active Ceased
- 2007-10-31 BR BRPI0718714A patent/BRPI0718714B8/pt active IP Right Grant
- 2007-10-31 KR KR1020097009417A patent/KR101152714B1/ko active Active
- 2007-10-31 CA CA2668399A patent/CA2668399C/en active Active
- 2007-10-31 EP EP07822118A patent/EP2091927B1/de active Active
- 2007-10-31 ES ES07822118T patent/ES2367455T3/es active Active
- 2007-10-31 AT AT07822118T patent/ATE517097T1/de active
- 2007-11-06 TW TW096141899A patent/TW200829584A/zh unknown
- 2007-11-06 CL CL200703192A patent/CL2007003192A1/es unknown
- 2007-11-07 AR ARP070104958A patent/AR063601A1/es unknown
- 2007-11-07 PE PE2007001531A patent/PE20081475A1/es not_active Application Discontinuation
- 2007-11-08 US US11/983,225 patent/US7786110B2/en active Active
-
2009
- 2009-04-22 IL IL198301A patent/IL198301A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101528717B (zh) | 2013-04-24 |
| WO2008055840A1 (en) | 2008-05-15 |
| IL198301A (en) | 2013-06-27 |
| KR20090086073A (ko) | 2009-08-10 |
| CN101528717A (zh) | 2009-09-09 |
| ES2367455T3 (es) | 2011-11-03 |
| AR063601A1 (es) | 2009-02-04 |
| AU2007316681B2 (en) | 2013-01-24 |
| US7786110B2 (en) | 2010-08-31 |
| BRPI0718714A2 (pt) | 2013-11-26 |
| KR20120034766A (ko) | 2012-04-12 |
| CA2668399A1 (en) | 2008-05-15 |
| PE20081475A1 (es) | 2008-10-18 |
| KR101152714B1 (ko) | 2012-06-18 |
| MX2009004900A (es) | 2009-05-19 |
| JP5084839B2 (ja) | 2012-11-28 |
| IL198301A0 (en) | 2010-02-17 |
| CL2007003192A1 (es) | 2008-06-20 |
| BRPI0718714B8 (pt) | 2021-05-25 |
| EP2091927B1 (de) | 2011-07-20 |
| EP2091927A1 (de) | 2009-08-26 |
| TW200829584A (en) | 2008-07-16 |
| JP2010509264A (ja) | 2010-03-25 |
| US20080132494A1 (en) | 2008-06-05 |
| KR101165936B1 (ko) | 2012-07-19 |
| BRPI0718714B1 (pt) | 2020-09-29 |
| CA2668399C (en) | 2015-01-27 |
| AU2007316681A1 (en) | 2008-05-15 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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