ATE523788T1 - ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN - Google Patents

ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN

Info

Publication number
ATE523788T1
ATE523788T1 AT06011829T AT06011829T ATE523788T1 AT E523788 T1 ATE523788 T1 AT E523788T1 AT 06011829 T AT06011829 T AT 06011829T AT 06011829 T AT06011829 T AT 06011829T AT E523788 T1 ATE523788 T1 AT E523788T1
Authority
AT
Austria
Prior art keywords
ratio
alzheimer
diagnosis
determination
secretase
Prior art date
Application number
AT06011829T
Other languages
English (en)
Inventor
Gerd Multhaup
Lisa Muenter
Original Assignee
Fu Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fu Berlin filed Critical Fu Berlin
Application granted granted Critical
Publication of ATE523788T1 publication Critical patent/ATE523788T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
AT06011829T 2006-06-08 2006-06-08 ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN ATE523788T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06011829A EP1865326B1 (de) 2006-06-08 2006-06-08 Assay zur Diagnose von Alzheimer basierend auf der Bestimmung des Verhältnisses von Sekretase-Aß-Spaltprodukten

Publications (1)

Publication Number Publication Date
ATE523788T1 true ATE523788T1 (de) 2011-09-15

Family

ID=36922150

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06011829T ATE523788T1 (de) 2006-06-08 2006-06-08 ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN

Country Status (6)

Country Link
US (1) US20100221759A1 (de)
EP (2) EP1865326B1 (de)
CN (1) CN101460853A (de)
AT (1) ATE523788T1 (de)
ES (1) ES2373048T3 (de)
WO (1) WO2007140843A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003063693A2 (en) * 2002-01-31 2003-08-07 Expressive Constructs, Inc. Method for detecting microorganisms
CA2669848A1 (en) * 2006-11-17 2008-05-22 Friedrich-Alexander-Universitaet Erlangen-Nuernberg Method of differentially diagnosing dementias
WO2008148098A2 (en) * 2007-05-24 2008-12-04 University Of Rochester Detection of fragments of nectin-1 for the diagnosis of alzheimer's disease
KR101682728B1 (ko) * 2008-07-31 2016-12-05 프로비오드룩 아게 신경변성 질환에 대한 진단적/예후적 지표로서 글루타미닐 사이클라제
EP2344881A4 (de) * 2008-09-26 2012-03-07 Univ Melbourne Biomarker für morbus alzheimer
DE102009054057A1 (de) * 2009-11-20 2011-05-26 Charité - Universitätsmedizin Berlin (Charité) Screening-Verfahren für Wirkstoffe für die Prophylaxe und Therapie neurodegenerativer Erkrankungen
EP2511296A1 (de) 2011-04-12 2012-10-17 Araclón Biotech, S. L. Antikörper, Kit und Verfahren zur Bestimmung von Amyloidpeptiden
US9678086B2 (en) 2012-09-10 2017-06-13 The Johns Hopkins University Diagnostic assay for Alzheimer's disease
ES2498465B1 (es) * 2013-02-20 2015-09-17 Universidad Miguel Hernández De Elche Método de diagnóstico y/o pronóstico de la enfermedad de alzheimer
ES2874704T3 (es) * 2013-11-20 2021-11-05 Univ Iowa Res Found Procedimiento para monitorizar la eficacia de un tratamiento de la enfermedad de Alzheimer con una isoforma de ApoE
CN106574930B (zh) 2014-05-22 2019-09-03 株式会社岛津制作所 评价脑内的淀粉样蛋白β肽蓄积状态的替代性生物标记物和其分析方法
CN105002172B (zh) * 2015-07-31 2017-07-11 北京泱深生物信息技术有限公司 检测eapp基因表达的试剂在诊治阿尔茨海默病中的应用
US20240003918A1 (en) 2020-11-30 2024-01-04 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021589A1 (en) * 1996-11-15 1998-05-22 The Trustees Of The University Of Pennsylvania Screening for modulators of amyloid processing
NZ510708A (en) * 1998-09-24 2003-12-19 Upjohn Co Alzheimer's disease and Asp1 and Asp2 cleaving APP site (beta secretase)
EP1297132A1 (de) * 2000-07-06 2003-04-02 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Eine weitere app mutation, die mit einer ungewöhnliche alzheimerkrankheitspathologie verbunden ist
CA2451795A1 (en) * 2001-06-26 2003-01-09 Paul M. Mathews Cell-based high-throughput screening methods
WO2003040183A2 (en) * 2001-11-09 2003-05-15 The Genetics Company, Inc Compounds for the diagnosis/prevention/treatment of alzheimer's disease
WO2003103593A2 (en) * 2002-06-05 2003-12-18 Buck Institute Secretases related to alzheimer's dementia
DE602005010241D1 (de) * 2004-05-24 2008-11-20 Univ Muenchen L Maximilians Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis

Also Published As

Publication number Publication date
WO2007140843A3 (en) 2008-04-24
EP1865326B1 (de) 2011-09-07
WO2007140843A2 (en) 2007-12-13
EP1865326A1 (de) 2007-12-12
CN101460853A (zh) 2009-06-17
ES2373048T3 (es) 2012-01-30
EP2032990A2 (de) 2009-03-11
US20100221759A1 (en) 2010-09-02

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