ATE521610T1 - Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität - Google Patents

Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität

Info

Publication number
ATE521610T1
ATE521610T1 AT04761819T AT04761819T ATE521610T1 AT E521610 T1 ATE521610 T1 AT E521610T1 AT 04761819 T AT04761819 T AT 04761819T AT 04761819 T AT04761819 T AT 04761819T AT E521610 T1 ATE521610 T1 AT E521610T1
Authority
AT
Austria
Prior art keywords
compounds
chemokine receptor
receptor activity
spir
methods
Prior art date
Application number
AT04761819T
Other languages
English (en)
Inventor
Chun Kong Laval Chan
Ming-Qiang Zhang
Christophe Moinet
Marc Courchesne
Thumkunta Reddy
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Application granted granted Critical
Publication of ATE521610T1 publication Critical patent/ATE521610T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04761819T 2003-09-10 2004-09-09 Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität ATE521610T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50140703P 2003-09-10 2003-09-10
PCT/CA2004/001656 WO2005023809A1 (en) 2003-09-10 2004-09-09 Spiro compounds and methods for the modulation of chemokine receptor activity

Publications (1)

Publication Number Publication Date
ATE521610T1 true ATE521610T1 (de) 2011-09-15

Family

ID=34273044

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04761819T ATE521610T1 (de) 2003-09-10 2004-09-09 Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität

Country Status (5)

Country Link
US (1) US7288548B2 (de)
EP (1) EP1786815B1 (de)
AT (1) ATE521610T1 (de)
CA (1) CA2579608A1 (de)
WO (1) WO2005023809A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2676B1 (en) * 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
US7709642B2 (en) 2004-06-25 2010-05-04 Virochem Pharma, Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
KR20070095310A (ko) 2004-12-09 2007-09-28 바이로켐 파마 인코포레이티드 신규 스피로트로판 화합물 및 케모카인 수용체 활성의 조절방법
EP1824853A4 (de) * 2004-12-09 2010-06-09 Virochem Pharma Inc Neue spirotropanverbindungen und verfahren zur modulation der aktivität des chemokinrezeptors
NZ556628A (en) * 2005-03-08 2009-09-25 Janssen Pharmaceutica Nv Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
WO2010129729A1 (en) * 2009-05-07 2010-11-11 Merck Sharp & Dohme Corp. Substituted spirocyclic amines useful as antidiabetic compounds
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
EP2961746B1 (de) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazolderivate als potente rock1- und rock2-inhibitoren
CN108982465B (zh) * 2018-06-06 2020-10-02 上海应用技术大学 酒中二氧化硫高通量sers在线检测方法
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP4073075A4 (de) * 2019-12-03 2023-12-27 Kallyope, Inc. Sstr5-antagonisten

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8401907A (nl) * 1983-06-27 1985-01-16 Sandoz Ag Spirosuccinimiden en werkwijzen voor het bereiden en toepassen van deze spirosuccinimiden.
EP1009405A4 (de) 1997-08-28 2001-05-09 Merck & Co Inc Payrrolidine und piperidine modulatoren der chemokine rezeptoraktivitaet
WO2000051609A1 (en) 1999-03-02 2000-09-08 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6303593B1 (en) 1999-03-02 2001-10-16 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
US6362201B1 (en) 1999-03-02 2002-03-26 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
WO2000051610A1 (en) 1999-03-02 2000-09-08 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
WO2001030780A2 (en) 1999-10-27 2001-05-03 Cor Therapeutics, Inc. Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation
JP2002095730A (ja) 2000-07-21 2002-04-02 Midori Anzen Co Ltd 脱臭材及びその製造方法
CA2425288A1 (en) 2000-10-11 2002-05-02 Sander G. Mills Pyrrolidine modulators of ccr5 chemokine receptor activity
NZ533567A (en) 2001-12-28 2007-06-29 Acadia Pharm Inc Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
AU2003301095A1 (en) 2002-12-23 2004-07-22 Merck And Co., Inc. 4(spiropiperidinyl)methyl substituted pyrrolidines as modulators of chemokine receptor activity
AU2003301197A1 (en) 2002-12-23 2004-07-22 Merck And Co., Inc. 4-((4-(carboxyethyl) piperidinyl) methyl) pyrrolidines as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
CA2579608A1 (en) 2005-03-17
EP1786815A1 (de) 2007-05-23
WO2005023809A1 (en) 2005-03-17
US7288548B2 (en) 2007-10-30
EP1786815A4 (de) 2009-03-18
EP1786815B1 (de) 2011-08-24
US20050070563A1 (en) 2005-03-31

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