ATE518874T1 - Synthetische lipid-a analogen und verwendungen davon - Google Patents

Synthetische lipid-a analogen und verwendungen davon

Info

Publication number: ATE518874T1
Authority: AT; Austria
Prior art keywords: lipid; synthetic; structures; novel; disaccharide
Prior art date: 1999-11-15

Application number

AT00980380T

Other languages

English (en)

Inventor

Zi-Hua Jiang

Mimi Bach

Damayanthi Yalamati

Rao Koganty

Michael Longenecker

Original Assignee

Oncothyreon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-15

Filing date

2000-11-15

Publication date

2011-08-15

2000-11-15 Application filed by Oncothyreon Inc filed Critical Oncothyreon Inc

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE518874T1 publication Critical patent/ATE518874T1/de

Links

GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 5
150000002016 disaccharides Chemical class 0.000 abstract 2
150000002632 lipids Chemical group 0.000 abstract 2
101001133056 Homo sapiens Mucin-1 Proteins 0.000 abstract 1
108010028921 Lipopeptides Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000000052 comparative effect Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000003308 immunostimulating effect Effects 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000002772 monosaccharides Chemical class 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT00980380T 1999-11-15 2000-11-15 Synthetische lipid-a analogen und verwendungen davon ATE518874T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16492899P	1999-11-15	1999-11-15
PCT/US2000/031281 WO2001036433A2 (en)	1999-11-15	2000-11-15	Synthetic lipid-a analogs and uses thereof

Publications (1)

Publication Number	Publication Date
ATE518874T1 true ATE518874T1 (de)	2011-08-15

Family

ID=22596692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00980380T ATE518874T1 (de)	1999-11-15	2000-11-15	Synthetische lipid-a analogen und verwendungen davon

Country Status (8)

Country	Link
US (1)	US7491707B1 (de)
EP (1)	EP1232168B1 (de)
JP (1)	JP2003514824A (de)
AT (1)	ATE518874T1 (de)
AU (1)	AU780577B2 (de)
CA (1)	CA2396744C (de)
ES (1)	ES2370262T3 (de)
WO (1)	WO2001036433A2 (de)

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JP2004533421A (ja)	2001-03-27	2004-11-04	バイオミラ，インコーポレイテッド	Ｔ１免疫応答とｔ２免疫応答との間で調節するためのワクチン
ES2375992T3 (es) *	2002-04-15	2012-03-08	Oncothyreon Inc.	Glucolipopéptidos sintéticos como vacunas.
JP5014573B2 (ja)	2002-05-09	2012-08-29	オンコサイレオンインコーポレーテッド	脂質ａおよび他の炭水化物リガンド類似体
WO2003106473A1 (ja) *	2002-06-18	2003-12-24	三共株式会社	グルコシルリピッドa1位カルボキシメチル類縁体
AU2002950657A0 (en) *	2002-08-08	2002-09-12	Alchemia Limited	Derivatives of monosaccharides for drug discovery
AU2002951995A0 (en)	2002-10-11	2002-10-31	Alchemia Limited	Classes of compounds that interact with gpcrs
CN101863930A (zh) *	2003-01-06	2010-10-20	科里克萨有限公司	一些氨烷基氨基葡糖苷磷酸酯化合物和它们的用途
US7960522B2 (en) *	2003-01-06	2011-06-14	Corixa Corporation	Certain aminoalkyl glucosaminide phosphate compounds and their use
EP1547581A1 (de) *	2003-12-23	2005-06-29	Vectron Therapeutics AG	Liposomaler Impstoff für die Behandlung von menschlichen hematologischen mlignen Erkrankungen
TWI395591B (zh)	2004-04-01	2013-05-11	Oncothyreon Inc	黏液性糖蛋白（ｍｕｃ-１）疫苗
US8871250B2 (en)	2005-06-28	2014-10-28	Oncothyreon Inc.	Method of treating patients with a mucinous glycoprotein (MUC-1) vaccine
EP1803814A1 (de)	2005-12-27	2007-07-04	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Methode zur Verbesserung der Antikörperselektionskapazität in einer Phagen-Display-Bibliothek
PL2068918T5 (pl)	2006-09-26	2024-12-02	Access To Advanced Health Institute	Kompozycja szczepionki zawierająca syntetyczny adiuwant
US20090181078A1 (en) *	2006-09-26	2009-07-16	Infectious Disease Research Institute	Vaccine composition containing synthetic adjuvant
WO2008059307A2 (en) *	2006-11-16	2008-05-22	Om Pharma	Functionalized beta 1,6 glucosamine disaccharides and process for their preparation
EA020604B1 (ru) *	2008-12-17	2014-12-30	Онкотиреон, Инк.	Композиция, содержащая липосомы малого размера, и способ ее получения
CA2764374C (en)	2009-06-05	2019-11-19	Infectious Disease Research Institute	Synthetic glucopyranosyl lipid adjuvants
CA2800911A1 (en) *	2010-06-11	2011-12-15	University Of Georgia Research Foundation, Inc.	Immunogenic vaccine
EP2678005A4 (de)	2011-02-24	2015-06-10	Oncothyreon Inc	Glycolipopeptid-impfstoff auf muc1-basis mit einem adjuvans
EA027236B1 (ru)	2011-04-08	2017-07-31	Иммьюн Дизайн Корп.	Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа
US20140328876A1 (en)	2011-11-18	2014-11-06	Variation Biotechnologies Inc.	Synthetic derivatives of mpl and uses thereof
US9518078B2 (en)	2012-04-12	2016-12-13	Avanti Polar Lipids, Inc.	Disaccharide synthetic lipid compounds and uses thereof
US9241988B2 (en) *	2012-04-12	2016-01-26	Avanti Polar Lipids, Inc.	Disaccharide synthetic lipid compounds and uses thereof
HRP20181102T1 (hr)	2012-05-16	2018-09-07	Immune Design Corp	Cjepiva za hsv-2
MX370573B (es)	2013-04-18	2019-12-17	Immune Design Corp	Monoterapia con glucopiranosil lipido a para usarse en el tratamiento del cancer.
US9463198B2 (en)	2013-06-04	2016-10-11	Infectious Disease Research Institute	Compositions and methods for reducing or preventing metastasis
EP3242883A4 (de)	2015-01-06	2018-10-17	ImmunoVaccine Technologies Inc.	Lipid-a-mimetika, verfahren zur herstellung und verwendungen davon
CN109125250B (zh) *	2018-08-30	2022-07-19	陕西中医药大学	一种小分子凝胶剂及制备方法和妇科用固-液互变型凝胶制剂
WO2020082162A1 (en) *	2018-10-26	2020-04-30	Alberta Research Chemicals Inc.	Synthetic innate immune receptor ligands and uses thereof
WO2021050778A1 (en) *	2019-09-10	2021-03-18	The Penn State Research Foundation	Lipopolysaccharide molecules for enhancing immune responses
CN113214329A (zh) *	2020-01-21	2021-08-06	上海医药工业研究院	Lipid X及其中间体的制备方法、其中间体
IL299253A (en)	2020-06-22	2023-02-01	Sumitomo Pharma Co Ltd	Helps with TLR4 agonist activity
CN117105888A (zh) *	2022-05-17	2023-11-24	北京科兴中维生物技术有限公司	一种mpla酰基链中间体的合成方法

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2000
- 2000-11-15 AT AT00980380T patent/ATE518874T1/de not_active IP Right Cessation
- 2000-11-15 CA CA2396744A patent/CA2396744C/en not_active Expired - Fee Related
- 2000-11-15 AU AU17647/01A patent/AU780577B2/en not_active Ceased
- 2000-11-15 WO PCT/US2000/031281 patent/WO2001036433A2/en not_active Ceased
- 2000-11-15 ES ES00980380T patent/ES2370262T3/es not_active Expired - Lifetime
- 2000-11-15 EP EP00980380A patent/EP1232168B1/de not_active Expired - Lifetime
- 2000-11-15 US US10/130,055 patent/US7491707B1/en not_active Expired - Fee Related
- 2000-11-15 JP JP2001538922A patent/JP2003514824A/ja active Pending

Also Published As

Publication number	Publication date
EP1232168A2 (de)	2002-08-21
WO2001036433A2 (en)	2001-05-25
CA2396744C (en)	2011-07-12
AU1764701A (en)	2001-05-30
US7491707B1 (en)	2009-02-17
WO2001036433A3 (en)	2002-05-10
EP1232168B1 (de)	2011-08-03
JP2003514824A (ja)	2003-04-22
ES2370262T3 (es)	2011-12-14
CA2396744A1 (en)	2001-05-25
AU780577B2 (en)	2005-04-07

Legal Events

Date	Code	Title	Description
2012-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE518874T1 (de)	2011-08-15	Synthetische lipid-a analogen und verwendungen davon
ATE232109T1 (de)	2003-02-15	Synthetische, vielfache tandemwiederholungen des mucinpeptides und seiner derivate und deren verwendung
AU591309B2 (en)	1989-11-30	Taxol derivatives, their preparation and pharmaceutical compositions containing them
EP2050465A3 (de)	2009-09-02	Zusammensetzungen mit dem Adjuvans QS-21 und Polysorbat oder Cyclodextrin als Hilfsstoff
CA2160566A1 (en)	1994-10-27	Novel sphingoglycolipids and uses thereof
YU182691A (sh)	1994-01-20	Postupak za dobijanje derivata taksana i dobijeni novi derivati
DE69531204D1 (de)	2003-08-07	Formulierungen fuer faktor ix
PT1319183E (pt)	2009-06-29	Métodos e produtos relacionados a heparina de baixo peso molecular
MXPA96003822A (es)	2004-08-17	Aislamiento de material celular bajo visualizacional microscopio.
NO20001105L (no)	2000-05-05	Transgene pattedyr som danner oligosakkarider i melken
BR9917230A (pt)	2002-01-08	Mistura de diésteres de nonanol isomérico de um ácido dicarboxìlico, e, uso da mesma
MXPA99001697A (es)	2004-04-05	Preparacion de derivados de carboxilato de ciclohexeno.
MXPA00012586A (es)	2004-05-21	Glicosulfopeptidos y metodos de sintesis y uso de los mismos.
ES2074734T5 (es)	2002-02-16	Utilizacion de composiciones a base de alcoholes grasos, para la preparacion de emulsiones; procedimiento de preparacion de emulsiones y emulsiones asi obtenidas.
DE69401204D1 (de)	1997-01-30	Gonadotropin enthaltende gefriergetrocknete troepfen
DE69729786D1 (de)	2004-08-12	Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen
CA2278201A1 (en)	1998-07-23	Novel modifications to 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonyl-aminobenzene, and processes for their preparation
DK1233969T3 (da)	2008-06-09	Mono- og disaccharridderivater
ECSP034442A (es)	2003-03-10	Mezclas de polisacaridos derivados de la heparina, su preparacion y las composiciones farmaceuticas que las contienen
DK0789590T3 (da)	2002-11-04	Chitosaninduceret immunforstærkning
AU1436097A (en)	1997-05-07	Sulphamate derivatives of 1,3,5(10)-estratriene derivatives, methods of producing them and pharmaceutical compounds containing them
MY120683A (en)	2005-11-30	New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
KR920702853A (ko)	1992-10-28	신규 글루코사민 유도체 및 이것을 막 구성성분으로서 함유한 리포솜
ATE546457T1 (de)	2012-03-15	Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika
IL141325A0 (en)	2002-03-10	Tan-1057 derivatives