ATE524458T1 - Als p2x7-rezeptor-antagonist wirkendes chinolinderivat - Google Patents

Als p2x7-rezeptor-antagonist wirkendes chinolinderivat

Info

Publication number
ATE524458T1
ATE524458T1 AT08855156T AT08855156T ATE524458T1 AT E524458 T1 ATE524458 T1 AT E524458T1 AT 08855156 T AT08855156 T AT 08855156T AT 08855156 T AT08855156 T AT 08855156T AT E524458 T1 ATE524458 T1 AT E524458T1
Authority
AT
Austria
Prior art keywords
receptor antagonist
quinoline derivative
derivative acting
acting
quinoline
Prior art date
Application number
AT08855156T
Other languages
English (en)
Inventor
Simon Guile
Toby Thompson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE524458T1 publication Critical patent/ATE524458T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
AT08855156T 2007-11-30 2008-11-28 Als p2x7-rezeptor-antagonist wirkendes chinolinderivat ATE524458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99126507P 2007-11-30 2007-11-30
PCT/SE2008/051370 WO2009070116A1 (en) 2007-11-30 2008-11-28 A quinoline derivative acting as a p2x7-receptor antagonist

Publications (1)

Publication Number Publication Date
ATE524458T1 true ATE524458T1 (de) 2011-09-15

Family

ID=40676391

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08855156T ATE524458T1 (de) 2007-11-30 2008-11-28 Als p2x7-rezeptor-antagonist wirkendes chinolinderivat

Country Status (9)

Country Link
US (1) US8106073B2 (de)
EP (1) EP2225222B1 (de)
JP (1) JP2011505356A (de)
AR (1) AR069508A1 (de)
AT (1) ATE524458T1 (de)
ES (1) ES2370960T3 (de)
PE (1) PE20091036A1 (de)
TW (1) TW200932229A (de)
WO (1) WO2009070116A1 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091225A1 (es) * 2007-03-22 2009-09-16 Astrazeneca Ab Derivados de quinolina como antagonistas del receptor p2x7
PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7
BR112012014180A2 (pt) * 2009-12-17 2015-09-15 Merck Sharp & Dohme composto, composição farmacêutica, uso da composição farmacêutica, e, método para tratar uma doença ou em distúrbio.
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
KR101995088B1 (ko) 2011-07-22 2019-07-02 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
MX336247B (es) 2012-01-20 2016-01-13 Actelion Pharmaceuticals Ltd Derivados de amida heterociclicos como antagonistas del receptor p2x7.
US9718774B2 (en) 2012-12-12 2017-08-01 Idorsia Pharmaceuticals Ltd Indole carboxamide derivatives as P2X7 receptor antagonist
AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
EP2956135B1 (de) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Heterocyclische amidderivate als p2x7-rezeptorantagonisten
KR102220847B1 (ko) 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
JP6692759B2 (ja) * 2014-06-05 2020-05-13 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 新規キノリン誘導体及び神経変性疾患におけるそれらの使用
EP3962493A2 (de) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Verfahren zur modulation der immunreaktivität/konzentration von irf oder sting oder zur behandlung von krebs mit der verabreichung eines sting-modulators und/oder eines purinergischen rezeptormodulators oder eines postzellularen signalisierungsfaktors

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IL53441A0 (en) 1977-11-22 1978-01-31 Teva Pharma Methyladamantyl hydrazines their preparation and pharmaceutical compositions containing them
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EP2225222B1 (de) 2011-09-14
WO2009070116A1 (en) 2009-06-04
US20090143428A1 (en) 2009-06-04
EP2225222A1 (de) 2010-09-08
PE20091036A1 (es) 2009-08-15
TW200932229A (en) 2009-08-01
US8106073B2 (en) 2012-01-31
ES2370960T3 (es) 2011-12-26
HK1148002A1 (en) 2011-08-26
JP2011505356A (ja) 2011-02-24
AR069508A1 (es) 2010-01-27

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