ATE519498T1 - Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen - Google Patents

Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen

Info

Publication number: ATE519498T1
Authority: AT; Austria
Prior art keywords: somatostatin; combination; receptor subtypes; analogas; different selectivity
Prior art date: 2006-02-09

Application number

AT07703319T

Other languages

English (en)

Inventor

Herbert Schmid

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-09

Filing date

2007-02-07

Publication date

2011-08-15

2007-02-07 Application filed by Novartis Ag filed Critical Novartis Ag

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE519498T1 publication Critical patent/ATE519498T1/de

Links

101000632994 Homo sapiens Somatostatin Proteins 0.000 title abstract 2
102000005157 Somatostatin Human genes 0.000 title abstract 2
108010056088 Somatostatin Proteins 0.000 title abstract 2
102000045305 human SST Human genes 0.000 title abstract 2
102000005962 receptors Human genes 0.000 title abstract 2
108020003175 receptors Proteins 0.000 title abstract 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
229960000553 somatostatin Drugs 0.000 title abstract 2
101000633010 Rattus norvegicus Somatostatin Proteins 0.000 abstract 1
108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
102000011096 Somatostatin receptor Human genes 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000000816 peptidomimetic Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
NHXLMOGPVYXJNR-UHFFFAOYSA-N srif Chemical compound N1C(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC=2C3=CC=CC=C3NC=2)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(NC(=O)CNC(=O)C(C)N)CSSCC(C(O)=O)NC(=O)C(CO)NC(=O)C(C(O)C)NC(=O)C1CC1=CC=CC=C1 NHXLMOGPVYXJNR-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Obesity (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)

AT07703319T 2006-02-09 2007-02-07 Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen ATE519498T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0602639.7A GB0602639D0 (en)	2006-02-09	2006-02-09	Organic compounds
PCT/EP2007/001036 WO2007096055A1 (en)	2006-02-09	2007-02-07	Combination of somatostatin-analogs with different selectivity for human somatostatin receptor subtypes

Publications (1)

Publication Number	Publication Date
ATE519498T1 true ATE519498T1 (de)	2011-08-15

Family

ID=36119810

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07703319T ATE519498T1 (de)	2006-02-09	2007-02-07	Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen

Country Status (15)

Country	Link
US (2)	US8450272B2 (de)
EP (1)	EP1988914B1 (de)
JP (1)	JP5189993B2 (de)
KR (1)	KR101466410B1 (de)
CN (1)	CN101378775B (de)
AT (1)	ATE519498T1 (de)
AU (1)	AU2007218297B2 (de)
BR (1)	BRPI0707560B8 (de)
CA (1)	CA2638065C (de)
ES (1)	ES2369155T3 (de)
GB (1)	GB0602639D0 (de)
PL (1)	PL1988914T3 (de)
PT (1)	PT1988914E (de)
RU (1)	RU2451520C2 (de)
WO (1)	WO2007096055A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006077362A1 (en)	2005-01-21	2006-07-27	Camurus Ab	Pharmaceutical lipid compositions
GB0602639D0 (en) *	2006-02-09	2006-03-22	Novartis Ag	Organic compounds
ES2399651T3 (es) *	2008-07-08	2013-04-02	Novartis Ag	Utilización de pasireotida para el tratamiento de la hipoglucemia hiperinsulenémica endógena
AU2013265210B2 (en) *	2012-05-25	2016-09-15	Camurus Ab	Somatostatin receptor agonist formulations
TWI633887B (zh)	2012-05-31	2018-09-01	大塚製藥股份有限公司	用於預防及／或治療多囊性腎臟病之藥物
WO2014165607A2 (en) *	2013-04-02	2014-10-09	Stealth Peptides International, Inc.	Aromatic-cationic peptide formulations, compositions and methods of use
EP3007704B1 (de) *	2013-06-13	2021-01-06	Antisense Therapeutics Ltd	Kombinationstherapie der akromegalie
CN120131956A (zh) *	2023-12-11	2025-06-13	中山大学中山眼科中心	生长激素抑制剂的用途、和含有生长激素抑制剂的药物组合物、制剂、及其装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2774591B1 (fr) *	1998-02-12	2000-05-05	Lipha	Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
GB0018891D0 (en) *	2000-08-01	2000-09-20	Novartis Ag	Organic compounds
DE60232203D1 (de) *	2001-03-06	2009-06-10	Il Consorzio Ferrara Richerche	Verfahren zur Modulation der Proliferation von Schilddrüsenkrebszellen
PL374174A1 (en) *	2001-06-25	2005-10-03	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof
US7094753B2 (en) *	2001-11-21	2006-08-22	Societe De Conseils De Recherches Et D'applications Scientifiques, Sas	Somatostatin analog and uses thereof
WO2005041901A2 (en)	2003-11-03	2005-05-12	Elixir Pharmaceuticals, Inc.	Therapeutics using somatostatin agonists
EP1689844A1 (de) *	2003-12-03	2006-08-16	The Procter & Gamble Company	Verfahren, gegenstände und zusammensetzungen zur reinigung von badezimmerflächen
ES2383303T3 (es) *	2005-11-10	2012-06-20	Chemi S.P.A.	Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
GB0602639D0 (en) *	2006-02-09	2006-03-22	Novartis Ag	Organic compounds

2006
- 2006-02-09 GB GBGB0602639.7A patent/GB0602639D0/en not_active Ceased
2007
- 2007-02-07 WO PCT/EP2007/001036 patent/WO2007096055A1/en not_active Ceased
- 2007-02-07 EP EP07703319A patent/EP1988914B1/de active Active
- 2007-02-07 AU AU2007218297A patent/AU2007218297B2/en active Active
- 2007-02-07 CN CN2007800049919A patent/CN101378775B/zh active Active
- 2007-02-07 PL PL07703319T patent/PL1988914T3/pl unknown
- 2007-02-07 CA CA2638065A patent/CA2638065C/en active Active
- 2007-02-07 ES ES07703319T patent/ES2369155T3/es active Active
- 2007-02-07 US US12/162,715 patent/US8450272B2/en active Active
- 2007-02-07 PT PT07703319T patent/PT1988914E/pt unknown
- 2007-02-07 KR KR1020087019493A patent/KR101466410B1/ko active Active
- 2007-02-07 RU RU2008136073/15A patent/RU2451520C2/ru active
- 2007-02-07 BR BRPI0707560A patent/BRPI0707560B8/pt active IP Right Grant
- 2007-02-07 AT AT07703319T patent/ATE519498T1/de active
- 2007-02-07 JP JP2008553675A patent/JP5189993B2/ja active Active
2013
- 2013-04-30 US US13/873,289 patent/US9149510B2/en active Active

Also Published As

Publication number	Publication date
AU2007218297B2 (en)	2010-09-09
BRPI0707560A2 (pt)	2011-05-10
BRPI0707560B1 (pt)	2019-06-04
CN101378775B (zh)	2013-06-12
JP2009526002A (ja)	2009-07-16
AU2007218297A1 (en)	2007-08-30
US20090029910A1 (en)	2009-01-29
RU2008136073A (ru)	2010-03-20
KR101466410B1 (ko)	2014-11-27
WO2007096055A1 (en)	2007-08-30
PL1988914T3 (pl)	2012-01-31
BRPI0707560B8 (pt)	2021-05-25
CA2638065A1 (en)	2007-08-30
RU2451520C2 (ru)	2012-05-27
US9149510B2 (en)	2015-10-06
CN101378775A (zh)	2009-03-04
EP1988914A1 (de)	2008-11-12
KR20080106896A (ko)	2008-12-09
EP1988914B1 (de)	2011-08-10
CA2638065C (en)	2016-03-29
US8450272B2 (en)	2013-05-28
US20130237480A1 (en)	2013-09-12
JP5189993B2 (ja)	2013-04-24
PT1988914E (pt)	2011-10-18
GB0602639D0 (en)	2006-03-22
ES2369155T3 (es)	2011-11-25

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