ATE521599T1 - Heterocyclische modulatoren von nukleären rezeptoren - Google Patents
Heterocyclische modulatoren von nukleären rezeptorenInfo
- Publication number
- ATE521599T1 ATE521599T1 AT02806505T AT02806505T ATE521599T1 AT E521599 T1 ATE521599 T1 AT E521599T1 AT 02806505 T AT02806505 T AT 02806505T AT 02806505 T AT02806505 T AT 02806505T AT E521599 T1 ATE521599 T1 AT E521599T1
- Authority
- AT
- Austria
- Prior art keywords
- nuclear receptors
- heterocyclic modulators
- compounds
- heterocyclic
- modulating
- Prior art date
Links
- 108020005497 Nuclear hormone receptor Proteins 0.000 title abstract 2
- 102000006255 nuclear receptors Human genes 0.000 title abstract 2
- 108020004017 nuclear receptors Proteins 0.000 title abstract 2
- 102100038495 Bile acid receptor Human genes 0.000 abstract 2
- 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004311 liver X receptors Human genes 0.000 abstract 2
- 108090000865 liver X receptors Proteins 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004164 orphan nuclear receptors Human genes 0.000 abstract 1
- 108090000629 orphan nuclear receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34272001P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/041224 WO2003060078A2 (en) | 2001-12-21 | 2002-12-20 | Heterocyclic modulators of nuclear receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE521599T1 true ATE521599T1 (de) | 2011-09-15 |
Family
ID=23342988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02806505T ATE521599T1 (de) | 2001-12-21 | 2002-12-20 | Heterocyclische modulatoren von nukleären rezeptoren |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6696473B2 (de) |
| EP (1) | EP1465882B1 (de) |
| AT (1) | ATE521599T1 (de) |
| AU (1) | AU2002367060A1 (de) |
| ES (1) | ES2367539T3 (de) |
| WO (1) | WO2003060078A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003508391A (ja) * | 1999-08-31 | 2003-03-04 | マキシア・ファーマシューティカルズ・インコーポレイテッド | ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用 |
| ES2367539T3 (es) * | 2001-12-21 | 2011-11-04 | X-Ceptor Therapeutics, Inc. | Moduladores heterocíclicos de receptores nucleares. |
| US6987121B2 (en) | 2002-04-25 | 2006-01-17 | Smithkline Beecham Corporation | Compositions and methods for hepatoprotection and treatment of cholestasis |
| US20040259948A1 (en) * | 2003-01-10 | 2004-12-23 | Peter Tontonoz | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors |
| WO2004113533A1 (ja) * | 2003-06-24 | 2004-12-29 | Sumitomo Chemical Company, Limited | 肝臓Ｘ受容体αスプライシング変異体タンパク質、その遺伝子及びそれらの利用 |
| AU2004267067A1 (en) | 2003-08-18 | 2005-03-03 | Wyeth | Human LXR alpha variants |
| MX2007001539A (es) * | 2004-08-10 | 2007-04-23 | Exelisis Inc | Compuestos heterociclicos como agentes farmaceuticos. |
| JP4553355B2 (ja) * | 2004-10-04 | 2010-09-29 | 富士フイルム株式会社 | トリパノソーマ原虫寄生感染症の予防又は治療用医薬組成物 |
| US7618956B2 (en) | 2005-05-31 | 2009-11-17 | The Gillette Company | Reduction of hair growth |
| WO2009009139A2 (en) * | 2007-07-11 | 2009-01-15 | The General Hospital Corporation | Rna ligase polypeptides and methods of selection and use thereof |
| US20100113581A1 (en) * | 2008-10-16 | 2010-05-06 | Aronne Louis J | Combination therapies for the treatment of obesity |
| US20100113580A1 (en) * | 2008-10-16 | 2010-05-06 | Aronne Louis J | Combination therapies for the treatment of obesity |
| WO2010045563A2 (en) * | 2008-10-16 | 2010-04-22 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| US20100113603A1 (en) * | 2008-10-16 | 2010-05-06 | Aronne Louis J | Combination therapies for the treatment of obesity |
| WO2010045416A2 (en) * | 2008-10-16 | 2010-04-22 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| US20100331419A1 (en) * | 2009-06-25 | 2010-12-30 | Aronne Louis J | Combination Therapies for the Treatment of Obesity |
| US20100331420A1 (en) * | 2009-06-26 | 2010-12-30 | Aronne Louis J | Combination Therapies for the Treatment of Obesity |
| WO2011008490A2 (en) * | 2009-06-29 | 2011-01-20 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| WO2011009115A2 (en) * | 2009-07-17 | 2011-01-20 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| US20110082407A1 (en) * | 2009-10-01 | 2011-04-07 | Aronne Louis J | Combination Therapies for the Treatment of Obesity |
| WO2012033353A2 (ko) | 2010-09-07 | 2012-03-15 | 서울대학교 산학협력단 | 세스터터핀 화합물 및 이들 물질의 용도 |
| SI3043865T1 (sl) | 2013-09-11 | 2021-04-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Metode in farmacevtski sestavki za zdravljenje virusne okužbe s hepatitisom B |
| WO2015106164A1 (en) | 2014-01-10 | 2015-07-16 | Rgenix, Inc. | Lxr agonists and uses thereof |
| WO2016198908A1 (en) | 2015-06-09 | 2016-12-15 | Abbvie Inc. | Ror nuclear receptor modulators |
| EP3402477A4 (de) | 2016-01-11 | 2019-08-21 | The Rockefeller University | Verfahren zur behandlung von erkrankungen im zusammenhang mit aus myeloid abgeleiteten suppressorzellen |
| WO2018178260A1 (en) | 2017-03-30 | 2018-10-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for reducing persistence and expression of episomal viruses |
| USRE50663E1 (en) | 2017-10-04 | 2025-11-18 | Bayer Aktiengesellschaft | Heterocycle derivatives as pesticides |
| CA3078981A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
| TWI888447B (zh) | 2019-12-13 | 2025-07-01 | 美商因思博納公司 | 金屬鹽及其用途 |
| CN111041014B (zh) * | 2019-12-31 | 2022-03-18 | 浙江工业大学 | 一种磁性固定化脂肪酶及其在拆分1-甲基-3-苯丙胺中的应用 |
| CN113181160A (zh) * | 2020-01-14 | 2021-07-30 | 无锡杰西医药股份有限公司 | 异硫氰酸酯类化合物的用途 |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US228607A (en) * | 1880-06-08 | Door-hanger | ||
| US181420A (en) * | 1876-08-22 | Improvement in stove-platforms | ||
| US132223A (en) * | 1872-10-15 | Improvement in bale-ties | ||
| US120137A (en) * | 1871-10-17 | Improvement in mill-bolts | ||
| GB489335A (en) * | 1937-01-22 | 1938-07-22 | Douglas James Fry | Improvements in or relating to the manufacture and use of dyestuffs suitable for sensitising photographic emulsions |
| US2454629A (en) * | 1940-01-27 | 1948-11-23 | Eastman Kodak Co | Polymethine dyes |
| FR1449800A (fr) | 1964-07-02 | 1966-05-06 | Kodak Pathe | Nouveaux colorants sensibilisateurs chromatiques |
| CA918992A (en) | 1968-02-21 | 1973-01-16 | Tsubota Motohiko | Direct positive photographic emulsion |
| US3635964A (en) * | 1969-02-10 | 1972-01-18 | Colgate Palmolive Co | 5-morpholinyl-2 1-benzisothiazolines |
| US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| FR2117337A5 (en) | 1970-12-04 | 1972-07-21 | Eastman Kodak Co | Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions |
| GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| US4044126A (en) * | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
| USRE28819E (en) * | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| IT1039699B (it) * | 1975-07-03 | 1979-12-10 | Prephar | Composizione spermicida a base di derivati benzisotiazolici |
| JPS53129633A (en) | 1977-04-19 | 1978-11-11 | Fuji Photo Film Co Ltd | Silver halide photographic material |
| US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| US4410545A (en) * | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4328245A (en) * | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4358603A (en) * | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4409239A (en) * | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| HU204253B (en) | 1982-11-22 | 1991-12-30 | Sandoz Ag | Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them |
| US5354772A (en) * | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| US4721721A (en) | 1984-12-18 | 1988-01-26 | Rorer Pharmaceutical Corporation | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses |
| US5583024A (en) * | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| US5221623A (en) * | 1986-07-22 | 1993-06-22 | Boyce Thompson Institute For Plant Research, Inc. | Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms |
| US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| AU614965B2 (en) * | 1987-06-06 | 1991-09-19 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Thiadiazinones |
| EP0303418A3 (de) * | 1987-08-11 | 1990-11-07 | Smithkline Beecham Laboratoires Pharmaceutiques | Substituierte Indolone, verwendbar in der Behandlung von Herz- oder Asthmakrankheiten |
| US5052558A (en) * | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) * | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5070012A (en) * | 1988-03-30 | 1991-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Monitoring of cells and trans-activating transcription elements |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5683888A (en) * | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| DE3932953A1 (de) | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| KR0164842B1 (ko) * | 1990-03-24 | 1999-01-15 | 손정삼 | 신규 벤즈옥사진, 벤조티아진 유도체 및 그 제조방법 |
| TW203049B (de) | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
| US5283179A (en) * | 1990-09-10 | 1994-02-01 | Promega Corporation | Luciferase assay method |
| US5177080A (en) * | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
| EP0510235A1 (de) | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Benzoxazin- oder Benzothiazinderivate und Verfahren zu deren Herstellung |
| JPH0527356A (ja) | 1991-07-23 | 1993-02-05 | Konica Corp | 分光増感されたハロゲン化銀写真感光材料 |
| US5323907A (en) * | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| JPH0620053A (ja) | 1992-07-03 | 1994-01-28 | Sankyo Seiki Mfg Co Ltd | パターン認識方法 |
| JP2879395B2 (ja) * | 1992-10-26 | 1999-04-05 | 富士写真フイルム株式会社 | ロダシアニン化合物及びシクロデキストリンを含有する抗癌性組成物 |
| US5476945A (en) * | 1992-11-17 | 1995-12-19 | Fuji Photo Film Co., Ltd. | Water-soluble methine derivatives of thiazole |
| US5618831A (en) * | 1992-11-17 | 1997-04-08 | Fuji Photo Film Co., Ltd. | Composition and method for treating cancer |
| JPH06234639A (ja) * | 1993-02-10 | 1994-08-23 | Fuji Photo Film Co Ltd | 免疫抑制剤 |
| FR2707120B1 (fr) * | 1993-07-02 | 1995-09-22 | Lectra Systemes Sa | Système de gradation de vêtements. |
| EP0737314A4 (de) | 1993-12-30 | 1999-11-03 | Salk Inst For Biological Studi | Verwendungen für gal 4-rezeptor-konstrukte |
| JP3466765B2 (ja) * | 1994-07-27 | 2003-11-17 | キッコーマン株式会社 | ビオチン化ホタルルシフェラーゼ、ビオチン化ホタルルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ、ビオチン化ホタルルシフェラーゼの製造法及び生物発光分析法 |
| US6005086A (en) * | 1995-01-13 | 1999-12-21 | The Salk Institute For Biological Studies | Farnesoid activated receptor polypeptides, and nucleic acid encoding the same |
| US5741657A (en) * | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
| AUPN449295A0 (en) * | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
| AU722191B2 (en) | 1995-08-18 | 2000-07-27 | Auckland Uniservices Limited | Radiation-activated cytotoxin therapy |
| US5955604A (en) * | 1996-10-15 | 1999-09-21 | The Regents Of The University Of California | Substrates for β-lactamase and uses thereof |
| US5707794A (en) * | 1996-11-22 | 1998-01-13 | Sterling Diagnostic Imaging, Inc. | Spectral sensitization of silver halide photographic elements |
| US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| CN1248916A (zh) * | 1997-01-24 | 2000-03-29 | 加利福尼亚大学董事会 | FXR、PPARα和LXRα激活剂恢复屏障功能、促进表皮分化和抑制增生的用途 |
| US7101681B1 (en) | 1997-11-21 | 2006-09-05 | Amgen, Inc. | Nuclear hormone receptor drug screens |
| MY153569A (en) * | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6468711B1 (en) | 1998-09-09 | 2002-10-22 | Fuji Photo Film Co., Ltd. | Photosensitive composition and method for manufacturing lithographic printing plate |
| EP1115853A2 (de) | 1998-09-23 | 2001-07-18 | Ludmila Solomin | "in vivo" analyse von ligand-activierten kernrezeptoren i |
| JP2002528721A (ja) | 1998-10-23 | 2002-09-03 | グラクソ グループ リミテッド | 核内受容体のリガンド用のアッセイ |
| JP2002532729A (ja) | 1998-12-23 | 2002-10-02 | グラクソ グループ リミテッド | 核内受容体のリガンドのアッセイ |
| WO2000040965A1 (en) | 1999-01-07 | 2000-07-13 | Tularik, Inc. | Fxr receptor-mediated modulation of cholesterol metabolism |
| WO2000042031A2 (en) | 1999-01-14 | 2000-07-20 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| US6071955A (en) * | 1999-02-25 | 2000-06-06 | The Regents Of The University Of California | FXR, PPARA and LXRA activators to treat acne/acneiform conditions |
| US6291676B1 (en) * | 1999-03-03 | 2001-09-18 | University Of Kentucky Research Foundation | Water-soluble derivatives of camptothecin/homocamptothecin |
| EP1165135B1 (de) | 1999-03-26 | 2004-09-01 | City of Hope | Verfahren zur selektion von fxr-rezeptormodulatoren |
| US20020132223A1 (en) | 1999-03-26 | 2002-09-19 | City Of Hope | Methods for modulating activity of the FXR nuclear receptor |
| US6316510B1 (en) * | 1999-04-13 | 2001-11-13 | Henry Sperber | Foamable binder composition and methods for producing the same |
| DE60007310D1 (de) * | 1999-06-04 | 2004-01-29 | Elan Pharma Int Ltd | Zusammensetzungen und methoden zur verhinderung des zelltods |
| BR0011743A (pt) | 1999-06-11 | 2002-03-05 | Allergan Sales Inc | Método para modular a atividade de receptor de fxr |
| HK1047752A1 (zh) * | 1999-06-11 | 2003-03-07 | Allergan, Inc. | 具有核激素受体调节活性的有机硅化合物 |
| CN100513570C (zh) | 1999-06-18 | 2009-07-15 | Cv治疗公司 | 结合框运输蛋白abc1的调节作用 |
| JP2001013617A (ja) | 1999-06-29 | 2001-01-19 | Konica Corp | ハロゲン化銀乳剤、ハロゲン化銀感光材料及び熱現像感光材料 |
| ATE260912T1 (de) | 1999-09-08 | 2004-03-15 | Glaxo Group Ltd | Oxazol ppar antagonisten |
| GB2354304A (en) | 1999-09-16 | 2001-03-21 | Barrus Ltd E P | A valve and a marine propulsion unit incorporating a valve |
| US6458789B1 (en) * | 1999-09-29 | 2002-10-01 | Lion Bioscience Ag | 2-aminopyridine derivatives and combinatorial libraries thereof |
| AU2000235960A1 (en) | 2000-02-14 | 2001-08-27 | Tularik, Inc. | Lxr modulators |
| US6586453B2 (en) * | 2000-04-03 | 2003-07-01 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 |
| WO2001082917A2 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Treatment of hypertriglyceridemia and other conditions using lxr modulators |
| GB0019290D0 (en) | 2000-08-04 | 2000-09-27 | Symphar Sa | Methods for inducing apolipoprotein E secretion |
| WO2002020463A2 (en) | 2000-09-05 | 2002-03-14 | Tularik Inc. | Fxr modulators |
| CN1489588A (zh) * | 2001-01-31 | 2004-04-14 | �Ʒ� | 用作pde4同功酶抑制剂的噻唑基,噁唑基,吡咯基,和咪唑基羧酸酰胺衍生物 |
| US20020119958A1 (en) | 2001-02-13 | 2002-08-29 | Shinichiro Tojo | Therapeutic agent for hyperlipidemia |
| AU2002308295B2 (en) | 2001-03-12 | 2007-08-23 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for FXR |
| ES2367539T3 (es) | 2001-12-21 | 2011-11-04 | X-Ceptor Therapeutics, Inc. | Moduladores heterocíclicos de receptores nucleares. |
| EP1465869B1 (de) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulatoren von lxr |
| ATE507210T1 (de) | 2002-03-07 | 2011-05-15 | X Ceptor Therapeutics Inc | Chinazolinon modulatoren von nukleinrezeptoren |
| US20030228607A1 (en) | 2002-04-15 | 2003-12-11 | Wagner Brandee Lynn | Screening method and modulators having an improved therapeutic profile |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| TW200401770A (en) | 2002-06-18 | 2004-02-01 | Sankyo Co | Fused-ring pyrimidin-4(3H)-one derivatives, processes for the preparation and uses thereof |
-
2002
- 2002-12-20 ES ES02806505T patent/ES2367539T3/es not_active Expired - Lifetime
- 2002-12-20 WO PCT/US2002/041224 patent/WO2003060078A2/en not_active Ceased
- 2002-12-20 AT AT02806505T patent/ATE521599T1/de not_active IP Right Cessation
- 2002-12-20 US US10/329,668 patent/US6696473B2/en not_active Expired - Lifetime
- 2002-12-20 EP EP02806505A patent/EP1465882B1/de not_active Expired - Lifetime
- 2002-12-20 AU AU2002367060A patent/AU2002367060A1/en not_active Abandoned
-
2003
- 2003-11-18 US US10/717,049 patent/US7115640B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7115640B2 (en) | 2006-10-03 |
| AU2002367060A8 (en) | 2003-07-30 |
| US6696473B2 (en) | 2004-02-24 |
| US20040180942A1 (en) | 2004-09-16 |
| EP1465882A2 (de) | 2004-10-13 |
| WO2003060078A3 (en) | 2004-06-24 |
| EP1465882B1 (de) | 2011-08-24 |
| EP1465882A4 (de) | 2005-04-06 |
| AU2002367060A1 (en) | 2003-07-30 |
| WO2003060078A8 (en) | 2004-04-29 |
| US20030212111A1 (en) | 2003-11-13 |
| WO2003060078A2 (en) | 2003-07-24 |
| ES2367539T3 (es) | 2011-11-04 |
| WO2003060078A9 (en) | 2004-02-19 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |