ATE523493T1 - 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate - Google Patents

2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate

Info

Publication number
ATE523493T1
ATE523493T1 AT07842137T AT07842137T ATE523493T1 AT E523493 T1 ATE523493 T1 AT E523493T1 AT 07842137 T AT07842137 T AT 07842137T AT 07842137 T AT07842137 T AT 07842137T AT E523493 T1 ATE523493 T1 AT E523493T1
Authority
AT
Austria
Prior art keywords
isochinolin
oxo
acetamide derivatives
acetamide
derivatives
Prior art date
Application number
AT07842137T
Other languages
English (en)
Inventor
Jeffrey Letourneau
Jui Hsiang Chan
Patrick Jokiel
Michael Ohlmeyer
Irina Neagu
Christopher Mark Riviello
John Richard Morphy
Susan Elizabeth Napier
Koc-Kan Ho
Original Assignee
Organon Nv
Pharmacopeia Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv, Pharmacopeia Llc filed Critical Organon Nv
Application granted granted Critical
Publication of ATE523493T1 publication Critical patent/ATE523493T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT07842137T 2006-09-11 2007-09-10 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate ATE523493T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84371306P 2006-09-11 2006-09-11
PCT/US2007/077999 WO2008033757A2 (en) 2006-09-11 2007-09-10 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives

Publications (1)

Publication Number Publication Date
ATE523493T1 true ATE523493T1 (de) 2011-09-15

Family

ID=39184481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07842137T ATE523493T1 (de) 2006-09-11 2007-09-10 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate

Country Status (9)

Country Link
US (1) US7906504B2 (de)
EP (1) EP2066640B1 (de)
JP (1) JP5271909B2 (de)
CN (1) CN101528703B (de)
AR (1) AR062734A1 (de)
AT (1) ATE523493T1 (de)
CA (1) CA2663193A1 (de)
MX (1) MX2009002685A (de)
WO (1) WO2008033757A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101600698B (zh) * 2006-09-11 2012-01-11 欧加农股份有限公司;药典有限责任公司 喹唑啉酮和异喹啉酮乙酰胺衍生物
PL2623499T3 (pl) 2010-10-01 2015-09-30 Taisho Pharmaceutical Co Ltd Pochodne 1,2,4-triazolonu
WO2013062027A1 (ja) 2011-10-27 2013-05-02 大正製薬株式会社 アゾール誘導体
NZ629944A (en) * 2012-03-30 2016-02-26 Taisho Pharmaceutical Co Ltd Fused azole derivative
JP7071917B2 (ja) 2015-12-09 2022-05-19 カデント セラピューティクス，インコーポレーテッド ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用
EP4006038A1 (de) 2015-12-09 2022-06-01 Cadent Therapeutics, Inc. Thienopyrimidinon-nmda-rezeptor-modulatoren und verwendungen davon
US11274107B2 (en) 2016-12-22 2022-03-15 Cadent Therapeutics, Inc. NMDA receptor modulators and uses thereof
AR115905A1 (es) 2018-08-03 2021-03-10 Cadent Therapeutics Inc 5-(3-cloro-4-fluorofenil)-7-ciclopropil-3-(2-(3-fluoro-3-metilazetidin-1-il)-2-oxoetil)-3,7-dihidro-4h-pirrolo[2,3-d]pirimidin-4-ona como modulador de los receptores de nmda

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2506767A1 (fr) * 1981-05-26 1982-12-03 Synthelabo Derives heterocycliques d'amidoximes, leur preparation et leur application en therapeutique
US6723736B2 (en) * 2000-10-10 2004-04-20 Theracos, Inc. Tricyclic compounds and uses thereof
PL374598A1 (en) * 2002-06-28 2005-10-31 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
CN101018552A (zh) * 2004-07-14 2007-08-15 利亘制药公司 细胞内受体调节剂化合物和方法
TW200643015A (en) * 2005-03-11 2006-12-16 Akzo Nobel Nv 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
CA2615577C (en) * 2005-07-26 2014-09-09 Sanofi-Aventis Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors
RS52241B (sr) * 2005-07-26 2012-10-31 Sanofi Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze

Also Published As

Publication number Publication date
WO2008033757A2 (en) 2008-03-20
JP5271909B2 (ja) 2013-08-21
EP2066640A4 (de) 2010-12-22
US7906504B2 (en) 2011-03-15
CA2663193A1 (en) 2008-03-20
WO2008033757A3 (en) 2008-12-11
US20080064678A1 (en) 2008-03-13
EP2066640B1 (de) 2011-09-07
AR062734A1 (es) 2008-11-26
JP2010502745A (ja) 2010-01-28
EP2066640A2 (de) 2009-06-10
MX2009002685A (es) 2009-10-13
CN101528703B (zh) 2011-09-07
CN101528703A (zh) 2009-09-09

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties