ATE521610T1 - Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität - Google Patents
Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivitätInfo
- Publication number
- ATE521610T1 ATE521610T1 AT04761819T AT04761819T ATE521610T1 AT E521610 T1 ATE521610 T1 AT E521610T1 AT 04761819 T AT04761819 T AT 04761819T AT 04761819 T AT04761819 T AT 04761819T AT E521610 T1 ATE521610 T1 AT E521610T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- chemokine receptor
- receptor activity
- spir
- methods
- Prior art date
Links
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title 1
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 abstract 1
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50140703P | 2003-09-10 | 2003-09-10 | |
| PCT/CA2004/001656 WO2005023809A1 (en) | 2003-09-10 | 2004-09-09 | Spiro compounds and methods for the modulation of chemokine receptor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE521610T1 true ATE521610T1 (de) | 2011-09-15 |
Family
ID=34273044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04761819T ATE521610T1 (de) | 2003-09-10 | 2004-09-09 | Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7288548B2 (de) |
| EP (1) | EP1786815B1 (de) |
| AT (1) | ATE521610T1 (de) |
| CA (1) | CA2579608A1 (de) |
| WO (1) | WO2005023809A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| WO2006000096A1 (en) * | 2004-06-25 | 2006-01-05 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
| WO2006060918A1 (en) * | 2004-12-09 | 2006-06-15 | Virochem Pharma Inc. | Novel spirotropane compounds and methods for the modulation of chemokine receptor activity |
| EP1831222A4 (de) | 2004-12-09 | 2009-10-21 | Virochem Pharma Inc | Neue spirotropanverbindungen und verfahren zur modulierung der aktivität des chemokinrezeptors |
| BRPI0608847A2 (pt) * | 2005-03-08 | 2010-02-02 | Janssen Pharmaceutica Nv | derivados de diaza-espiro-[4,4]-nonano substituìdos e seu uso como antagonistas de neurocinina |
| AU2010245889A1 (en) * | 2009-05-07 | 2011-11-03 | Merck Sharp & Dohme Corp. | Substituted spirocyclic amines useful as antidiabetic compounds |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| CN108982465B (zh) * | 2018-06-06 | 2020-10-02 | 上海应用技术大学 | 酒中二氧化硫高通量sers在线检测方法 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP2023516235A (ja) * | 2019-12-03 | 2023-04-19 | キャリーオペ，インク． | Ｓｓｔｒ５アンタゴニスト |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT36793A (en) * | 1983-06-27 | 1985-10-28 | Sandoz Ag | Process for producing new spirosuccunimide derivatives and pharmaceutical composition containing them |
| WO1999009984A1 (en) | 1997-08-28 | 1999-03-04 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| AU3389300A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AU3386700A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
| WO2000051609A1 (en) | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity |
| US6362201B1 (en) | 1999-03-02 | 2002-03-26 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| US6248755B1 (en) | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| JP2003514777A (ja) | 1999-10-27 | 2003-04-22 | シーオーアール セラピューティクス インコーポレイテッド | フィブリノゲン依存性血小板凝集の阻害剤としてのピリジル含有スピロ環化合物 |
| JP2002095730A (ja) | 2000-07-21 | 2002-04-02 | Midori Anzen Co Ltd | 脱臭材及びその製造方法 |
| US7125887B2 (en) | 2000-10-11 | 2006-10-24 | Merck & Co., Inc. | Pyrrolidine modulators of CCR5 chemokine receptor activity |
| CN101050215A (zh) | 2001-12-28 | 2007-10-10 | 阿卡蒂亚药品公司 | 作为单胺受体调节剂的螺氮杂环化合物 |
| WO2004058763A1 (en) | 2002-12-23 | 2004-07-15 | Merck & Co., Inc. | 4(spiropiperidinyl)methyl substituted pyrrolidines as modulators of chemokine receptor activity |
| AU2003301197A1 (en) | 2002-12-23 | 2004-07-22 | Merck And Co., Inc. | 4-((4-(carboxyethyl) piperidinyl) methyl) pyrrolidines as modulators of chemokine receptor activity |
-
2004
- 2004-09-09 AT AT04761819T patent/ATE521610T1/de not_active IP Right Cessation
- 2004-09-09 CA CA002579608A patent/CA2579608A1/en not_active Abandoned
- 2004-09-09 EP EP04761819A patent/EP1786815B1/de not_active Expired - Lifetime
- 2004-09-09 WO PCT/CA2004/001656 patent/WO2005023809A1/en not_active Ceased
- 2004-09-10 US US10/937,880 patent/US7288548B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1786815A1 (de) | 2007-05-23 |
| CA2579608A1 (en) | 2005-03-17 |
| US20050070563A1 (en) | 2005-03-31 |
| EP1786815A4 (de) | 2009-03-18 |
| EP1786815B1 (de) | 2011-08-24 |
| WO2005023809A1 (en) | 2005-03-17 |
| US7288548B2 (en) | 2007-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |