BRPI0707560B8 - combinação de análogos de somatostatina com seletividade diferente para subtipos de receptores de somatostatina humana, seu uso, composição farmacêutica, e embalagem comercial - Google Patents
combinação de análogos de somatostatina com seletividade diferente para subtipos de receptores de somatostatina humana, seu uso, composição farmacêutica, e embalagem comercialInfo
- Publication number
- BRPI0707560B8 BRPI0707560B8 BRPI0707560A BRPI0707560A BRPI0707560B8 BR PI0707560 B8 BRPI0707560 B8 BR PI0707560B8 BR PI0707560 A BRPI0707560 A BR PI0707560A BR PI0707560 A BRPI0707560 A BR PI0707560A BR PI0707560 B8 BRPI0707560 B8 BR PI0707560B8
- Authority
- BR
- Brazil
- Prior art keywords
- somatostatin
- combination
- receptor subtypes
- pharmaceutical composition
- different selectivity
- Prior art date
Links
- 101000632994 Homo sapiens Somatostatin Proteins 0.000 title abstract 2
- 102000045305 human SST Human genes 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 title abstract 2
- 108020003175 receptors Proteins 0.000 title abstract 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
- 238000004806 packaging method and process Methods 0.000 title 1
- 229940075620 somatostatin analogue Drugs 0.000 title 1
- 101000633010 Rattus norvegicus Somatostatin Proteins 0.000 abstract 1
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- 108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
- 102000011096 Somatostatin receptor Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
- NHXLMOGPVYXJNR-UHFFFAOYSA-N srif Chemical compound N1C(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC=2C3=CC=CC=C3NC=2)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(NC(=O)CNC(=O)C(C)N)CSSCC(C(O)=O)NC(=O)C(CO)NC(=O)C(C(O)C)NC(=O)C1CC1=CC=CC=C1 NHXLMOGPVYXJNR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
Abstract
combinação de análogos de somatostatina com seletividade diferente para subtipos de receptores de somatostatina humana. a presente invenção refere-se a uma combinação de dois ou mais peptidomiméticos de somatostatina (srif) (também chamados de análogos de somatostatina ou srif) que possuem seletividade diferente para os cinco subtipos de receptores de somatostatina humanos, ao uso de tal combinação no tratamento de uma doença mediada pela ativação de receptores de somatostatina, e a composições farmacêuticas compreendendo tal combinação.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB06026397 | 2006-02-09 | ||
| GB0602639.7 | 2006-02-09 | ||
| GBGB0602639.7A GB0602639D0 (en) | 2006-02-09 | 2006-02-09 | Organic compounds |
| PCT/EP2007/001036 WO2007096055A1 (en) | 2006-02-09 | 2007-02-07 | Combination of somatostatin-analogs with different selectivity for human somatostatin receptor subtypes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0707560A2 BRPI0707560A2 (pt) | 2011-05-10 |
| BRPI0707560B1 BRPI0707560B1 (pt) | 2019-06-04 |
| BRPI0707560B8 true BRPI0707560B8 (pt) | 2021-05-25 |
Family
ID=36119810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0707560A BRPI0707560B8 (pt) | 2006-02-09 | 2007-02-07 | combinação de análogos de somatostatina com seletividade diferente para subtipos de receptores de somatostatina humana, seu uso, composição farmacêutica, e embalagem comercial |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8450272B2 (pt) |
| EP (1) | EP1988914B1 (pt) |
| JP (1) | JP5189993B2 (pt) |
| KR (1) | KR101466410B1 (pt) |
| CN (1) | CN101378775B (pt) |
| AT (1) | ATE519498T1 (pt) |
| AU (1) | AU2007218297B2 (pt) |
| BR (1) | BRPI0707560B8 (pt) |
| CA (1) | CA2638065C (pt) |
| ES (1) | ES2369155T3 (pt) |
| GB (1) | GB0602639D0 (pt) |
| PL (1) | PL1988914T3 (pt) |
| PT (1) | PT1988914E (pt) |
| RU (1) | RU2451520C2 (pt) |
| WO (1) | WO2007096055A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101245022B1 (ko) | 2005-01-21 | 2013-03-19 | 카무러스 에이비 | 약제학적 지질 조성물 |
| GB0602639D0 (en) * | 2006-02-09 | 2006-03-22 | Novartis Ag | Organic compounds |
| DK2310042T3 (da) | 2008-07-08 | 2013-03-04 | Novartis Ag | Anvendelse af pasireotid til behandling af endogen hyperinsulinæmisk hypoglykæmi |
| ES2834318T3 (es) * | 2012-05-25 | 2021-06-17 | Camurus Ab | Formulaciones de agonistas de receptores de la somatostatina |
| TWI633887B (zh) * | 2012-05-31 | 2018-09-01 | 大塚製藥股份有限公司 | 用於預防及／或治療多囊性腎臟病之藥物 |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
| DK3007704T3 (da) * | 2013-06-13 | 2021-03-29 | Antisense Therapeutics Ltd | Kombinationsterapi til akromegali |
| CN120131956A (zh) * | 2023-12-11 | 2025-06-13 | 中山大学中山眼科中心 | 生长激素抑制剂的用途、和含有生长激素抑制剂的药物组合物、制剂、及其装置 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2774591B1 (fr) * | 1998-02-12 | 2000-05-05 | Lipha | Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie |
| GB0018891D0 (en) * | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| EP1813625B1 (en) * | 2001-03-06 | 2009-04-29 | Il Consorzio Ferrara Richerche | Method of modulating the profileration of medullary thyroid carcinoma cells |
| PL374174A1 (en) * | 2001-06-25 | 2005-10-03 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof |
| AR037665A1 (es) * | 2001-11-21 | 2004-12-01 | Sod Conseils Rech Applic | Analogo de somatostatina y sus usos |
| WO2005041901A2 (en) * | 2003-11-03 | 2005-05-12 | Elixir Pharmaceuticals, Inc. | Therapeutics using somatostatin agonists |
| US7842654B2 (en) * | 2003-12-03 | 2010-11-30 | The Procter & Gamble Company | Method, articles and compositions for cleaning bathroom surfaces |
| ATE549011T1 (de) * | 2005-11-10 | 2012-03-15 | Chemi Spa | Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten |
| GB0602639D0 (en) * | 2006-02-09 | 2006-03-22 | Novartis Ag | Organic compounds |
-
2006
- 2006-02-09 GB GBGB0602639.7A patent/GB0602639D0/en not_active Ceased
-
2007
- 2007-02-07 CA CA2638065A patent/CA2638065C/en active Active
- 2007-02-07 ES ES07703319T patent/ES2369155T3/es active Active
- 2007-02-07 AT AT07703319T patent/ATE519498T1/de active
- 2007-02-07 CN CN2007800049919A patent/CN101378775B/zh active Active
- 2007-02-07 BR BRPI0707560A patent/BRPI0707560B8/pt active IP Right Grant
- 2007-02-07 PT PT07703319T patent/PT1988914E/pt unknown
- 2007-02-07 JP JP2008553675A patent/JP5189993B2/ja active Active
- 2007-02-07 RU RU2008136073/15A patent/RU2451520C2/ru active
- 2007-02-07 EP EP07703319A patent/EP1988914B1/en active Active
- 2007-02-07 US US12/162,715 patent/US8450272B2/en active Active
- 2007-02-07 WO PCT/EP2007/001036 patent/WO2007096055A1/en not_active Ceased
- 2007-02-07 KR KR1020087019493A patent/KR101466410B1/ko active Active
- 2007-02-07 AU AU2007218297A patent/AU2007218297B2/en active Active
- 2007-02-07 PL PL07703319T patent/PL1988914T3/pl unknown
-
2013
- 2013-04-30 US US13/873,289 patent/US9149510B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101378775A (zh) | 2009-03-04 |
| AU2007218297B2 (en) | 2010-09-09 |
| JP5189993B2 (ja) | 2013-04-24 |
| JP2009526002A (ja) | 2009-07-16 |
| CA2638065C (en) | 2016-03-29 |
| ES2369155T3 (es) | 2011-11-25 |
| ATE519498T1 (de) | 2011-08-15 |
| AU2007218297A1 (en) | 2007-08-30 |
| KR20080106896A (ko) | 2008-12-09 |
| US9149510B2 (en) | 2015-10-06 |
| BRPI0707560A2 (pt) | 2011-05-10 |
| CA2638065A1 (en) | 2007-08-30 |
| PT1988914E (pt) | 2011-10-18 |
| PL1988914T3 (pl) | 2012-01-31 |
| GB0602639D0 (en) | 2006-03-22 |
| CN101378775B (zh) | 2013-06-12 |
| EP1988914A1 (en) | 2008-11-12 |
| BRPI0707560B1 (pt) | 2019-06-04 |
| RU2451520C2 (ru) | 2012-05-27 |
| US20130237480A1 (en) | 2013-09-12 |
| KR101466410B1 (ko) | 2014-11-27 |
| WO2007096055A1 (en) | 2007-08-30 |
| RU2008136073A (ru) | 2010-03-20 |
| US20090029910A1 (en) | 2009-01-29 |
| EP1988914B1 (en) | 2011-08-10 |
| US8450272B2 (en) | 2013-05-28 |
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| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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